Wanying Tang, Ming Zhang, Yu Wang, Dan Ma, Mi Hu, Yangkai Zhang, Huiling Lin, Weiwei Jiang, Yuxin Ouyang, Liping Jiang, Pingping He, Guojun Zhao, Xinping Ouyang
Insulin growth factor‑1 (IGF‑1) is an endocrine regulator that plays an important role in normal growth and development. IGF‑1 mediated effects may result in protecting macrophages from immunometabolic response. However, it is unclear whether IGF‑1 has a protective effect on fatty acid‑induced macrophages damage. In the present study, THP‑1 cells were differentiated into macrophages and stimulated with palmitic acid (PA) in the absence or presence of IGF‑1. Macrophages apoptosis was measured by Cell Counting Kit‑8 assay, flow cytometry, Hoechst 33342 staining and western blotting...
December 2023: Molecular Medicine Reports