journal
https://read.qxmd.com/read/38790149/autophagy-associated-non-coding-rnas-unraveling-their-impact-on-parkinson-s-disease-pathogenesis
#1
REVIEW
Md Sadique Hussain, Ehssan Moglad, Muhammad Afzal, Shilpa Sharma, Gaurav Gupta, G V Sivaprasad, Mahamedha Deorari, Waleed Hassan Almalki, Imran Kazmi, Sami I Alzarea, Moyad Shahwan, Kumud Pant, Haider Ali, Sachin Kumar Singh, Kamal Dua, Vetriselvan Subramaniyan
BACKGROUND: Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence suggests a significant role for disrupted autophagy-a crucial cellular process for maintaining protein and organelle integrity. METHODS: This review focuses on the role of non-coding RNAs (ncRNAs) in modulating autophagy in PD. We conducted a comprehensive review of recent studies to explore how ncRNAs influence autophagy and contribute to PD pathophysiology...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38790106/efficacy-and-safety-of-apheresis-therapy-in-aqp4-antibody-positive-nmosd-attack-a-propensity-score-matched-cohort-study
#2
JOURNAL ARTICLE
Yun Xu, Huabing Wang, Tian Song, Linlin Yin, Yajun Yao, Yuzhen Wei, Hengri Cong, Jiali Sun, Xinghu Zhang, De-Cai Tian
OBJECTIVE: Plasma exchange (PE) and immunoadsorption (IA) are recognized as effective ways to treat attacks in AQP4 antibody-positive NMOSD, but high-quality evidence was lacking. To evaluate the efficacy and safety of PE/IA plus intravenous methylprednisolone (IVMP) in NMOSD attacks using propensity scores to match IVMP as control. METHODS: Patients were from a prospective observational cohort study. Stratification and interval propensity score matching (PSM) were used to reduce selection bias by matching baseline characteristics (gender, age, time to IVMP, EDSS at attack) between PE/IA + IVMP and IVMP group (in a ratio of 1:2)...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38783536/mesenchymal-stem-cell-derived-exosomes-improve-neurogenesis-and-cognitive-function-of-mice-with-methamphetamine-addiction-a-novel-treatment-approach
#3
JOURNAL ARTICLE
Solmaz Fallahi, Hamid Soltani Zangbar, Fereshteh Farajdokht, Reza Rahbarghazi, Fariba Ghiasi, Gisou Mohaddes
BACKGROUND: Methamphetamine (METH) is a psychostimulant substance with highly addictive and neurotoxic effects, but no ideal treatment option exists to improve METH-induced neurocognitive deficits. Recently, mesenchymal stem cells (MSCs)-derived exosomes have raised many hopes for treating neurodegenerative sequela of brain disorders. This study aimed to determine the therapeutic potential of MSCs-derived exosomes on cognitive function and neurogenesis of METH-addicted rodents. METHODS: Male BALB/c mice were subjected to chronic METH addiction, followed by intravenous administration of bone marrow MSCs-derived exosomes...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38780008/electroacupuncture-regulates-rab5a-mediating-ngf-transduction-to-improve-learning-and-memory-ability-in-the-early-stage-of-ad-mice
#4
JOURNAL ARTICLE
Jianhong Li, Minguang Yang, Yaling Dai, Xiaoqin Guo, Yanyi Ding, Xiaoling Li, Shenghang Zhang, Wenshan Xu, Lidian Chen, Jing Tao, Weilin Liu
AIMS: Nerve growth factor (NGF) loss is a potential factor for the degeneration of basal forebrain cholinergic neurons (BFCNs) in Alzheimer's disease (AD), and Rab5a is a key regulatory molecule of NGF signaling transduction. Here, we investigated the changes of Rab5a in 5 × FAD mice and further explored the mechanism of Electroacupuncture (EA) treatment in improving cognition in the early stage of AD. METHODS: The total Rab5a and Rab5a-GTP in 5-month-old 5 × FAD mice and wild-type mice were detected using WB and IP technologies...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38775183/dehydration-in-cerebral-venous-sinus-thrombosis
#5
MULTICENTER STUDY
Jiayue Ding, Duo Lan, Xiaoming Zhang, Xiangyu Li, Yanli Duan, Xiaobing Tian, Zhangyuan Liao, Xuanye Yue, Ming Zou, Ran Meng
AIMS: This study aimed to unravel the dehydration status of patients with cerebral venous sinus thrombosis (CVST) to facilitate the understanding of dehydration in CVST. METHODS: This was a multicenter retrospective study and three populations were recruited, namely, patients with CVST, CVST mimics, and healthy subjects. Blood samples were obtained 1-2 days after admission to assess dehydration status. Stata 15.1 was performed for statistical analysis. RESULTS: A total of 208 patients were diagnosed with CVST, 237 with CVST mimics, and 200 healthy individuals were enrolled...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38775149/exosomes-as-a-therapeutic-tool-to-promote-neurorestoration-and-cognitive-function-in-neurological-conditions-achieve-two-ends-with-a-single-effort
