journal
Journals Drug Design, Development and T...

Drug Design, Development and Therapy

https://read.qxmd.com/read/38707614/network-and-experimental-pharmacology-on-mechanism-of-yixintai-regulates-the-tmao-pkc-nf-%C3%AE%C2%BAb-signaling-pathway-in-treating-heart-failure
#21
JOURNAL ARTICLE
Ziyan Wang, Chengxin Liu, Jiaming Wei, Hui Yuan, Min Shi, Fei Zhang, Qinghua Zeng, Aisi Huang, Lixin Du, Ya Li, Zhihua Guo
OBJECTIVE: This study aims to explore the mechanism of action of Yixintai in treating chronic ischemic heart failure by combining bioinformatics and experimental validation. MATERIALS AND METHODS: Five potential drugs for treating heart failure were obtained from Yixintai (YXT) through early mass spectrometry detection. The targets of YXT for treating heart failure were obtained by a search of online databases. Gene ontology (GO) functional enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were conducted on the common targets using the DAVID database...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38707613/dose-response-study-of-phenylephrine-for-preventing-spinal-induced-hypotension-during-cesarean-delivery-with-combined-spinal-epidural-anesthesia-under-the-effect-of-prophylactic-intravenous-ondansetron
#22
RANDOMIZED CONTROLLED TRIAL
Xiao-Xia Sun, Jing Qian, Jia-Ming Fan, Lin Liu, Xia-Fang Jin, Fei Xiao
BACKGROUND: Ondansetron reduces the median effective dose (ED50) of prophylactic phenylephrine to prevent spinal-induced hypotension (SIH) during cesarean delivery. However, the exact dose response of phenylephrine in combination with prophylactic ondansetron for preventing SIH is unknown. Therefore, this study aimed to determine the dose-response of phenylephrine to prevent SIH in cesarean delivery when 4 mg of ondansetron was used as a preventive method. METHODS: A total of 80 parturients were enrolled and divided randomly into four groups (n = 20 in each group) who received either 0...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38707612/the-molecular-biological-mechanism-of-hydrogen-therapy-and-its-application-in-spinal-cord-injury
#23
REVIEW
Quan Hu, Yingxiao Li, Zhaochen Lin, Hao Zhang, Haoyue Chen, Cui Chao, Chuanliang Zhao
Hydrogen, which is a novel biomedical molecule, is currently the subject of extensive research involving animal experiments and in vitro cell experiments, and it is gradually being applied in clinical settings. Hydrogen has been proven to possess anti-inflammatory, selective antioxidant, and antiapoptotic effects, thus exhibiting considerable protective effects in various diseases. In recent years, several studies have provided preliminary evidence for the protective effects of hydrogen on spinal cord injury (SCI)...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38689609/research-progress-of-long-non-coding-rna-in-tumor-drug-resistance-a-new-paradigm
#24
REVIEW
Jing Zhang, Le Wu, Chenchen Wang, Xin Xie, Yuying Han
In the past few decades, chemotherapy has been one of the most effective cancer treatment options. Drug resistance is currently one of the greatest obstacles to effective cancer treatment. Even though drug resistance mechanisms have been extensively investigated, they have not been fully elucidated. Recent genome-wide investigations have revealed the existence of a substantial quantity of long non-coding RNAs (lncRNAs) transcribed from the human genome, which actively participate in numerous biological processes, such as transcription, splicing, epigenetics, the cell cycle, cell differentiation, development, pluripotency, immune microenvironment...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38681210/dynasore-alleviates-lps-induced-acute-lung-injury-by-inhibiting-nlrp3-inflammasome-mediated-pyroptosis
#25
JOURNAL ARTICLE
Mengtian Shan, Huimin Wan, Linyu Ran, Jihui Ye, Wang Xie, Jingjing Lu, Xueping Hu, Shengjie Deng, Wenyu Zhang, Miao Chen, Feilong Wang, Zhongliang Guo
BACKGROUND: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe respiratory disorders without available pharmacological therapies. Dynasore is a cell-permeable molecule that inhibits GTPase activity and exerts protective effects in several disease models. However, whether dynasore can alleviate lipopolysaccharide (LPS)-induced ALI is unknown. This study investigated the effect of dynasore on macrophage activation and explored its potential mechanisms in LPS-induced ALI in vitro and in vivo...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38681209/the-median-effective-dose-of-intrathecal-hyperbaric-bupivacaine-for-cesarean-section-at-moderately-high-altitude
