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International Journal of Rheumatic Diseases

Zohra Layegh, Jill Ruwaard, Renske C F Hebing, Merel J L' Ami, Wilfred van der Weele, Mike T Nurmohamed, Charlotte Krieckaert, Gertjan Wolbink
OBJECTIVES: To evaluate the transition from reference infliximab Remicade to biosimilar Remsima in patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA). METHODS: Patients were informed through a letter about the transition to a biosimilar and were subsequently contacted for possible additional questions and whether they agreed upon the transition. Once agreed, Remsima was administered at the same dosage and interval as previous treatment with Remicade...
February 14, 2019: International Journal of Rheumatic Diseases
Kai-Chun Wang, Hsien-Tzung Liao, Wei-Sheng Chen, Chien-Chih Lai, Chung-Tei Chou, Ming-Han Chen, Chang-Youh Tsai
AIM: To assess the real-world effectiveness and safety of rituximab (RTX) at 24 months in patients with established rheumatoid arthritis (RA) and to identify predictors of low disease activity/remission and a good European League Against Rheumatism (EULAR) response. METHODS: Seventy RTX-treated RA patients were enrolled. Predictors for low disease activity/remission and a good EULAR response at 24 months were identified by multivariate analyses. RESULTS: At 24 months, the mean Disease Activity Score of 28 joints-erythrocyte sedimentation rate (DAS28-ESR) decreased from 6...
February 13, 2019: International Journal of Rheumatic Diseases
Xiaoyun Peng, Zhiguang Qiao, You Wang, Huiqin Li, Yilin Xie, Mei Xin, Zhongdong Qiao, Zhaoxia Wang
PROBLEM: Osteoarthritis (OA) is a chronic disease with a very high incidence and the pathology of which is quite complex. Epidemiological investigation showed that OA may be related to smoking and estrogen levels, but there are few studies focused on the cross-effect of these two factors. This research aims to investigate the molecular mechanism of nicotine and estrogen effects on chondrocytes to study the effect of smoking on the incidence of osteoarthritis in women. METHOD OF THE STUDY: Nicotine was added to obtain inflammatory supernatants of macrophages, which were used to induce chondrocyte inflammation...
February 11, 2019: International Journal of Rheumatic Diseases
Na Zhang, Mengtao Li, Junyan Qian, Qian Wang, Jiuliang Zhao, Zhenwen Yang, Zhuang Tian, Xiao Zhang, Xiaoxia Zuo, Miaojia Zhang, Ping Zhu, Shuang Ye, Wei Zhang, Yi Zheng, Wufang Qi, Yang Li, Zhuoli Zhang, Feng Ding, Jieruo Gu, Yi Liu, Wei Wei, Xiaofeng Zeng
AIM: Pulmonary arterial hypertension (PAH) is a complex and devastating complication of systemic lupus erythematosus (SLE). We sought to describe the baseline characteristics of right heart catheterization (RHC)-confirmed SLE-associated PAH and identify risk factors for PAH in SLE patients. METHODS: A multicenter, cross-sectional study was conducted using the Chinese SLE Treatment and Research group (CSTAR) registry. Baseline data for patients with SLE-associated PAH and SLE patients without PAH were collected and compared...
February 11, 2019: International Journal of Rheumatic Diseases
Maryam Hemmatzadeh, Farhad Babaie, Fatemeh Ezzatifar, Fatemeh S Mohammadi, Mehrdad Ebrazeh, Shirin Golabi Aghdam, Mehrzad Hajaliloo, Gholamreza Azizi, Arezoo Gowhari Shabgah, Najibeh Shekari, Nasrin Sehati, Ramin Hosseinzadeh, Hamed Mohammadi, Zohreh Babaloo
AIM: To evaluate the association of ERAP1 gene single nucleotide polymorphisms (SNPs) with the risk of ankylosing spondylitis (AS) and their role in modulation of the inflammatory interleukin (IL)-17/IL-23 axis in the disease. METHODS: For genotyping, 190 AS cases and 190 healthy controls were enrolled. After DNA extraction, all the subjects were genotyped for rs17482078, rs469876, and rs27038 polymorphisms using single specific primer polymerase chain reaction (PCR) assay...
February 10, 2019: International Journal of Rheumatic Diseases
Bon San Koo, Yoonah Song, Ji Hui Shin, Seunghun Lee, Tae-Hwan Kim
AIM: This study investigated the use of fat fraction (FF) measurements in the sacroiliac (SI) joint to determine radiologic progression in patients with spondyloarthritis (SpA). METHOD: A total of 138 patients who underwent pelvic magnetic resonance imaging (MRI) between September 2014 and March 2015 were retrospectively evaluated. The FF based upon fat deposition (%) using fat signaling on T1 and T2 weighted images in the sacroiliac joint was quantified using a 6-echo variant of the modified Dixon technique...
