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Gastroenterology Research and Practice

Kazunari Nakahara, Yosuke Michikawa, Ryo Morita, Keigo Suetani, Nozomi Morita, Junya Sato, Kensuke Tsuji, Hiroki Ikeda, Kotaro Matsunaga, Tsunamasa Watanabe, Nobuyuki Matsumoto, Shinjiro Kobayashi, Takehito Otsubo, Fumio Itoh
Background/Aims: Endoscopic sphincterotomy (EST) is often performed before fully covered self-expandable metal stent (FCSEMS) placement in order to prevent pancreatitis. However, it is not clear whether EST prevents pancreatitis or affects other adverse events (AEs). This study is conducted to evaluate the necessity of EST before FCSEMS placement for distal malignant biliary strictures due to a pancreatic head tumor. Methods: This study included 68 patients who underwent FCSEMS placement for distal malignant biliary stricture due to a pancreatic head tumor...
2019: Gastroenterology Research and Practice
Gianluca Cassese, Alfonso Amendola, Francesco Maione, Mariano Cesare Giglio, Gianluca Pagano, Marco Milone, Giovanni Aprea, Gaetano Luglio, Giovanni Domenico De Palma
Prompt diagnosis and correct management of the so called "serrated lesions" (SLs) of the colon-rectum are generally considered of crucial importance in the past years, mainly due to their histological heterogeneity and peculiar clinical and molecular patterns; sometimes, they are missed at conventional endoscopy and are possibly implicated in the genesis of interval cancers. The aim of this review is to focus on the diagnostic challenges of serrated lesions, underlying the role of both conventional endoscopy and novel technologies...
2019: Gastroenterology Research and Practice
Arash Assadsangabi, Caroline A Evans, Bernard M Corfe, Alan Lobo
Inflammatory bowel disease (IBD) is a chronic relapsing/remitting inflammatory illness of the gastrointestinal tract of unknown aetiology. Despite recent advances in decoding the pathophysiology of IBD, many questions regarding disease pathogenesis remain. Genome-wide association studies (GWAS) and knockout mouse models have significantly advanced our understanding of genetic susceptibility loci and inflammatory pathways involved in IBD pathogenesis. Despite their important contribution to a better delineation of the disease process in IBD, these genetic findings have had little clinical impact to date...
2019: Gastroenterology Research and Practice
Keiichiro Abe, Keiichi Tominaga, Akira Kanamori, Tsunehiro Suzuki, Hitoshi Kino, Masakazu Nakano, Takeshi Sugaya, Kouhei Tsuchida, Yuichi Majima, Toshimitsu Murohisa, Makoto Iijima, Kenichi Goda, Atsushi Irisawa
Objective: There is no consensus regarding administration of propofol for performing endoscopic submucosal dissection (ESD) in patients with comorbidities. The aim of this study was to evaluate the safety and efficacy of propofol-induced sedation administered by nonanesthesiologists during ESD of gastric cancer in patients with comorbidities classified according to the American Society of Anesthesiologists (ASA) physical status. Methods: Five hundred and twenty-two patients who underwent ESD for gastric epithelial tumors under sedation by nonanesthesiologist-administrated propofol between April 2011 and October 2017 at Dokkyo Medical University Hospital were enrolled in this study...
2019: Gastroenterology Research and Practice
Erminia Ridolo, Irene Martignago, Irene Pellicelli, Cristoforo Incorvaia
Background: Up to one-third of the patients suffering from eosinophilic esophagitis (EoE) present a refractory form, as defined by nonresponsiveness in clinical, endoscopic, or histological assessment after first-line therapy. Several studies recently investigated which factors can influence the development of this disease, but very few analyzed the factors underlying refractory EoE. Methods: Medical charts of patients affected by EoE were retrospectively evaluated...
2019: Gastroenterology Research and Practice
Diana-Maria Bunu, Cristian-Eugen Timofte, Manuela Ciocoiu, Mariana Floria, Claudia-Cristina Tarniceriu, Oana-Bogdana Barboi, Daniela-Maria Tanase
Inflammatory bowel disease (IBD) refers to a group of chronic inflammatory diseases that targets mainly the gastrointestinal tract. The clinical presentation of IBD includes both gastrointestinal manifestations and extraintestinal manifestations (EIM). The reported cardiovascular manifestations in IBD patients include pericarditis, myocarditis, venous and arterial thromboembolism, arrhythmias, atrioventricular block, heart failure, endocarditis, valvulopathies, and Takayasu arteritis. The aim of this article is to review the available literature about the possible pathogenic mechanisms and determine preventive measures capable of reducing the incidence and severity of the cardiovascular manifestations...
