journal
https://read.qxmd.com/read/36960867/genetic-factors-involved-in-the-co%C3%A2-occurrence-of-endometriosis-with-ankylosing-spondylitis-review
#1
JOURNAL ARTICLE
Maria I Zervou, Louis Papageorgiou, Dimitrios Vlachakis, Demetrios A Spandidos, Elias Eliopoulos, George N Goulielmos
Previous research has revealed an association between endometriosis and various autoimmune diseases, while recent data suggest, for the first time, an association between endometriosis and the risk of developing ankylosing spondylitis (AS). AS, the prototype of spondyloarthritides diseases, is a systemic, chronic, immune‑mediated inflammatory arthritis, which primarily affects the spine and sacroiliac joints, as well as the axial skeleton with or without extraspinal manifestations. AS is of polygenic inheritance and numerous immunologically relevant genes contribute to its development...
May 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36960866/two-fragments-of-hbv-dna-integrated-into-chrx-11009033-and-its-genetic-regulation-in-hepg2-2-15
#2
JOURNAL ARTICLE
Peng Ruan, Rui Zhou, Chunping He, Chao Huang, Mengjuan Lin, Haisen Yin, Xiufang Dai, Jun Sun
Hepatitis B virus (HBV) integration into human genome causes hepatocellular carcinoma (HCC). The present study used inverse nested PCR; the full sequence of HBV DNA fragments of the chrX: 111009033 integration site was detected (987 bp), containing two fragments of double‑stranded linear DNA with the same orientation (1,744‑1,094 and 1,565‑1,228 nt). By reverse transcription‑quantitative PCR, HBV‑cell fusion transcript was observed in HepG2.2.15 cells. The mean copy number of this site in cells with H2 O2 treatment (8...
May 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36960863/-corrigedum-mir%C3%A2-185-inhibits-non%C3%A2-small-cell-lung-cancer-cell-proliferation-and-invasion-through-targeting-of-sox9-and-regulation-of-wnt-signaling
#3
Zhengwen Lei, Hongcan Shi, Wei Li, Duonan Yu, Feiyang Shen, Xi Yu, Dan Lu, Chao Sun, Kai Liao
Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, for the Transwell invasion assay experiments with the SK‑MES‑1 cell line shown in Fig. 4A on p. 1748, the 'mimic'NC' and 'inhibitor‑NC' data panels showed overlapping sections, such that these data may have been derived from the same original source even though they were intending to show the results of different experiments. The authors have consulted their original data, and realize that the 'inhibitor‑NC' data panel was inadvertently selected incorrectly for Fig...
May 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36960862/-retracted-microrna%C3%A2-21-promotes-migration-and-invasion-of-glioma-cells-via-activation-of-sox2-and-%C3%AE-%C3%A2-catenin-signaling
#4
Guoxuan Luo, Wentao Luo, Xiaohui Sun, Jinzhi Lin, Mo Wang, Yang Zhang, Weishi Luo, Yong Zhang
Following the publication of the above paper, a concerned reader drew to the Editor's attention that there were several data panels showing the results of Transwell migration and invasion assay experiments in Figs. 1A and 2A that contained overlapping sections of data, such that these data, which were intended to have shown the results from differently performed experiments, appeared to have been derived from a smaller number of original sources. Furthermore, the data panels shown in Fig. 3A for the 'Control/U343' and 'Control/172', and the 'miR‑21/β‑catenin' and 'Control/T98', experiments were also found to be unexpectedly similar, given that these were likewise intended to show the results from differently performed experiments...
