journal
Journals Gastroenterology Research and ...

Gastroenterology Research and Practice

https://read.qxmd.com/read/37287936/comparison-of-gastric-cancer-risk-classifications-using-conventional-and-new-pepsinogen-criteria
#21
JOURNAL ARTICLE
Tae Sasakabe, Yuki Obata, Sayo Kawai, Yingsong Lin, Shogo Kikuchi
BACKGROUND: New serum pepsinogen (PG) criteria have been shown to indicate more accurately infection with Helicobacter pylori ( H. pylori ). We sought to improve risk classification for gastric cancer by adopting the new PG criteria with the addition of an H. pylori antibody test. METHODS: The study participants were 275 patients with gastric cancer and 275 apparently healthy controls from case-control study data. We cross-sectionally compared the results of gastric cancer risk classifications that were based on a combination of the new PG criteria (PG II ≥ 10 ng/mL or PG I/II ≤ 5) and an H...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/37274947/acupuncture-improved-the-function-of-the-lower-esophageal-sphincter-and-esophageal-motility-in-chinese-patients-with-refractory-gastroesophageal-reflux-disease-symptoms-a-randomized-trial
#22
JOURNAL ARTICLE
Tang Yuming, Zhao Yuping, Lin Yihan, Zhu Ying, Huang Jia, Shen Hanbing, Zou Duowu, Yao Weiyan
OBJECTIVES: Acupuncture is therapeutic for refractory gastroesophageal reflux disease by an unclear mechanism. This study was aimed at investigating the effect of acupuncture on esophageal motility in patients with symptoms of refractory gastroesophageal reflux disease. METHODS: Sixty-eight patients with refractory gastroesophageal reflux disease symptoms were prospectively enrolled from August 2014 to December 2018 and randomized into acupuncture and control groups ( n = 33 and 35, respectively)...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/37197307/risk-of-gastrointestinal-bleeding-in-patients-with-end-stage-renal-disease-the-link-between-gut-heart-and-kidneys
#23
JOURNAL ARTICLE
Avleen Kaur, Syed M Baqir, Kundan Jana, Kalyana C Janga
Patients with end-stage renal disease (ESRD) have a five times higher risk of gastrointestinal bleed (GIB) and mortality than the general population. Aortic stenosis (AS) has been associated with GIB from intestinal angiodysplasia. In this retrospective analysis, we obtained data from the 2012 and 2019 National Inpatient Sample. The primary outcome of interest was all-cause in-hospital mortality and risk factors of mortality in patients with ESRD with GIB with aortic valve disorders especially AS. We identified all patients (≥18 years of age) with ESRD ( n = 1,707,452) and analyzed based on discharge diagnosis of valvular heart disease ( n = 6521) in patients with GIB compared with those without GIB ( n = 116,560)...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/37101782/artificial-intelligence-in-inflammatory-bowel-disease-endoscopy-advanced-development-and-new-horizons
#24
REVIEW
Yu Chang, Zhi Wang, Hai-Bo Sun, Yu-Qin Li, Tong-Yu Tang
Inflammatory bowel disease (IBD) is a complex chronic immune disease with two subtypes: Crohn's disease and ulcerative colitis. Considering the differences in pathogenesis, etiology, clinical presentation, and response to therapy among patients, gastroenterologists mainly rely on endoscopy to diagnose and treat IBD during clinical practice. However, as exemplified by the increasingly comprehensive ulcerative colitis endoscopic scoring system, the endoscopic diagnosis, evaluation, and treatment of IBD still rely on the subjective manipulation and judgment of endoscopists...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/37065685/endoscopic-screening-for-missed-lesions-of-synchronous-multiple-early-gastric-cancer-during-endoscopic-submucosal-dissection
#25
JOURNAL ARTICLE
Jiangnan Wan, Yi Fang, Haizhong Jiang, Bujiang Wang, Lei Xu, Chunjiu Hu, Honghui Chen, Xiaoyun Ding
AIMS: To evaluate the value of endoscopic screening during endoscopic submucosal dissection (ESD) in the detection of synchronous multiple early gastric cancer (SMEGC) and the risk factors for missed diagnosis of SMEGC. METHODS: We conducted gastric endoscopic screening during ESD operation in 271 patients with early gastric cancer (EGC) referred for ESD, and endoscopic follow-up within 1 year after the operation. The detection and characteristics of SMEGC were analyzed in three stages: before ESD, during ESD operation, and within 1 year after ESD...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/37021078/astaxanthin-alleviates-inflammatory-response-in-neonatal-necrotizing-enterocolitis-rats-by-regulating-nod2-tlr4-pathway
#26
JOURNAL ARTICLE
Xuandong Zhang, Yujia Luo, Rui Gu, Zhou Jiang
