Izael S Costa, Amanda F Medeiros, Fabiana M C Carvalho, Vanessa C O Lima, Raphael P Serquiz, Alexandre C Serquiz, Vivian N Silbiger, Raul H Bortolin, Bruna L L Maciel, Elizeu A Santos, Ana H A Morais
OBJECTIVE: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. METHODS: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the ob gene in subcutaneous adipose tissue were assessed...
December 11, 2018: Obesity Facts