journal
https://read.qxmd.com/read/39018773/spatial-correlation-between-in-vivo-imaging-and-immunohistochemical-biomarkers-a-methodological-study
#1
JOURNAL ARTICLE
Hilde J G Smits, Edwin Bennink, Lilian N Ruiter, Gerben E Breimer, Stefan M Willems, Jan W Dankbaar, Marielle E P Philippens
In this study, we present a method that enables voxel-by-voxel comparison of in vivo imaging to immunohistochemistry (IHC) biomarkers. As a proof of concept, we investigated the spatial correlation between dynamic contrast enhanced (DCE-)CT parameters and IHC biomarkers Ki-67 (proliferation), HIF-1α (hypoxia), and CD45 (immune cells). 54 whole-mount tumor slices of 15 laryngeal and hypopharyngeal carcinomas were immunohistochemically stained and digitized. Heatmaps of biomarker positivity were created and registered to DCE-CT parameter maps...
July 16, 2024: Translational Oncology
https://read.qxmd.com/read/39018772/multi-omics-profiling-to-identify-early-plasma-biomarkers-in-pre-diagnostic-pancreatic-ductal-adenocarcinoma-a-nested-case-control-study
#2
JOURNAL ARTICLE
Emmy Borgmästars, Benjamin Ulfenborg, Mattias Johansson, Pär Jonsson, Ola Billing, Oskar Franklin, Christina Lundin, Sara Jacobson, Maja Simm, Zelmina Lubovac-Pilav, Malin Sund
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor survival. Novel biomarkers are urgently needed to improve the outcome through early detection. Here, we aimed to discover novel biomarkers for early PDAC detection using multi-omics profiling in pre-diagnostic plasma samples biobanked after routine health examinations. A nested case-control study within the Northern Sweden Health and Disease Study was designed. Pre-diagnostic plasma samples from 37 future PDAC patients collected within 2...
July 16, 2024: Translational Oncology
https://read.qxmd.com/read/39002207/non-genetic-heterogeneity-and-immune-subtyping-in-breast-cancer-implications-for-immunotherapy-and-targeted-therapeutics
#3
JOURNAL ARTICLE
Mudassir Hassan, Lütfi Tutar, Duygu Sari-Ak, Azhar Rasul, Ejaz Basheer, Yusuf Tutar
Breast cancer (BC) is a complex and multifactorial disease, driven by genetic alterations that promote tumor growth and progression. However, recent research has highlighted the importance of non-genetic factors in shaping cancer evolution and influencing therapeutic outcomes. Non-genetic heterogeneity refers to diverse subpopulations of cancer cells within breast tumors, exhibiting distinct phenotypic and functional properties. These subpopulations can arise through various mechanisms, including clonal evolution, genetic changes, epigenetic changes, and reversible phenotypic transitions...
July 12, 2024: Translational Oncology
https://read.qxmd.com/read/38991463/cdyl-loss-promotes-cervical-cancer-aggression-by-increasing-pd-l1-expression-via-the-suppression-of-irf2bp2-transcription
#4
JOURNAL ARTICLE
Ying Cui, Yuxi Zhao, Guihua Shen, Qiubo Lv, Linlin Ma
BACKGROUND: Recurrent or metastatic cervical cancer have an extremely low 5-year survival rates about 17% due to limited therapeutic options. CDYL plays a critical role in multiple cancer development, as an oncogene or tumor suppressor in a context-dependent manner. However, the role of CDYL in cervical carcinogenesis has not yet been explored. METHODS: CDYL expression was examined in cervical cancer and cell lines. The effect of CDYL/IRF2BP2/PD-L1 axis on malignant phenotypes of cervical cancer cells were tested with gain-of-function experiments...
