journal
https://read.qxmd.com/read/38528613/tp63-truncating-mutation-causes-increased-cell-apoptosis-and-premature-ovarian-insufficiency-by-enhanced-transcriptional-activation-of-clca2
#1
JOURNAL ARTICLE
Yali Fan, Shuya Chen, Chunfang Chu, Xiaodan Yin, Jing Jin, Lingyan Zhang, Huihui Yan, Zheng Cao, Ruixia Liu, Mingwei Xin, Lin Li, Chenghong Yin
BACKGROUND: Premature ovarian insufficiency (POI) is a severe disorder leading to female infertility. Genetic mutations are important factors causing POI. TP63-truncating mutation has been reported to cause POI by increasing germ cell apoptosis, however what factors mediate this apoptosis remains unclear. METHODS: Ninety-three patients with POI were recruited from Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Whole-exome sequencing (WES) was performed for each patient...
March 25, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38504307/cre-loxp-and-tamoxifen-induced-deletion-of-ovarian-quiescin-sulfhydryl-oxidase-2-showed-disruption-of-ovulatory-activity-in-mice
#2
JOURNAL ARTICLE
Shih-Yun Chen, Tse-En Wang, Wei-Yun Lee, Ya-Yi Yang, Hong-Chun Lai, Fuko Matsuda, Haruhiko Kosek, You-Tzung Chen, Sheng-Hsiang Li, Pei-Shiue Tsai
BACKGROUND: Quiescin sulfhydryl oxidase 2 (QSOX2) is a flavin adenine dinucleotide-dependent sulfhydryl oxidase that is known to be involved in protein folding, cell growth regulation, and redox state modification through oxidative activities. Earlier studies demonstrated the tissue and cellular localization of QSOX2 in the male reproductive tract, as well as the highly-regulated mechanism of QSOX2 protein synthesis and expression through the coordinated action of testosterone and epididymal-enriched amino acid, glutamate...
March 19, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38500173/corpus-luteum-presence-in-the-bovine-ovary-increase-intrafollicular-progesterone-concentration-consequences-in-follicular-cells-gene-expression-and-follicular-fluid-small-extracellular-vesicles-mirna-contents
#3
JOURNAL ARTICLE
Paola Maria da Silva Rosa, Alessandra Bridi, Giuliana de Ávila Ferronato, Cibele Maria Prado, Natália Marins Bastos, Juliano Rodrigues Sangalli, Flávio Vieira Meirelles, Felipe Perecin, Juliano Coelho da Silveira
BACKGROUND: It is well described that circulating progesterone (P4) plays a key role in several reproductive events such as oocyte maturation. However, during diestrus, when circulating P4 is at the highest concentrations, little is known about its local impact on the follicular cells such as intrafollicular P4 concentration due to corpus luteum (CL) presence within the same ovary. Based on that, our hypothesis is that the CL presence in the ovary during diestrus alters intrafollicular P4 concentrations, oocyte competence acquisition, follicular cells gene expression, and small extracellular vesicles (sEVs) miRNAs contents...
March 18, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38493179/identification-and-validation-of-irf6-related-to-ovarian-cancer-and-biological-function-and-prognostic-value
#4
JOURNAL ARTICLE
Shihao Hong, Ni Fu, Shanliang Sang, Xudong Ma, Fangying Sun, Xiao Zhang
BACKGROUND: Ovarian cancer (OC) is a severe gynecological malignancy with significant diagnostic and therapeutic challenges. The discovery of reliable cancer biomarkers can be used to adjust diagnosis and improve patient care. However, serous OC lacks effective biomarkers. We aimed to identify novel biomarkers for OC and their pathogenic causes. METHODS: The present study used the differentially expressed genes (DEGs) obtained from the "Limma" package and WGCNA modules for intersection analysis to obtain DEGs in OC...
March 16, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38491534/a-novel-machine-learning-framework-based-on-early-embryo-morphokinetics-identifies-a-feature-signature-associated-with-blastocyst-development
#5
JOURNAL ARTICLE
S Canosa, N Licheri, L Bergandi, G Gennarelli, C Paschero, M Beccuti, D Cimadomo, G Coticchio, L Rienzi, C Benedetto, F Cordero, A Revelli
BACKGROUND: Artificial Intelligence entails the application of computer algorithms to the huge and heterogeneous amount of morphodynamic data produced by Time-Lapse Technology. In this context, Machine Learning (ML) methods were developed in order to assist embryologists with automatized and objective predictive models able to standardize human embryo assessment. In this study, we aimed at developing a novel ML-based strategy to identify relevant patterns associated with the prediction of blastocyst development stage on day 5...
