journal
https://read.qxmd.com/read/38383460/the-impact-of-clinical-and-laboratory-parameters-on-clinical-pregnancy-and-live-birth-rates-in-fresh-cycles-a-retrospective-study-of-9608-high-quality-cleavage-stage-embryos
#21
JOURNAL ARTICLE
Haijing Zhao, Keer Gan, Xiaohui Ji, Lingyan Zheng, Songbang Ou, Mei Mei, Qingxue Zhang, Hui Chen, Ping Yuan, Wenjun Wang
BACKGROUND: Evidence from the Istanbul consensus workshop suggests correlations between morphological parameters and embryo developments. 8-cell embryos are the best blastomere stage on day 3. No good quality evidence exists to support high-quality embryonic selection following blastulation and clinical outcomes. This study aimed to investigate the factors that affect blastocyst formation, blastocyst quality, and clinical outcomes of high-quality cleavage-stage embryos in fresh cycles...
February 21, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38378652/efficacy-of-natural-products-on-premature-ovarian-failure-a-systematic-review-and-meta-analysis-of-preclinical-studies
#22
REVIEW
Hangqi Hu, Jiacheng Zhang, Xiyan Xin, Yuxin Jin, Yutian Zhu, Haolin Zhang, Ruiwen Fan, Yang Ye, Dong Li
OBJECTIVE: This study aims to investigate the effects of natural products on animal models of premature ovarian failure (POF). METHODS: We conducted comprehensive literature searches and identified relevant studies that examined the protective effects of natural products on experimental POF. We extracted quantitative data on various aspects such as follicular development, ovarian function, physical indicators, oxidative stress markers, inflammatory factors, and protein changes...
February 20, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38378582/an-integrated-machine-learning-based-model-for-joint-diagnosis-of-ovarian-cancer-with-multiple-test-indicators
#23
JOURNAL ARTICLE
Yiwen Feng
OBJECTIVE: To construct a machine learning diagnostic model integrating feature dimensionality reduction techniques and artificial neural network classifiers to develop the value of clinical routine blood indexes for the auxiliary diagnosis of ovarian cancer. METHODS: Patients with ovarian cancer clearly diagnosed in our hospital were collected as a case group (n = 185), and three groups of patients with other malignant otolaryngology tumors (n = 138), patients with benign otolaryngology diseases (n = 339) and those with normal physical examination (n = 92) were used as an overall control group...
February 20, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38374173/arachidonic-acid-inhibit-granulosa-cell-function-by-affecting-metabolic-function-of-liver-in-brown-adipose-transplantation-rats
#24
JOURNAL ARTICLE
Yan Yan, Fangfang Di, Ruoxi Zhang, Liwen Song, Runjie Zhang, Jin Qiu
BACKGROUND: Polycystic ovary syndrome (PCOS) is a gynecological endocrine disease and could be considered a metabolic disease because it is often accompanied by obesity and insulin resistance. Brown adipose tissue (BAT) transplantation has been shown to be effective in treating PCOS rats. RESULTS: The study demonstrated that BAT successfully recovered the reproductive and metabolic phenotype of PCOS rats. The disorder estrous cycle, abnormal hyperglycemia and the expression of liver factors were improved...
February 19, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38374055/structural-basis-for-antibody-recognition-of-the-proximal-muc16-ectodomain
#25
JOURNAL ARTICLE
Kwangkook Lee, Kay Perry, Mengyao Xu, Irva Veillard, Raj Kumar, Thapi Dharma Rao, Bo R Rueda, David R Spriggs, Oladapo O Yeku
BACKGROUND: Mucin 16 (MUC16) overexpression is linked with cancer progression, metastasis, and therapy resistance in high grade serous ovarian cancer and other malignancies. The cleavage of MUC16 forms independent bimodular fragments, the shed tandem repeat sequence which circulates as a protein bearing the ovarian cancer biomarker (CA125) and a proximal membrane-bound component which is critical in MUC16 oncogenic behavior. A humanized, high affinity antibody targeting the proximal ectodomain represents a potential therapeutic agent against MUC16 with lower antigenic potential and restricted human tissue expression...