July 10, 2024: Translational Oncology
https://read.qxmd.com/read/38986222/prophylaxis-with-abemaciclib-delays-tumorigenesis-in-dmmr-mice-by-altering-immune-responses-and-reducing-immunosuppressive-extracellular-vesicle-secretion
#5
JOURNAL ARTICLE
Annabell Wolff, Paula Krone, Johanna Maennicke, Julia Henne, Sonja Oehmcke-Hecht, Caterina Redwanz, Wendy Bergmann-Ewert, Christian Junghanss, Larissa Henze, Claudia Maletzki
BACKGROUND: The CDK4/6 inhibitor abemaciclib is an FDA-approved agent and induces T-cell-mediated immunity. Previously, we confirmed the therapeutic potential of abemaciclib on mismatch repair-deficient (dMMR) tumors in mice. Here, we applied a prophylactic administration/dosage setting using two preclinical mouse models of dMMR-driven cancer. METHODS: Mlh1-/- and Msh2loxP/loxP mice received repeated prophylactic applications of abemaciclib mesylate (75 mg/kg bw, per oral) as monotherapy or were left untreated...
July 9, 2024: Translational Oncology
https://read.qxmd.com/read/38981247/real-world-results-of-locally-advanced-and-metastatic-lung-cancer-patients-treated-with-platinum-doublet-chemotherapy-in-first-line-moroccan-cohort
#6
JOURNAL ARTICLE
Hassan Abdelilah Tafenzi, Farah Choulli, Edwin Kelly Haag, Anass Baladi, Ismail Essaadi, Rhizlane Belbaraka
BACKGROUND: Doublet platin-chemotherapy was the old standard treatment for different histology types of advanced and metastatic lung cancer (LC) and is still an option for patients who are not eligible for immune checkpoint inhibitors. However, in low- and middle-income countries, chemotherapy, either in monotherapy or in combination with platinum, is still the only accessible option in public institutions. The efficacy of different platin-based chemotherapy in patients with LC who are treatment-naïve is unknown...
July 8, 2024: Translational Oncology
https://read.qxmd.com/read/38981246/metformin-induces-tumor-immunogenic-cell-death-in-ovarian-cancer-by-activating-ampk-pathway
#7
JOURNAL ARTICLE
Yixiong Chen, Lufang Wang, Na Chen, Guiju Tang
Inducing immunogenic cell death (ICD) process may be an important antitumor strategy in ovarian cancer (OC). Metformin (Met) has been shown to have antitumor effects in OC, but whether it mediates the ICD to inhibit OC process is unclear. Human OC cell lines (SKOV3 and A2780) were treated with Met. Dendritic cell (DC) and CD8+ T cells were isolated from the peripheral blood mononuclear cells of volunteers. Cell counting kit 8 assay was used to measure cell viability, and immunofluorescence staining was performed to detect the percentages of membrane and intracellular calreticulin (CRT)...
July 8, 2024: Translational Oncology
https://read.qxmd.com/read/38981245/application-of-predictive-model-based-on-ct-radiomics-and-machine-learning-in-diagnosis-for-occult-locally-advanced-esophageal-squamous-cell-carcinoma-before-treatment-a-two-center-study
#8
JOURNAL ARTICLE
Shu-Han Xie, Wan-Fei Zhang, Yue Wu, Zi-Lu Tang, Li-Tao Yang, Yun-Jing Xue, Jiang-Bo Lin, Ming-Qiang Kang
PURPOSE: Development and validation of a radiomics model for predicting occult locally advanced esophageal squamous cell carcinoma (LA-ESCC) on computed tomography (CT) radiomic features before implementation of treatment. METHODS: The study retrospectively collected 574 patients with esophageal squamous cell carcinoma (ESCC) from two medical centers, which were divided into three cohorts for training, internal and external validation. After delineating volume of interest (VOI), radiomics features were extracted and subjected to feature selection using three robust methods...