#6
REVIEW
Solmaz Fallahi, Hamid Soltani Zangbar, Fereshteh Farajdokht, Reza Rahbarghazi, Gisou Mohaddes, Fariba Ghiasi
Exosomes possess a significant role in intercellular communications. In the nervous system, various neural cells release exosomes that not only own a role in intercellular communications but also eliminate the waste of cells, maintain the myelin sheath, facilitate neurogenesis, and specifically assist in normal cognitive function. In neurological conditions including Parkinson's disease (PD), Alzheimer's disease (AD), traumatic brain injury (TBI), and stroke, exosomal cargo like miRNAs take part in the sequela of conditions and serve as a diagnostic tool of neurological disorders, too...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38757390/astrocytic-hilpda-promotes-lipid-droplets-generation-to-drive-cognitive-dysfunction-in-mice-with-sepsis-associated-encephalopathy
#7
JOURNAL ARTICLE
Ling Li, Du Lixia, Guifen Gan, Jin Li, Lin Yang, You Wu, Zongping Fang, Xijing Zhang
AIMS: Sepsis-associated encephalopathy (SAE) is manifested as a spectrum of disturbed cerebral function ranging from mild delirium to coma. However, the pathogenesis of SAE has not been clearly elucidated. Astrocytes play important roles in maintaining the function and metabolism of the brain. Most recently, it has been demonstrated that disorders of lipid metabolism, especially lipid droplets (LDs) dyshomeostasis, are involved in a variety of neurodegenerative diseases. The aim of this study was to investigate whether LDs are involved in the underlying mechanism of SAE...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38757378/the-causal-relationship-between-sarcopenia-related-traits-and-ischemic-stroke-insights-from-univariable-and-multivariable-mendelian-randomization-analyses
#8
JOURNAL ARTICLE
Jiahao Song, Da Zhou, Jingrun Li, Mengqi Wang, Lina Jia, Duo Lan, Haiqing Song, Xunming Ji, Ran Meng
AIMS: The causal relationship between sarcopenia-related traits and ischemic stroke (IS) remains poorly understood. This study aimed to explore the causal impact of sarcopenia-related traits on IS and to identify key mediators of this association. METHODS: We conducted univariable, multivariable two-sample, and two-step Mendelian randomization (MR) analyses using genome-wide association study (GWAS) data. This included data for appendicular lean mass (ALM), hand grip strength (HGS), and usual walking pace (UWP) from the UK Biobank, and IS data from the MEGASTROKE consortium...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38752512/transcutaneous-vagus-nerve-stimulation-modulates-depression-like-phenotype-induced-by-high-fat-diet-via-p2x7r-nlrp3-il-1%C3%AE-in-the-prefrontal-cortex
#9
JOURNAL ARTICLE
Shaoyuan Li, Yuzhengheng Zhang, Yu Wang, Zixuan Zhang, Chen Xin, Yifei Wang, Peijing Rong
BACKGROUND: Depression is a common psychiatric disorder in diabetic patients. Depressive mood associated with obesity/metabolic disorders is related to the inflammatory response caused by long-term consumption of high-fat diets, but its molecular mechanism is unclear. In this study, we investigated whether the antidepressant effect of transcutaneous auricular vagus nerve stimulation (taVNS) in high-fat diet rats works through the P2X7R/NLRP3/IL-1β pathway. METHODS: We first used 16S rRNA gene sequencing analysis and LC-MS metabolomics assays in Zucker diabetic fatty (ZDF) rats with long-term high-fat diet (Purina #5008) induced significant depression-like behaviors...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38747078/an-update-on-noninvasive-neuromodulation-in-the-treatment-of-patients-with-prolonged-disorders-of-consciousness
#10
REVIEW
Xiaoping Wan, Ye Zhang, Yanhua Li, Weiqun Song
