journal
https://read.qxmd.com/read/38904207/differential-effects-of-montelukast-and-zafirlukast-on-mda%C3%A2-mb%C3%A2-231-triple%C3%A2-negative-breast-cancer-cells-cell-cycle-regulation-apoptosis-autophagy-dna-damage-and-endoplasmic-reticulum-stress
#1
JOURNAL ARTICLE
Pornpun Vivithanaporn, Thanaporn Sriwantana, Kanokpan Krueaprasertkul, Nathawut Sibmooh, Suttinee Phuagkhaopong, Piyanuch Wonganan
Montelukast and zafirlukast, cysteinyl leukotriene receptor antagonists (LTRAs), trigger apoptosis and inhibit cell proliferation of triple‑negative breast cancer MDA‑MB‑231 cells. By contrast, only zafirlukast induces G0 /G1 cell cycle arrest. The present study compared the effects of these drugs on proteins regulating cell proliferation, apoptosis, autophagy, and endoplasmic reticulum (ER) and oxidative stress using reverse transcription‑quantitative PCR, western blotting and flow cytometry...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38904206/bmsc%C3%A2-derived-exosome%C3%A2-mediated-mir%C3%A2-25%C3%A2-3p-delivery-protects-against-myocardial-ischemia-reperfusion-injury-by-constraining-m1%C3%A2-like-macrophage-polarization
#2
JOURNAL ARTICLE
Jingxia Du, Yibo Dong, Jingjing Song, Hanqi Shui, Chengyao Xiao, Yue Hu, Shiyao Zhou, Shanshan Wang
Myocardial ischemia/reperfusion injury (MIRI) is a significant challenge in the management of myocardial ischemic disease. Extensive evidence suggests that the macrophage‑mediated inflammatory response may play a vital role in MIRI. Mesenchymal stem cells and, in particular, exosomes derived from these cells, may be key mediators of myocardial injury and repair. However, whether exosomes protect the heart by regulating the polarization of macrophages and the exact mechanisms involved are poorly understood...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38904201/estrogen-receptor-signaling-and-targets-bones-breasts-and-brain-review
#3
REVIEW
Meropi Toumba, Alexandros Kythreotis, Konstantina Panayiotou, Nicos Skordis
Estrogens are involved in a number of physiological functions, including in the development of the brain, growth, reproduction and metabolism. The biological actions of estrogens are achieved by binding to estrogen receptors (ERs) in numerous types of tissues. ERα and ERβ belong to the nuclear receptor superfamily and the G‑protein coupled ER1 (GPER1) is a membrane receptor. The primary biologically active estrogen, 17β‑estradiol demonstrates a high affinity for ERs. Mechanistically, estrogens bind to the ERs in the nucleus, and the complex then dimerize and bind to estrogen response elements (EREs) located in the promoter regions of the target genes...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38904199/microrna%C3%A2-17%C3%A2-5p-alleviates-sepsis%C3%A2-related-acute-kidney-injury-in-mice-by-modulating-inflammation-and-apoptosis
#4
JOURNAL ARTICLE
Jian Sun, Lei Niu, Yang Wang, Gang Zhao, Lujia Tang, Jiamei Jiang, Shuming Pan, Xiaoli Ge
Septic acute kidney injury (AKI) is considered as a severe and frequent complication that occurs during sepsis. Mounting evidence has confirmed the pivotal pathogenetic roles of microRNA (miRNA or miR) in sepsis‑induced AKI; however, the role of miRNAs and their underlying mechanisms in sepsis‑induced AKI have not been entirely understood. The present study aimed to elucidate the functions of special miRNAs during sepsis‑induced AKI and its underlying mechanism. First, a number of differently expressed miRNAs was identified based on the microarray dataset GSE172044...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38904198/tgf%C3%A2-%C3%AE-smad-signaling-in-chronic-kidney-disease-exploring-post%C3%A2-translational-regulatory-perspectives-review
#5
REVIEW
Jianchun Li, Yuanxia Zou, Jiraporn Kantapan, Hongwei Su, Li Wang, Nathupakorn Dechsupa