July 8, 2024: Translational Oncology
https://read.qxmd.com/read/38972174/construction-of-a-5-gene-super-enhancer-related-signature-for-osteosarcoma-prognosis-and-the-regulatory-role-of-tnfrsf11b-in-osteosarcoma
#9
JOURNAL ARTICLE
Jun Liu, Chengfeng Yi, Deliang Gong, Qingzhong Zhao, Han Xie, Shibing Zhao, Hang Yu, Jianwei Lv, Erbao Bian, Dasheng Tian
Osteosarcoma, one of the most common primary malignancies in children and adolescents, has the primary characteristics of a poor prognosis and high rate of metastasis. This study used super-enhancer-related genes derived from two different cell lines to construct five novel super-enhancer-related gene prognostic models for patients with osteosarcoma. The training and testing datasets were used to confirm the prognostic models of the five super-enhancer-related genes, which resulted in an impartial predictive element for osteosarcoma...
July 6, 2024: Translational Oncology
https://read.qxmd.com/read/38970916/cinobufacini-enhances-the-therapeutic-response-of-5-fluorouracil-against-gastric-cancer-by-targeting-cancer-stem-cells-via-akt-gsk-3%C3%AE-%C3%AE-catenin-signaling-axis
#10
JOURNAL ARTICLE
Jiejie Sun, Sufeng Zhang, Meng Wang, Hui Cheng, Yuqing Wang, Shiming He, Qiang Zuo, Ning Wang, Qinglin Li, Manman Wang
BACKGROUND: Gastric cancer stem cells (GCSCs) play crucial role in the development, recurrence, and resistance of gastric cancer (GC). Cinobufacini, a traditional Chinese medicine, offers significant advantages in improving tumor therapy. However, pre-clinical investigation into the antitumor effect and mechanism of Cinobufacini on GC is still lacking. Additionally, it has not been reported whether Cinobufacini is related to cancer stem cells (CSCs). METHODS: The CCK-8, clone formation, EdU staining, transwell and wound healing experiments were performed to assess the cell toxicity of Cinobufacini and demonstrate the preventive effects of Cinobufacini on proliferation, invasion, and migration of GC cells...
July 5, 2024: Translational Oncology
https://read.qxmd.com/read/38970915/the-prognostic-value-and-its-relationship-with-immune-infiltration-of-acly-in-clear-cell-renal-cell-carcinoma
#11
JOURNAL ARTICLE
Beibei Yin, Qiang Liu, Yabing Zheng, Huayu Gao, Yun Lin, Zuohui Zhao
ATP citrate lyase (ACLY) is activated in various cancers, but its role in clear cell renal cell carcinoma (ccRCC) remains poorly understood. Herein, we investigated the prognostic role and potential mechanism of ACLY in ccRCC. The expression profile of ACLY in ccRCC was explored using Gene Expression Profiling Interactive Analysis 2 (GEPIA2), Gene Expression Omnibus (GEO), UALCAN and western blotting assays. The prognosis was investigated using immunohistochemistry (IHC) and Kaplan-Meier plotter assays. The relationship with immune infiltration was further evaluated using Tumor Immune Estimation Resource 2 (TIMER2) and Tumor Immune System Interactions and DrugBank (TISIDB) databases, respectively...
July 5, 2024: Translational Oncology
https://read.qxmd.com/read/38964032/usp9x-inhibits-metastasis-in-pulmonary-sarcomatoid-carcinoma-by-regulating-epithelial-mesenchymal-transition-angiogenesis-and-immune-infiltration
#12
JOURNAL ARTICLE
Qin Feng, Qian Liu, Zi Liu, Jianyu Xu, Yang Yang, Ying Zhu, Guangxian Lu, Guangjuan Xu, Dan Wu, Feng Wang, Biao Liu, Wenjuan Wang, Xinyuan Ding
BACKGROUND: Pulmonary sarcomatoid carcinoma (PSC) is a highly invasive pulmonary malignancy with an extremely poor prognosis. The results of previous studies suggest that ubiquitin-specific peptidase 9X (USP9X) contributes to the progression of numerous types of cancer. Nevertheless, there is little knowledge about the molecular mechanisms and functions of USP9X in the metastasis of PSC. METHODS: Immunohistochemistry and western blotting were used to detect USP9X expression levels in PSC tissues and cells...
