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Current Aging Science

Onaolapo Adejoke Yetunde, Obelawo Adebimpe Yemisi, Onaolapo Olakunle James
BACKGROUND: Age-related cognitive decline has been suggested to result from an increase in brain neurone loss, which is attributable to continued derangement of the brain's oxidant/antioxidant balance. Increased oxidative stress and a concomitant decrease in the brain's antioxidant defense system have been associated with functional senescence and organismal ageing. However, nature has configured certain foods to be rich sources of nootropic agents, with research showing that increased consumption of such foods or food ingredients may be protective against ageing-related memory decline...
March 11, 2019: Current Aging Science
A A Zulfiqar, A Hajjam, E Andrès
Telemedicine is now in vogue, allowing computer and communication tools to be deployed in different fields of health, such as Cardiology, Dermatology, areas in which it has received interest, and in international studies. As the population ages, older people are increasingly concerned about this innovative practice. This is a narrative review of both the literature and Internet pertaining to telemedicine projects within the field of geriatric subjects in France. Since the beginning of the 2000's, several telemedicine projects and trials focused on chronic heart failure have been developed in the elderly, and also in the field of dermatology...
March 3, 2019: Current Aging Science
Amit Ghosh, Abhijith Dharmarajan, Prafulla Kumar Swain, Debasish Das, Poonam Verma, Prabhas Ranjan Tripathy
Background Pulse Wave Velocity (PWV) is the propagation speed of the wave-induced along the aorta and arterial tree, each time heartbeats. PWV increases with increased arterial stiffness, thus establishing it as a reliable prognostic marker for cardiovascular morbidity and mortality. On the other hand, total vascular resistance (TVR) is the overall resistance offered by systemic circulation and pulmonary circulation. This resistance needs to be overcome in order to create the flow of blood through the circulatory system...
February 26, 2019: Current Aging Science
Gabrielle B Britton, Sid E O'Bryant, Leigh A Johnson, James R Hall, Alcibiades E Villarreal, Diana C Oviedo, Ambar R Pérez Lao, María B Carreira, Shantal Grajalesa For The Panama Aging Research Initiative
BACKGROUND: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. OBJECTIVE: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults. METHOD: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments...
February 15, 2019: Current Aging Science
A Seifan, A C Ganzer, K Ryon, M Lin, R Mahmudur, A Henriquez, C Shih, A R Jacobs, M Greenwald, R S Isaacson
BACKGROUND/AIMS: Prodromal Neurodegenerative Disease (ND) due to Alzheimer's disease, Parkinson's disease, and Frontotemporal Lobar Degeneration presents with neurological, psychiatric and medical symptomatology prior to the onset of cognitive changes. Currently, recognition of clinical syndromes during prodromal ND stages is clinically challenging. Fragmentation in care across medical specialties for people with neurological or psychiatric symptoms challenge our ability to recognize clear-cut syndromes because different doctors are paying attention to different aspects of the patient's case...
February 3, 2019: Current Aging Science
Mahboube Ahmadi, Masoud Golalipour, Nader Mansour Samaei
BACKGROUND: Age-related decrease in the mitochondrial activity has been reported in several tissues. Reactive Oxygen Species (ROS) produced from defected mitochondria leads to aging and accumulate through time. However, studies about the mitochondrial DNA mutation level in blood is contradictory. Other lifestyle factors may modify the effects of age in post-mitotic tissues such as blood. The BMI represents the sum of the various lifestyle factors. OBJECTIVE: We proposed that age, obesity and mtDNA deletion are three ROS producing factors, which may interact with each other and induce senescence...
February 1, 2019: Current Aging Science
Lucy Beishon, Jatinder S Minhas, Kate Patrick, Iswariya Shanmugam, Claire A L Williams, Ronney B Panerai, Thompson G Robinson, Victoria J Haunton
Background Transcranial Doppler Ultrasonography (TCD) can be utilised to measure the tight coupling of cerebral blood flow velocity (CBFv) in response to cognitive demand by task activation, termed neurovascular coupling. AIMS: To investigate the differences in neurovascular coupling between healthy older (>50 years) and younger (18-49 years) adults in response to cognitive testing. METHODS: Fifty-four older (n=25) and younger (n=29) adults underwent continuous bilateral TCD, beat-to-beat blood pressure (MAP; Finapres), heart rate (HR; electrocardiogram), and end-tidal CO2 (ETCO2; capnography) monitoring...
