Hamdi Mohamed Isse, Robert Lukande, Senai Goitom Sereke, Fualal Jane Odubu, Rita Nassanga, Samuel Bugeza
BACKGROUND: Ultrasonography is a noninvasive modality for the initial assessment of thyroid nodules. The American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) has demonstrated good performance in differentiating malignant thyroid nodules. However, the combination of ACR TI-RADS categories and cytology has not been studied extensively, in Uganda. The study aims to correlate ACR TI-RADS with cytology among patients referred for US-guided fine-needle aspiration at Mulago National Referral Hospital...
September 1, 2023: Thyroid Research
Simone de Leo, Bijay Vaidya
No abstract text is available yet for this article.
September 1, 2023: Thyroid Research
Michael Cordes, Theresa Ida Götz, Stephan Coerper, Torsten Kuwert, Christian Schmidkonz
BACKGROUND: Ultrasound is the first-line imaging modality for detection and classification of thyroid nodules. Certain features observable by ultrasound have recently been equated with potential malignancy. This retrospective cohort study was conducted to test the hypothesis that radiomics of the four categorical divisions (medullary [MTC], papillary [PTC], or follicular [FTC] carcinoma and follicular thyroid adenoma [FTA]) demonstrate distinctive sonographic characteristics. Using an artificial neural network model for proof of concept, these sonographic features served as input...
August 28, 2023: Thyroid Research
Moawia Mohammed Ali Elhassan, Mohamed Dafalla Awadalla Gismalla, Sahar Abdelrahman Hamid Mohamed, Areeg Faggad
BACKGROUND: In Sudan, there is limited knowledge on the epidemiology, clinical characteristics and pathological patterns of thyroid cancer. To address this shortcoming, we studied the clinical, pathological and treatment patterns of thyroid cancer at the National Cancer Institute ‒ University of Gezira (NCI-UG), Sudan. METHODS: We performed a retrospective health facility-based study of patients with thyroid cancer who were treated at NCI-UG from January 2009 to December 2017...
August 25, 2023: Thyroid Research
Steven Raeymaeckers, Maurizio Tosi, Bastiaan Sol, Johan De Mey
BACKGROUND: The literature considers sclerotherapy to be a safe and effective treatment for benign thyroid cysts. No subsequent diagnostic problems have been reported as a complication. We report the occurrence of focal inflammation after said therapy, mimicking a thyroid malignancy. CASE PRESENTATION: We report a case of a young male with a solitary strongly suspicious lesion in the thyroid. The patient had undergone prior sclerotherapy of a thyroid cyst with Doxycycline...
August 17, 2023: Thyroid Research
Pav Gounder, Huw Oliphant, Valerie Juniat, Michael Koenig, Dinesh Selva, Saul N Rajak
PURPOSE: Lacrimal gland enlargement can be a feature of thyroid eye disease (TED). Unilateral or asymmetric lacrimal gland enlargement is poorly described and may impede diagnosis. We present the histological and clinical findings of four patients with asymmetric lacrimal gland enlargement. METHODS: A retrospective case note review was performed for patients over two tertiary orbital clinics (Royal Adelaide Hospital, South Australia and the Sussex Eye Hospital, Brighton, United Kingdom) presenting with an asymmetrical lacrimal gland enlargement with a background of TED that underwent biopsy to exclude alternate diagnoses...
August 14, 2023: Thyroid Research
Suzanne Murray, Vivek Subbiah, Steven I Sherman, Sophie Péloquin, Anthony Sireci, Christian Grohé, Patrick Bubach, Patrice Lazure
BACKGROUND: The discovery of driver oncogenes for thyroid carcinomas and the identification of genomically targeted therapies to inhibit those oncogenes have altered the treatment algorithm in thyroid cancer (TC), while germline testing for RET mutations has become indicated for patients with a family history of RET gene mutations or hereditary medullary TC (MTC). In the context of an increasing number of selective RET inhibitors approved for use, this paper aims to describe challenges and barriers affecting providers' ability to deliver optimal care for patients with RET-altered TC across the patient healthcare journey...
August 14, 2023: Thyroid Research
Kanako Kawasaki, Keita Kai, Nariyuki Tanaka, Shinichi Kido, Arisa Ibi, Akimichi Minesaki, Moriyasu Yamauchi, Yuichiro Kuratomi, Shinichi Aishima, Masahiro Nakashima, Masahiro Ito
BACKGROUND: Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) are common differentiated thyroid cancers, but the detection of a collision tumor is an extremely rare event. CASE PRESENTATION: The patient was a 69-year-old Japanese female with multiple cervical lymph node swellings and a thyroid tumor. Preoperative fine needle aspiration cytology of the enlarged lymph node revealed a cytological diagnosis of papillary thyroid carcinoma (PTC)...