July 3, 2024: Translational Oncology
https://read.qxmd.com/read/38964031/comprehensive-investigation-in-oncogenic-functions-and-immunological-roles-of-ncbp2-and-its-validation-in-prostate-cancer
#13
JOURNAL ARTICLE
Jian Wang, Tao Guo, Xiaomin Zhang, Jiacheng Guo, Xiangyu Meng, Shi Yan, Ye Wang, Yutian Xiao, Weidong Xu, Xuedong Wei, Keke Ding, Jun Zhang, Yuanyuan Mi, Sheng Wu, Jie Chen, Yuhua Huang, Shancheng Ren, Jianquan Hou
BACKGROUND: Nuclear cap-binding protein 2 (NCBP2), as the component of the cap-binding complex, participates in a number of biological processes, including pre-mRNA splicing, transcript export, translation regulation and other gene expression steps. However, the role of NCBP2 on the tumor cells and immune microenvironment remains unclear. To systematically analyze and validate functions of NCBP2, we performed a pan-cancer analysis using multiple approaches. METHODS: The data in this study were derived from sequencing, mutation, and methylation data in the TCGA cohort, normal sample sequencing data in the GTEx project, and cell line expression profile data in the CCLE database...
July 3, 2024: Translational Oncology
https://read.qxmd.com/read/38959710/a-meta-analysis-of-liquid-biopsy-versus-tumor-histology-for-detecting-egfr-mutations-in-non-small-cell-lung-cancer
#14
JOURNAL ARTICLE
Jing Cai, Wanning Wang, Wenlong Zhang
OBJECTIVE: To assess the consistency of liquid biopsy and histologic analysis for detecting epidermal growth factor receptor (EGFR) gene mutations in patients with advanced non-small cell lung cancer (NSCLC). METHODS: The PubMed, Cochrane Library, and CNKI et al. databases were searched to collect studies comparing liquid biopsy and histopathologic specimens. The EGFR mutation status was extracted from the studies, and meta-analysis was carried out using Stata 12...
July 2, 2024: Translational Oncology
https://read.qxmd.com/read/38959709/preclinical-evidence-for-employing-mek-inhibition-in-nras-mutated-pediatric-gastroenteropancreatic-neuroendocrine-like-tumors
#15
JOURNAL ARTICLE
Colin H Quinn, Andee M Beierle, Adele P Williams, Raoud Marayati, Laura V Bownes, Hooper R Market, Michael E Erwin, Jamie M Aye, Jerry E Stewart, Elizabeth Mroczek-Musulman, Karina J Yoon, Elizabeth A Beierle
BACKGROUND: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults. Trametinib is a kinase inhibitor that targets MEK1/2 and has been employed in the treatment of cancers harboring mutations in the Ras pathway. METHODS: We utilized an established human pediatric gastroenteropancreatic neuroendocrine-like tumor patient-derived xenograft (PDX) with a known NRAS mutation to study the effects of MEK inhibition...
July 2, 2024: Translational Oncology
https://read.qxmd.com/read/38959708/kr%C3%A3-ppel-like-factor-12-decreases-progestin-sensitivity-in-endometrial-cancer-by-inhibiting-the-progesterone-receptor-signaling-pathway
#16
JOURNAL ARTICLE
Haimeng Shi, Jian Li, Tong Yan, Ling Zhou, Yu Zhu, Feifei Guo, Sihui Yang, Xiangyi Kong, Huaijun Zhou
OBJECTIVE: This study aimed to clarify the mechanism by which Krüppel-like factor 12 (KLF12) affects progesterone sensitivity in endometrial cancer (EC) through the progesterone receptor PGR signaling pathway. METHODS: The relationship of KLF12 with PGR in EC patients was examined by immunohistochemistry, and the expression of KLF12 and PGR in EC cell lines was detected by real-time PCR and western blotting. Cell proliferation assay, plate clone formation, cell apoptosis assay, and cell cycle analysis were conducted to determine the impact of KLF12 intervention on progesterone therapy...