January 31, 2019: Current Aging Science
Maire Aru, Karin Alev, Ando Pehme, Priit Purge, Lauri Onnik, Anu Ellam, Priit Kaasik, Teet Seene
BACKGROUND: Aging leads to changes in skeletal muscle quantity and quality and is accompanied with increase in body mass and fat mass, whereas fat-free mass either decreases or remains unchanged. The body composition of rodents has been an important factor for clinical trials in the laboratory. Glucocorticoids such as dexamethasone are widely used in clinical medicine, but may induce myopathy, characterized by muscle weakness, atrophy, and fatigue. In animals treated with glucocorticoids has been observed a dose-dependent reduction of body weight...
January 14, 2019: Current Aging Science
Kedar N Prasad, Stephen C Bondy
Prion diseases are a group of incurable infectious terminal neurodegenerative diseases caused by the aggregated misfolded PrPsc in selected mammals including humans. The complex physical interaction between normal prion protein PrPc and infectious PrPsc causes conformational change from the α- helix structure of PrPc to the β-sheet structure of PrPsc, and this process is repeated. Increased oxidative stress is one of the factors that facilitate conversion of PrPc to PrPsc. This overview presents evidence to show that increased oxidative stress and inflammation are involved in the progression of this disease...
January 10, 2019: Current Aging Science
Jennine Harvey, Scott Seeman, Deborah von Hapsburg
BACKGROUND: Dual-task procedures are commonly implemented to examine cognitive load and listening effort as individual differences in cognition often determine successful listening. However, what methods are most efficacious is unclear. Specifically, standardized, targeted assessment procedures for establishing cognitive function, and age related changes that might account for changes in dual-task performance have yet to be established. Additional data are needed across aging populations, including middle-aged adults and older adults to establish the trend of performance changes throughout the aging process...
December 12, 2018: Current Aging Science
Angela Ida Pincelli, Mario Perotti, Francesca Massariello, Antonella Gatti, Damiano Calella, Vincenzo Cimino, Justin Haas, Giuseppe Bellelli, Paolo Mazzola, Giorgio Annoni
INTRODUCTION: Doege-Potter syndrome (DPS) is a rare but life-threatening paraneoplastic syndrome, characterized by non-islet cell tumor-induced hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT), which secretes an incompletely processed form of insulin-like growth factor 2 (IGF-2). RESULTS: A 96-year-old woman was admitted with head trauma due to an accidental fall. During her hospital stay she experienced frequent hypoglycemic episodes. Multiple injections of 33% dextrose and continuous infusion with 10% dextrose were required to maintain normal blood glucose levels...
December 5, 2018: Current Aging Science
Marios Kyriazis
The question whether aging is a disease or not, has been asked by many professionals who are involved in the study of age-related degeneration. However, not only an agreement on this remains elusive, but also effective clinical treatments against human aging have not been forthcoming. In this Opinion paper I suggest that the complexity involved in aging is such that we need to remodel our thinking to involve a much more 'systems-oriented' approach. I explore four main principles which should be employed by those who are working on finding treatments against age-related degeneration...
October 25, 2018: Current Aging Science
Nurul Aliah Achin, Tan Jen Kit, Wan Zurinah Wan Ngah, Suzana Makpol, Musalmah Mazlan, Hamizah Shahirah Hamezah, Hanafi Ahmad Damanhuri
Background Cognitive frailty emerges as one of the threat to healthy aging. It is in continuum with advancing of age with uncertain indicator between pathological and physiological changes. Alterations in pathways associated to the aging process have been observed including oxidative stress, lipid metabolism, and inflammation. However, the exact mechanisms leading to cognitive decline are still unclear. Objective This study was sought to assess the level of cognitive functions and linked with blood oxidative status during normal aging in rats...