BACKGROUND: Necrotizing enterocolitis (NEC) is often associated with exaggerated activation of inflammatory response. Astaxanthin has been shown in studies to have a positive and advantageous effect on anti-inflammatory response. Hence, it is of great significance to study the protective effect of astaxanthin in NEC disease and its molecular mechanism. OBJECTIVE: The present study was to investigate whether astaxanthin attenuates NEC rats and to explore its potential mechanism...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/37008256/emp1-as-a-potential-biomarker-in-liver-fibrosis-a-bioinformatics-analysis
#27
JOURNAL ARTICLE
Xuchen Chen, Xinliang Lv, Manman Han, Yexiao Hu, Wanqiong Zheng, Haibo Xue, Zhuokai Li, Kui Li, Wei Tan
Liver fibrosis is a wound-healing response to chronic injury, which may result in cirrhosis and liver failure. Studies have been carried on the mechanisms and pathogenesis of liver fibrosis. However, the potential cell-specific expressed marker genes involved in fibrotic processes remain unknown. In this study, we combined a publicly accessible single-cell transcriptome of human liver with microarray datasets to evaluate the cell-specific expression patterns of differentially expressed genes in the liver. We noticed that EMP1 (epithelial membrane protein 1) is significantly active not only in CCl4 (carbon tetrachloride)-treated mouse liver fibrosis but also in BDL (bile duct ligation)-induced liver fibrosis and even in human fibrotic liver tissues such as alcoholic hepatitis, NASH (nonalcoholic steatohepatitis), and advanced stage liver fibrosis...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36911254/monitoring-a-mandatory-nonmedical-switching-policy-from-originator-to-biosimilar-infliximab-in-patients-with-inflammatory-bowel-diseases-a-population-based-cohort-study
#28
JOURNAL ARTICLE
Anat Fisher, Jason D Kim, Colin R Dormuth
BACKGROUND: On September 5, 2019, British Columbia announced a new policy (the Biosimilars Initiative) to switch from originator to biosimilar infliximab for patients with inflammatory bowel diseases. OBJECTIVE: To monitor the impacts of the policy on the use of medications and health services during the first year of the policy. METHODS: In this population-based cohort study, we used administrative health data to construct three historical cohorts and one policy cohort of patients with inflammatory bowel diseases who used the originator infliximab...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36911253/comparison-between-submucosal-tunneling-endoscopic-resection-and-endoscopic-submucosal-dissection-for-prepyloric-submucosal-tumors-a-case-matched-controlled-study
#29
JOURNAL ARTICLE
Wengang Zhang, Jiafeng Wang, Ningli Chai, Enqiang Linghu
OBJECTIVES: Endoscopic submucosal dissection (ESD) has become a well-established treatment method for gastric submucosal tumors (SMTs). However, there existed some challenges to perform ESD for prepyloric SMTs on account of the special location. Recently, submucosal tunneling endoscopic resection (STER) provided a novel option for prepyloric SMTs. This study aimed to make a comprehensive comparison between prepyloric STER (P-STER) and ESD for the treatment of prepyloric SMTs. METHODS: Patients with prepyloric SMTs undergoing P-STER treatment between January 2016 and October 2021 were retrospectively reviewed and individually matched at 1 : 1 ratio with those with ESD treatment according to lesion size, lesion location, pathologic diagnosis, lesion origin, and surgery date, forming P-STER and ESD group, respectively...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36879620/economic-consequences-of-surgery-for-adhesive-small-bowel-obstruction-a-population-based-study
#30
JOURNAL ARTICLE
Thorbjörn Sakari, Sophie Langenskiöld, Filip Sköldberg, Urban Karlbom
BACKGROUND AND AIMS: Most patients develop adhesions after abdominal surgery, some will be hospitalized with small bowel obstruction (SBO), and some also require surgery. The operations and follow-up are expensive, but recent data of costs are scarce. The aim of this study was to describe the direct costs of SBO-surgery and follow-up, in a population-based setting. The association between cost of SBO and peri- and postoperative data was also studied. METHODS: In a retrospective cohort study, all patients ( n = 402) operated for adhesive SBO in Gävleborg and Uppsala counties (2007-2012) were studied...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36865983/the-efficacy-of-surgical-resection-versus-radiofrequency-ablation-for-the-treatment-of-single-hepatocellular-carcinoma-a-seer-based-study
#31
JOURNAL ARTICLE
Fang Wu, Chao Wei, Shicun Zhang, Shanshan Jia, Jidong Zhang