March 15, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38491479/fto-attenuates-the-cytotoxicity-of-cisplatin-in-kgn-granulosa-cell-like-tumour-cells-by-regulating-the-hippo-yap1-signalling-pathway
#6
JOURNAL ARTICLE
Rongli Wang, Feiyan Cheng, Xinyuan Yang
Premature ovarian failure (POF) is a devastating condition for women under 40 years old. Chemotherapy, especially the use of cisplatin, has been demonstrated to promote the apoptosis of granulosa cells in primary and secondary follicles, leading to POF. Our previous studies demonstrated that fat mass- and obesity-associated (FTO) plays an essential role in protecting granulosa cells from cisplatin-induced cytotoxicity. Various studies have suggested that the Hippo/YAP signalling pathway plays a significant role in regulating cell apoptosis and proliferation...
March 15, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38486335/unraveling-the-molecular-mechanisms-of-lymph-node-metastasis-in-ovarian-cancer-focus-on-meox1
#7
JOURNAL ARTICLE
Jiajia Li, Yihua Sun, Xiuling Zhi, Yating Sun, Zulimire Abudousalamu, Qianhan Lin, Bin Li, Liangqing Yao, Mo Chen
BACKGROUND: Lymph node metastasis (LNM) is a major factor contributing to the high mortality rate of ovarian cancer, making the treatment of this disease challenging. However, the molecular mechanism underlying LNM in ovarian cancer is still not well understood, posing a significant obstacle to overcome. RESULTS: Through data mining from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, we have identified MEOX1 as a specific gene associated with LNM in ovarian cancer...
March 14, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38486276/efficacy-and-safety-of-follitropin-delta-for-ovarian-stimulation-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycles-a-systematic-review-with-meta-analysis
#8
REVIEW
Stefano Palomba, Donatella Caserta, Paolo Emanuele Levi-Setti, Andrea Busnelli
BACKGROUND: Follitropin delta is a novel recombinant follicle stimulating hormone preparation uniquely expressed in a human fetal retinal cell line by recombinant DNA technology. To date, no systematic review was available about the safety and the efficacy of the follitropin delta. The objective of this study was systematically reviewing the available literature and to provide updated evidence regarding the efficacy-safety profile of follitropin delta when compared to other gonadotropin formulations for ovarian stimulation in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles...
March 14, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38481252/development-and-clinical-validation-of-a-seven-gene-signature-based-on-tumor-stem-cell-related-genes-to-predict-ovarian-cancer-prognosis
#9
JOURNAL ARTICLE
Guangwei Wang, Xiaofei Liu, Yue You, Silei Chen, Xiaohan Chang, Qing Yang
OBJECTIVE: Tumors are highly heterogeneous, and within their parenchyma, a small population of tumor-stem cells possessing differentiation potential, high oncogenicity, and self-renewal capabilities exists. These cells are pivotal in mediating tumor development, chemotherapy resistance, and recurrence. Ovarian cancer shares characteristics with tumor stem cells, making it imperative to investigate molecular markers associated with these cells. METHODS: Stem cell-related genes were collected, and molecular subtypes were established based on gene expression profiles from The Cancer Genome Atlas using the R package tool "ConsensusClusterPlus...
March 13, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38481236/mucin-producing-tumors-of-the-ovary-preoperative-differentiation-between-metastatic-ovarian-mucinous-carcinoma-and-primary-mucinous-malignant-tumors
#10
MULTICENTER STUDY
Song-Qi Cai, Min-Rong Wu, Xiao-Liang Ma, Jing-Jing Lu, Jin-Wei Qiang, Yin-Yin Guan, Meng-Su Zeng, Jian-Jun Zhou
OBJECTIVE: To investigate the clinical and magnetic resonance imaging (MRI) features for preoperatively discriminating  primary ovarian mucinous malignant tumors (POMTs) and metastatic mucinous carcinomas involving the ovary (MOMCs). METHODS: This retrospective multicenter study enrolled 61 patients with 22 POMTs and 49 MOMCs, which were pathologically proved between November 2014 to Jane 2023. The clinical and MRI features were evaluated and compared between POMTs and MOMCs...