The TGF‑β/Smad signaling pathway plays a pivotal role in the onset of glomerular and tubulointerstitial fibrosis in chronic kidney disease (CKD). The present review delves into the intricate post‑translational modulation of this pathway and its implications in CKD. Specifically, the impact of the TGF‑β/Smad pathway on various biological processes was investigated, encompassing not only renal tubular epithelial cell apoptosis, inflammation, myofibroblast activation and cellular aging, but also its role in autophagy...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38904195/-retracted-microrna%C3%A2-336-directly-targets-sox%C3%A2-2-in-osteosarcoma-to-inhibit-tumorigenesis
#6
Yong Cao, Tianding Wu, Dongzhe Li, Jianzhong Hu, Hongbin Lu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell migration and invasion assay data in Fig. 3C and D, and the tumour images shown in Fig. 4A were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had already been published. In addition, certain of the data panels shown in Fig. 3C were overlapping, such that the data from the same original source had been selected to represent the results from allegedly differently performed experiments...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38904193/from-metabolic-to-epigenetic-insight-into-trained-macrophages-in-atherosclerosis-review
#7
REVIEW
Tianxin Li, Wanting Feng, Wenyue Yan, Tingting Wang
Atherosclerosis (AS) is a chronic inflammatory disease caused by the deposition of lipoproteins and sequent immune responses. Within the atherosclerotic plaque, macrophages are the most abundant immune cells and play a great part as protagonists and promoters of AS. In the past decade, the concept of 'trained immunity' has emerged, which highlights the memory characteristics of innate immunity, thus opening up a new avenue of research. Evidence suggests that trained immunity may regulate the onset and progression of AS with trained macrophages playing an important and dynamic role in atherogenesis...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38874001/-retracted-2-3-5-4%C3%A2-tetrahydroxy-diphenylethylene%C3%A2-2%C3%A2-o%C3%A2-glucoside-inhibits-the-adhesion-and-invasion-of-a549-human-lung-cancer-cells
#8
Ming Xu, Cong Wang, Minglin Zhu, Xianguo Wang, Li Zhang, Jinping Zhao
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the data featured in Figs. 1, 4 and 5 (including western blotting data) were strikingly similar to data that had appeared in a different form in a different article by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been accepted for publication in another article prior to its submission to Molecular Medicine Reports , the Editor has decided that this paper should be retracted from the Journal...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38873986/lactoferrin-alleviates-chronic-low%C3%A2-grade-inflammation-response-in-obese-mice-by-regulating-intestinal-flora
#9
JOURNAL ARTICLE
Wuji Wang, Jing Zhang, Yanyi Li, Si Su, Lisi Wei, Li Li, Rilebagen Hu
Chronic low‑grade inflammation defines obesity as a metabolic disorder. Alterations in the structure of gut flora are strongly associated with obesity. Lactoferrin (LF) has a biological function in regulating intestinal flora. The present study aimed to investigate the therapeutic and anti‑-inflammatory effects of LF in obese mice based on intestinal flora. A total of 30 C57BL/6 mice were divided into three groups consisting of 10 mice each. Subsequently, one group was fed a normal diet (Group K), another group was fed a high‑fat diet (Group M) and the remaining group switched from regular drinking to drinking 2% LF water (Group Z2) after 2 weeks of high‑fat diet; all mice were fed for 12 weeks...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38873985/hydrogen-sulfide-mitigates-ox%C3%A2-ldl%C3%A2-induced-nlrp3-caspase%C3%A2-1-gsdmd-dependent-macrophage-pyroptosis-by-s%C3%A2-sulfhydrating-caspase%C3%A2-1
#10
JOURNAL ARTICLE
Zhenli Jia, Xulin Zhang, Zhiyi Li, Hanyu Yan, Xiangqin Tian, Chenghua Luo, Ketao Ma, Ling Li, Liang Zhang
Macrophage pyroptosis mediates vascular inflammation and atherosclerosis (AS). Hydrogen sulfide (H2S) exerts a protective role in preventing inflammation and AS. However, its molecular mechanisms of regulating the pyroptosis signaling pathway and inhibiting macrophage pyroptosis remain unexplored. The present study aimed to determine whether H2S mitigates macrophage pyroptosis by downregulating the pyroptosis signaling pathway and S‑sulfhydrating caspase‑1 under the stimulation of oxidized low‑density lipoprotein (ox‑LDL), a pro‑atherosclerotic factor...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38873983/serum-metabolomics-analysis-of-patients-with-chronic-obstructive-pulmonary-disease-and-frequent-exacerbator-phenotype