August 7, 2023: Thyroid Research
Mojtaba Abrishami, Aliakbar Sabermoghaddam, Zeinab Salahi, Elham Bakhtiari, Mehrdad Motamed Shariati
PURPOSE: The aim of this study was to evaluate macular blood flow in patients with thyroid-associated orbitopathy (TAO) as compared to healthy subjects. The inflammatory nature of the disease, as well as the vascular congestion caused by the increase in the volume of orbital soft tissue and extraocular muscles, rationalize the assessment of retinal blood flow changes in these patients. METHODS: This is a cross-sectional study with the convenience sampling method...
August 2, 2023: Thyroid Research
Minoru Kihara, Akira Miyauchi, Makoto Fujishima, Tomo Ishizaka, Akihide Matsunaga, Shiori Kawano, Masashi Yamamoto, Takahiro Sasaki, Hiroo Masuoka, Takuya Higashiyama, Yasuhiro Ito, Naoyoshi Onoda, Akihiro Miya, Takashi Akamizu
The thyroid gland's neurovascular relationship is commonly portrayed as the recurrent laryngeal nerve (RLN) coursing posteriorly to the thyroid gland. We report a rare case with the RLN running anteriorly to a thyroid tumor. A 56-year-old Japanese woman underwent a thyroidectomy for a benign thyroid tumor. Preoperatively, computed tomography confirmed that part of the tumor had extended into the mediastinum and was descending posteriorly up to the brachiocephalic artery. Intraoperatively, when the sternothyroid muscle was incised to expose the thyroid gland, a cord (nerve)-like structure was observed directly anterior to the thyroid tumor...
July 20, 2023: Thyroid Research
Nicholas Angelopoulos, Rodis D Paparodis, Ioannis Androulakis, Panagiotis Anagnostis, Anastasios Boniakos, Leonidas Duntas, Spyridon N Karras, Sarantis Livadas
BACKGROUND: In the last decade, the combination of the widespread use of streptavidin-biotin technology and biotin-containing supplements (BCS) in the daily clinical practice, have led to numerous reports of erroneous hormone immunoassay results. However, there are no studies assessing the clinical and biochemical significance of that phenomenon, when treating patients with hypothyroidism. Therefore, a prospective study was designed to investigate the potential alterations in the measurement of thyroid hormone concentrations and clinical consequences in patients with hypothyroidism using low -dose BCS containing less than 300 μg/day...
July 17, 2023: Thyroid Research
Evgeny Sidorov, Aruna Paul, Chao Xu, Claire Delpirou Nouh, Allshine Chen, Albina Gosmanova, Niyaz Gosmanov, David Lee Gordon, Irina Baranskaya, Juliane Chainakul, Robert Hamilton, Alexander Mdzinarishvili
BACKGROUND: Thyroid hormones are of fundamental importance for brain function. While low triiodothyronine levels during acute ischemic stroke (AIS) are associated with worse clinical outcomes, dynamics of thyroid function after AIS remains unknown. Thus, we longitudinally evaluated thyroid hormones after stroke and related them to stroke severity. METHODS: We prospectively traced thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxin (fT4) levels from the hyper-acute (within 24 h) to acute (3-5 days) and chronic (3-6 months) stages of ischemic stroke using a mixed regression model...
July 13, 2023: Thyroid Research
(no author information available yet)
No abstract text is available yet for this article.
July 11, 2023: Thyroid Research
Floortje Mols, Dounya Schoormans, Romana Netea-Maier, Olga Husson, Sandra Beijer, Katrijn Van Deun, Wouter Zandee, Marleen Kars, Pleun C M Wouters van Poppel, Suat Simsek, Patrick van Battum, Jérôme M H Kisters, Jan Paul de Boer, Elske Massolt, Rachel van Leeuwaarde, Wilma Oranje, Sean Roerink, Mechteld Vermeulen, Lonneke van de Poll-Franse
BACKGROUND: Thyroid cancer (TC) patients are understudied but appear to be at risk for poor physical and psychosocial outcomes. Knowledge of the course and determinants of these deteriorated outcomes is lacking. Furthermore, little is known about mediating biological mechanisms. OBJECTIVES: The WaTCh-study aims to; 1. Examine the course of physical and psychosocial outcomes. 2. Examine the association of demographic, environmental, clinical, physiological, and personality characteristics to those outcomes...