February 10, 2019: International Journal of Rheumatic Diseases
Yan Li, Limin Ren, Xu Liu, Xiaotao Zhao, Fanlei Hu, Zhanguo Li
AIM: To investigate the impact of corticosteroids on the outcome of antiviral therapy in rheumatic patients with cytomegalovirus (CMV)-emia. METHOD: Sixty-two patients with rheumatic disease complicated by CMV infection from 2011 to 2014 were retrospectively analyzed. RESULTS: Fifty-five of 62 patients were diagnosed with CMV-DNAemia. Most patients (43/55, 78.2%) achieved viral clearance within 5 weeks. It was shown that, while undergoing active antiviral therapy, there was no significant difference in the CMV-DNAemia clearance rate between the pulse methylprednisolone (MPSL) therapy group and non-pulse group (8/9, 88...
February 10, 2019: International Journal of Rheumatic Diseases
Zi-Wei Dai, Zhi-Hui Wang, Yuan-Yuan Dong, Yue Wu, Hai-Li Wang, De-Guang Wang, Bin Wang, Dong-Qing Ye
AIM: To evaluate the overall diagnostic value of anti-citrullinated fibrinogen (ACF) antibody in patients with rheumatoid arthritis (RA). METHODS: Published studies were systematically retrieved from PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wan Fang, China Biology Medicine (CBM) disc, and Chinese VIP databases. QUADAS-2 tool was applied to evaluate the quality of eligible studies. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity...
February 6, 2019: International Journal of Rheumatic Diseases
Ha-Rim Park, SeulGi Im, Hyoungyoung Kim, Sun-Young Jung, Dalho Kim, Eun Jin Jang, Yoon-Kyoung Sung, Soo-Kyung Cho
BACKGROUND: To identify knee osteoarthritis (OA) patients among OA patients in the claims database. METHODS: All patients with OA diagnostic codes for any sites (M15 to M19) in 2014 were recruited from a single academic referral hospital. After excluding patients who had inflammatory arthritis or were less than 50 years of age, we identified data for the overall OA population. Radiographic knee OA of Kellgren and Lawrence grades ≥2 is considered the gold standard for knee OA, and we evaluated the sensitivity, specificity, and positive predictive value (PPV) of three operational definitions using the diagnostic codes in the claims database...
February 6, 2019: International Journal of Rheumatic Diseases
Kumutha Gopal, Malathi Thevarajah, Choung Min Ng, Jasmin Raja
AIM: Vitamin D3 or 25(OH)D3 may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro-inflammatory cytokines including interleukin-6 (IL-6). The aim of this study is to determine the clinical factors of vitamin D deficiency in multi-ethnic Malaysian RA patients and its association with disease activity, functional disability and serum IL-6 levels. METHOD: One hundred RA patients and 50 healthy controls, sex- and age-matched, were recruited...
February 6, 2019: International Journal of Rheumatic Diseases
Toby Smith, Tom S Collier, Benjamin Smith, Michael Mansfield
OBJECTIVES: To determine the characteristics of individuals with hip and/or knee osteoarthritis who are recommended to seek physiotherapy or exercise treatment, and to explore which people are more or less likely to follow such recommendations. METHODS: All data were obtained from Wave 4 of the English Longitudinal Study of Ageing (ELSA) cohort (2008-2009), a prospectively collected community-based dataset. Eligibility was justified by a patient-reported diagnosis of hip and/or knee osteoarthritis with a visual analog scale (VAS) pain score of 1 or above...
February 6, 2019: International Journal of Rheumatic Diseases
Hyun Yi Kook, So-Hee Jin, Pu-Reum Park, Seung-Jin Lee, Hong-Joon Shin, Tae-Jong Kim
OBJECTIVE: Serum microRNA (miR) in ankylosing spondylitis (AS) patients has been rarely identified. The objective of this study was to find AS-specific miR in sera of patients with AS. METHODS: Total RNAs were isolated from whole sera of patients with AS, patients with rheumatoid arthritis (RA), and healthy controls (HC) using miRNeasy Serum/Plasma Kit. The presence of miR was assayed using Agilent 2100 Bioanalyzer Small RNA assay. Each RNA sample was used for miR microarray...
February 6, 2019: International Journal of Rheumatic Diseases
Anand Kumthekar, Sarah Shull, Travis I Lovejoy, Benjamin J Morasco, Michael Chang, Jennifer Barton
OBJECTIVE: To assess the impact of direct acting anti-viral (DAA) therapy for hepatitis C virus (HCV) infection on changes in pain intensity and prescription opioid use among Veterans. METHODS: We conducted a retrospective cohort study of Veterans with HCV who were seen in a rheumatology clinic at least once while receiving DAA therapy between January 1, 2010 and December 31st 2016. Demographic characteristics, HCV status, HCV treatment characteristics, numeric rating scale (NRS) pain scores and opioid prescription data were extracted from the electronic medical record...