February 19, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38374053/metformin-versus-metformin-plus-pioglitazone-on-gonadal-and-metabolic-profiles-in-normal-weight-women-with-polycystic-ovary-syndrome-a-single-center-open-labeled-prospective-randomized-controlled-trial
#26
RANDOMIZED CONTROLLED TRIAL
Han Zhao, Jiaqi Zhang, Chuan Xing, Xiangyi Cheng, Bing He
OBJECTIVE: To investigate the effects of metformin (MET) monotherapy and pioglitazone plus MET (PIOMET) therapy on gonadal and metabolic profiles in normal-weight women with polycystic ovary syndrome (PCOS). METHODS: Sixty normal-weight women with PCOS were recruited between January and September 2022 at the Shengjing Hospital of China Medical University. They were randomly assigned to the MET or PIOMET groups for 12 weeks of MET monotherapy or PIOMET therapy. Anthropometric measurements, menstrual cycle changes, gonadal profiles, and the oral glucose insulin-releasing test (OGIRT) were performed at baseline and after the 12-week treatment...
February 19, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38373971/high-levels-of-fatty-acid-binding-protein-5-excessively-enhances-fatty-acid-synthesis-and-proliferation-of-granulosa-cells-in-polycystic-ovary-syndrome
#27
JOURNAL ARTICLE
Jingyu Liu, Jie Li, Xin Wu, Mei Zhang, Guijun Yan, Haixiang Sun, Dong Li
BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most complex endocrine disorders in women of reproductive age. Abnormal proliferation of granulosa cells (GCs) is an important cause of PCOS. This study aimed to explore the role of fatty acid-binding protein 5 (FABP5) in granulosa cell (GC) proliferation in polycystic ovary syndrome (PCOS) patients. METHODS: The FABP5 gene, which is related to lipid metabolism, was identified through data analysis of the gene expression profiles of GSE138518 from the Gene Expression Omnibus (GEO) database...
February 19, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38355537/cai-s-prescription-inhibits-granulosa-cell-apoptosis-through-arhgap4-on-poor-ovarian-responders
#28
JOURNAL ARTICLE
Zheng Wang, Denghao Liu, Yonghong Nie, Qinhua Zhang
PURPOSE: Poor ovarian response (POR) is a big challenge for in vitro fertilization. The traditional Chinese medicine, Cai's Prescription of Tonifying Kidney and Strengthening Vitals (Cai's Prescription) has yielded satisfactory results for POR treatment clinically, but systematic scientific research of Cai's Prescription is not well reported. This study aimed to investigate the clinical effect of Cai's Prescription on poor ovarian responders and its biological mechanism. METHODS: Serum was collected from poor ovarian responders, and IL-1β, INFγ, FSH, E2 and AMH levels were analyzed by ELISA...
February 14, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38347608/from-clinical-management-to-personalized-medicine-novel-therapeutic-approaches-for-ovarian-clear-cell-cancer
#29
REVIEW
Zesi Liu, Chunli Jing, Fandou Kong
Ovarian clear-cell cancer is a rare subtype of epithelial ovarian cancer with unique clinical and biological features. Despite optimal cytoreductive surgery and platinum-based chemotherapy being the standard of care, most patients experience drug resistance and a poor prognosis. Therefore, novel therapeutic approaches have been developed, including immune checkpoint blockade, angiogenesis-targeted therapy, ARID1A synthetic lethal interactions, targeting hepatocyte nuclear factor 1β, and ferroptosis. Refining predictive biomarkers can lead to more personalized medicine, identifying patients who would benefit from chemotherapy, targeted therapy, or immunotherapy...
February 12, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38347589/knowledge-graph-construction-based-on-granulosa-cells-transcriptome-from-polycystic-ovary-syndrome-with-normoandrogen-and-hyperandrogen
#30
JOURNAL ARTICLE
Wensu Liu, Tianyu Tang, Jianwei Feng, Chunyu Wang, Lin Lin, Shengli Wang, Kai Zeng, Renlong Zou, Zeyu Yang, Yue Zhao
PCOS is a widespread disease that primarily caused in-pregnancy in pregnant-age women. Normoandrogen (NA) and Hyperandrogen (HA) PCOS are distinct subtypes of PCOS, while bio-markers and expression patterns for NA PCOS and HA PCOS have not been disclosed. We performed microarray analysis on granusola cells from NA PCOS, HA PCOS and normal tissue from 12 individuals. Afterwards, microarray data were processed and specific genes for NA PCOS and HA PCOS were identified. Further functional analysis selected IL6R and CD274 as new NA PCOS functional markers, and meanwhile selected CASR as new HA PCOS functional marker...
