journal
Journals Gastroenterology Research and ...

Gastroenterology Research and Practice

https://read.qxmd.com/read/35935715/efficacy-and-safety-of-exploring-deeper-sections-of-the-infrapapillary-area-of-the-duodenum-by-using-sedative-esophagogastroduodenoscopy
#61
JOURNAL ARTICLE
Ming-Tse Hsu, Chi-Yi Chen, Kai-Sheng Liao, Wei-Sheng Chung
Background: Using conventional esophagogastroduodenoscopy (EGD) to evaluate the infrapapillary area is not feasible. The use of sedative EGD may enable endoscopists to investigate the infrapapillary condition of the duodenum. In this study, we aimed to evaluate lesions in the infrapapillary regions by using sedative EGD. Methods: In this retrospective observational study, we used the data of patients who underwent sedative EGD examinations at a tertiary hospital in southern Taiwan...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35935714/exploring-different-effects-of-exclusive-enteral-nutrition-een-and-corticosteroids-on-the-gut-microbiome-in-crohn-s-disease-based-on-a-three-stage-strategy
#62
JOURNAL ARTICLE
Dong Guo, Liang Fang, Ruiqing Liu, Yu Li, Liang Lv, Zhaojiao Niu, Dong Chen, Yanbing Zhou, Weiming Zhu
The objective of this study was to compare the efficacy of exclusive enteral nutrition (EEN) and corticosteroids on the gut microbiome in Crohn's disease. Methods . Data were collected for 16 patients newly diagnosed with CD as the test group and 10 healthy volunteers as the control group. The 16 patients were randomly divided into the EEN group and the corticosteroids group. For subsequent analysis, 6 patients in the EEN group with follow-up were enrolled to compare the 0-month, 1-month, and 3-month outcomes...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35911080/acute-pancreatitis-and-recurrent-acute-pancreatitis-in-children-a-10-year-retrospective-study
#63
JOURNAL ARTICLE
Chaohui Wang, Bao Fu, De Su, Ping Huang, Xiaoyun Fu
AIM: To compare the clinical characteristics of acute pancreatitis (AP) and recurrent acute pancreatitis (ARP) in children. METHOD: From January 2011 to January 2021, a total of 275 pediatric patients with AP admitted to a tertiary teaching hospital were enrolled. RESULTS: The median age of 275 children was 12.0 years. Among them, 55 cases were ARP. The leading causes of pediatric pancreatitis were biliary tract and virus infection. The percent of male in the AP group was higher than that in the ARP group...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35873353/magnifying-chromoendoscopy-with-flexible-spectral-imaging-color-enhancement-indigo-carmine-and-crystal-violet-in-predicting-the-histopathology-of-colorectal-polyps-diagnostic-value-in-a-scare-setting-resource
#64
JOURNAL ARTICLE
Nguyen Binh Pham, Khanh Truong Vu, Nam Hoai Nguyen, Ha Thi-Ngoc Doan, Thanh Trung Tran
Background and Aims: Virtual magnifying chromoendoscopy with flexible spectral imaging color enhancement (FICE), image-enhanced endoscopy techniques, and dye-staining magnifying chromoendoscopy (with Indigo carmine and Crystal violet) have contributed to better visualization of the pit pattern and vascular structure of colorectal polyp. Therefore, magnifying chromoendoscopy is capable of predicting the histopathological results of colorectal polyp without biopsy and remains their diagnostic values over time, especially in scare-setting resources...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35873352/effects-of-autologous-platelet-rich-plasma-on-healing-of-peptic-ulcers-a-randomized-controlled-trial
#65
JOURNAL ARTICLE
Ting Xu, Yin Tian, Yi Wang, Zhongmei Yi, Chenchen Li, Shichun Wang, Yahan Fan, Chunyan Yao, Guiyong Peng, Hua Lu
Purpose: Peptic ulcer is a multifactorial and complex disease and affects a wide range of people worldwide. We provided a novel therapeutic approach for peptic ulcer and observed its effect. Methods: Peptic ulcer patients were enrolled from 2016 to 2017 in Chongqing and randomly assigned to two groups: a control group that used only rabeprazole and a platelet-rich plasma (PRP) group that received a combination therapy of autologous PRP (aPRP) and rabeprazole. The therapeutic effect was assessed via the ulcer size and symptom score...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35844837/differential-expression-profiles-of-mrna-and-noncoding-rna-and-analysis-of-competitive-endogenous-rna-regulatory-networks-in-nonalcoholic-steatohepatitis
