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JOURNAL ARTICLE
Christopher R Ellis, Arnold J Greenspon, John A Andriulli, Paul A Gould, Roger Carillo, Matthew J Kolek, Rachel Donegan, Ansel P Amaral, Suneet Mittal
BACKGROUND: Cardiac implantable electronic device (CIED) infection has a high mortality. Previous investigations showed reduced postoperative infections using skin preparation with chlorhexidine, preoperative intravenous antibiotics, and a TYRX-a antibacterial envelope. The additional benefit of antibiotic pocket wash and postoperative antibiotics has not been systematically studied. METHODS: ENVELOPE was a prospective, multicenter, randomized, controlled trial enrolling patients undergoing CIED procedures with ≥2 risk factors for infection...
March 24, 2023: Circulation. Arrhythmia and Electrophysiology
#2
EDITORIAL
Syeda Atiqa Batul, Pugazhendhi Vijayaraman
No abstract text is available yet for this article.
March 23, 2023: Circulation. Arrhythmia and Electrophysiology
#3
JOURNAL ARTICLE
Jannis Dickow, Shinwan Kany, Victor Roth Cardoso, Patrick T Ellinor, Georgios V Gkoutos, Holly K Van Houten, Paulus Kirchhof, Andreas Metzner, Peter A Noseworthy, Xiaoxi Yao, Andreas Rillig
BACKGROUND: A recent subanalysis of the EAST-AFNET 4 (Early Treatment of Atrial Fibrillation for Stroke Prevention Trial) suggests a stronger benefit of early rhythm control (ERC) in patients with atrial fibrillation and a high comorbidity burden when compared to patients with a lower comorbidity burden. METHODS: We identified 109 739 patients with newly diagnosed atrial fibrillation in a large United States deidentified administrative claims database (OptumLabs) and 11 625 patients in the population-based UKB (UK Biobank)...
March 21, 2023: Circulation. Arrhythmia and Electrophysiology
#4
LETTER
Marc D Lemoine, Celine Mencke, Moritz Nies, Julius Obergassel, Katharina Scherschel, Hartwig Wieboldt, Ruben Schleberger, Ilaria My, Laura Rottner, Julia Moser, Shinwan Kany, Jan-Per Wenzel, Fabian Moser, Leon Dinshaw, Paula Münkler, Bruno Reissmann, Feifan Ouyang, Christian Meyer, Stefan Blankenberg, Tanja Zeller, Larissa Fabritz, Andreas Rillig, Andreas Metzner, Paulus Kirchhof
No abstract text is available yet for this article.
March 20, 2023: Circulation. Arrhythmia and Electrophysiology
#5
JOURNAL ARTICLE
XiaoHui Kuang, Xi Zhang, YanJu Cui, FeiYu Wei, Peng Wu, XiaoLong Gao, Hong Xiang, HaiYan Wu, Li-Lin Wang, Xiaohong Zhou, Weijian Huang, Jie Fan
BACKGROUND: Multiple screw-in attempts under fluoroscopy are often needed to place the pacing lead tip near or at the left bundle branch (LBB). This study was conducted to evaluate the feasibility of implanting an LBB pacing lead in the proximal LBB (PLBB) guided by intracardiac echocardiography (ICE). METHODS: The distribution of the LBB was initially determined by ICE anatomic imaging and 3-dimensional electrical mapping of His and LBB potentials in 20 patients in the first parts of the study...
March 16, 2023: Circulation. Arrhythmia and Electrophysiology
#6
LETTER
Effect of Bilateral Cardiac Sympathetic Denervation on Burden of Premature Ventricular Contractions.
Aadhavi Sridharan, Amber Tang, Julie M Sorg, Nir N Hoftman, Jay M Lee, Jane Yanagawa, Marmar Vaseghi
No abstract text is available yet for this article.
March 14, 2023: Circulation. Arrhythmia and Electrophysiology
#7
LETTER
Ning Li, Brian J Hansen, James Kennelly, Anuradha Kalyanasundaram, Adel Kanaan, Orlando P Simonetti, Peter J Mohler, Bryan Whitson, John D Hummel, Jichao Zhao, Vadim V Fedorov
No abstract text is available yet for this article.
March 14, 2023: Circulation. Arrhythmia and Electrophysiology
#8
JOURNAL ARTICLE
Anna Füting, Nico Reinsch, Lenny Brokkaar, Stefan Hartl, Dennis Höwel, Anika Essling, John Bell, Eva Rausch, Kars Neven
BACKGROUND: Thermal left atrial ablation can cause bronchial damage. Pulsed-field ablation (PFA) is a novel, nonthermal ablation modality for paroxysmal atrial fibrillation. We report on bronchial effects after pulmonary vein isolation using PFA for paroxysmal atrial fibrillation. METHODS: A computed tomography scan showing the respiratory tract adjacent to the left atrial was obtained. Oral anticoagulation was interrupted on procedure day. Peri-procedurally, patients received heparin with an activated clotting time goal of >350 seconds...
