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Journal of Hematology & Oncology

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https://read.qxmd.com/read/30975222/recent-advances-of-therapeutic-targets-based-on-the-molecular-signature-in-breast-cancer-genetic-mutations-and-implications-for-current-treatment-paradigms
#1
REVIEW
Zeinab Safarpour Lima, Mostafa Ghadamzadeh, Farzad Tahmasebi Arashloo, Ghazaleh Amjad, Mohammad Reza Ebadi, Ladan Younesi
Breast cancer is the most common malignancy in women all over the world. Genetic background of women contributes to her risk of having breast cancer. Certain inherited DNA mutations can dramatically increase the risk of developing certain cancers and are responsible for many of the cancers that run in some families. Regarding the widespread multigene panels, whole exome sequencing is capable of providing the evaluation of genetic function mutations for development novel strategy in clinical trials. Targeting the mutant proteins involved in breast cancer can be an effective therapeutic approach for developing novel drugs...
April 11, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30971294/cd73-promotes-hepatocellular-carcinoma-progression-and-metastasis-via-activating-pi3k-akt-signaling-by-inducing-rap1-mediated-membrane-localization-of-p110%C3%AE-and-predicts-poor-prognosis
#2
Xiao-Lu Ma, Min-Na Shen, Bo Hu, Bei-Li Wang, Wen-Jing Yang, Li-Hua Lv, Hao Wang, Yan Zhou, An-Li Jin, Yun-Fan Sun, Chuan-Yan Zhang, Shuang-Jian Qiu, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence. Accumulating evidence shows that CD73-expressing tumor cell is implicated in development of several types of cancer. However, the role of CD73 in HCC cell has not been systematically investigated and its underlying mechanism remains elusive. METHODS: CD73 expression in HCC cell was determined by RT-PCR, Western blot, and immunohistochemistry staining...
April 11, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30940163/differential-roles-of-stat1-and-stat2-in-the-sensitivity-of-jak2v617f-vs-bcr-abl-positive-cells-to-interferon-alpha
#3
Claudia Schubert, Manuel Allhoff, Stefan Tillmann, Tiago Maié, Ivan G Costa, Daniel B Lipka, Mirle Schemionek, Kristina Feldberg, Julian Baumeister, Tim H Brümmendorf, Nicolas Chatain, Steffen Koschmieder
BACKGROUND: Interferon alpha (IFNa) monotherapy is recommended as the standard therapy in polycythemia vera (PV) but not in chronic myeloid leukemia (CML). Here, we investigated the mechanisms of IFNa efficacy in JAK2V617F- vs. BCR-ABL-positive cells. METHODS: Gene expression microarrays and RT-qPCR of PV vs. CML patient PBMCs and CD34+ cells and of the murine cell line 32D expressing JAK2V617F or BCR-ABL were used to analyze and compare interferon-stimulated gene (ISG) expression...
April 2, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30935402/molecular-pathogenic-pathways-in-extranodal-nk-t-cell-lymphoma
#4
REVIEW
Sanjay de Mel, Susan Swee-Shan Hue, Anand D Jeyasekharan, Wee-Joo Chng, Siok-Bian Ng
Extranodal NK/T cell lymphoma, nasal type (ENKTL) is an aggressive malignancy with a dismal prognosis. Although L-asparaginase-based chemotherapy has resulted in improved response rates, relapse occurs in up to 50% of patients with disseminated disease. There is hence an urgent need for effective targeted therapy, especially for patients with relapsed or refractory disease. Novel insights gleaned from high-throughput molecular and genomic profiling studies in recent years have contributed significantly to the understanding of the molecular biology of ENKTL, which exemplifies many of the hallmarks of cancer...
April 2, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30935414/activating-cgas-sting-pathway-for-the-optimal-effect-of-cancer-immunotherapy
#5
REVIEW
Anping Li, Ming Yi, Shuang Qin, Yongping Song, Qian Chu, Kongming Wu
During tumor progression, a subset of cancer cells escape from immune surveillance and eventually develop into measurable tumor mass. Cancer immunotherapy eradicates tumor cells by enhancing multiple steps in cancer-immunity cycle including antigen presentation, T cell priming, activation, and immune killing activity. Immunotherapy has been verified as an effective strategy in multiple cancers, but some problems still exist in actual clinical practice such as frequent primary and adaptive resistance. Combination with other adjuvant therapies gives us a new perspective to overcome the emerging obstacles in immunotherapy application...
April 1, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30925886/ferroptosis-a-new-form-of-cell-death-opportunities-and-challenges-in-cancer
#6
REVIEW
Yanhua Mou, Jun Wang, Jinchun Wu, Dan He, Chunfang Zhang, Chaojun Duan, Bin Li
Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the current findings of ferroptosis regulation and especially focus on the function of ncRNAs in mediating the process of cell ferroptotic death and on how ferroptosis was in relation to other regulated cell deaths. Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some "conventional" drugs or natural compounds as ferroptosis inducers in cancer...