March 13, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38444028/meta-analysis-of-trigger-timing-in-normal-responders-undergoing-gnrh-antagonist-ovarian-hyperstimulation-protocol
#11
REVIEW
Qijun Xie, Danyu Ni, Sisi Chen, Wenjie Zhang, Jue Wang, Xiufeng Ling, Rong Shen
IMPORTANCE: The first meta-analysis focused only on gonadotropin-releasing hormone (GnRH) antagonists, which helped determine the effect of delay trigger on pregnancy outcomes. OBJECTIVE: To evaluate the impact of delay trigger compared with standard trigger in normal responders undergoing GnRH antagonist protocol in improving pregnancy outcomes. METHODS: Studies published before April 2023 in PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Wanfang, VIP and CBM databases were searched...
March 5, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38444005/a-real-world-study-of-treatment-patterns-following-disease-progression-in-epithelial-ovarian-cancer-patients-undergoing-poly-adp-ribose-polymerase-inhibitor-maintenance-therapy
#12
JOURNAL ARTICLE
Nan Zhang, Hong Zheng, Yunong Gao, Tong Shu, Hongguo Wang, Yan Cai
BACKGROUND: The efficacy of subsequent therapy after poly-ADP-ribose polymerase (PARP) inhibitor maintenance treatment has raised concerns. Retrospective studies show worse outcomes for platinum-based chemotherapy after progression of PARP inhibitor-maintenance therapy, especially in BRCA-mutant patients. We aimed to describe subsequent therapy in ovarian cancer patients after PARP inhibitor-maintenance therapy and evaluate their response to treatment. We focused on chemotherapy for patients with a progression-free interval (PFI) of ≥ 6 months after prior platinum treatment, based on BRCA status...
March 5, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38444000/mesonephric-like-adenocarcinoma-of-the-ovary
#13
JOURNAL ARTICLE
Yun Yang, Mengru Zhao, Qiuchen Jia, Huimin Tang, Tingwei Xing, Yang Li, Bin Tang, Lin Xu, Weiwei Wei, Hong Zheng, Ruxia Shi, Bairong Xia, Jiming Chen
Mesonephric-like adenocarcinoma is a new class of rare subtypes of the female reproductive system. Its clinical symptoms are similar to other types of ovarian tumors. The diagnosis is based on pathological and immunohistochemical methods. The main treatment option is surgery combined with chemotherapy. Few cases have been reported at home and abroad. We reported a case of a 45-year-old woman with a cystic solid mass in the left adnexa. The postoperative pathological diagnosis was mesonephric-like adenocarcinoma of the left ovary and mature cystic teratoma (partial infiltration of the small intestine)...
March 5, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38431654/meiotic-and-developmental-competence-of-growing-pig-oocytes-derived-from-small-antral-follicles-is-enhanced-in-culture-medium-containing-fgf2-lif-and-igf1-fli-medium
#14
JOURNAL ARTICLE
Alexandra Rosenbaum Bartková, Lucie Němcová, Veronika Kinterová, Dominika Radová, František Strejček, Tereza Toralová, Jozef Laurinčík, Radek Procházka
BACKGROUND: Oocytes of large animal species isolated from small ovarian follicles (< 2 mm) are less competent to support early embryonic development after in vitro maturation and fertilization than their counterparts isolated from medium-sized and preovulatory follicles. This study aimed to assess the effect of a new maturation medium containing FGF2, LIF, and IGF1 (FLI medium) on the meiotic and developmental competence of pig cumulus-oocytes complexes (COCs) derived from the small and medium-sized follicles...
March 2, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38409030/parp-inhibitor-era-in-ovarian-cancer-treatment-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
István Baradács, Brigitta Teutsch, Alex Váradi, Alexandra Bilá, Ádám Vincze, Péter Hegyi, Tamás Fazekas, Balázs Komoróczy, Péter Nyirády, Nándor Ács, Ferenc Bánhidy, Balázs Lintner
BACKGROUND: Ovarian cancer is the eighth leading cause of cancer-related death among women, characterized by late diagnosis and a high relapse rate. In randomized controlled trials, we aimed to evaluate the efficacy and safety of PARP inhibitors (PARPi) in treating advanced ovarian cancer. METHODS: This review was registered on PROSPERO (CRD42021283150), included all phase II and phase III randomized controlled trials (RCTs) assessing the effect of PARPi on ovarian cancer until the 13th of April, 2022...