March 13, 2023: Circulation. Arrhythmia and Electrophysiology
#9
JOURNAL ARTICLE
Adam E Berman, Mina Kabiri, Tom Wei, Thibaut Galvain, Qun Sha, Karl-Heinz Kuck
BACKGROUND: Radiofrequency catheter ablation (RFCA) is an established treatment for atrial fibrillation (AF) refractory to antiarrhythmic drugs. The economic value of RFCA in delaying disease progression has not been quantified. METHODS: An individual-level, state-transition health economic model estimated the impact of delayed AF progression using RFCA versus antiarrhythmic drug treatment for a hypothetical sample of patients with paroxysmal AF. The model incorporated the lifetime risk of progression from paroxysmal AF to persistent AF, informed by data from the ATTEST (Atrial Fibrillation Progression Trial)...
March 9, 2023: Circulation. Arrhythmia and Electrophysiology
#10
JOURNAL ARTICLE
Yi Zhang, He Jiang, Jian Cui, Mei-Ting Li, Hui-Ming Zhou, Xiao-Mei Li
BACKGROUND: To investigate the clinical features of preexcitation-induced dilated cardiomyopathy in infants and evaluate safety and efficacy of radiofrequency ablation (RFCA) in these patients. METHODS: This study included 10 infants (4 males and 6 females) with mean age of 6.78±3.14 months, mean weight of 8.11±1.71 kg, and mean left ventricular ejection fraction (LVEF) was 32.6±10.34%. Tachycardiomyopathy has been excluded and all patients were refractory to the drugs...
March 9, 2023: Circulation. Arrhythmia and Electrophysiology
#11
JOURNAL ARTICLE
Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, Hai Huang, Hirohiko Kohjitani, Misato Nishikawa, Kazuhisa Chonabayashi, Megumi Fukuyama, Hiromi Manabe, Kouichi Nakau, Tsutomu Wada, Koichi Kato, Futoshi Toyoda, Yoshinori Yoshida, Naomasa Makita, Knut Woltjen, Seiko Ohno, Nagomi Kurebayashi, Takashi Murayama, Takashi Sakurai, Minoru Horie, Takeshi Kimura
BACKGROUND: CaM (calmodulin) is a ubiquitously expressed, multifunctional Ca2+ sensor protein that regulates numerous proteins. Recently, CaM missense variants have been identified in patients with malignant inherited arrhythmias, such as long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT). However, the exact mechanism of CaM-related CPVT in human cardiomyocytes remains unclear. In this study, we sought to investigate the arrhythmogenic mechanism of CPVT caused by a novel variant using human induced pluripotent stem cell (iPSC) models and biochemical assays...
March 3, 2023: Circulation. Arrhythmia and Electrophysiology
#12
JOURNAL ARTICLE
Karim Benali, Valentin Barré, Alexis Hermida, Vincent Galand, Antoine Milhem, Séverine Philibert, Serge Boveda, Clément Bars, Frédéric Anselme, Baptiste Maille, Clémentine André, Albin Behaghel, Ghassan Moubarak, Nicolas Clémenty, Antoine Da Costa, Marine Arnaud, Sandrine Venier, Frédéric Sebag, Laurence Jésel-Morel, Audrey Sagnard, Laure Champ-Rigot, Duc Dang, Benoit Guy-Moyat, Selim Abbey, Rodrigue Garcia, Olivier Césari, Nicolas Badenco, Antoine Lepillier, Sandro Ninni, Stéphane Boulé, Philippe Maury, Vincent Algalarrondo, Babé Bakouboula, Jacques Mansourati, François Lesaffre, Philippe Lagrange, Abdeslam Bouzeman, Lucian Muresan, Raoul Bacquelin, Agustin Bortone, Sok-Sithikun Bun, Dominique Pavin, Laurent Macle, Raphaël P Martins
BACKGROUND: Recurrences of atrial fibrillation (AF) after pulmonary vein isolation (PVI) are mainly due to pulmonary vein reconnection. However, a growing number of patients have AF recurrences despite durable PVI. The optimal ablative strategy for these patients is unknown. We analyzed the impact of current ablation strategies in a large multicenter study. METHODS: Patients undergoing a redo ablation for AF and presenting durable PVI were included. The freedom from atrial arrhythmia after pulmonary vein-based, linear-based, electrogram-based, and trigger-based ablation strategies were compared...
February 20, 2023: Circulation. Arrhythmia and Electrophysiology
#13
LETTER
Yuji Wakamatsu, Koichi Nagashima, Yoshiaki Kaneko, Hitoshi Mori, Kenta Tsutsui, Masaharu Maegaki, Kazumasa Sonoda, Naoto Otsuka, Shu Hirata, Moyuru Hirata, Ritsushi Kato, Naokata Sumitomo, Yasuo Okumura
No abstract text is available yet for this article.