#66
JOURNAL ARTICLE
Mengjia Gao, Jingxin Xin, Xiaoling Li, Ling Gao, Shanshan Shao, Meng Zhao
Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct a circRNA-miRNA-mRNA regulatory network. On this basis, a total of 38 circRNAs, 7 miRNAs, and 10 mRNAs were screened out...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35837663/prediction-of-prognosis-in-patients-with-hepatocellular-carcinoma-based-on-molecular-subtypes-of-immune-genes
#67
JOURNAL ARTICLE
Suming Du, Jinhui Xu, Jiajia Shen, Xiaojin Zhang, Huanzhang Hu, Xinghua Huang
For those patients with hepatocellular carcinoma (HCC), it is really a heavy burden. Herein, the immune genes of HCC were analyzed in groups to determine prognostic biomarkers related to immune genes in HCC. The mRNA data, clinical data in TCGA-LIHC dataset, and immune gene in the ImmPort database were collected for the combining usage with K -means concordance clustering to cluster HCC patients according to the immune gene matrix. Based on ssGSEA analysis result, HCC patients were sorted into high- and low-immune subtypes, and survival curve presented that patients in high-immune subtypes had a better prognosis...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35795381/baseline-serum-estradiol-level-is-associated-with-acute-kidney-injury-in-patients-with-moderately-severe-and-severe-acute-pancreatitis
#68
JOURNAL ARTICLE
Jia-Jia Pan, Wei-Li Liu, Guo-Tao Lu, Xing-Jie Ma, Qing-Bin Zheng, Guang-Fa Wei, Ge-Yan Tian, Li-Jun Meng
Background: Sexual dimorphism with critical diseases has been documented. However, the role of serum sex hormones for the presence of acute kidney injury (AKI) in moderately or severe acute pancreatitis (MSAP and SAP) patients remains controversial. Here we set out to evaluate whether early (first 48 h) serum estradiol level is associated with AKI in patients with MSAP and SAP. Patients and Methods . We retrospectively collected data from patients with preliminary diagnosis of MSAP and SAP from the Affiliated Hospital of Yangzhou University between January 2014 and June 2018...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35782337/research-progress-on-the-mechanism-of-acupuncture-treatment-for-nonalcoholic-fatty-liver-disease
#69
REVIEW
Bai Li, Li Fang
Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease worldwide, ranging from simple steatosis and nonalcoholic steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. Acupuncture is a long-established treatment in traditional Chinese medicine. In recent years, increasing evidence has pointed to the effectiveness of acupuncture in the treatment of NAFLD, and a certain degree of progress has been made in the study of related mechanisms. However, previous systematic reviews have not discussed the characteristics and the related mechanisms of acupuncture in the treatment of NAFLD...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35761833/on-the-association-between-gastrointestinal-symptoms-and-extragastric-manifestations
#70
JOURNAL ARTICLE
G Naoum, S L Markantonis, E Fanerou, G Siagkas, F Petropoulos, E Zafiris, R Kousovista, V Karalis
The aim of this study was to investigate the relationship between gastrointestinal (GI) symptoms and extragastric manifestations such as headache, fatigue, and dizziness. A prospective cohort study was conducted in a tertiary hospital in Athens, where patients with GI problems and extragastric symptoms were treated only for their GI problems, and improvement in extragastric manifestations was recorded. Inclusion criteria were an age older than 18 years, the presence of at least one of the three extragastric symptoms investigated in this study (headache, dizziness, and fatigue), and the concomitant presence of at least one gastrointestinal symptom (e...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35756502/gel-immersion-endoscopic-mucosal-resection-emr-for-superficial-nonampullary-duodenal-epithelial-tumors-may-reduce-procedure-time-compared-with-underwater-emr-with-video
