Catherine J Libby, Sajina Gc, Gloria A Benavides, Jennifer L Fisher, Sarah E Williford, Sixue Zhang, Anh Nhat Tran, Emily R Gordon, Amber B Jones, Kaysaw Tuy, William Flavahan, Juan Gordillo, Ashlee Long, Sara J Cooper, Brittany N Lasseigne, Corinne E Augelli-Szafran, Victor Darley-Usmar, Anita B Hjelmeland
The multifaceted roles of metabolism in invasion have been investigated across many cancers. The brain tumor glioblastoma (GBM) is a highly invasive and metabolically plastic tumor with an inevitable recurrence. The neuronal glucose transporter 3 (GLUT3) was previously reported to correlate with poor glioma patient survival and be upregulated in GBM cells to promote therapeutic resistance and survival under restricted glucose conditions. It has been suggested that the increased glucose uptake mediated by GLUT3 elevation promotes survival of circulating tumor cells to facilitate metastasis...
December 2021: Cell Adhesion & Migration