BACKGROUND: With the improvement of emergency techniques, the survival rate of patients with severe brain injury has increased. However, this has also led to an annual increase in the number of patients with prolonged disorders of consciousness (pDoC). Hence, recovery of consciousness is an important part of treatment. With advancing techniques, noninvasive neuromodulation seems a promising intervention. The objective of this review was to summarize the latest techniques and provide the basis for protocols of noninvasive neuromodulations in pDoC...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38739217/unveiling-convergent-and-divergent-intrinsic-brain-network-alternations-in-depressed-adolescents-engaged-in-non-suicidal-self-injurious-behaviors-with-and-without-suicide-attempts
#11
JOURNAL ARTICLE
Linling Li, Zhen Liang, Guohua Li, Hong Xu, Xing Yang, Xia Liu, Xin Zhang, Jianhong Wang, Zhiguo Zhang, Yongjie Zhou
AIMS: Limited understanding exists regarding the neurobiological mechanisms underlying non-suicidal self-injury (NSSI) and suicide attempts (SA) in depressed adolescents. The maturation of brain network is crucial during adolescence, yet the abnormal alternations in depressed adolescents with NSSI or NSSI+SA remain poorly understood. METHODS: Resting-state functional magnetic resonance imaging data were collected from 114 depressed adolescents, classified into three groups: clinical control (non-self-harm), NSSI only, and NSSI+SA based on self-harm history...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38739106/cd22-blockade-aggravates-eae-and-its-role-in-microglia-polarization
#12
JOURNAL ARTICLE
Weiwei Xiang, Kan Wang, Lu Han, Ze Wang, Zhiyang Zhou, Shuwei Bai, Jing Peng, Chong Xie, Yangtai Guan
AIMS: Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease. Microglia are reportedly involved in the pathogenesis of MS. However, the key molecules that control the inflammatory activity of microglia in MS have not been identified. METHODS: Experimental autoimmune encephalomyelitis (EAE) mice were randomized into CD22 blockade and control groups. The expression levels of microglial CD22 were measured by flow cytometry, qRT-PCR, and immunofluorescence...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38739094/a-predictive-nomogram-for-short-term-outcomes-of-myasthenia-gravis-patients-treated-with-low-dose-rituximab
#13
JOURNAL ARTICLE
Yufan Zhou, Rongjing Guo, Xingyu Xia, Sisi Jing, Jun Lu, Zhe Ruan, Sushan Luo, Xiao Huan, Chongbo Zhao, Ting Chang, Jianying Xi
BACKGROUND: This study aims to establish and validate a predictive nomogram for the short-term clinical outcomes of myasthenia gravis (MG) patients treated with low-dose rituximab. METHODS: We retrospectively reviewed 108 patients who received rituximab of 600 mg every 6 months in Huashan Hospital and Tangdu Hospital. Of them, 76 patients from Huashan Hospital were included in the derivation cohort to develop the predictive nomogram, which was externally validated using 32 patients from Tangdu Hospital...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38739004/tnf-%C3%AE-can-promote-membrane-invasion-by-activating-the-mapk-mmp9-signaling-pathway-through-autocrine-in-bone-invasive-pituitary-adenoma
#14
JOURNAL ARTICLE
Xinzhi Wu, Lei Gong, Bin Li, Jiwei Bai, Chuzhong Li, Yazhuo Zhang, Haibo Zhu
AIMS: A bone-invasive pituitary adenoma exhibits aggressive behavior, leading to a worse prognosis. We have found that TNF-α promotes bone invasion by facilitating the differentiation of osteoclasts, however, before bone-invasive pituitary adenoma invades bone tissue, it needs to penetrate the dura mater, and this mechanism is not yet clear. METHODS: We performed transcriptome microarrays on specimens of bone-invasive pituitary adenomas (BIPAs) and noninvasive pituitary adenomas (NIPAs) and conducted differential expressed gene analysis and enrichment analysis...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38738958/the-biological-behavior-and-clinical-outcome-of-pituitary-adenoma-are-affected-by-the-microenvironment
#15
REVIEW
Yuhe Li, Xiufang Ren, Wei Gao, Ruikai Cai, Jianqi Wu, Tianqi Liu, Xin Chen, Daoming Jiang, Chong Chen, Quan Cheng, Anhua Wu, Wen Cheng