#11
JOURNAL ARTICLE
Huan-Zhang Ding, Hui Wang, Di Wu, Fan-Chao Zhou, Jie Zhu, Jia-Bing Tong, Ya-Ting Gao, Ze-Geng Li
Chronic obstructive pulmonary disease (COPD) exacerbations accelerate loss of lung function and increased mortality. The complex nature of COPD presents challenges in accurately predicting and understanding frequent exacerbations. The present study aimed to assess the metabolic characteristics of the frequent exacerbation of COPD (COPD‑FE) phenotype, identify potential metabolic biomarkers associated with COPD‑FE risk and evaluate the underlying pathogenic mechanisms. An internal cohort of 30 stable patients with COPD was recruited...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38818834/-retracted-silencing-of-rtkn2-by-sirna-suppresses-proliferation-and-induces-g1-arrest-and-apoptosis-in-human-bladder-cancer-cells
#12
Yi-Xiang Liao, Jin-Min Zeng, Jia-Jie Zhou, Guang-Hua Yang, Kun Ding, Xian-Jue Zhang
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell migration assay data shown in Fig. 4D on p. 4876 were strikingly similar to data that had already been published in different form in another article written by different authors at a different research institute. In addition, a pair of the data panels in Fig. 4D were overlapping, indicating that data derived from the same original source had been used to represent what were intended to be the results obtained from differently performed experiments...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38818832/mechanism-of-flavonoids-in-the-treatment-of-gouty-arthritis-review
#13
REVIEW
Feifan Liu, Yuanmei Bai, Yan Wan, Jinglin He, Qiongchao Li, Yuhuan Xie, Peixin Guo
The present review expounds the advancements in the application and mechanisms of flavonoids in gouty arthritis, highlighting their significance in managing the disease. Gouty arthritis is among the most common and severe inflammatory diseases, caused by hyperuricemia and the deposition of sodium urate crystals in the joints and surrounding tissues, posing a serious threat to human life and health. Flavonoids, extracted from various herbs, have attracted significant attention due to their efficacy in improving gouty arthritis...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38818814/gctrp3-inhibits-oophorectomy%C3%A2-induced-osteoporosis-by-activating-the-ampk-sirt1-nrf2-signaling-pathway-in-mice
#14
JOURNAL ARTICLE
Xiaojuan Zhang, Di Zhang, Huan Zhao, Jing Qin, Hao Qi, Feiyu Zu, Yaru Zhou, Yingze Zhang
C1q/tumor necrosis factor‑related protein 3 (CTRP3) expression is markedly reduced in the serum of patients with osteoporosis. The present study aimed to investigate whether CTRP3 reduces bone loss in oophorectomy (OVX)‑induced mice via the AMP‑activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/nuclear factor E2‑related factor 2 (Nrf2) signaling pathway. Female C57BL/6J mice and MC3T3‑E1 cells were used to construct in vivo and in vitro models of osteoporosis, respectively...
August 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38818815/research-progress-in-the-metabolic-reprogramming-of-hepatocellular-carcinoma-review
#15
REVIEW
Wenyue Gao, Jing Wang, Yuting Xu, Hongbo Yu, Sitong Yi, Changchuan Bai, Qingwei Cong, Ying Zhu
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and its morbidity is increasing worldwide due to increasing prevalence. Metabolic reprogramming has been recognized as a hallmark of cancer and serves a role in cancer progression. Glucose, lipids and amino acids are three major components whose altered metabolism can directly affect the energy production of cells, including liver cancer cells. Nutrients and energy are indispensable for the growth and proliferation of cancer cells, thus altering the metabolism of hepatoma cells can inhibit the progression of HCC...