February 12, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38336796/loss-of-calponin-2-causes-premature-ovarian-insufficiency-in-mice
#31
JOURNAL ARTICLE
Tzu-Bou Hsieh, Jian-Ping Jin
BACKGROUND: Premature ovarian insufficiency (POI) is a condition defined as women developing menopause before 40 years old. These patients display low ovarian reserve at young age and difficulties to conceive even with assisted reproductive technology. The pathogenesis of ovarian insufficiency is not fully understood. Genetic factors may underlie most of the cases. Actin cytoskeleton plays a pivotal role in ovarian folliculogenesis. Calponin 2 encoded by the Cnn2 gene is an actin associated protein that regulates motility and mechanical signaling related cellular functions...
February 9, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38326864/maternal-and-perinatal-risks-for-monozygotic-twins-conceived-following-frozen-thawed-embryo-transfer-a-retrospective-cohort-study
#32
JOURNAL ARTICLE
Jing Lin, Kai Zhang, Fenglu Wu, Bian Wang, Weiran Chai, Qianqian Zhu, Jialyu Huang, Jiaying Lin
BACKGROUND: The present study aimed to explore the maternal and perinatal risks in cases of monozygotic twins (MZT) following frozen-thawed embryo transfer (FET). METHODS: All twin births that were conceived following FET from 2007 to 2021 at Shanghai Ninth People's Hospital in Shanghai, China were retrospectively reviewed. The exposure variable was twin type (monozygotic and dizygotic). The primary outcome was the incidence of neonatal death while secondary outcomes included hypertensive disorders of pregnancy, gestational diabetes, intrahepatic cholestasis of pregnancy, placenta previa, placental abruption, preterm premature rupture of the membranes, Cesarean delivery, gestational age, birth weight, weight discordance, stillbirth, birth defects, pneumonia, respiratory distress syndrome, necrotizing enterocolitis, and neonatal jaundice...
February 7, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38317224/progestin-and-adipoq-receptor-7-paqr7-mediate-the-anti-apoptotic-effect-of-p4-on-human-granulosa-cells-and-its-deficiency-reduces-ovarian-function-in-female-mice
#33
JOURNAL ARTICLE
Jia Li, Yiting Liu, Jinxia He, Zixuan Wu, Fang Wang, Jian Huang, Liping Zheng, Tao Luo
PURPOSE: PAQR7 plays a key role in cell apoptosis as a progesterone membrane receptor. The physiological mechanism of PAQR7 in ovarian function and its anti-apoptotic action in mammals remain poorly understood. METHODS: We first added 0.2 µM aminoglutethimide (AG), an inhibitor of endogenous progesterone (P4) secretion, and transfected siPAQR7 co-incubated with P4 in human KGN cells to identify granulosa cell apoptosis, respectively. Additionally, we used Paqr7 knockout (PAQR7 KO) mice to assess the role of PAQR7 in the ovary...
February 6, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38317250/controlled-ovarian-stimulation-in-cancer-patients-under-18-years-old-a-case-series
#34
JOURNAL ARTICLE
Azar Yahyaei, Mahdieh Moridi, Firouzeh Ghaffari
BACKGROUND: Fertility preservation for adolescent pubescent girls is a concern of the healthcare system and parents. Oocyte cryopreservation is regarded as a standard medical intervention for patients with a minimum age of 18 years. Evidence suggests that mature oocyte cryopreservation is possible for adolescent pubescent girls, although, ovarian stimulation for these patients remains a challenge. CASES PRESENTATION: This case series is the first report regarding ovarian stimulation with oocyte cryopreservation in younger than 18 years cancerous girls, who refer to ROYAN institute, Tehran, Iran, prior to the start of the treatment of cancer (November 2015 to February 2021)...
February 5, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38317200/setdb1-promotes-progression-through-upregulation-of-sf3b4-expression-and-regulates-the-immunity-in-ovarian-cancer
#35
JOURNAL ARTICLE
Hongjuan Yang, Lei Sui, Cuicui Cai, Huijun Chu, Yuchao Diao
BACKGROUND: Ovarian cancer (OC) is the most lethal gynecologic malignant tumour. The mechanism promoting OC initiation and progression remains unclear. SET domain bifurcated histone lysine methyltransferase 1(SETDB1) acts as an oncogene in a variety of tumours. This study aims to explore the role of SETDB1 in OC. METHODS: GEO, TCGA, CSIOVDB and CPTAC databases jointly analysed SETDB1 mRNA and protein expression. Effect of SETDB1 expression on the clinical prognosis of OC patients was analysed through online Kaplan‒Meier plotter and CSIOVDB database...