#26
JOURNAL ARTICLE
Chen Yang, Wangjun Dong, Jianbo Luo, Mengzhao Ma, Yeyue Gao, Lijie Ni, Huixing Liu, Chengjun Cha, Yangli Xiao, Shaoqiang Huang
OBJECTIVE: Alterations in altitude can lead to an augmented requirement for local anesthesia among patients. Nevertheless, the necessity for an elevated dosage of local anesthetic for parturients at moderately high altitudes during spinal anesthesia for cesarean section remains uninvestigated. This up-down sequential study endeavors to determine the ED50 dose of bupivacaine required for spinal anesthesia during cesarean sections at moderately high-altitude. METHODS: Thirty singleton parturients at moderately high altitude underwent elective cesarean section under combined spinal-epidural anesthesia...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38681208/propofol-and-dexmedetomidine-ameliorate-endotoxemia-associated-encephalopathy-via-inhibiting-ferroptosis
#27
JOURNAL ARTICLE
Ye Zhou, Yangliang Yang, Liang Yi, Mengzhi Pan, Weiqing Tang, Hongwei Duan
BACKGROUND: Sepsis is recognized as a multiorgan and systemic damage caused by dysregulated host response to infection. Its acute systemic inflammatory response highly resembles that of lipopolysaccharide (LPS)-induced endotoxemia. Propofol and dexmedetomidine are two commonly used sedatives for mechanical ventilation in critically ill patients and have been reported to alleviate cognitive impairment in many diseases. In this study, we aimed to explore and compare the effects of propofol and dexmedetomidine on the encephalopathy induced by endotoxemia and to investigate whether ferroptosis is involved, finally providing experimental evidence for multi-drug combination in septic sedation...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38681207/rna-based-antipsoriatic-gene-therapy-an-updated-review-focusing-on-evidence-from-animal-models
#28
REVIEW
Zih-Chan Lin, Chi-Feng Hung, Ibrahim A Aljuffali, Ming-Hsien Lin, Jia-You Fang
Psoriasis presents as a complex genetic skin disorder, characterized by the interaction between infiltrated immune cells and keratinocytes. Substantial progress has been made in understanding the molecular mechanisms of both coding and non-coding genes, which has positively impacted clinical treatment approaches. Despite extensive research into the genetic aspects of psoriasis pathogenesis, fully grasping its epigenetic component remains a challenging endeavor. In response to the pressing demand for innovative treatments to alleviate inflammatory skin disorders, various novel strategies are under consideration...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38681206/validation-of-core-ingredients-and-molecular-mechanism-of-cinobufotalin-injection-against-liver-cancer
#29
JOURNAL ARTICLE
Shipeng Chen, Mengna Li, Changning Xue, Xiangting Zhou, Jianxia Wei, Lemei Zheng, Yumei Duan, Hongyu Deng, Faqing Tang, Wei Xiong, Bo Xiang, Ming Zhou
PURPOSE: Cinobufotalin injection has obvious curative effects on liver cancer patients with less toxicity and fewer side effects than other therapeutic approaches. However, the core ingredients and mechanism underlying these anti-liver cancer effects have not been fully clarified due to its complex composition. METHODS: Multidimensional network analysis was used to screen the core ingredients, key targets and pathways underlying the therapeutic effects of cinobufotalin injection on liver cancer, and in vitro and in vivo experiments were performed to confirm the findings...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38681205/effect-of-fluid-therapy-in-early-morning-on-the-incidence-of-post-induction-hypotension-during-non-cardiac-surgery-after-noon-a-single-center-retrospective-study
#30
JOURNAL ARTICLE
Ying Zhang, Xinxin Wang, Xiaoqiao Sang, Zhou Zhou, Guangrong Dai, Xiaobao Zhang