February 26, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38402194/effect-of-repeated-vitrification-of-human-embryos-on-pregnancy-and-neonatal-outcomes
#16
JOURNAL ARTICLE
Yan Huang, Yi Cheng, Min Zhang, Yiqing Chen, Rong Zhou, Dewei Lin, Xinyu Guo
BACKGROUND: Repeated cryopreservation of embryos should occasionally be considered when embryos were not suitable for transfer. The effect of re-cryopreservation on embryos remains contentious. METHODS: This retrospective cohort study aimed to evaluate the pregnancy and neonatal outcomes of twice vitrificated blastocyst derived from once vitrified embryos. Total 410 vitrified-warmed blastocyst transfer cycles were divided into two groups according to the times of embryo vitrification: (1) vitrified blastocysts derived from fresh blastocysts (control group, n = 337); (2) twice vitrified blastocysts derived from once vitrified embryos (n = 73)...
February 24, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38402185/the-mir-1290-ogn-axis-in-ovarian-cancer-associated-fibroblasts-modulates-cancer-cell-proliferation-and-invasion
#17
JOURNAL ARTICLE
Biyao Jiang, Songshu Xiao, Shan Zhang, Fang Xiao
Despite receiving first-line treatment, ovarian cancer patients continue to experience a high rate of recurrence; nearly all women with ovarian cancer develop chemoresistance and succumb to the disease. In this study, cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) were isolated from tumor-containing and normal omenta, respectively, and the downregulation of osteoglycin (OGN) in CAFs was observed. OGN overexpression in CAFs significantly inhibited ovarian cancer cell viability, DNA synthesis, and cell invasion...
February 24, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38396022/synergistic-suppression-of-ovarian-cancer-by-combining-nrf2-and-gpx4-inhibitors-in-vitro-and-in-vivo-evidence
#18
JOURNAL ARTICLE
Ning Li, Xingmei Jiang, Qingyu Zhang, Yongmei Huang, Jinbin Wei, Haitao Zhang, Hui Luo
Ovarian cancer is a significant challenge in women's health due to the lack of effective screening and diagnostic methods, often leading to late detection and the highest mortality rate among all gynecologic tumors worldwide. Recent research has shown that ovarian cancer has an "iron addiction" phenotype which makes it vulnerable to ferroptosis inducers. We tested the combination of NRF2-targeted inhibitors with GPX4-targeted inhibitors in ovarian cancer through in vitro and in vivo experiment. The data showed that combination treatment effectively suppressed adherent cell growth, inhibited suspended cell spheroid formation, and restrained the ability of spheroid formation in 3D-culture...
February 23, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38395907/novel-prognostic-marker-tgfbi-affects-the-migration-and-invasion-function-of-ovarian-cancer-cells-and-activates-the-integrin-%C3%AE-v%C3%AE-3-pi3k-akt-signaling-pathway
#19
JOURNAL ARTICLE
Hao Wang, Yin-Hai Xu, Yi Guo
BACKGROUND: Individual patients with ovarian cancer show remarkably different prognosis. Present prognostic models for ovarian cancer mainly focus on clinico-pathological parameters, so quantifiable prognostic markers at molecular level are urgently needed. Platelets contribute to ovarian cancer progression, but have not been considered as biomarkers likely due to their instability. Here, we aimed to search for a stable prognostic marker from platelet-treated ovarian cancer cells, and explore its functions and mechanisms...
February 23, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38389075/development-and-validation-of-an-ultrasound%C3%A2-based-radiomics-nomogram-to-predict-lymph-node-status-in-patients-with-high-grade-serous-ovarian-cancer-a-retrospective-analysis
#20
JOURNAL ARTICLE
Yue Qi, Jinchi Liu, Xinyue Wang, Yuqing Zhang, Zhixun Li, Xinyu Qi, Ying Huang
BACKGROUND: Despite advances in medical imaging technology, the accurate preoperative prediction of lymph node status remains challenging in ovarian cancer. This retrospective study aimed to investigate the feasibility of using ultrasound-based radiomics combined with preoperative clinical characteristics to predict lymph node metastasis (LNM) in patients with high-grade serous ovarian cancer (HGSOC). RESULTS: Patients with 401 HGSOC lesions from two institutions were enrolled: institution 1 for the training cohort (n = 322) and institution 2 for the external test cohort (n = 79)...
February 22, 2024: Journal of Ovarian Research
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