2019: Gastroenterology Research and Practice
Shasha Tang, Xiaolong Ge, Weilin Qi, Wei Liu, Qian Cao, Wei Zhou
Background: Many patients with Crohn's disease (CD) require surgery in their life. Their future outlook is crucial to psychological and mental health after surgery. This study is aimed at assessing CD patient's outlook after experiencing bowel resection and determining factors associated with patient's outlook. Methods: We used an ad hoc questionnaire (modified WHOQOL-BREF) to assess patients' outlook for the future after bowel resection in CD. All patients who experienced bowel resection for CD from 2015 to 2017 were included in this study...
2019: Gastroenterology Research and Practice
Si-Liang Chen, Peng Hu, Zhi-Peng Lin, Jian-Bo Zhao
Purpose: To evaluate the effect of puncture sites of the portal vein in transjugular intrahepatic portosystemic shunt (TIPS) on long-term clinical efficacy. Methods: A retrospective review was performed, including consecutive 171 patients who underwent TIPS with ePTFE-covered stents. All patients were divided into 3 groups according to the puncture site of the portal vein: intrahepatic bifurcation of the portal vein (group A, n = 88), right branch of the portal vein (group B, n = 48), and left branch of the portal vein (group C, n = 35)...
2019: Gastroenterology Research and Practice
Bo Zhang, Ketong Wu, Yang Liu, Haiyang Lai, Zhaofei Zeng
Objective: To evaluate the strategy in the management of patients with synchronous gastrointestinal tumor and abdominal aortic aneurysm (AAA) or abdominal aortic dissection (AAD) undergoing endovascular repair followed by tumor resection. Materials and Methods: Five patients with synchronous gastrointestinal tumor and AAA or AAD were treated by endovascular repair followed by tumor resection. Clinical data were retrospectively analyzed with respect to the management strategy, safety, and outcome...
2019: Gastroenterology Research and Practice
S Sibio, A Di Giorgio, M Campanelli, S Di Carlo, A Divizia, C Fiorani, R Scaramuzzo, C Arcudi, G Del Vecchio Blanco, L Biancone, G Sica
Background: One-third of Crohn's disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum under anesthesia (EUA). This procedure is mainly conducted as a day case surgery. Unfortunately, it is not always possible to proceed within the ideal timing and any delay may well represent a relevant clinical issue. The aim of this study was to evaluate the feasibility of outpatient treatment of symptomatic perianal fistulas in CD patients...
2018: Gastroenterology Research and Practice
Paola Parente, Pietro Parcesepe, Claudia Covelli, Nunzio Olivieri, Andrea Remo, Massimo Pancione, Tiziana Pia Latiano, Paolo Graziano, Evaristo Maiello, Guido Giordano
Pancreatic ductal adenocarcinoma is a lethal disease for which radical surgery and chemotherapy represent the only curative options for a small proportion of patients. Recently, FOLFIRINOX and nab-paclitaxel plus gemcitabine have improved the survival of metastatic patients but prognosis remains poor. A pancreatic tumor microenvironment is a dynamic milieu of cellular and acellular elements, and it represents one of the major limitations to chemotherapy efficacy. The continued crosstalk between cancer cells and the surrounding microenvironment causes immunosuppression within pancreatic immune infiltrate increasing tumor aggressiveness...
2018: Gastroenterology Research and Practice
Fu-Wei Wang, Su-Chi Young, Ru-Yih Chen, Kung-Hung Lin, Yan-Hua Chen, Ping-I Hsu, Hsien-Chung Yu
Background: To determine the risk factors and prevalence of asymptomatic gastric polyps in the general population of Taiwan. Methods: Consecutive asymptomatic individuals completing a health examination during October 2015-March 2016 were enrolled in the study and subjected to upper GI endoscopy. Their demographic data and medical history were collected, and the prevalence of gastric polyps was calculated. The risk factors of gastric polyps were identified by analyzing these data through univariate and multivariate logistic regression...
2018: Gastroenterology Research and Practice
Davide Giuseppe Ribaldone, Rinaldo Pellicano
No abstract text is available yet for this article.
