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Journals Journal of Aerosol Medicine an...

Journal of Aerosol Medicine and Pulmonary Drug Delivery

https://read.qxmd.com/read/38768422/new-generation-nebulizers
#1
REVIEW
Martin Knoch
Standard nebulizers are intended for general purpose use and typically are continuously operated jet or ultrasonic nebulizers. Evolutionary developments such as breath-enhanced and breath-triggered devices have improved delivery efficiency and ease of use, yet are still suitable for delivery of nebulized medications approved in this category. However, recent developments of vibrating membrane or mesh nebulizers have given rise to a significant increase in delivery efficiency requiring reformulation of former drug products or development of new formulations to match the enhanced delivery characteristics of these new devices...
May 20, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38687321/safety-and-efficacy-of-2-5%C3%A2-mg-and-1-25%C3%A2-mg-nebulized-salbutamol-compared-with-placebo-on-transient-tachypnea-of-the-newborns-a-triple-blind-phase-ii-iii-parallel-randomized-controlled-trial
#2
JOURNAL ARTICLE
Farhad Abolhasan Choobdar, Zahra Vahedi, Ali Mazouri, Mohammad Torkaman, Nastaran Khosravi, Nasrin Khalesi, Zahra Soltani, Arash Mohazzab, Rezvan Ashkanipour
Background: To evaluate the safety and efficacy of 2.5 and 1.25 mg nebulized salbutamol on Transient Tachypnea of the Newborn (TTN) compared with placebo. Methods: We conducted a triple-blind, phase II/III parallel randomized controlled trial in two university-affiliated hospitals with neonatal intensive care units. Newborns with a confirmed diagnosis of TTN, with gestational age >35 weeks and gestational weight >2 kg were included. Cases of asphyxia, meconium aspiration syndrome, and persistent pulmonary hypertension were excluded...
May 2, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38683652/nebulizers
#3
JOURNAL ARTICLE
James B Fink, Kevin W Stapleton
Nebulizers generate aerosols from liquid-based solutions and suspensions. Nebulizers are particularly well suited to delivering larger doses of medication than is practical with inhalers and are used with a broad range of liquid formulations. When the same drug is available in liquid or inhaler form, nebulizers are applicable for use with patients who will not or cannot reliably use a pressurized metered-dosed inhaler (pMDI) or dry powder inhaler (DPI) due to poor lung function, hand-breath coordination, cognitive abilities (e...
April 29, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38683575/optimizing-aerosolized-drug-delivery-in-clinical-trials-in-patients-undergoing-mechanical-ventilation
#4
EDITORIAL
Thomas G O'Riordan
No abstract text is available yet for this article.
April 29, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38669118/research-progress-on-liposome-pulmonary-delivery-of-mycobacterium-tuberculosis-nucleic-acid-vaccine-and-its-mechanism-of-action
#5
REVIEW
Danyang Zhang, Haimei Zhao, Ping Li, Xueqiong Wu, Yan Liang
Traditional vaccines have played an important role in the prevention and treatment of infectious diseases, but they still have problems such as low immunogenicity, poor stability, and difficulty in inducing lasting immune responses. In recent years, the nucleic acid vaccine has emerged as a relatively cheap and safe new vaccine. Compared with traditional vaccines, nucleic acid vaccine has some unique advantages, such as easy production and storage, scalability, and consistency between batches. However, the direct administration of naked nucleic acid vaccine is not ideal, and safer and more effective vaccine delivery systems are needed...
April 26, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38687136/acute-effect-of-e-cigarette-inhalation-on-mucociliary-clearance-in-e-cigarette-users
#6
JOURNAL ARTICLE
William D Bennett, Phillip W Clapp, Kirby L Zeman, Jihong Wu, Brian Ring, Ilona Jaspers
Background: Recent studies show e-cigarette (EC) users have increased rates of chronic bronchitic symptoms that may be associated with depressed mucociliary clearance (MCC). Little is known about the acute or chronic effects of EC inhalation on in vivo MCC. Methods: In vivo MCC was measured in young adult vapers ( n  = 5 males, mean age = 21) after controlled inhalation of a radiolabeled (Tc99m sulfur colloid) aerosol. Whole-lung clearance of radiolabeled deposited particles was measured over a 90-minute period for baseline MCC and associated with controlled periodic vaping over the first 60 minutes of MCC measurements...