July 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38785160/recent-advances-in-potential-therapeutic-targets-of-ferroptosis%C3%A2-associated-pathways-for-the-treatment-of-stroke-review
#16
REVIEW
Hao Dong, Ya-Ping Ma, Mei-Mei Cui, Zheng-Hao Qiu, Mao-Tao He, Bao-Gang Zhang
Stroke is a severe neurological disease that is associated with high rates of morbidity and mortality, and the underlying pathological processes are complex. Ferroptosis fulfills a significant role in the progression and treatment of stroke. It is well established that ferroptosis is a type of programmed cell death that is distinct from other forms or types of cell death. The process of ferroptosis involves multiple signaling pathways and regulatory mechanisms that interact with mechanisms inherent to stroke development...
July 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38785157/tributyltin-chloride-induces-chondrocyte-damage-through-the-activation-of-nlrp3%C3%A2-mediated-inflammation-and-pyroptosis
#17
JOURNAL ARTICLE
Silong Xia, Rong Ma
Tributyltin chloride (TBTC) is known to have effects and mechanisms in various diseases; however, whether TBTC is detrimental to joints and causes osteoarthritis (OA), as well as its underlying mechanism, has not yet been fully elucidated. The present study explored the effects of TBTC on rat chondrocytes, as well as on mouse OA. The toxicity of TBTC toward rat chondrocytes was detected using a lactate dehydrogenase (LDH) leakage assay and cell viability was evaluated using the Cell Counting Kit‑8 assay...
July 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38785156/-retracted-microrna%C3%A2-584-prohibits-hepatocellular-carcinoma-cell-proliferation-and-invasion-by-directly-targeting-bdnf
#18
Yanan Song, Guoyu Wang, Juhua Zhuang, Jing Ni, Suiliang Zhang, Ying Ye, Wei Xia
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the Transwell invasion assay data shown in Fig. 2C and D on p. 1997 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published, or were submitted for publication at around the same time (and in some cases, have subsequently been retracted).  Owing to the fact that the contentious data in the above article had already been published prior to its submission to Molecular Medicine Reports , the Editor has decided that this paper should be retracted from the Journal...
July 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38785154/possible-association-of-g6pc2-and-muc6-induced-by-low%C3%A2-dose%C3%A2-rate-irradiation-in-mouse-intestine-with-inflammatory-bowel-disease
#19
JOURNAL ARTICLE
Sohi Kang, Min Ji Bae, Min Kook Kang, Hyojin Kim, Yeong-Rok Kang, Wol Soon Jo, Chang Geun Lee, Bokyung Jung, Jeongmin Lee, Changjong Moon, Yeonghoon Son, Hae-June Lee, Joong Sun Kim
Although there are several types of radiation exposure, it is debated whether low‑dose‑rate (LDR) irradiation (IR) affects the body. Since the small intestine is a radiation‑sensitive organ, the present study aimed to evaluate how it changes when exposed to LDR IR and identify the genes sensitive to these doses. After undergoing LDR (6.0 mGy/h) γ radiation exposure, intestinal RNA from BALB/c mice was extracted 1 and 24 h later. Mouse whole genome microarrays were used to explore radiation‑induced transcriptional alterations...
July 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38785153/estrogen-inhibits-tgf%C3%A2-%C3%AE-1%C3%A2-stimulated-cardiac-fibroblast-differentiation-and-collagen-synthesis-by-promoting-cdc42
#20
JOURNAL ARTICLE
Jingyi Xu, Feng Wang, Yuan Li, Ping Li, Yiqing Zhang, Guidong Xu, Kangyun Sun, Ying Huang
17β‑estradiol (E2) can inhibit cardiac fibrosis in female patients with heart failure (HF) and activate cell division cycle 42 (Cdc42), however it is unknown whether 17β‑estradiol (E2) can ameliorate differentiation and collagen synthesis in TGF‑β1‑stimulated mouse cardiac fibroblasts (MCFs) by regulating cell division cycle 42 (Cdc42). The present study aimed to investigate the roles of estrogen and Cdc42 in preventing myocardial fibrosis and the underlying molecular mechanisms...
July 2024: Molecular Medicine Reports
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