Romana Mikyskova, Olena Sapeg, Miroslav Psotka, Ondrej Novotny, Zdeněk Hodny, Sona Balintova, David Malinak, Jana Svobodova, Rudolf Andrys, David Rysanek, Kamil Musilek, Milan Reinis
Signal transducer and activator of transcription 3 (STAT3) signalling serves an important role in carcinogenesis and cellular senescence, and its inhibition in tumour cells represents an attractive therapeutic target. Premature cellular senescence, a process of permanent proliferative arrest of cells in response to various inducers, such as cytostatic drugs or ionizing radiation, is accompanied by morphological and secretory changes, and by altered susceptibility to chemotherapeutic agents, which can thereby complicate their eradication by cancer therapies...
April 2023: Molecular Medicine Reports