BACKGROUND: Pituitary adenoma is one of the most common brain tumors. Most pituitary adenomas are benign and can be cured by surgery and/or medication. However, some pituitary adenomas show aggressive growth with a fast growth rate and are resistant to conventional treatments such as surgery, drug therapy, and radiation therapy. These tumors, referred to as refractory pituitary adenomas, often relapse or regrow in the early postoperative period. The tumor microenvironment (TME) has recently been identified as an important factor affecting the biological manifestations of tumors and acts as the main battlefield between the tumor and the host immune system...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38738952/meta-analysis-and-transcriptomic-analysis-reveal-that-nkrf-and-zbtb17-regulate-the-nf-%C3%AE%C2%BAb-signaling-pathway-contributing-to-the-shared-molecular-mechanisms-of-alzheimer-s-disease-and-atherosclerosis
#16
JOURNAL ARTICLE
Di Zhang, Keyan Chen, Li Shen Shan
INTRODUCTION: Alzheimer's disease (AD) and atherosclerosis (AS) are widespread diseases predominantly observed in the elderly population. Despite their prevalence, the underlying molecular interconnections between these two conditions are not well understood. METHODS: Utilizing meta-analysis, bioinformatics methodologies, and the GEO database, we systematically analyzed transcriptome data to pinpoint key genes concurrently differentially expressed in AD and AS. Our experimental validations in mouse models highlighted the prominence of two genes, NKRF (NF-κB-repressing factor) and ZBTB17 (MYC-interacting zinc-finger protein 1)...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38727596/expert-opinions-from-the-2024-closed-door-round-table-discussion-on-improving-stroke-prehospital-care-globally
#17
EDITORIAL
Renyu Liu, Jing Zhao, Jeyaraj Durai Pandian, Gary A Ford, Qiuhong Ji, Siju V Abraham, Xunming Ji, Anthony Rudd
No abstract text is available yet for this article.
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38727582/outcomes-and-risk-factors-for-infection-after-endovascular-treatment-in-patients-with-acute-ischemic-stroke
#18
JOURNAL ARTICLE
Xin Jiang, Yaowen Hu, Jian Wang, Mengmeng Ma, Jiajia Bao, Jinghuan Fang, Li He
AIMS: Infection is a common complication following acute ischemic stroke (AIS) and significantly contributes to poor functional outcomes after stroke. This study aimed to investigate the effects of infection after endovascular treatment (post-EVT infection) on clinical outcomes and risk factors in patients with AIS. METHODS: We retrospectively analyzed AIS patients treated with endovascular treatment (EVT) between January 2016 and December 2022. A post-EVT infection was defined as any infection diagnosed within 7 days after EVT...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38727518/cerebral-autoregulation-a-reliable-predictor-of-prognosis-in-patients-receiving-intravenous-thrombolysis
#19
JOURNAL ARTICLE
Zhen-Ni Guo, Yang Qu, Zi-Duo Shen, Jia Liu, Zhong-Xiu Wang, Ying-Ying Sun, Ke-Jia Zhang, Junlei Chang, Xiang-Kun Si, Hang Jin, Xin Sun, Yi Yang
AIMS: To investigate the characteristics of dynamic cerebral autoregulation (dCA) after intravenous thrombolysis (IVT) and assess the relationship between dCA and prognosis. METHODS: Patients with unilateral acute ischemic stroke receiving IVT were prospectively enrolled; those who did not were selected as controls. All patients underwent dCA measurements, by quantifying the phase difference (PD) and gain, at 1-3 and 7-10 days after stroke onset. Simultaneously, two dCA-based nomogram models were established to verify the predictive value of dCA for patients with mild-to-moderate stroke...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38727249/current-evidence-of-synaptic-dysfunction-after-stroke-cellular-and-molecular-mechanisms
#20
REVIEW
Chuan Li, Min Jiang, Zhi-Ting Fang, Zhiying Chen, Li Li, Ziying Liu, Junmin Wang, Xiaoping Yin, Jian Wang, Moxin Wu
BACKGROUND: Stroke is an acute cerebrovascular disease in which brain tissue is damaged due to sudden obstruction of blood flow to the brain or the rupture of blood vessels in the brain, which can prompt ischemic or hemorrhagic stroke. After stroke onset, ischemia, hypoxia, infiltration of blood components into the brain parenchyma, and lysed cell fragments, among other factors, invariably increase blood-brain barrier (BBB) permeability, the inflammatory response, and brain edema. These changes lead to neuronal cell death and synaptic dysfunction, the latter of which poses a significant challenge to stroke treatment...
May 2024: CNS Neuroscience & Therapeutics
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