May 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36960871/mechanism-of-dioscin-ameliorating-renal-fibrosis-through-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway%C3%A2-mediated-inflammatory-response
#5
JOURNAL ARTICLE
Yang Wang, Peng Liu, Guijie Ma, Chenguang Wu, Wenhui Zhu, Pengce Sun, Wenya Lu, Xinyu Yang, Yilun Zhang, Na Liu, Ping Li
Dioscin (DIS) is a natural compound derived from Chinese herbal medicine. In recent years, multiple studies have reported that DIS has immunoregulation, anti‑fibrosis, anti‑inflammation, anti‑viral and anti‑tumor effects. However, the mechanism by which DIS ameliorates renal fibrosis and inflammation remains to be elucidated. The aim of the present study was to investigate the role of DIS in renal fibrosis and inflammation and to explore its underlying mechanism. It used network pharmacology to predict the targets of DIS for the treatment of renal interstitial fibrosis...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36960865/5-%C3%A2-isomir-is-the-most-abundant-sequence-of-mir%C3%A2-1246-a-candidate-biomarker-of-lung-cancer-in-serum
#6
JOURNAL ARTICLE
Toshiko Aiso, Makiko Ueda
MicroRNA (miRNA/miR) 5'‑isoforms (5'‑isomiRs) differ from canonical sequences registered in the microRNA database in the length of their 5' ends. The 'seed sequence' of miRNAs that bind to target mRNAs is 2‑8 nucleotides from the 5' end; thus, shifts at the 5' end can cause a 'seed shift'. Accumulating data from miRNA deep sequencing have revealed that, in a substantial number of miRNAs, sequences corresponding to specific isomiRs, not the canonical form, are the most abundant. Studies have so far focused on circulating miRNAs as either markers or intercellular communication factors...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36960857/vav3-regulates-glioblastoma-cell-proliferation-migration-invasion-and-cancer-stem%C3%A2-like-cell-self%C3%A2-renewal
#7
JOURNAL ARTICLE
Rui Miao, Dong Huang, Kaitao Zhao, Yang Li, Xiaomei Zhang, Yi Cheng, Na Guo
Glioblastoma multiforme (GBM; World Health Organization grade IV) is one of the most common and aggressive malignant brain tumors and has no effective treatment. Therefore, elucidation of the molecular mechanism of glioma development is very important for finding new therapeutic strategies. The present study evaluated the expression level of Vav guanine nucleotide exchange factor 3 (VAV3) using bioinformatics analysis and demonstrated that VAV3 was overexpressed in human glioblastoma and associated with patient survival...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36928400/-retracted-bmi%C3%A2-1%C3%A2-targeting-suppresses-osteosarcoma-aggressiveness-through-the-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway
#8
Jiaguo Liu, Bin Luo, Meng Zhao
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the immunohistochemical data shown in Fig. 1C and F, the cell invasion assay data shown in Fig. 2C and D, and all the data shown in Fig. 4D‑F were strikingly similar to data appearing in different form in other articles by different authors at different research institutes; moreover, some of the scratch‑wound data shown in Fig. 2B appeared to have been duplicated, such that the same data were shown to represent experiments that were meant to have been performed under different experimental conditions...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36896787/-retracted-downregulation-of-%C3%AE-opioid-receptor-by-rna-interference-enhances-the-sensitivity-of-bel-fu-drug%C3%A2-resistant-human-hepatocellular-carcinoma-cells-to-5%C3%A2-fu
#9
Bo Tang, Zhigao Hu, Yang Li, Shengguang Yuan, Zhenran Wang, Shuiping Yu, Songqing He
Subsequently to the publication of the above article, and a Corrigendum that was published with the intention of showing corrected data for the flow cytometric plots shown in Fig. 3 (DOI: 10.3892/mmr.2018.9415; published online on August 21, 2018), it was drawn to the Editors' attention by a concerned reader that the β‑actin agarose gel electrophoretic blots shown in Fig. 1A were strikingly similar to data appearing in different form in another article by different authors at a different research institute which had already been published elsewhere prior to this paper's submission to Molecular Medicine Reports ...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36896782/non%C3%A2-viral-transfection-methods-optimized-for-mirna-delivery-to-human-dermal-fibroblasts
#10
JOURNAL ARTICLE