BACKGROUND: There is controversy regarding whether patients with single hepatocellular carcinoma (HCC) should be offered radiofrequency ablation (RFA) as a first-line treatment option. Thus, this study compared overall survival after surgical resection (SR) and RFA for single HCC. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used for this retrospective study. The study included 30- to 84-year-old patients diagnosed with HCC from 2000 to 2018...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36852194/sedation-is-associated-with-higher-polyp-and-adenoma-detection-rates-during-colonoscopy-a-retrospective-cohort-study
#32
JOURNAL ARTICLE
Chenghu Xu, Dehua Tang, Ying Xie, Muhan Ni, Min Chen, Yonghua Shen, Xiaotan Dou, Lin Zhou, Guifang Xu, Lei Wang, Ying Lv, Shu Zhang, Xiaoping Zou
BACKGROUND AND AIMS: Currently sedation is a common practice in colonoscopy to reduce pain of patients and improve the operator satisfaction, whereas its impact on examination quality, especially adenoma detection rate (ADR) is still controversial. Thus, we aimed to investigate the association of sedation with ADR. METHODS: Consecutive patients receiving colonoscopy between January 2017 and January 2020 at the Nanjing Drum Tower Hospital, Nanjing, China, were collected...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36756091/primary-esophageal-lymphoma-a-histopathological-experience-from-two-tertiary-hospitals-western-saudi-arabia
#33
JOURNAL ARTICLE
Jaudah Al-Maghrabi, Sahar Al-Maghrabi
BACKGROUND: Primary esophageal lymphoma (PEL) is a rare disorder. The objective of this study was to document the clinicopathological features of PEL at two tertiary hospitals in the western region of the Kingdom of Saudi Arabia. METHODS: All PELs diagnosed between May 2002 and June 2022 were retrieved. Histopathological and immunohistochemical slides were reviewed. Additional immunohistochemistry stains were performed in selected cases. Follow-up data were collected...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36743531/6-ohda-induced-changes-in-colonic-segment-contractility-in-the-rat-model-of-parkinson-s-disease
#34
JOURNAL ARTICLE
Maria Del Pilar Murillo, Ebba Johansson, Victoria Bryntesson, Patrik Aronsson, Gunnar Tobin, Michael Winder, Thomas Carlsson
BACKGROUND: Gastrointestinal dysfunction is one of the most common non-motor symptoms in Parkinson's disease (PD). The exact mechanisms behind these symptoms are not clearly understood. Studies in the well-established 6-hydroxydopamine (6-OHDA) lesioned rats of PD have shown altered contractility in isolated circular and longitudinal smooth muscle strips of distal colon. Contractile changes in proximal colon and distal ileum are nevertheless poorly studied. Moreover, segments may serve as better tissue preparations to understand the interplay between circular and longitudinal smooth muscle...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36691432/downregulation-of-lncrna-snhg7-sensitizes-colorectal-cancer-cells-to-resist-anlotinib-by-regulating-mir-181a-5p-gata6
#35
JOURNAL ARTICLE
Deng Pan, Kehe Chen, Ping Chen, Yu Liu, Yingying Wu, Jingning Huang
Long noncoding RNAs are a novel class of regulators in human cancers. It has been reported that small nucleolar RNA hostgene 7 (SNHG7) can sponge microRNAs to regulate colorectal cancer (CRC) progression. Given its important regulatory role in cancer biology, we wondered whether SNHG7 is involved in drug resistance to anlotinib (ATB) in CRC. To answer this, we quantified the expression of SNHG7 by quantitative real-time PCR. We performed the Cell Counting Kit-8 and Colony formation assay, flow cytometric analysis, RNA pull-down, RNA-binding protein immunoprecipitation assay, and Luciferase reporter assay to confirm the interaction among SNHG7, miR-181a-5p, and GATA6...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36644482/risk-factors-associated-with-acute-pancreatitis-after-percutaneous-biliary-intervention-we-do-not-know-nearly-enough
#36
REVIEW
Jing Song, Jun Deng, Feng Wen
Percutaneous transhepatic cholangiodrainage (PTCD) and percutaneous transhepatic biliary stenting (PTBS) may be used as a palliative treatment for inoperable patients with malignant biliary obstruction (MBO) to improve the prognosis and their quality of life. However, acute pancreatitis is a common and severe complication that cannot be ignored after PTCD and PTBS in patients with MBO. A few cases may develop severe pancreatitis with a higher mortality rate. In this study, we summarize the known risk factors for acute pancreatitis after percutaneous biliary interventional procedures and investigate possible risk factors to reduce its occurrence by early identifying high-risk patients and taking appropriate measures...