PURPOSE: Post-induction hypotension (PIH) is a common clinical phenomenon linked to increased morbidity and mortality in various non-cardiac surgeries. Patients with surgery in the afternoon may have preoperative hypovolemia caused by prolonged fasting and dehydration, which increases the risk of hypotension during the induction period. However, studies on the fluid therapy in early morning combating PIH remain inadequate. Therefore, we aimed to investigate the influence of prophylactic high-volume fluid in the early morning of the operation day on the incidence of PIH during non-cardiac surgery after noon...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38681204/natural-and-synthetic-drugs-approached-for-the-treatment-of-recurrent-aphthous-stomatitis-over-the-last-decade
#31
REVIEW
Cszahreyloren Vitamia, Ghina Nadhifah Iftinan, Irma Rahayu Latarissa, Gofarana Wilar, Arief Cahyanto, Khaled M Elamin, Nasrul Wathoni
Recurrent aphthous stomatitis (RAS) refers to a sore and frequently recurring inflammation of the oral tissues, distinguished by the presence of small ulcers that cause significant discomfort and cannot be attributed to any underlying disease. Different treatments have been used for RAS. This review aims to provide a comprehensive overview of the treatment options over the past decade for recurrent aphthous stomatitis (RAS), encompassing both natural and synthetic treatments. It will utilize clinical efficacy studies conducted in vivo and in vitro, along with a focus on the pharmaceutical approach through advancements in drug delivery development...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38654923/cinnamaldehyde-inhibits-the-function-of-osteosarcoma-by-suppressing-the-wnt-%C3%AE-catenin-and-pi3k-akt-signaling-pathways-retraction
#32
(no author information available yet)
[This retracts the article DOI: 10.2147/DDDT.S277160.].
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38651136/obacunone-alleviates-inflammatory-pain-by-promoting-m2-microglial-polarization-and-by-activating-nrf2-ho-1-signaling-pathway
#33
JOURNAL ARTICLE
Fubei Nan, Qingxin Tian, Shuangdong Chen
BACKGROUND: Treating inflammatory pain (IP) continues to pose clinical challenge, because of the lack of effective pharmacological interventions. Microglial polarization serves as pivotal determinant in IP progress. Obacunone (OB), a low-molecular-weight compound with a diverse array of biological functions, having reported as an activator of nuclear factor E2-related factor 2 (Nrf2), exhibits anti-inflammatory property. However, it remains uncertain whether OB can alleviate IP by facilitating the transition of microglial polarization from the M1 to M2 state through modulating Nrf2/ heme oxygenase-1 (HO-1) pathway...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38645991/dexamethasone-versus-dexmedetomidine-as-adjuvants-in-ultrasound-popliteal-sciatic-nerve-block-for-hallux-valgus-surgery-a-mono-centric-retrospective-comparative-study
#34
COMPARATIVE STUDY
Antonio Coviello, Carmine Iacovazzo, Dario Cirillo, Alessio Bernasconi, Annachiara Marra, Francesco Squillacioti, Marco Martone, Eleonora Garone, Filomena Coppola, Andrea Uriel de Siena, Maria Vargas, Giuseppe Servillo
BACKGROUND AND AIM: Ultrasound popliteal sciatic nerve block (UPSNB) is commonly performed in foot and ankle surgery. This study aims to assess the use of dexmedetomidine and dexamethasone as adjuvants in UPSNB for hallux valgus (HV) surgery, comparing their efficacy in producing motor and sensory block and controlling postoperative pain. The adverse event rate was also evaluated. METHODS: This mono-centric retrospective study included 62 adult patients undergoing HV surgery: 30 patients received lidocaine 2% 200 mg, ropivacaine 0...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38645990/effect-of-s-ketamine-on-postoperative-nausea-and-vomiting-in-patients-undergoing-video-assisted-thoracic-surgery-a-randomized-controlled-trial
#35
RANDOMIZED CONTROLLED TRIAL
Yu Qi, Meiyan Zhou, Wenting Zheng, Yaqi Dong, Weihua Li, Long Wang, Haijun Xu, Miao Zhang, Dunpeng Yang, Liwei Wang, Hai Zhou