Mirosław Kucharski, Patrycja Mrowiec, Szymon Białka, Hanna Misiołek, Maciej Misiołek, Andrzej Sechman, Dorota Zięba-Przybylska, Ewa Ocłoń
Fibroblasts are beneficial model cells for in vitro studies and are frequently used in tissue engineering. A number of transfection reagents have been employed to deliver microRNAs (miRNAs/miRs) into cells for genetic manipulation. The present study aimed to establish an effective method of transient miRNA mimic transfection into human dermal fibroblasts. The experimental conditions included three different methods: Physical/mechanical nucleofection, and two lipid‑based methods, Viromer® Blue and INTERFERin® ...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36896775/knockdown-of-the-long-non%C3%A2-coding-rna-malat1-ameliorates-tnf%C3%A2-%C3%AE-%C3%A2-mediated-endothelial-cell-pyroptosis-via-the-mir%C3%A2-30c%C3%A2-5p-cx43-axis
#11
JOURNAL ARTICLE
Zhang-Jian Yang, Rong Liu, Xiao-Jian Han, Cheng-Lin Qiu, Guan-Lin Dong, Zi-Qin Liu, Li-Hua Liu, Yan Luo, Li-Ping Jiang
Long noncoding RNAs (lncRNAs) are related to the development of atherosclerosis (AS). However, the role of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in tumor necrosis factor‑α (TNF‑α)‑induced rat aortic endothelial cell (RAOEC) pyroptosis, as well as the underlying mechanisms, remain unclear. RAOEC morphology was assessed using an inverted microscope. The mRNA and/or protein expression levels of MALAT1, microRNA(miR)‑30c‑5p and connexin 43 (Cx43) were assessed using reverse transcription‑quantitative PCR (RT‑qPCR) and/or western blotting, respectively...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36896766/alcohol-extracts-from-anemone%C3%A2-flaccida-fr-schmidt-treat-rheumatoid-arthritis-via-inhibition-of-synovial-hyperplasia-and-angiogenesis
#12
JOURNAL ARTICLE
Qi Rao, Xin Zhao, Fenghua Wu, Xiaohong Guo, Yundan Xu, He Yu, Dayong Cai, Gang Zhao
Anemone flaccida Fr. Schmidt, a Traditional Chinese Medicine, has been used in the treatment of rheumatoid arthritis (RA) for numerous years. However, the specific mechanisms remain to be elucidated. Thus, the present study aimed to investigate the main chemical constituents and potential mechanisms of Anemone flaccida Fr. Schmidt. The ethanol extract obtained from Anemone flaccida Fr. Schmidt (EAF) was analyzed using mass spectrometry to determine the main components and the therapeutic effects of EAF on RA were verified using a collagen‑induced arthritis (CIA) rat model...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36866740/apolipoprotein-e-mimetic-peptide-cog1410-alleviates-blood%C3%A2-brain-barrier-injury-in-a-rat-model-of-ischemic-stroke
#13
JOURNAL ARTICLE
Yunwen Xue, Minhua Gu, Cuilan Chen, Yujian Yao, Yuzhen Li, Guohu Weng, Yong Gu
Blood‑brain barrier (BBB) damage is one of the main causes of poor outcomes and increased mortality rates following cerebral ischemia‑reperfusion injury. Apolipoprotein E (ApoE) and its mimetic peptide have been previously reported to exhibit potent neuroprotective properties in various central nervous system disease models. Therefore, the present study aimed to investigate the possible role of the ApoE mimetic peptide COG1410 in cerebral ischemia‑reperfusion injury and its potential underlying mechanism...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36866739/transfer-of-exosomal-micrornas-confers-doxorubicin-resistance-in-osteosarcoma-cells
#14
JOURNAL ARTICLE
Tao Cai, Chunlin Zhang, Taichen Zhan
Osteosarcoma (OS) is the commonest primary malignant bone tumor in children and adolescents. However, chemotherapy resistance is a major challenge for the treatment of OS. Exosomes have been reported to serve an increasingly important role in different stages of tumor progression and chemotherapy resistance. The present study investigated whether exosomes derived from doxorubicin‑resistant OS cells (MG63/DXR) could be taken up in doxorubicin‑sensitive OS cells (MG63) and induce a doxorubicin‑resistant phenotype...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36866735/-retracted-anti%C3%A2-carcinogenic-activity-of-anandamide-on-human-glioma-in%C3%A2-vitro-and-in%C3%A2-vivo
#15
Chao Ma, Ting-Ting Wu, Pu-Cha Jiang, Zhi-Qiang Li, Xin-Jun Chen, Kai Fu, Wei Wang, Rui Gong