#71
JOURNAL ARTICLE
Takeshi Yamashina, Masaaki Shimatani, Yu Takahashi, Masahiro Takeo, Natsuko Saito, Hironao Matsumoto, Takeshi Kasai, Masataka Kano, Kimi Sumimoto, Toshiyuki Mitsuyama, Hiroyuki Marusawa, Akiyoshi Nishio, Takafumi Yuba, Toshihito Seki, Makoto Naganuma
Materials and Methods: This was a retrospective cohort study conducted in two municipal hospitals. We identified 24 patients with SNADETs of 3-18 mm in diameter who underwent UEMR or GIEMR. One lesion was excluded from the analysis because it was found to be in the stomach after surgery. The primary outcome was procedure time. Results: GIEMR significantly reduced the procedure time compared with UEMR (5 min vs. 10 min, P = 0.016). There was no significant difference between the UEMR and GIEMR groups for en bloc resection rate (93% vs...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35747248/identification-and-validation-of-a-novel-immune-infiltration-based-diagnostic-score-for-early-detection-of-hepatocellular-carcinoma-by-machine-learning-strategies
#72
JOURNAL ARTICLE
Xuli Guo, Hailin Xiong, Shaoting Dong, Xiaobing Wei
Objective: To investigate the diagnostic gene biomarkers for hepatocellular carcinoma (HCC) and identify the immune cell infiltration characteristics in this pathology. Methods: Five gene expression datasets were obtained through Gene Expression Omnibus (GEO) portal. After batch effect removal, differentially expressed genes (DEGs) were conducted between 209 HCC and 146 control tissues and functional correlation analyses were performed. Two machine learning algorithms were used to develop diagnostic signatures...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35721824/acute-pancreatitis-in-pregnancy-a-ten-year-noninterventional-retrospective-cohort-experience
#73
JOURNAL ARTICLE
Zhao Haiyan, Peng Na, He Jialin, Lv Qingjian, Bai Jianying, Bai Xiumei
BACKGROUND: The study is aimed at evaluating the clinical attributes, types, and risk factors associated with poor outcomes in women with acute pancreatitis (AP) during pregnancy. METHODS: From 2011 to 2020, 45 antenatal mothers with AP were included in this noninterventional, retrospective study. The correlation between etiology of AP, its severity, biochemical parameters, length of stay, and treatment was analyzed. Based on the presence of organ failure and systemic complications, the severity of AP was classified according to the revised Atlantic criteria...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35721823/effect-of-coffee-consumption-on-postoperative-ileus-after-colorectal-surgery-a-meta-analysis-of-randomized-controlled-trials
#74
REVIEW
Junjia Zhu, Wenlong Xu, Qi Sun, Jun Geng, Yifeng Yu, Zhenguo Zhao
Background: Postoperative ileus (POI) is an important complication after elective colorectal surgery, which prolongs hospital stay and increases hospital costs. Coffee has been reported to be beneficial for the recovery of gastrointestinal function. We aimed to investigate the effectiveness of coffee consumption in the treatment of POI, following elective colorectal surgery. Methods: A comprehensive literature search for medical subject heading (MeSH) terms, including coffee, caffeine, colon, rectum, and colorectal surgery was conducted in PubMed, Embase, and Cochrane Library until November 2021...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35721822/the-effect-and-related-mechanism-of-action-of-astragalus-compatible-with-curcumin-against-colon-cancer-metastasis-in-mice
#75
JOURNAL ARTICLE
Jiafei Wu, Decai Tang
Colon cancer (CC) is the third most common tumor worldwide. Colon carcinogenesis is strongly linked to inflammation. The initiation and progression of colon cancer may be influenced by epigenetic processes. Cancer metastasis is a multistep process involving several genes and their products. During tumor metastasis, cancer cells first enhance their proliferative capacity by lowering autophagy and apoptosis, and then, their capacity is stimulated by boosting tumors' ability to take nutrients from the outside via angiogenesis...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35693325/risk-factors-of-early-liver-metastasis-for-pancreatic-ductal-adenocarcinoma-after-radical-resection