July 2, 2024: Translational Oncology
https://read.qxmd.com/read/38954975/cuet-overcomes-regorafenib-resistance-by-inhibiting-epithelial-mesenchymal-transition-through-suppression-of-the-erk-pathway-in-hepatocellular-carcinoma
#17
JOURNAL ARTICLE
Ding Ma, Shuwen Liu, Kua Liu, Qinyu He, Lili Hu, Weiwei Shi, Yin Cao, Guang Zhang, Qilei Xin, Zhongxia Wang, Junhua Wu, Chunping Jiang
BACKGROUND AND PURPOSE: Regorafenib was approved by the US Food and Drug Administration (FDA) for hepatocellular carcinoma (HCC) patients showing progress on sorafenib treatment. However, there is an inevitably high rate of drug resistance associated with regorafenib, which reduces its effectiveness in clinical treatment. Thus, there is an urgent need to find a potential way to solve the problem of regorafenib resistance. The metabolite of disulfiram complexed with copper, the Diethyldithiocarbamate-copper complex (CuET), has been found to be an effective anticancer drug candidate...
July 1, 2024: Translational Oncology
https://read.qxmd.com/read/38954974/akr1c3-promotes-progression-and-mediates-therapeutic-resistance-by-inducing-epithelial-mesenchymal-transition-and-angiogenesis-in-small-cell-lung-cancer
#18
JOURNAL ARTICLE
Wenting Liu, Guoli Li, Dingzhi Huang, Tingting Qin
OBJECTIVE: Small cell lung cancer (SCLC) is a high-grade neuroendocrine tumor characterized by initial sensitivity to chemotherapy, followed by the development of drug resistance. The underlying mechanisms of resistance in SCLC have not been fully elucidated. Aldo-keto reductase family 1 member C3 (AKR1C3), is known to be associated with chemoradiotherapy resistance in diverse tumors. We aim to evaluate the prognostic significance and immune characteristics of AKR1C3 and investigate its potential role in promoting drug resistance in SCLC...
July 1, 2024: Translational Oncology
https://read.qxmd.com/read/38945020/incidence-and-severity-of-acute-radiation-induced-toxicities-among-breast-cancer-patients-treated-with-adjuvant-radiotherapy-at-a-major-cancer-treatment-center-in-ghana
#19
JOURNAL ARTICLE
K A Kyei, J Daniels, F Pratt-Ainooson, S Anim-Sampong, E O Nkansah, K A Amoabeng, W K Antwi
BACKGROUND: Adjuvant radiotherapy after mastectomy or breast conserving surgery (BCS) is the standard of care for majority of patients with breast cancer. This is however associated with mucosal and epidermal toxicity of organs at risk (OARs). Breast cancer patients are exposed to a plethora of wrong perceptions, misinformation and myths concerning the usefulness and adverse effects of radiotherapy. There is paucity of literature on the incidence and severity of radiation-induced acute toxicities experienced by patients with breast cancer in Ghana...
June 29, 2024: Translational Oncology
https://read.qxmd.com/read/38943923/plasma-extracellular-vesicles-proteomics-in-meningioma-patients
#20
JOURNAL ARTICLE
Yiqiang Zhou, Yanxin Lu, Xiaolong Wu, Jie Bai, Xupeng Yue, Yifei Liu, Yanling Cai, Xinru Xiao
Tumor derived Extracellular vesicles (EVs) in circulating system may contain tumor-specific markers, and EV detection in body fluids could become an important tool for early tumor diagnosis, prognosis assessment. Meningiomas are the most common benign intracranial tumors, few studies have revealed specific protein markers for meningiomas from patients' body fluids. In this study, using proximity labeling technology and non-tumor patient plasma as a control, we detected protein levels of EVs in plasma samples from meningioma patients before and after surgery...
June 28, 2024: Translational Oncology
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