2023: Gastroenterology Research and Practice
https://read.qxmd.com/read/36388633/early-post-operative-endoscopy-is-associated-with-lower-surgical-recurrence-of-crohn-s-disease-a-retrospective-study-of-three-successive-cohorts
#37
JOURNAL ARTICLE
Caroline Amicone, Carla Coimbra Marques, Catherine Reenaers, Catherine Van Kemseke, Laurence Seidel, Edouard Louis
BACKGROUND: The severity of endoscopic recurrence during the first year after intestinal resection for Crohn's disease is predictive of clinical recurrence. The aim of our study was to assess the impact of the implementation of an ileocolonoscopy during the first year after surgery on surgical recurrence. METHODS: All patients who underwent a first intestinal resection for Crohn's disease between 1992 and 2018 at the University Hospital of Liège were retrospectively included...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/36329782/serum-lactate-dehydrogenase-is-a-sensitive-predictor-of-systemic-complications-of-acute-pancreatitis
#38
JOURNAL ARTICLE
Dong-Ni Huang, Hao-Jie Zhong, Ying-Li Cai, Wen-Rui Xie, Xing-Xiang He
BACKGROUND: Acute pancreatitis (AP) is a common and potentially life-threatening inflammatory disease that can cause various complications, including systemic inflammatory response syndrome (SIRS), pleural effusion, ascitic fluid, myocardial infarction, and acute kidney injury (AKI). However, there is still a lack of rapid and effective indicators to assess the disease. The aim of this study was to investigate the associations of high serum lactate dehydrogenase (LDH) levels with AP severity and systemic complications...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/36317106/detection-and-treatment-of-helicobacter-pylori-problems-and-advances
#39
REVIEW
Hang Yang, Liwen Guan, Bing Hu
Helicobacter pylori ( H. pylori ) infection is chronic and etiologically linked to gastric cancer (GC) derived from gastric epithelium. The potential mechanism is complex, covering chronic inflammation, epithelial senescence, NF- κ B activation, the cytotoxin-associated gene A protein translocation, and related abnormal signaling pathways. In clinical practice, the test-and-treat strategy, endoscopy-based strategy, and (family-based) screen-and-treat strategy are recommended to detect H. pylori and prevent GC...
2022: Gastroenterology Research and Practice
https://read.qxmd.com/read/36311294/znf521-is-correlated-with-tumor-immune-cell-infiltration-and-act-as-a-valuable-prognostic-biomarker-in-gastric-cancer
#40
JOURNAL ARTICLE
Li Li, Zheng-Hui Liu, Hui-Ju Wang, Lei Wang, Guo-Qing Ru, Yuan-Yu Wang
Aim: To explore the correlations between the expression of zinc finger protein 521 (ZNF521) with immune invasion and prognosis of gastric cancer. Methods: Expression of ZNF521 was examined by immunohistochemistry in gastric cancer cases. Kaplan-Meier plotter was used to determine the relationships between ZNF521 and prognosis. TIMER and GEPIA were used to analyze the correlation between ZNF521 expression and gene markers of immune cell infiltration. Results: The expression of ZNF521 was up-regulated in gastric cancer samples...
2022: Gastroenterology Research and Practice
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