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the scratch-wound data shown in Fig. 3A were strikingly similar to data appearing in different form in another article by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to Molecular Medicine Reports , the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36866732/effect-of-electroacupuncture-on-haemodynamic-changes-during-intubation-for-general-anaesthesia-is-mediated-by-nitric-oxide-synthase%C3%A2-3-via-the-regulation-of-microrna%C3%A2-155-microrna%C3%A2-335-and-microrna%C3%A2-383
#16
JOURNAL ARTICLE
Wei Wang, Kang Wang, Xing Zhong
Intubation for general anaesthesia is a life‑threatening risk because it can cause haemodynamic changes. Electroacupuncture (EA) has been reported to alleviate the risk of intubation. In the present study, haemodynamic changes were measured at different time points before and after EA. Reverse transcription‑quantitative PCR was performed to measure the expression of micro (mi)RNAs and endothelial NO synthase (eNOS) mRNA. Western blotting was performed to evaluate the expression of eNOS protein...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36866725/ginsenoside-rg3-has-effects-comparable-to-those-of-ginsenoside-re-on-diabetic-kidney-disease-prevention-in-db-db-mice-by-regulating-inflammation-fibrosis-and-ppar%C3%AE
#17
JOURNAL ARTICLE
Zhe Sui, Dayun Sui, Min Li, Qian Yu, Hongjun Li, Yichuan Jiang
Ginsenoside Rg3 (Rg3) is an adjuvant antitumor drug, while ginsenoside Re (Re) is an adjuvant antidiabetic drug. Our previous studies demonstrated that Rg3 and Re both have hepatoprotective effects in db/db mice. The present study aimed to observe the renoprotective effects of Rg3 on db/db mice, with Re as the control. The db/db mice were randomly assigned to receive daily oral treatment with Rg3, Re or vehicle for 8 weeks. Body weight and blood glucose were examined weekly. Blood lipids, creatinine, and BUN were examined by biochemical assay...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36825576/-corrigendum-high-glucose-and-high-insulin-conditions-promote-mcf%C3%A2-7%C3%A2-cell-proliferation-and-invasion-by-upregulating-irs1-and-activating-the-ras-raf-erk-pathway
#18
Mei-Lin Wei, Peng Duan, Zhi-Ming Wang, Miao Ding, Ping Tu
Subsequently to the publication of this paper, an interested reader drew to the authors' attention that, in the wound‑healing assays portrayed in Fig. 2A on p. 6692, in the 0 h row, the 'NG + LI' and 'HG + HI' panels contained overlapping data, such that they appeared to have been derived from the same original source. After having examined their original data, the authors have realized that this figure was inadvertently assembled incorrectly. The corrected version of Fig...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36825575/a-novel-missense-mutation-in-spast-causes-hereditary-spastic-paraplegia-in-male-members-of-a-family-a-case-report
#19
JOURNAL ARTICLE
Xing-Chen Wang, Rui-Han Liu, Ting Wang, Yanling Wang, Yan Jiang, Dan-Dan Chen, Xin-Yu Wang, Tong-Shu Hou, Qing-Xia Kong
Hereditary spastic paraplegia (HSP) comprises a group of hereditary and neurodegenerative diseases that are characterized by axonal degeneration or demyelination of bilateral corticospinal tracts in the spinal cord; affected patients exhibit progressive spasticity and weakness in the lower limbs. The most common manifestation of HSP is spastic paraplegia type 4 (SPG4), which is caused by mutations in the spastin ( SPAST ) gene. The present study reports the clinical characteristics of affected individuals and sequencing analysis of a mutation that caused SPG4 in a family...
April 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36825563/stat3-inhibitor-stattic-and-its-analogues-inhibit-stat3-phosphorylation-and-modulate-cytokine-secretion-in-senescent-tumour-cells
#20
JOURNAL ARTICLE
Romana Mikyskova, Olena Sapeg, Miroslav Psotka, Ondrej Novotny, Zdeněk Hodny, Sona Balintova, David Malinak, Jana Svobodova, Rudolf Andrys, David Rysanek, Kamil Musilek, Milan Reinis
Signal transducer and activator of transcription 3 (STAT3) signalling serves an important role in carcinogenesis and cellular senescence, and its inhibition in tumour cells represents an attractive therapeutic target. Premature cellular senescence, a process of permanent proliferative arrest of cells in response to various inducers, such as cytostatic drugs or ionizing radiation, is accompanied by morphological and secretory changes, and by altered susceptibility to chemotherapeutic agents, which can thereby complicate their eradication by cancer therapies...
April 2023: Molecular Medicine Reports
journal
journal
42013
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.