February 6, 2019: International Journal of Rheumatic Diseases
Kuo-Tung Tang, Tsu-Yi Hsieh, Ya-Hsuan Chao, Ju-Pi Li, Joung-Liang Lan, Chi-Chien Lin, Der-Yuan Chen
AIM: Dysregulated apoptosis has been implicated in autoimmune diseases. In the present study, we investigated the apoptosis-related cytokines and apoptosis in patients with primary antiphospholipid syndrome (pAPS). METHOD: We prospectively recruited 12 pAPS patients, 17 antiphospholipid antibody (APA)-positive systemic lupus erythematosus (SLE) patients without APS manifestations (APA+ SLE), 13 SLE patients with secondary APS (APS+ SLE) and 10 healthy controls (HCs)...
February 6, 2019: International Journal of Rheumatic Diseases
Nelly Ziade, Ghada Abi Karam, Georges Merheb, Iyad Mallak, Laure Irani, Elie Alam, Jamil Messaykeh, Jeanine Menassa, Kamel Mroue', Imad Uthman, Abdel Fattah Masri, Pierre Ghorra, Torsten Witte, Xenofon Baraliakos
AIM: To calculate the prevalence of human leukocyte antigen (HLA)-B27 in axial spondyloarthritis patients (axSpA) compared to blood donors (BD) in Lebanon, to identify the clinical and radiological findings associated with HLA-B27 and to estimate the proportion of patients fulfilling the clinical arm of the Assessment of the Spondyloarthritis International Association (ASAS) criteria. METHOD: Consecutive Lebanese adult axSpA patients fulfilling the ASAS classification criteria were included from 12 rheumatology clinics across Lebanon...
February 6, 2019: International Journal of Rheumatic Diseases
Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
AIM: The prognostic nutritional index (PNI), calculated by serum albumin and peripheral blood lymphocyte count, is considered to reflect immune-related nutritional status. In this study, we first investigated the clinical significance of PNI in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHOD: Medical records of 160 patients classified as AAV from October 2000 to September 2017 were reviewed. We calculated the Birmingham vasculitis activity score (BVAS) and collected laboratory data including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, white blood cell, lymphocyte, and platelet counts, and serum albumin, aspartate aminotransferase, and alanine aminotransferase levels at diagnosis...
February 6, 2019: International Journal of Rheumatic Diseases
Linhui Li, Jian Chen, Yongmei Jiang
No abstract text is available yet for this article.
February 6, 2019: International Journal of Rheumatic Diseases
Harunobu Iida, Hironari Hanaoka, Yukinori Okada, Tomofumi Kiyokawa, Yukiko Takakuwa, Hidehiro Yamada, Takahiro Okazaki, Shoichi Ozaki, Kenichiro Yamaguchi, Yasuo Nakajima, Kimito Kawahata
AIM: This study investigated the prognostic factors of cardiac death or cardiac failure using cardiac scintigraphy, echocardiography (UCG), and magnetic resonance imaging (MRI) in asymptomatic systemic sclerosis (SSc) patients. METHODS: We retrospectively evaluated SSc patients who had undergone cardiac scintigraphy using 99m thallium (99m Tl) and 123 I-β-methyl-P-iodophenyl-pentadecanoic acid (123 I-BMIPP), UCG, and cardiac MRI. We calculated the mismatch score in scintigraphy by subtracting the uptake of 123 I-BMIPP from that of 99m Tl...
February 6, 2019: International Journal of Rheumatic Diseases
Gil Bornstein, Ilan Ben-Zvi, Nadav Furie, Chagai Grossman
AIM: Anti-neutrophil cytoplasmic antibodies (ANCA) have a role in the diagnostic workup of ANCA-associated vasculitis. However, the clinical significance of positive ANCA in the absence of vasculitis is yet to be determined. Therefore, we sought to investigate the clinical spectrum and rate of patients with a positive ANCA without evidence of vasculitis. METHODS: Retrospective analysis of patients positive for cytoplasmic ANCA (C-ANCA) and proteinase 3 (PR3) or P-ANCA and myeloperoxidase (MPO) between 2007 and 2016 in the Chaim Sheba Medical Center, Israel...
February 6, 2019: International Journal of Rheumatic Diseases
Kookwan Sawadpanich, Pisit Soison, Kitti Chunlertrith, Pisaln Mairiang, Wattana Sukeepaisarnjaroen, Apichat Sangchan, Tanita Suttichaimongkol, Chingching Foocharoen
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) results in nutrient malabsorption and malnutrition, thereby increasing the morbidity and mortality in systemic sclerosis (SSc) patients. OBJECTIVES: To evaluate the prevalence and associated factors of SIBO in SSc patients. METHOD: A cross-sectional study was conducted between July 2015 and January 2016 in SSc patients over 18, using the glucose H2 /CH4 breath test to evaluate SIBO. RESULTS: Eighty-nine SSc patients (30 male and 59 female) underwent the glucose H2 /CH4 breath test...
February 6, 2019: International Journal of Rheumatic Diseases
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