February 5, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38310280/oligogenic-basis-of-premature-ovarian-insufficiency-an-observational-study
#36
JOURNAL ARTICLE
Panpan Long, Le Wang, Hangjing Tan, Ruping Quan, Zihao Hu, Minghua Zeng, Ziheng Deng, Hualin Huang, Jonathan Greenbaum, Hongwen Deng, Hongmei Xiao
BACKGROUND: The etiology of premature ovarian insufficiency, that is, the loss of ovarian activity before 40 years of age, is complex. Studies suggest that genetic factors are involved in 20-25% of cases. The aim of this study was to explore the oligogenic basis of premature ovarian insufficiency. RESULTS: Whole-exome sequencing of 93 patients with POI and whole-genome sequencing of 465 controls were performed. In the gene-burden analysis, multiple genetic variants, including those associated with DNA damage repair and meiosis, were more common in participants with premature ovarian insufficiency than in controls...
February 3, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38310251/hyperinsulinemia-impairs-decidualization-via-akt-nr4a1-signaling-new-insight-into-polycystic-ovary-syndrome-pcos-related-infertility
#37
JOURNAL ARTICLE
Nan-Xing Jiang, Wei-Jie Zhao, Hao-Ran Shen, Dan-Feng Du, Xue-Lian Li
BACKGROUND: Investigating the underlying molecular mechanisms responsible for endometrial dysfunction in women with PCOS is essential, particularly focusing on the role of hyperinsulinemia. METHODS: We explored the role of insulin in the decidualization process using a synthetic decidualization assay. To dissect the effects of PI3K/AKT-NR4A signaling, we employed small interfering RNAs (siRNAs) targeting the NR4A genes and inhibitors of the PI3K/AKT pathway. We also investigated the disruption of AKT-NR4A1 signaling in the endometrium of PCOS female rats induced with dehydroepiandrosterone (DHEA)...
February 3, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38308314/aneuploid-serves-as-a-prognostic-marker-and-favors-immunosuppressive-microenvironment-in-ovarian-cancer
#38
JOURNAL ARTICLE
Ming Du, Qingqing Cai, Jiaan Sun, Mingxing Zhang, Shuo Zhang, Xiaoxia Liu, Mengyu Zhang, Xiaoyan Zhang
Ovarian cancer is the most lethal gynecologic neoplasm, and most patients experience recurrence and chemoresistance. Even the promising immunotherapy showed limited efficacy in ovarian cancer, probably due to the immunosuppressive microenvironment. However, the behind mechanisms of the immune exclusion or cold phenotype in ovarian cancer still remain to be explored. As a cancer dominated by copy number variations instead of mutations, ovarian cancer contains a high fraction of aneuploid, which might correlate with immune inhibition...
February 2, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38302986/bushenhuoluo-decoction-improves-polycystic-ovary-syndrome-by-regulating-exosomal-mir-30a-5p-socs3-mtor-nlrp3-signaling-mediated-autophagy-and-pyroptosis
#39
JOURNAL ARTICLE
Qun Huang, Yuanbin Li, Zhuang Chen, Huiping Ou, Yanjiao Tan, Hui Lin
BACKGROUND: Polycystic ovary syndrome (PCOS) is a frequent and complicated endocrine disease that remains a major reason for infertility. Bushenhuoluo Decotion (BSHLD) has been validated to exhibit curative effects on PCOS. This study was aimed to explore the potential mechanism underlying the therapeutic action of BSHLD. METHODS: PCOS rat model was induced by dehydroepiandrosterone (DHEA). Serum hormone and cytokines levels and ovarian pathological alterations were measured to assess ovarian function...
February 1, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38297375/sestrin1-2-and-3-are-dispensable-for-female-fertility-in-mice
#40
JOURNAL ARTICLE
Mengchen Wang, Wenhui Chen, Xinxin Zeng, Taojun Wang, Yingpu Sun, Qingling Yang
BACKGROUND: Sestrins have been implicated in regulating aging in various organs through multiple pathways. However, their roles in ovarian aging remain unrevealed. METHODS: Female Sestrin1-/- , Sestrin2-/- , and Sestrin3-/- mice were generated using the CRISPR-Cas9 system. Body weights, little sizes, ovarian weights, estrous cyclicity, and follicle number in female mice were observed. ELISA was utilized to measure serum anti-Müllerian hormone (AMH) levels. Real time PCR, western blot, immunofluorescence, and Masson trichrome staining were employed for assessment of aging-related change...
February 1, 2024: Journal of Ovarian Research
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