April 22, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38648279/optimal-inhalation-profile-of-pressurized-metered-dry-powder-inhaler-using-a-valved-holding-chamber-a-dynamic-analysis
#7
JOURNAL ARTICLE
Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Shigeto Horiuchi, Kazunari Maeda, Shunichi Tobe, Riko Kamada, Shigehiro Watanabe
Background : The combined use of a pressurized metered-dose inhaler and valved holding chamber (pMDI+VHC) is recommended to improve efficiency and safety; however, aerosol release is likely to vary with the inhalation maneuver. This in vitro study investigated the aerodynamic characteristics and aerosol release features of pMDI+VHC (Aerochamber, Trudell Medical International). Methods : The static and dynamic changes in the airway resistance ( R aw ) during inhalation (withdrawal) through pMDI+VHC were measured...
April 22, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38563793/effect-of-interrupting-heated-humidification-on-nebulized-drug-delivery-efficiency-temperature-and-absolute-humidity-during-mechanical-ventilation-a-multi-lab-in-vitro-study
#8
JOURNAL ARTICLE
Sophie Jacquier, Hui-Ling Lin, Jie Li, Caylie A Sheridan, Paul Karabelas, Jui-Fang Liu, Stephan Ehrmann, James B Fink
Introduction: During mechanical ventilation (MV), inspired gases require heat and humidification. However, such conditions may be associated with reduced aerosol delivery efficiency. The practice of turning off heated humidification before nebulization and the impact of nebulization on humidity in a dry ventilator circuit remain topics of debate. This study aimed to assess the effect of turning off heated humidification on inhaled dose and humidity with nebulizer use during adult MV. Methods: A bronchodilator (albuterol) and two antibiotics (Colistimethate sodium and Amikacin sulfate) were nebulized with a vibrating mesh nebulizer placed at the humidifier inlet and in the inspiratory limb at the Y-piece...
April 2, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38563958/the-effects-of-inspiratory-flows-inspiratory-pause-and-suction-catheter-on-aerosol-drug-delivery-with-vibrating-mesh-nebulizers-during-mechanical-ventilation
#9
JOURNAL ARTICLE
Hui-Ling Lin, James B Fink, Jie Li
Background: Some experts recommend specific ventilator settings during nebulization for mechanically ventilated patients, such as inspiratory pause, high inspiratory to expiratory ratio, and so on. However, it is unclear whether those settings improve aerosol delivery. Thus, we aimed to evaluate the impact of ventilator settings on aerosol delivery during mechanical ventilation (MV). Methods: Salbutamol (5.0 mg/2.5 mL) was nebulized by a vibrating mesh nebulizer (VMN) in an adult MV model. VMN was placed at the inlet of humidifier and 15 cm away from the Y-piece of the inspiratory limb...
April 1, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38478800/dr-michael-newhouse-march-21-1935-december-25-2023-a-global-legacy-in-respiratory-medicine-and-aerosol-therapy-my-mentor
#10
JOURNAL ARTICLE
Israel Amirav
No abstract text is available yet for this article.
March 13, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38640447/developing-dry-powder-inhaler-formulations
#11
REVIEW
David A V Morton, David Barling
This section aims to provide a concise and contemporary technical perspective and reference resource covering dry powder inhaler (DPI) formulations. While DPI products are currently the leading inhaled products in terms of sales value, a number of confounding perspectives are presented to illustrate why they are considered surprisingly, and often frustratingly, poorly understood on a fundamental scientific level, and most challenging to design from first principles. At the core of this issue is the immense complexity of fine cohesive powder systems...
April 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38640446/liposomes-for-inhalation
#12
JOURNAL ARTICLE
Hui Xin Ong, Daniela Traini, Paul M Young
Inhalation of liposomes formulated with phospholipids similar to endogenous lung surfactants and lipids offers biocompatibility and versatility within the pulmonary medicine field to treat a range of diseases such as lung cancer, cystic fibrosis and lung infections. Manipulation of the physicochemical properties of liposomes enables innovative design of the carrier to meet specific delivery, release and targeting requirements. This delivery system offers several benefits: improved pharmacokinetics with reduced toxicity, enhanced therapeutic efficacy, increased delivery of poorly soluble drugs, taste masking, biopharmaceutics degradation protection and targeted cellular therapy...
April 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38354286/hypertonic-aerosols-hydrate-airways-longer-and-reduce-acidification-risk-with-nonpermeating-cation-and-permeating-anion-salts
#13
JOURNAL ARTICLE
Ana Flavia Zuim, Aurélie Edwards, Dennis Ausiello, Deen Bhatta, David A Edwards
Background: Hyperosmolar aerosols appear to promote or suppress upper airway dysfunction caused by dehydration in a composition-dependent manner. We sought to explore this composition dependence experimentally, in an interventional human clinical study, and theoretically, by numerical analysis of upper airway ion and water transport. Methods: In a double-blinded, placebo-controlled clinical study, phonation threshold pressure (PTP) was measured prenasal and postnasal inhalation of hypertonic aerosols of NaCl, KCl, CaCl2 , and MgCl2 in seven human subjects...
