journal
https://read.qxmd.com/read/38358074/no-reflow-after-stroke-reperfusion-therapy-an-emerging-phenomenon-to-be-explored
#21
REVIEW
Milan Jia, Feiyang Jin, Sijie Li, Changhong Ren, Mangal Ruchi, Yuchuan Ding, Wenbo Zhao, Xunming Ji
In the field of stroke thrombectomy, ineffective clinical and angiographic reperfusion after successful recanalization has drawn attention. Partial or complete microcirculatory reperfusion failure after the achievement of full patency of a former obstructed large vessel, known as the "no-reflow phenomenon" or "microvascular obstruction," was first reported in the 1960s and was later detected in both experimental models and patients with stroke. The no-reflow phenomenon (NRP) was reported to result from intraluminal occlusions formed by blood components and extraluminal constriction exerted by the surrounding structures of the vessel wall...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38358062/transcutaneous-auricular-vagus-nerve-stimulation-ameliorates-adolescent-depressive-and-anxiety-like-behaviors-via-hippocampus-glycolysis-and-inflammation-response
#22
JOURNAL ARTICLE
Lan Sun, Shixiang Ma, Yun Yu, Xiangji Li, Qianwen Wei, Li Min, Peijing Rong
BACKGROUND: Transcutaneous auricular vagus nerve stimulation (taVNS) is a crucial neuromodulation therapy for depression, yet its molecular mechanism remains unclear. Here, we aim to unveil the underlying mechanisms of antidepression by systematically evaluating the change of gene expression in different brain regions (i.e., hippocampus, anterior cingulate cortex, and medial prefrontal cortex). METHODS: The adolescent depression rat model was established by chronic unpredictable mild stress (CUMS), followed by the taVNS treatment for 3 weeks...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38358054/brain-computer-interface-digital-prescription-for-neurological-disorders
#23
REVIEW
Xiaoke Chai, Tianqing Cao, Qiheng He, Nan Wang, Xuemin Zhang, Xinying Shan, Zeping Lv, Wenjun Tu, Yi Yang, Jizong Zhao
Neurological and psychiatric diseases can lead to motor, language, emotional disorder, and cognitive, hearing or visual impairment By decoding the intention of the brain in real time, the Brain-computer interface (BCI) can first assist in the diagnosis of diseases, and can also compensate for its damaged function by directly interacting with the environment; In addition, provide output signals in various forms, such as actual motion, tactile or visual feedback, to assist in rehabilitation training; Further intervention in brain disorders is achieved by close-looped neural modulation...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38358002/the-role-of-glutamate-and-glutamine-metabolism-and-related-transporters-in-nerve-cells
#24
REVIEW
Dongyang Zhang, Zhongyan Hua, Zhijie Li
BACKGROUND: Glutamate and glutamine are the most abundant amino acids in the blood and play a crucial role in cell survival in the nervous system. Various transporters found in cell and mitochondrial membranes, such as the solute carriers (SLCs) superfamily, are responsible for maintaining the balance of glutamate and glutamine in the synaptic cleft and within cells. This balance affects the metabolism of glutamate and glutamine as non-essential amino acids. AIMS: This review aims to provide an overview of the transporters and enzymes associated with glutamate and glutamine in neuronal cells...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38357857/gdf15-is-a-dynamic-biomarker-of-the-integrated-stress-response-in-the-central-nervous-system
#25
JOURNAL ARTICLE
Jyoti Asundi, Chunlian Zhang, Diana Donnelly-Roberts, Josè Zavala Solorio, Malleswari Challagundla, Caitlin Connelly, Christina Boch, Jun Chen, Mario Richter, Mohammad Mehdi Maneshi, Andrew M Swensen, Lauren Lebon, Raphael Schiffmann, Subhabrata Sanyal, Carmela Sidrauski, Ganesh Kolumam, Amos Baruch
AIM: Characterize Growth Differentiation Factor 15 (GDF15) as a secreted biomarker of the integrated stress response (ISR) within the central nervous system (CNS). METHODS: We determined GDF15 levels utilizing in vitro and in vivo neuronal systems wherein the ISR was activated. Primarily, we used the murine model of vanishing white matter disease (VWMD), a neurological disease driven by persistent ISR in the CNS, to establish a link between levels of GDF15 in the cerebrospinal fluid (CSF) and ISR gene expression signature in the CNS...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38357854/inhibiting-acid-sensing-ion-channel-exerts-neuroprotective-effects-in-experimental-epilepsy-via-suppressing-ferroptosis