October 19, 2018: Current Aging Science
Dorothy Keine, John Q Walker, Brian K Kennedy, Marwan N Sabbagh
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative condition in which individuals exhibit memory loss, dementia, and impaired metabolism. Nearly all previous single-treatment studies to treat AD have failed, likely because it is a complex disease with multiple underlying drivers contributing to risk, onset, and progression. Here, we explored the efficacy of a multi-therapy approach based on the disease risk factor status specific to individuals with AD diagnosis or concern...
October 18, 2018: Current Aging Science
Raul O Dominguez, Enrique R Marschoff, Liliana M Oudkerk, Luis J Neira, Jorge A Serra
BACKGROUND: Acute systemic diseases (ASD) impact in extended leukoaraiosis (ExL-A) have been seldom described. We study the deterioration in daily life activities (DLA) and cognition associated with ASD events compared with the well described impacts of stroke in patients with leukoaraiosis (L-A). METHODS: Cross-sectional surveys of aged adults from the emergency room after an acute event of ASD or stroke, hospitalized or receiving home care, were followed for one year...
October 18, 2018: Current Aging Science
Jose Roberto Wajman, Leticia Lessa Mansur, Monica Sanches Yassuda
BACKGROUND: Dementias due to neurodegenerative disorders and more specifically, Alzheimer's disease (AD) are the most frequent of all diseases within the industrialized world. Besides this alarming fact, it is noted too that almost three-quarter of people with AD reside in low or middle-income nations. In recent years, cognitive and behavioral neuroscientists have focused on a possible correlation between environmental agents and genetic risk factors for these dementias. METHOD: In this narrative review, a close review of Medical Literature Analysis and Retrieval System was conducted...
October 3, 2018: Current Aging Science
Zsofia Budai, Laszlo Balogh, Zsolt Sarang
BACKGROUND: During aging, muscle tissue undergoes profound changes which lead to a decline in its functional and regenerative capacity. We utilized global gene expression analysis and gene set enrichment analysis to characterize gene expression changes in aging muscle satellite cells. METHOD: Gene expression data; obtained from Affymetrix Mouse Genome 430 2.0 Array, for 14 mouse muscle satellite cell samples (5 young, 4 middle-aged, and 5 aged), were retrieved from public Gene Expression Omnibus repository...
September 24, 2018: Current Aging Science
Maria Helena Vianna Metello Jacob, Rafael Oliveira Fernandes, Jessica Hellen Poletto Bonetto, Roberta Hack Mendes, Alex Sander da Rosa Araujo, Adriane Bello-Klein, Maria Flavia Marques Ribeiro
Dehydroepiandrosterone (DHEA) is an important precursor of active steroid hormone, produced abundantly by the adrenal cortex with an age-dependent pattern. We investigated whether chronic DHEA administration impacts on redox status and on Akt protein activation in skeletal muscle during the aging process (3 and 24 month-old rats). Rats received one weekly dose/5 weeks of DHEA (10 mg/kg) or vehicle. Gastrocnemius muscle was removed to evaluate glutathione system, hydrogen peroxide, antioxidant enzymes, and expression of Akt kinase protein...
August 3, 2018: Current Aging Science
Peter Lloyd-Sherlock, Fransesc Gomez-Olive, Sizzy Ngobeni, Ryan Wagner, Stephen Tollman
Background This paper describes a pilot study to assess the feasibility of a novel intervention to improve the management of hypertension among older people in rural South Africa. Older South Africans have the highest rates of uncontrolled hypertension recorded for any country. Notably, South Africa has a widely-available old age grant (pension), which is delivered on a monthly basis to citizens living in rural villages. Methods We assessed the feasibility of engaging with older people at the point of pension delivery in the Agincourt sub-district of Mpumalanga Province...
July 17, 2018: Current Aging Science
Francisco J Amaro-Gahete, Alejandro de la O, Lucas Jurado-Fasoli, Jonatan R Ruiz, Manuel J Castillo, Angel Gutierrez
Humans have long sought means to extend longevity and counteract the effects of aging on physical and mental functioning. Exercise is a highly effective way for treating and preventing the main causes of morbidity and mortality, most of which are associated with aging. Interestingly, the Klotho gene is involved in the aging process. Indeed, overexpression of the Klotho gene is associated with longevity, and experimental animals lacking this gene seem to develop multiple disorders resembling human aging and present a shortened lifespan...
July 1, 2018: Current Aging Science
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