February 17, 2023: Circulation. Arrhythmia and Electrophysiology
#14
JOURNAL ARTICLE
Carl Schulz, Marc D Lemoine, Giulia Mearini, Jussi Koivumäki, Jascha Sani, Edzard Schwedhelm, Paulus Kirchhof, Amer Ghalawinji, Monika Stoll, Arne Hansen, Thomas Eschenhagen, Torsten Christ
BACKGROUND: Electrical remodeling in human persistent atrial fibrillation is believed to result from rapid electrical activation of the atria, but underlying genetic causes may contribute. Indeed, common gene variants in an enhancer region close to PITX2 (paired-like homeodomain transcription factor 2) are strongly associated with atrial fibrillation, but the mechanism behind this association remains unknown. This study evaluated the consequences of PITX2 deletion (PITX2-/- ) in human induced pluripotent stem cell-derived atrial cardiomyocytes...
February 10, 2023: Circulation. Arrhythmia and Electrophysiology
#15
LETTER
Shinsuke Miyazaki, Atsushi Kobori, Hikari Jo, Takehiko Keida, Kazuyasu Yoshitani, Moe Mukai, Yuichiro Sagawa, Tetsuya Asakawa, Eiji Sato, Kazuya Yamao, Tomoki Horie, Mamoru Manita, Hidehira Fukaya, Hidemori Hayashi, Kojiro Tanimoto, Tadateru Iwayama, Suguru Chiba, Akinori Sato, Yukio Sekiguchi, Kenta Sugiura, Shinsuke Iwai, Yuhei Isonaga, Naoyuki Miwa, Nobutaka Kato, Osamu Inaba, Takayoshi Hirota, Yasutoshi Nagata, Yuichi Ono, Hitoshi Hachiya, Yasuteru Yamauchi, Masahiko Goya, Junichi Nitta, Hiroshi Tada, Tetsuo Sasano
No abstract text is available yet for this article.
February 6, 2023: Circulation. Arrhythmia and Electrophysiology
#16
JOURNAL ARTICLE
Natália Quintella Sangiorgi Olivetti, Luciana Sacilotto, Fanny Wulkan, Gabrielle D'Arezzo Pessente, Mariana Lombardi Peres de Carvalho, Danilo Bora Moleta, Denise Tessariol Hachul, Pedro Veronese, Carina Hardy, Cristiano Pisani, Tan Chen Wu, Marcelo Luiz Campos Vieira, Lucas Arraes de França, Matheus de Souza Freitas, Carlos Eduardo Rochitte, Sávia Christina Bueno, Vitor Bastos Lovisi, José Eduardo Krieger, Maurício Scanavacca, Alexandre da Costa Pereira, Francisco da Costa Darrieux
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disease, causes ventricular tachycardia, sudden cardiac death, and heart failure (HF). We investigated ARVC clinical features, genetic findings, natural history, and the occurrence of life-threatening arrhythmic events (LTAEs), HF death, or heart transplantation (HF-death/HTx) to identify risk factors. METHODS: The clinical course of 111 consecutive patients with definite ARVC, predictors of LTAE, HF-death/HTx, and combined events were analyzed in the entire cohort and in a subgroup of 40 patients without sustained ventricular arrhythmia before diagnosis...
January 31, 2023: Circulation. Arrhythmia and Electrophysiology
#17
EDITORIAL
Timothy M Markman, David S Frankel
No abstract text is available yet for this article.
January 30, 2023: Circulation. Arrhythmia and Electrophysiology
#18
JOURNAL ARTICLE
Andrew P Landstrom, Qixin Yang, Bo Sun, Robin M Perelli, Minu-Tshyeto Bidzimou, Zhushan Zhang, Yuriana Aguilar-Sanchez, Katherina M Alsina, Shuyi Cao, Julia O Reynolds, Tarah A Word, Niels M R van der Sangen, Quinn Wells, Prince J Kannankeril, Andreas Ludwig, Jeffrey J Kim, Xander H T Wehrens
BACKGROUND: Spontaneously depolarizing nodal cells comprise the pacemaker of the heart. Intracellular calcium (Ca2+ ) plays a critical role in mediating nodal cell automaticity and understanding this so-called Ca2+ clock is critical to understanding nodal arrhythmias. We previously demonstrated a role for Jph2 (junctophilin 2) in regulating Ca2+ -signaling through inhibition of RyR2 (ryanodine receptor 2) Ca2+ leak in cardiac myocytes; however, its role in pacemaker function and nodal arrhythmias remains unknown...
January 27, 2023: Circulation. Arrhythmia and Electrophysiology
#19
LETTER
Xavier Galloo, Jan Stassen, Kensuke Hirasawa, Bart J A Mertens, Bernard Cosyns, Pieter van der Bijl, Victoria Delgado, Nina Ajmone Marsan, Jeroen J Bax
No abstract text is available yet for this article.
January 25, 2023: Circulation. Arrhythmia and Electrophysiology
#20
LETTER
Stacey J Howell, Jonathan W Dukes, Eric Vittinghoff, Janet Tang, Joshua D Moss, Randall J Lee, Byron K Lee, Zian H Tseng, Vasanth Vedantham, Jeffrey E Olgin, Melvin M Scheinman, Henry Hsia, Edward P Gerstenfeld, Gregory M Marcus
No abstract text is available yet for this article.
January 23, 2023: Circulation. Arrhythmia and Electrophysiology
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