Read by QxMD icon Read

CNS Neuroscience & Therapeutics

Shang-De Guo, Chun-Yun Liu, Jing-Wen Yu, Zhi Chai, Qing Wang, Xi-Ting Mi, Guo-Bin Song, Yan-Hua Li, Peng-Wei Yang, Ling Feng, Bao-Guo Xiao, Cun-Gen Ma
AIM: Multiple sclerosis (MS) is a relapsing-remitting inflammatory demyelinating disease that requires long-term treatment. Although Rho kinase inhibitor Fasudil shows good therapeutic effect in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, certain side effects may limit its clinical use. This study aimed at observing the therapeutic potential of Fasudil-modified encephalitogenic mononuclear cells (MNCs) via nasal delivery in EAE and exploring possible mechanisms of action...
February 18, 2019: CNS Neuroscience & Therapeutics
Jorge Matías-Guiu, Laura Torre-Fuentes, Ulises Gomez-Pinedo, Jordi A Matías-Guiu
No abstract text is available yet for this article.
February 18, 2019: CNS Neuroscience & Therapeutics
Lei Zhang, Wen-Jie Fang, Ke-Ming Zhang, Wei-Wei Jiang, Min Chen, Wan-Qing Liao, Wei-Hua Pan
AIMS: LncRNAs play a vital role in the pathological and physiological process. This study aimed to explore the involvement of lncRNAs in cryptococcal meningitis. METHODS: Microarray was performed in cryptococcal meningitis patients, and then, GO and KEGG pathways were analyzed. Coexpression relationship between lncRNA and mRNA was explored. The expressions of the lncRNAs and mRNAs, and their changes after treatment were detected by PCR. RESULTS: A total of 325 mRNAs (201 upregulated and 124 downregulated) and 497 lncRNAs (263 upregulated and 234 downregulated) were identified...
February 14, 2019: CNS Neuroscience & Therapeutics
Kawita M S Kanhai, Jenny A Nij Bijvank, Yorick L Wagenaar, Erica S Klaassen, KyoungSoo Lim, Sandrin C Bergheanu, Axel Petzold, Ajay Verma, Jacob Hesterman, Mike P Wattjes, Bernard M J Uitdehaag, Laurentius J van Rijn, Geert Jan Groeneveld
AIM: To examine whether the velocity of saccadic eye movements in internuclear ophthalmoparesis (INO) improves with fampridine treatment in patients with multiple sclerosis (MS). METHODS: Randomized, double-blind, placebo-controlled, cross-over trial with fampridine in patients with MS and INO. Horizontal saccades were recorded at baseline and at multiple time points post-dose. Main outcome measures were the change of peak velocity versional dysconjugacy index (PV-VDI) and first-pass amplitude VDI (FPA-VDI)...
February 12, 2019: CNS Neuroscience & Therapeutics
Katrina Cowan, Oleg Anichtchik, Shouqing Luo
The mitochondrion is a unique organelle with a diverse range of functions. Mitochondrial dysfunction is a key pathological process in several neurodegenerative diseases. Mitochondria are mostly important for energy production; however, they also have roles in Ca2+ homeostasis, ROS production, and apoptosis. There are two major systems in place, which regulate mitochondrial integrity, mitochondrial dynamics, and mitophagy. These two processes remove damaged mitochondria from cells and protect the functional mitochondrial population...
February 11, 2019: CNS Neuroscience & Therapeutics
Yin-Xi Zhang, Yang Zheng, Meng-Ting Cai, Lei Wu, Bao-Rong Zhang
No abstract text is available yet for this article.
February 6, 2019: CNS Neuroscience & Therapeutics
Ling Zhou, Peng Li, Na Chen, Li-Fang Dai, Kai Gao, Yi-Nan Liu, Li Shen, Jing-Min Wang, Yu-Wu Jiang, Ye Wu
AIMS: Vanishing white matter disease (VWM) is an inherited leukoencephalopathy in children attributed to mutations in EIF2B1-5, encoding five subunits of eukaryotic translation initiation factor 2B (eIF2B). Although the defects are in the housekeeping genes, glial cells are selectively involved in VWM. Several studies have suggested that astrocytes are central in the pathogenesis of VWM. However, the exact pathomechanism remains unknown, and no model for VWM induced pluripotent stem cells (iPSCs) has been established...
February 5, 2019: CNS Neuroscience & Therapeutics
Yuan-Yuan Zhang, Meng-Ying Liu, Zhi Liu, Ji-Kai Zhao, Yan-Gang Zhao, Li He, Wei Li, Ji-Qiang Zhang
AIMS: The G-protein-coupled estrogen receptor GPR30 (also referred to as GPER) has been implicated in the estrogenic regulation of hippocampal plasticity and spatial memory; however, the molecular mechanisms are largely unclear. METHODS: In this study, we initially examined the levels of GPR30 in the hippocampus of postnatal, ovariectomy (OVX)- and letrozole (LET)-treated female mice. Under G1, G15, and/or OVX treatment, the spatial memory, spine density, levels of ERα, ERβ, and SRC-1, selected synaptic proteins, mTORC2 signals (Rictor and p-AKT Ser473), and actin polymerization dynamics were subsequently evaluated...