PURPOSE: Postoperative nausea and vomiting (PONV) frequently occur in patients after surgery. In this study, the authors investigated whether perioperative S-ketamine infusion could decrease the incidence of PONV in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy. PATIENTS AND METHODS: This prospective, randomized, double-blinded, controlled study was conducted a total of 420 patients from September 2021 to May 2023 at Xuzhou Central Hospital in China, who underwent elective VATS lobectomy under general anesthesia with tracheal intubation...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38645989/network-pharmacology-and-molecular-docking-identify-the-potential-mechanism-and-therapeutic-role-of-scutellaria-baicalensis-in-alzheimer-s-disease
#36
JOURNAL ARTICLE
Yutao Peng, Chanjuan Zhou
AIM: Scutellaria baicalensis , a traditional Chinese medicinal herb renowned for its anti-inflammatory, antioxidant, and anti-tumor properties, has shown promise in alleviating cognitive impairment associated with Alzheimer's disease. Nonetheless, the exact neuroprotective mechanism of Scutellaria baicalensis against Alzheimer's disease remains unclear. In this study, network pharmacology was employed to explore the possible mechanisms by which Scutellaria baicalensis protects against Alzheimer's disease...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38645988/sinomenine-hydrochloride-protects-iga-nephropathy-through-regulating-cell-growth-and-apoptosis-of-t-and-b-lymphocytes
#37
JOURNAL ARTICLE
Jun-Jian Li, Li Li, Shuang Li, Xin-Yi Tang, Hui-Feng Sun, Jian-Xin Liu
PURPOSE: Sinomenine hydrochloride (SH) is used to treat chronic inflammatory diseases such as rheumatoid arthritis and may also be efficacious against Immunoglobulin A nephropathy (IgAN). However, no trial has investigated the molecular mechanism of SH on IgAN. Therefore, this study aims to investigate the effect and mechanism of SH on IgAN. METHODS: The pathological changes and IgA and C3 depositions in the kidney of an IgAN rat model were detected by periodic acid-Schiff (PAS) and direct immunofluorescence staining...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38645987/clinical-application-and-research-progress-of-remimazolam-for-pediatric-patients
#38
REVIEW
Chen Bai, Mingcan Xu, Yan Guo, Yanwu Jin, Xin Zhao
Remimazolam is a novel ultrashort-acting benzodiazepine that allosterically modulates γ-aminobutyric acid type A (GABAA) receptors to exert sedative effects. Remimazolam has the properties of controllable sedation, rapid onset, and a short duration of action, along with minor depression of circulation and respiration. Remimazolam has been approved for clinical use since 2020 in Japan, and it has been applied for procedural sedation, general anesthesia induction and maintenance, and sedation in ICU patients, and has been proven to be safe and effective...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38645986/a-novel-network-pharmacology-strategy-based-on-the-universal-effectiveness-common-mechanism-of-medical-herbs-uncovers-therapeutic-targets-in-traumatic-brain-injury
#39
JOURNAL ARTICLE
Zhe Yu, Ruoqi Ding, Qiuju Yan, Menghan Cheng, Teng Li, Fei Zheng, Lin Zhu, Yang Wang, Tao Tang, En Hu
PURPOSE: Many herbs can promote neurological recovery following traumatic brain injury (TBI). There must lie a shared mechanism behind the common effectiveness. We aimed to explore the key therapeutic targets for TBI based on the common effectiveness of the medicinal plants. MATERIAL AND METHODS: The TBI-effective herbs were retrieved from the literature as imputes of network pharmacology. Then, the active ingredients in at least two herbs were screened out as common components...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38623566/citric-acid-controls-the-activity-of-yoph-bacterial-tyrosine-phosphatase
#40
JOURNAL ARTICLE
Joanna Styszko, Tomasz Kostrzewa, Magdalena Gorska-Ponikowska, Alicja Kuban-Jankowska
PURPOSE: Citric acid (CA) is a tricarboxylic acid with antioxidant and antimicrobial properties. Based on previous studies, the small compound with its three carboxylic groups can be considered a protein tyrosine phosphatase inhibitor. YopH, a protein tyrosine phosphatase, is an essential virulence factor in Yersinia bacteria. MATERIALS AND METHODS: We performed enzymatic activity assays of YopH phosphatase after treatment with citric acid in comparison with the inhibitory compound trimesic acid, which has a similar structure...
2024: Drug Design, Development and Therapy
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