#76
JOURNAL ARTICLE
Jingshu Tong, Shengdong Wu, Changjiang Lu, Yong Yang, Shuqi Mao, Caide Lu
Background: Liver metastasis arises in many postoperative patients with PDAC, occurring in the early stage appears to lead to a very poor prognosis. Objective: We aimed to analyze the risk factors for early liver metastasis after radical resection for patients with pancreatic ductal adenocarcinoma (PDAC) and to indicate the poor prognosis of early liver metastasis. Methods: Patients who underwent pancreatectomy for PDAC at the Ningbo Medical Centre Lihuili Hospital between January 2015 and June 2021 were included...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35677724/expression-of-trp-channels-in-colonic-mucosa-of-ibs-d-patients-and-its-correlation-with-the-severity-of-the-disease
#77
JOURNAL ARTICLE
Li Cheng, Qing-Qing Luo, Sheng-Liang Chen
Aim: Lots of researches have endeavored to elucidate the pathogenetic mechanism of visceral hypersensitivity in order to guide the therapy of diarrhea predominant-irritable bowel syndrome (IBS-D). Transient receptor potential (TRP) channels and their role in visceral nociception have been vastly investigated. We investigated the expression of TRP channels in IBS-D colonic biopsies and its correlation with the severity of the disease. Methods: Sigmoid biopsies were obtained from 34 IBS-D patients and 28 healthy controls (HCs)...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35677723/differentiation-of-isolated-small-bowel-crohn-s-disease-from-other-small-bowel-ulcerative-diseases-clinical-features-and-double-balloon-enteroscopy-characteristics
#78
JOURNAL ARTICLE
Meng Niu, Zheng-Hao Chen, Meng Li, Xing Zhang, Chun-Xiao Chen
Background: The diagnosis of isolated small bowel Crohn's disease (ISBCD) has always been challenging. Aims: This study is aimed at comparing the clinical features and double-balloon enteroscopy (DBE) characteristics of ISBCD with those of other small bowel ulcerative diseases (OSBUD). Methods: Patients with coexisting colonic and/or ileal valve lesions ( n = 45) or whose final diagnosis was not determined ( n = 29) were excluded. One hundred thirty-nine patients with ISBCD and 62 patients with OSBUD found by DBE were retrospectively analyzed...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35663334/a-comparison-of-endoscopic-closure-and-laparoscopic-repair-for-gastric-wall-defection
#79
JOURNAL ARTICLE
Qiao Qiao, Huiming Tu, Bojian Fei, Kebin Xu, Fan Yang, Jie Li, Qizhong Gao
Objective: To compare the effectiveness and safety of endoscopic closure and laparoscopic repair for gastric wall defection. Method: The clinical data of 120 patients with submucosal tumours enrolled at our hospital between January 2014 and December 2019 were retrospectively analysed. Patients were divided into two groups according to the surgery they underwent: an endoscopic closure group ( n = 60) and a laparoscopic repair group ( n = 60). The clinical characteristics, perioperative complications, and postoperative follow-up results of the two groups were analysed...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/35615737/bhlhe41-overexpression-alleviates-the-malignant-behavior-of-colon-cancer-cells-induced-by-hypoxia-via-modulating-hif-1-%C3%AE-emt-pathway
#80
JOURNAL ARTICLE
Sheng Chen, Quan-Jin Dong, Zi-Ang Wan, Shan Gao, Shi-Liang Tu, Rui Chai
Objective: BHLHE41 has been shown to be a marker of tumorigenesis. Colon cancer (CC) is a common malignant tumor of colonic mucosa. This study mainly explored the mechanism of BHLHE41 in alleviating malignant behavior of hypoxia-induced CC cells. Methods: The levels of BHLHE41 in CC and normal cell lines were tested by Western blot and qRT-PCR. After, CC cells were subjected to hypoxia treatment and BHLHE41 overexpression transfection, and the BHLHE41 expression, the effect of BHLHE41 on CC cell viability, apoptosis, migration, and invasion and cell cycle were tested by qRT-PCR and relevant cell functional experiments...
2022: Gastroenterology Research and Practice
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