February 14, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38064481/tracheomalacia-reduces-aerosolized-drug-delivery-to-the-lung
#14
JOURNAL ARTICLE
Chamindu C Gunatilaka, Christopher McKenzie, Erik B Hysinger, Qiwei Xiao, Nara S Higano, Jason C Woods, Alister J Bates
Rationale: Neonates with respiratory issues are frequently treated with aerosolized medications to manage lung disease or facilitate airway clearance. Dynamic tracheal collapse (tracheomalacia [TM]) is a common comorbidity in these patients, but it is unknown whether the presence of TM alters the delivery of aerosolized drugs. Objectives: To quantify the effect of neonatal TM on the delivery of aerosolized drugs. Methods: Fourteen infant subjects with respiratory abnormalities were recruited; seven with TM and seven without TM...
February 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38285475/quantifying-exhaled-particles-in-healthy-humans-during-various-respiratory-activities-under-realistic-conditions
#15
JOURNAL ARTICLE
Katharina Schwarz, Nadja Struß, Liudmila Banari, Jens M Hohlfeld
Background: Quantitatively collecting and characterizing exhaled aerosols is vital for infection risk assessment, but the entire droplet size spectrum has often been neglected. We analyzed particle number and size distribution of healthy participants in various respiratory activities, considering inter-individual variability, and deployed a simplified far-field model to inform on infection risks. Methods: Participants repeated the same respiratory activities on two visits. Particles were collected using an airtight extraction helmet supplied with High Efficiency Particulate Air (HEPA) filtered air...
January 29, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38237032/practical-considerations-in-dose-extrapolation-from-animals-to-humans
#16
REVIEW
Anthony J Hickey, Sara E Maloney, Phillip J Kuehl, Jonathan E Phillips, Ronald K Wolff
Animal studies are an important component of drug product development and the regulatory review process since modern practices have been in place, for almost a century. A variety of experimental systems are available to generate aerosols for delivery to animals in both liquid and solid forms. The extrapolation of deposited dose in the lungs from laboratory animals to humans is challenging because of genetic, anatomical, physiological, pharmacological, and other biological differences between species. Inhaled drug delivery extrapolation requires scrutiny as the aerodynamic behavior, and its role in lung deposition is influenced not only by the properties of the drug aerosol but also by the anatomy and pulmonary function of the species in which it is being evaluated...
January 17, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38197850/aerosolizable-pyrazinamide-loaded-biodegradable-nanoparticles-for-the-management-of-pulmonary-tuberculosis
#17
JOURNAL ARTICLE
Komal Parmar, Swati Sondarva
Background: Pyrazinamide is a Biopharmaceutical Classification System class III antibiotic indicated for active tuberculosis. Methods: In the present work, pyrazinamide-loaded biodegradable polymeric nanoparticles (PNPs) based dry powder inhaler were developed using the double emulsion solvent evaporation technique and optimized using design of experiments to provide direct pulmonary administration with minimal side effects. Batches were characterized for various physicochemical and aerosol performance properties...
January 10, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38052057/modeling
#18
REVIEW
Neil A Miller
Modeling is coming to the fore as it is now widely accepted and indeed expected during drug discovery and development. Modeling integrates knowledge, increases understanding and provides the ability to predict an outcome either before it occurs or when it is not possible to measure. This makes modeling an attractive option for inhaled drugs as it is not possible to routinely measure what is occurring to the drug (pharmacokinetics) and what effect the drug is having (pharmacodynamics) at local microscopic sites of such a diverse and complex organ as the lung...
December 5, 2023: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38016133/dry-powder-inhalers-an-overview
#19
REVIEW
Anthony J Hickey
Dry powder inhaler products have played an important role in the treatment and prevention of asthma and more recently chronic obstructive pulmonary disease. The considerations that go into formulation development to support these products cover a unique range of disciplines including analytical and physical chemistry, aerosol physics, device technology, process engineering and industrial design. An enormous research effort has been expended in the last half century to provide understanding of this complex dosage form...
December 2023: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38016124/dry-powder-inhalers-from-bench-to-bedside
#20
JOURNAL ARTICLE
Henry Chrystyn, Wahida Azouz, Walid Tarsin
Dry powder inhalers (DPIs) are now widely prescribed and preferred by the majority of patients. These devices have many advantages over the traditional pressurized metered-dose inhaler (pMDI) but they do have disadvantages. The characteristics of the dose emitted from a DPI are affected by the inhalation manoeuvre used by a patient. Each patient is different and the severity of their lung disease varies from mild to very severe. This affects how they use an inhaler and so determines the type of dose they inhale...
December 2023: Journal of Aerosol Medicine and Pulmonary Drug Delivery
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