February 3, 2019: CNS Neuroscience & Therapeutics
Ming-Yue Xu, Yang-Fan Wang, Peng-Ju Wei, Yan-Qin Gao, Wen-Ting Zhang
AIMS: Neonatal hypoxia-ischemia (H/I) results in gray and white matter injury, characterized by neuronal loss, failure of neural network formation, retarded myelin formation, and abnormal accumulation of oligodendrocyte progenitor cells (OPCs). These changes lead to severe neurological deficits and mortality. Sublethal hypoxic preconditioning (HPC) can protect the developing brain against H/I. However, limited evidence is available concerning its effect on white matter injury. METHODS: In this study, P6 neonatal Sprague-Dawley rats were subjected to normoxic (21% O2 ) or HPC (7...
January 28, 2019: CNS Neuroscience & Therapeutics
Jie Zhang, Jiang-Jiang Bi, Guo-Jun Guo, Ling Yang, Bin Zhu, Gao-Feng Zhan, Shan Li, Nian-Nian Huang, Kenji Hashimoto, Chun Yang, Ai-Lin Luo
AIMS: Anesthesia and surgery can cause delirium-like symptoms postoperatively. Increasing evidence suggests that gut microbiota is a physiological regulator of the brain. Herein, we investigated whether gut microbiota plays a role in postoperative delirium (POD). METHODS: Mice were separated into non-POD and POD phenotypes after abdominal surgery by applying hierarchical clustering analysis to behavioral tests. Fecal samples were collected, and 16S ribosomal RNA gene sequencing was performed to detect differences in gut microbiota composition among sham, non-POD, and POD mice...
January 24, 2019: CNS Neuroscience & Therapeutics
Wei Chen, Xing-Zhu Ju, Yan Lu, Xiao-Wei Ding, Chang-Hong Miao, Jia-Wei Chen
AIMS: Hypoxia may damage blood-brain barrier (BBB). The neuroprotective effect of propofol has been reported. We aimed to identify whether and how propofol improved hypoxia-induced impairment of BBB integrity. METHODS: Mouse brain microvascular endothelial cells (MBMECs) and astrocytes were cocultured to establish in vitro BBB model. The effects of hypoxia and propofol on BBB integrity were examined. Further, zonula occludens-1 (ZO-1) expression and phosphorylation, hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression, intracellular calcium concentration and Ca2+ /calmodulin-dependent protein kinase II (CAMKII) activation were measured...
January 24, 2019: CNS Neuroscience & Therapeutics
Bei Zhang, Timothy J Kopper, Xiaodong Liu, Zheng Cui, Steven G Van Lanen, John C Gensel
INTRODUCTION: Azithromycin (AZM) and other macrolide antibiotics are applied as immunomodulatory treatments for CNS disorders. The immunomodulatory and antibiotic properties of AZM are purportedly independent. AIMS: To improve the efficacy and reduce antibiotic resistance risk of AZM-based therapies, we evaluated the immunomodulatory and neuroprotective properties of novel AZM derivatives. We semisynthetically prepared derivatives by altering sugar moieties established as important for inhibiting bacterial protein synthesis...
January 24, 2019: CNS Neuroscience & Therapeutics
Zhou-Qing Chen, Hao Yu, Hai-Ying Li, Hai-Tao Shen, Xiang Li, Ju-Yi Zhang, Zhu-Wei Zhang, Zhong Wang, Gang Chen
AIMS: To investigate the critical role of Tim-3 in the polarization of microglia in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI). METHODS: An in vivo ICH model was established by autologous whole blood injection into the right basal ganglia in rats. The primary cultured microglia were treated with oxygen-hemoglobin (OxyHb) to mimic ICH in vitro. In this experiment, specific siRNA for Tim-3 and recombinant human TIM-3 were exploited both in vivo and in vitro...
January 24, 2019: CNS Neuroscience & Therapeutics
Ming-Feng Zhou, Zhan-Peng Feng, Yi-Chao Ou, Jun-Jie Peng, Kai Li, Hao-Dong Gong, Bing-Hui Qiu, Ya-Wei Liu, Yong-Jia Wang, Song-Tao Qi
AIMS: Central diabetes insipidus (CDI), a typical complication caused by pituitary stalk injury, often occurs after surgery, trauma, or tumor compression around hypothalamic structures such as the pituitary stalk and optic chiasma. CDI is linked to decreased arginine vasopressin (AVP) neurons in the hypothalamic supraoptic nucleus and paraventricular nucleus, along with a deficit in circulating AVP and oxytocin. However, little has been elucidated about the changes in AVP neurons in CDI...