July 10, 2023: Thyroid Research
Basavaraj Rangalakshmi Ashwini, Chandran Nirmala, Muthuvelu Natarajan, Dayananda S Biligi
INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common malignant lesion of the thyroid characterized by unique histological features like nuclear grooving, nuclear clearing, and intra-nuclear inclusions. However, nuclear grooves are observed even in benign thyroid lesions (BTL) like nodular goiter (NG), Hashimoto's thyroiditis (HT), and follicular adenoma (FA) resulting in diagnostic dilemma of the presence of PTC in such BTL. RET/PTC gene translocation is one of the most common oncogenic rearrangements seen in PTC, known to be associated with nuclear grooving...
July 3, 2023: Thyroid Research
Hawa Nuradin Mohamed, Abdi Karim Ahmed Ghedi, Sevgi Ozturk, Mohamed Osman Omar Jeele, Ahmed Muhammad Bashir
BACKGROUND: Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare complication of hyperthyroidism characterized by thyrotoxicosis, hypokalemia, and paralysis. It is the most common form of acquired periodic paralysis. THPP is precipitated by strenuous exercise, a high carbohydrate diet, stress, infection, alcohol, albuterol, and corticosteroid therapy. It is most common in Asian men with hyperthyroidism and exceptionally rare in black people. CASE PRESENTATION: A 29-year-old man was admitted to the emergency department in Somalia with a sudden onset of paralysis after a high carbohydrate meal...
June 12, 2023: Thyroid Research
Nanna Maria Uldall Torp, Inge Bülow Pedersen, Allan Carlé, Jesper Scott Karmisholt, Eva Ebbehøj, Diana Grove-Laugesen, Thomas Heiberg Brix, Steen Joop Bonnema, Bieke F Schrijvers, Birte Nygaard, Lena Bjergved Sigurd, Ulla Feldt-Rasmussen, Marianne Klose, Åse Krogh Rasmussen, Stig Andersen, Stine Linding Andersen
BACKGROUND: Graves' disease (GD) is the main cause of hyperthyroidism in women of the fertile age. In pregnant women, the disease should be carefully managed and controlled to prevent maternal and fetal complications. Observational studies provide evidence of the adverse effects of untreated hyperthyroidism in pregnancy and have in more recent years substantiated a risk of teratogenic side effects with the use of antithyroid drugs (ATDs). These findings have challenged the clinical recommendations regarding the choice of treatment when patients become pregnant...
June 12, 2023: Thyroid Research
Mohamed Asiri, Faisal Alsarrani, Abdullah Altasan, Faisal Alqahtani, Lujain Akram Ali, Majed Pharaon, Saad Alshehri, Awad Alshahrani
BACKGROUND: Leiomyosarcoma (LMS) is a soft tissue malignant tumor that has a predilection to the abdominopelvic and limb smooth muscles. LMS of the thyroid is exceptionally rare. Papillary thyroid cancer (PTC) is the most common thyroid malignancy and originates from the thyroid epithelial layer. To our knowledge, the presence of both tumors in the same patient has not been reported previously. CASE PRESENTATION & LITERATURE REVIEW: A 42-year-old woman presented with a progressively enlarging neck mass for a few months...
June 5, 2023: Thyroid Research
Avivar Awasthi, Partha Pratim Chakraborty, Neeti Agrawal, Anirban Sinha, Anuj Kumar Pandey, Animesh Maiti
BACKGROUND: One of the common causes of suboptimal control of thyroid stimulating hormone (TSH) in levothyroxine-treated hypothyroidism is coadministration of proton pump inhibitors (PPIs). Morning administration of pantoprazole has been shown to suppress intragastric pH to a greater extent. We therefore aimed to determine the effect of pantoprazole at different time points of the day on thyroid function test (TFT) in levothyroxine-treated overt primary hypothyroidism. METHODS: In this single centre, hospital based, prospective, two arm cross-over study (AB, BA), participants were randomized into 2 groups based on morning (6:00 am - 7:00 am simultaneously with the scheduled levothyroxine tablet) (group M) and evening (30 min before dinner) intake of 40 mg pantoprazole tablet (group N)...
June 1, 2023: Thyroid Research
Peter N Taylor, Andrew Lansdown, Justyna Witczak, Rahim Khan, Aled Rees, Colin M Dayan, Onyebuchi Okosieme
No abstract text is available yet for this article.
May 30, 2023: Thyroid Research
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