#26
JOURNAL ARTICLE
Xiaorui Shi, Ru Liu, Yingting Wang, Tingting Yu, Kai Zhang, Chao Zhang, Yuyu Gu, Limin Zhang, Jianping Wu, Qun Wang, Fei Zhu
BACKGROUND: Epilepsy is a chronic neurological disease characterized by repeated and unprovoked epileptic seizures. Developing disease-modifying therapies (DMTs) has become important in epilepsy studies. Notably, focusing on iron metabolism and ferroptosis might be a strategy of DMTs for epilepsy. Blocking the acid-sensing ion channel 1a (ASIC1a) has been reported to protect the brain from ischemic injury by reducing the toxicity of [Ca2+ ]i . However, whether inhibiting ASIC1a could exert neuroprotective effects and become a novel target for DMTs, such as rescuing the ferroptosis following epilepsy, remains unknown...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38357846/differential-inflammation-responses-determine-the-variable-phenotypes-of-epilepsy-induced-by-gabrg2-mutations
#27
JOURNAL ARTICLE
Jiahui Sui, Longwu Zhan, Shengtao Ji, Wenwen Wu, Yuhan Chen, Feng Yun, Wenpeng Liang, Jie Wang, Maohong Cao, Dingding Shen, Qi Zhang
OBJECTIVE: To explore the mechanism involved in variable phenotypes of epilepsy models induced by γ-aminobutyric acid type A γ2 subunit (GABRG2) mutations. METHODS: The zebrafish carrying wild-type (WT) GABRG2, mutant GABRG2(P282S), GABRG2(F343L) and GABRG2(I107T) were established by Tol2kit transgenesis system and Gateway method. Behavioral analysis of different transgenic zebrafish was performed with the DanioVision Video-Track framework and the brain activity was analyzed by field potential recording with MD3000 Bio-signal Acquisition and Processing System...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38353058/chronic-but-not-acute-nicotine-treatment-ameliorates-acute-inflammation-induced-working-memory-impairment-by-increasing-crtc1-and-hcn2-in-adult-male-mice
#28
JOURNAL ARTICLE
Xiaona Wang, Qian Wang, Min Song, Yihui Wang, Xianzhi Shen, Yanyun Sun, Chun Guo, Panpan Geng, Chaolin Ma, Xinchun Jin
BACKGROUND: Systemic inflammation in which lipopolysaccharide (LPS) is released into circulation can cause cognitive dysfunction and we have previously shown that LPS impaired working memory (WM) which refers to the ability to guide incoming behavior by retrieving recently acquired information. However, the mechanism is not very clear, and currently, there is no approved strategy to improve inflammation-induced WM deficit. Notably, epidemiological studies have demonstrated a lower occurrence rate of inflammatory-related diseases in smoking patients, suggesting that inflammation-induced WM impairment may be improved by nicotine treatment...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38353051/overexpression-of-ephb2-in-the-basolateral-amygdala-is-crucial-for-inducing-visceral-pain-sensitization-in-rats-subjected-to-water-avoidance-stress
#29
JOURNAL ARTICLE
Guang-Bing Duan, Jun-Wen Wang, Hui-Hui Sun, Zhi-Yu Dong, Yan Zhang, Zhen-Xiang Wang, Ye Chen, Ying Chen, Ying Huang, Shu-Chang Xu
AIMS: Basolateral amygdala (BLA), as a center for stress responses and emotional regulation, is involved in visceral hypersensitivity of irritable bowel syndrome (IBS) induced by stress. In the present study, we aimed to investigate the role of EphB2 receptor (EphB2) in BLA and explore the underlying mechanisms in this process. METHODS: Visceral hypersensitivity was induced by water avoidance stress (WAS). Elevated plus maze test, forced swimming test, and sucrose preference test were applied to assess anxiety- and depression-like behaviors...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38348765/trem2-gene-induces-differentiation-of-induced-pluripotent-stem-cells-into-dopaminergic-neurons-and-promotes-neuronal-repair-via-tgf-%C3%AE-activation-in-6-ohda-lesioned-mouse-model-of-parkinson-s-disease
#30
JOURNAL ARTICLE
Hanbai Liang, Ping Liu, Zijing Wang, Huan Xiong, Cheng Yin, Dongdong Zhao, Chunhui Wu, Longyi Chen
OBJECTIVE: Induced pluripotent stem cells (iPSCs) hold a promising potential for rescuing dopaminergic neurons in therapy for Parkinson's disease (PD). This study clarifies a TREM2-dependent mechanism explaining the function of iPSC differentiation in neuronal repair of PD. METHODS: PD-related differentially expressed genes were screened by bioinformatics analyses and their expression was verified using RT-qPCR in nigral tissues of 6-OHDA-lesioned mice. Following ectopic expression and depletion experiments in iPSCs, cell differentiation into dopaminergic neurons as well as the expression of dopaminergic neuronal markers TH and DAT was measured...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334258/efficacy-of-the-iron-chelating-agent-deferiprone-in-patients-with-parkinson-s-disease-a-systematic-review-and-meta-analysis