January 24, 2019: CNS Neuroscience & Therapeutics
Xin Jin, Ming-Yan Liu, Dong-Fang Zhang, Xin Zhong, Ke Du, Ping Qian, Wei-Fan Yao, Hua Gao, Min-Jie Wei
AIMS: Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi, has been established to have potent anti-inflammation and neuroprotective properties; however, its effects during Alzheimer's disease (AD) treatment have not been well studied. This study aimed to investigate the effects of BAI pretreatment on cognitive impairment and neuronal protection against microglia-induced neuroinflammation and to explore the mechanisms underlying its anti-inflammation effects...
January 24, 2019: CNS Neuroscience & Therapeutics
Bao-Yi Huang, Hong-Bing Huang, Zhi-Jing Zhang, Zhi-Gang Liu, Jun Luo, Min Liu, Tao Luo
AIMS: It is well established that exposure of common anesthetic isoflurane in early life can induce neuronal apoptosis and long-lasting cognitive deficit, but the underlying mechanisms were not well understood. The cell cycle protein Cyclin B1 plays an important role in the survival of postmitotic neurons. In the present study, we investigated whether cyclin B1-mediated cell cycle activation pathway is a contributing factor in developmental isoflurane neurotoxicity. METHODS: Postnatal day 7 mice were exposed to 1...
January 24, 2019: CNS Neuroscience & Therapeutics
Yu-Ting Shen, Jian-Wei Wang, Min Wang, Yan Zhi, Jun-Yi Li, Yong-Sheng Yuan, Xi-Xi Wang, Hui Zhang, Ke-Zhong Zhang
AIMS: We aimed to explore effects of bone marrow stromal cell antigen-1 (BST1) rs4698412 allelic variant on brain activation and associative clinical symptoms in Parkinson's disease (PD). METHODS: A total of 49 PD patients and 47 healthy control (HC) subjects were recruited for clinical evaluations, blood samples collection for genotypes, and resting-state functional MRI (rs-fMRI) scans. Based on BST1 rs4698412 allelic variant (G → A), participants were further divided into 18 PD-GG, 31 PD-GA/AA, 20 HC-GG, and 27 HC-GA/AA carriers, which respectively indicated subjects carrying ancestral or risk allele in that locus in PD or HC...
January 24, 2019: CNS Neuroscience & Therapeutics
Jia-Yue Ding, Li-Qun Pan, Yan-Yu Hu, Gary B Rajah, Da Zhou, Chao-Bo Bai, Jing-Yuan Ya, Zhong-Ao Wang, Ke-Xin Jin, Jing-Wei Guan, Yu-Chuan Ding, Xun-Ming Ji, Ran Meng
AIMS: The objective of this study was to evaluate cerebral venous recanalization with magnetic resonance black-blood thrombus imaging (MRBTI) in patients with cerebral venous thrombosis (CVT) who underwent batroxobin treatment in combination with anticoagulation. METHODS: A total of 31 CVT patients were enrolled in this real-world registry study. The patients were divided into batroxobin (n = 21) and control groups (n = 10). In addition to the same standard anticoagulation as in the control group, patients in the batroxobin group underwent intravenous batroxobin for a total of three times...
January 23, 2019: CNS Neuroscience & Therapeutics
Claudio Liguori, Katherine Turner, Francesca Izzi, Martina Assogna, Maria P Canevini, Nicola B Mercuri, Fabio Placidi
AIMS: Irritability has been described as a frequent adverse event in patients affected by epilepsy and treated with perampanel (PER), levetiracetam (LEV), and less frequently with valproic acid (VPA). Since the questionnaire for irritability (I-EPI) is a validated instrument to measure this psychiatric manifestation in patients affected by epilepsy, in this study we aimed at investigating the effect of PER as first add-on therapy on I-EPI. Moreover, we compared the effectiveness and I-EPI scores obtained at 12-month follow-up visits in patients treated by PER, LEV, or VPA in order to measure irritability as a consequence of these treatments...
January 23, 2019: CNS Neuroscience & Therapeutics
Francisco M Torres-Cruz, Israel César Vivar-Cortés, Isaac Moran, Ernesto Mendoza, Victor Gómez-Pineda, Francisco García-Sierra, Elizabeth Hernández-Echeagaray
Neurotrophins are related to survival, growth, differentiation and neurotrophic maintenance as well as modulation of synaptic transmission in different regions of the nervous system. BDNF effects have been studied in the striatum due to the trophic role of BDNF in medium spiny neurons; however, less is known about the effects of NT-4/5, which is also present in the striatum and activates the TrkB receptor along with BDNF. If both neurotrophins are present in the striatum, the following question arises: What role do they play in striatal physiology? Thus, the aim of this study was to determine the physiological effect of the sequential application and coexistence of BDNF and NT-4/5 on the modulation of corticostriatal synapses...
January 21, 2019: CNS Neuroscience & Therapeutics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"