2018: Gastroenterology Research and Practice
Sung Won Chung, Young Chang, Hyo Young Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Yoon Jun Kim
Aim: The efficacy of tenofovir disoproxil fumarate (TDF) monotherapy as maintenance therapy in multidrug-resistant (MDR) hepatitis B virus (HBV) patients after complete virologic suppression (CVS) has not been well evaluated. We evaluated the efficacy of maintenance TDF monotherapy compared with conventional TDF plus entecavir combination therapy after CVS of MDR HBV. Methods: In this single-center retrospective study, patients with MDR HBV who were previously treated with entecavir plus TDF combination therapy and achieved CVS were included...
2018: Gastroenterology Research and Practice
Davide Giuseppe Ribaldone, Marco Astegiano
No abstract text is available yet for this article.
2018: Gastroenterology Research and Practice
Lei Ding, Lianxiang Xiao, Xiangtao Lin, Chunmei Xiong, Lingbo Lin, Shijun Chen
Background: Few studies focused on the region of interest- (ROI-) related heterogeneity of liver intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). The aim of the study was to evaluate the differences of liver IVIM parameters among liver segments in cirrhotic livers (chronic viral hepatitis). Material and Methods: This was a retrospective study of 82 consecutive patients with chronic liver disease who underwent MRI examination at the Jinan Infectious Diseases Hospital between January 2015 and December 2016...
2018: Gastroenterology Research and Practice
Lingjuan Ruan, Lifei Huang, Lilai Zhao, Qiang Wang, Xiaocheng Pan, Anmin Zhang, Qiuping Bai, Zongjun Lv
Hepatitis B virus (HBV) infection is a major risk factor for the development of hepatic cirrhosis (HC) and hepatocellular carcinoma (HCC), which are associated with very high morbidity and mortality rates worldwide. Many studies have shown that long noncoding RNAs (lncRNAs) that are highly expressed in HCC (lncRNA-HEIH) and highly upregulated in liver cancer (lncRNA-HULC) have been implicated in the development and progression of hepatitis B-related HC and HCC. In this study, reverse transcription and quantitative PCR were used to detect the expression of lncRNA-HEIH and lncRNA-HULC and western blot analysis to detect the expression of hepatitis B X-interacting protein (HBXIP)...
2018: Gastroenterology Research and Practice
Yong Wang, Qing Pang, Hao Jin, Lei Zhou, Xiaosi Hu, Zhen Qian, Zhongran Man, Song Yang, Huichun Liu
Aim: Child-Pugh (CP) grade has been used to assess liver function and postoperative outcomes in biliary tract neoplasms. The aim of this study was to preliminarily explore the prognostic significance of an alternative model of liver function, called albumin-bilirubin (ALBI) grade, in patients with extrahepatic cholangiocarcinoma (EHC). Methods: A total of 109 advanced EHC patients, who received percutaneous transhepatic biliary stenting combined with iodine-125 seed implantation from January 2012 to April 2017 in our department, were enrolled...
2018: Gastroenterology Research and Practice
Seok-Hoon Lee, Nam-Seok Joo, Kwang-Min Kim, Kyu-Nam Kim
Backgrounds: Recent studies suggest that diarrhea-predominant irritable bowel syndrome (IBS) is associated with intestinal bacterial microflora, colonic inflammation, and small intestinal bacterial overgrowth (SIBO). The purpose of this study was to evaluate the effect of a multistrain probiotic intake on these associated factors in patients with diarrhea-predominant IBS. Methods: The recruited volunteers were adults who were diagnosed with diarrhea-predominant IBS according to the Rome III criteria...
2018: Gastroenterology Research and Practice
Zhao-Yong Xie, Rui-Mei Chai, Guo-Cheng Ding, Yi Liu, Ke Ren
Aim: This study is aimed at comparing gastric cancer T and N staging between virtual monochromatic energy images and fusion images generated by dual-source computed tomography (DSCT) dual-energy mode data acquisition prospectively while measuring the iodine concentration of gastric cancer and lymph nodes at different T and N stages from iodine map retrospectively. Methods: A total of 71 patients (50 males and 21 females; mean age: 59 ± 11 years) confirmed with gastric cancer by endoscopic biopsy with no neoadjuvant chemotherapy were enrolled for the CT examination before surgeries...
2018: Gastroenterology Research and Practice
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