#31
REVIEW
Ahmed Negida, Nafisa M Hassan, Heba Aboeldahab, Youmna E Zain, Yasmin Negida, Shirin Cadri, Nivin Cadri, Leslie J Cloud, Matthew J Barrett, Brian Berman
INTRODUCTION: Several studies have reported iron accumulation in the basal ganglia to be associated with the development of Parkinson's Disease (PD). Recently, a few trials have examined the efficacy of using the iron-chelating agent Deferiprone (DFP) for patients with PD. We conducted this meta-analysis to summarize and synthesize evidence from published randomized controlled trials about the efficacy of DFP for PD patients. METHODS: A comprehensive literature search of four electronic databases was performed, spanning until February 2023...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334254/mri-biomarkers-and-neuropsychological-assessments-of-hippocampal-and-parahippocampal-regions-affected-by-als-a%C3%A2-systematic-review
#32
REVIEW
Sana Mohammadi, Sadegh Ghaderi, Farzad Fatehi
BACKGROUND AND OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a progressive motor and extra-motor neurodegenerative disease. This systematic review aimed to examine MRI biomarkers and neuropsychological assessments of the hippocampal and parahippocampal regions in patients with ALS. METHODS: A systematic review was conducted in the Scopus and PubMed databases for studies published between January 2000 and July 2023. The inclusion criteria were (1) MRI studies to assess hippocampal and parahippocampal regions in ALS patients, and (2) studies reporting neuropsychological data in patients with ALS...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334239/the-relationship-between-physical-function-and-psychological-symptoms-in-parkinson-s-disease-a-systematic-review-and-meta-regression-analysis
#33
REVIEW
Philip Hodgson, Alastair Jordan, Charikleia Sinani, Divine Charura, Samuel T Orange
AIMS: This systematic review and meta-regression aimed to examine available literature reporting measures of physical function, anxiety, and/or depression and whether any relationships exist between these measures in individuals with Parkinson's disease. METHODS: MEDLINE, CINAHL, AMED, and APA PsychInfo databases were systematically searched. Screening, quality assessment, and data extraction were completed alongside meta-regression analysis. RESULTS: Of 1175 studies retrieved, 40 were selected for analysis with only one study assessing the relationship between physical and psychological outcomes within their cohort...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334236/emerging-functions-and-therapeutic-targets-of-il-38-in-central-nervous-system-diseases
#34
REVIEW
Yuan Gao, Luwei Cai, Yulu Wu, Min Jiang, Yidan Zhang, Wenjing Ren, Yirui Song, Lili Li, Ziguang Lei, Youzhuang Wu, Luwen Zhu, Jing Li, Dongya Li, Guohong Li, Chengliang Luo, Luyang Tao
Interleukin (IL)-38 is a newly discovered cytokine of the IL-1 family, which binds various receptors (i.e., IL-36R, IL-1 receptor accessory protein-like 1, and IL-1R1) in the central nervous system (CNS). The hallmark physiological function of IL-38 is competitive binding to IL-36R, as does the IL-36R antagonist. Emerging research has shown that IL-38 is abnormally expressed in the serum and brain tissue of patients with ischemic stroke (IS) and autism spectrum disorder (ASD), suggesting that IL-38 may play an important role in neurological diseases...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334231/dysregulation-of-iron-homeostasis-and-ferroptosis-in-sevoflurane-and-isoflurane-associated-perioperative-neurocognitive-disorders
#35
REVIEW
Mengrong Miao, Yaqian Han, Yangyang Wang, Jie Wang, Ruilou Zhu, Yitian Yang, Ningning Fu, Ningning Li, Mingyang Sun, Jiaqiang Zhang
In recent years, sevoflurane and isoflurane are the most popular anesthetics in general anesthesia for their safe, rapid onset, and well tolerant. Nevertheless, many studies reported their neurotoxicity among pediatric and aged populations. This effect is usually manifested as cognitive impairment such as perioperative neurocognitive disorders. The wide application of sevoflurane and isoflurane during general anesthesia makes their safety a major health concern. Evidence indicates that iron dyshomeostasis and ferroptosis may establish a role in neurotoxicity of sevoflurane and isoflurane...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334213/the-alleviative-effects-comparison-of-four-flavonoids-from-bamboo-leaves-on-ulcerative-colitis-in-an-alzheimer-mouse-model
#36
JOURNAL ARTICLE
Taiyu Zhang, Cuicui Jia, Longyi Ran, Jiarui Shi, Tsendsuren Amarmend, Huiying Li
BACKGROUND: Clinically, patients with dementia are at high risk of developing enteritis, especially those with AD. This study explored the potential therapeutic benefits of bamboo leaf flavonoids (BLF) for ulcerative colitis (UC) treatment in Alzheimer's disease (AD) mouse model. METHODS: Various methods were employed, including pathological staining of brain/colon tissue, inflammatory cytokine detection in serum, and oxidative stress indicator assessment to compare ulcerative enteritis (UC) injury in normal and AD mice and determine whether AD mice were susceptible to colitis...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334212/mitochondria-in-depression-the-dysfunction-of-mitochondrial-energy-metabolism-and-quality-control-systems
#37
REVIEW
Mengruo Jiang, Liyuan Wang, Hui Sheng
BACKGROUND: Depression is the most disabling neuropsychiatric disorder, causing difficulties in daily life activities and social interactions. The exact mechanisms of depression remain largely unclear. However, some studies have shown that mitochondrial dysfunction would play a crucial role in the occurrence and development of depression. AIMS: To summarize the known knowledge about the role of mitochondrial dysfunction in the pathogenesis of depression. METHODS: We review the recent literature, including 105 articles, to summarize the mitochondrial energy metabolism and quality control systems in the occurrence and development of depression...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334061/electroacupuncture-ameliorates-neuroinflammation-by-inhibiting-trpv4-channel-in-ischemic-stroke
#38
JOURNAL ARTICLE
Xueqi Ren, Xinyi Gao, Ziqing Li, Yangyang Ding, Ao Xu, Lixia Du, Yufang Yang, Deheng Wang, Zhifei Wang, Shi Shu
AIMS: We investigated the potential mechanisms underlying the therapeutic efficacy of electroacupuncture (EA) at the Shuigou (GV26) and Baihui (GV20) acupoints in the treatment of ischemic stroke. METHODS: We assessed the therapeutic effects of EA on MCAO mice through behavioral studies and TTC staining. Various techniques, such as RT-PCR, immunofluorescence, and Western blots, were employed to evaluate the activation and polarization of microglia/macrophages, and changes in the TRPV4 ion channel...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334030/sevoflurane-causes-cognitive-impairment-by-inducing-iron-deficiency-and-inhibiting-the-proliferation-of-neural-precursor-cells-in-infant-mice
#39
JOURNAL ARTICLE
Yong Zuo, Jinhong Xie, Xue Zhang, Anand Thirupathi, Xiaopeng Liu, Di Zhang, Jianhua Zhang, Zhenhua Shi
AIMS: Numerous studies on animals have shown that exposure to general anesthetics in infant stage may cause neurocognitive impairment. However, the exact mechanism is not clear. The dysfunction of iron metabolism can cause neurodevelopmental disorders. Therefore, we investigated the effect of iron metabolism disorder induced by sevoflurane (Sev) on cognitive function and the proliferation of neural precursor cells (NPCs) and neural stem cells (NSCs) in infant mice. METHODS: C57BL/6 mice of postnatal day 14 and neural stem cells NE4C were treated with 2% Sev for 6 h...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38334027/neurite-orientation-dispersion-and-density-imaging-quantifies-microstructural-impairment-in-the-thalamus-and-its-connectivity-in-amyotrophic-lateral-sclerosis
#40
JOURNAL ARTICLE
Yun-Bin Cao, Ye Wu, Qiu-Yi Dong, Nao-Xin Huang, Zhang-Yu Zou, Hua-Jun Chen
AIMS: To evaluate microstructural impairment in the thalamus and thalamocortical connectivity using neurite orientation dispersion and density imaging (NODDI) in amyotrophic lateral sclerosis (ALS). METHODS: This study included 47 healthy controls and 43 ALS patients, whose structural and diffusion-weighted data were collected. We used state-of-the-art parallel transport tractography to identify thalamocortical pathways in individual spaces. Thalamus was then parcellated into six subregions based on its connectivity pattern with the priori defined cortical (i...
February 2024: CNS Neuroscience & Therapeutics
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