March 29, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30898137/trabectedin-triggers-direct-and-nk-mediated-cytotoxicity-in-multiple-myeloma
#7
Maria Cucè, Maria Eugenia Gallo Cantafio, Maria Anna Siciliano, Caterina Riillo, Daniele Caracciolo, Francesca Scionti, Nicoletta Staropoli, Valeria Zuccalà, Lorenza Maltese, Anna Di Vito, Katia Grillone, Vito Barbieri, Mariamena Arbitrio, Maria Teresa Di Martino, Marco Rossi, Nicola Amodio, Pierosandro Tagliaferri, Pierfrancesco Tassone, Cirino Botta
BACKGROUND: Genomic instability is a feature of multiple myeloma (MM), and impairment in DNA damaging response (DDR) has an established role in disease pathobiology. Indeed, a deregulation of DNA repair pathways may contribute to genomic instability, to the establishment of drug resistance to genotoxic agents, and to the escape from immune surveillance. On these bases, we evaluated the role of different DDR pathways in MM and investigated, for the first time, the direct and immune-mediated anti-MM activity of the nucleotide excision repair (NER)-dependent agent trabectedin...
March 21, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30885250/elucidating-the-mechanism-of-action-of-domatinostat-4sc-202-in-cutaneous-t-cell-lymphoma-cells
#8
Marion Wobser, Alexandra Weber, Amelie Glunz, Saskia Tauch, Kristina Seitz, Tobias Butelmann, Sonja Hesbacher, Matthias Goebeler, René Bartz, Hella Kohlhof, David Schrama, Roland Houben
BACKGROUND: Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach. Here, we compared the mode of action of romidepsin (FK228), an established class I histone deacetylase inhibitor, and domatinostat (4SC-202), a novel inhibitor of class I HDACs, which has been reported to also target the lysine-specific histone demethylase 1A (LSD1). METHODS: We performed MTS assays and flow cytometric analyses of propidium iodide or annexin V-stained cells to assess drug impact on cellular proliferation, cell cycle distribution, and survival...
March 18, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30885244/early-myeloid-derived-suppressor-cells-hla-dr-low-cd33-cd16-expanded-by-granulocyte-colony-stimulating-factor-prevent-acute-graft-versus-host-disease-gvhd-in-humanized-mouse-and-might-contribute-to-lower-gvhd-in-patients-post-allo-hsct
#9
Ke Wang, Meng Lv, Ying-Jun Chang, Xiang-Yu Zhao, Xiao-Su Zhao, Yuan-Yuan Zhang, Yu-Qian Sun, Zhi-Dong Wang, Pan Suo, Yang Zhou, Dan Liu, Shu-Zhen Zhai, Yan Hong, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang
INTRODUCTION: Myeloid-derived suppressor cells (MDSCs) are proposed to control graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the definition of human MDSCs has not yet reached consensus, and the mechanism of MDSCs to control GVHD remains unclear. METHODS: Immature myeloid cells (HLA-DR-/low CD33+ CD16- ) were tested before and after granulocyte colony-stimulating factor (G-CSF) administration in healthy donor and isolated for suppression assays and co-culture with T cells in vitro...
March 18, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30876441/molecular-markers-and-potential-therapeutic-targets-in-non-wnt-non-shh-group-3-and-group-4-medulloblastomas
#10
REVIEW
Otília Menyhárt, Felice Giangaspero, Balázs Győrffy
Childhood medulloblastomas (MB) are heterogeneous and are divided into four molecular subgroups. The provisional non-wingless-activated (WNT)/non-sonic hedgehog-activated (SHH) category combining group 3 and group 4 represents over two thirds of all MBs, coupled with the highest rates of metastases and least understood pathology. The molecular era expanded our knowledge about molecular aberrations involved in MB tumorigenesis, and here, we review processes leading to non-WNT/non-SHH MB formations.The heterogeneous group 3 and group 4 MBs frequently harbor rare individual genetic alterations, yet the emerging profiles suggest that infrequent events converge on common, potentially targetable signaling pathways...
March 15, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30876435/pathogenesis-and-biomarkers-of-natural-killer-t-cell-lymphoma-nktl
#11
REVIEW
Nagavalli Somasundaram, Jing Quan Lim, Choon Kiat Ong, Soon Thye Lim
Natural killer T cell lymphoma (NKTL) is an aggressive disease with very poor treatment outcomes in the advanced stages. With chemotherapy, initial response rates to treatment are high but responses are short lived. A better understanding of the complex molecular pathogenesis of this disease is essential in order to design and develop better therapeutics with improved efficacy. This review aims to summarise the key pathogenic mechanisms in NKTL which may have significant prognostic and therapeutic implications...
March 15, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30866992/recent-advances-on-anti-angiogenesis-receptor-tyrosine-kinase-inhibitors-in-cancer-therapy
#12
REVIEW
Shuang Qin, Anping Li, Ming Yi, Shengnan Yu, Mingsheng Zhang, Kongming Wu
Angiogenesis has always been the topic of major scientific interest in the field of malignant tumors. Nowadays, targeting angiogenesis has achieved success in various carcinomas by several mechanisms, including the use of anti-angiogenic small molecule receptor tyrosine kinase inhibitors (TKIs). The development of TKIs targeting pro-angiogenic receptors, mainly vascular endothelial growth factor receptor (VEGFR) family, have significantly improved the outcome of certain types of cancers, like renal cell carcinoma, hepatocellular carcinoma, and colorectal carcinoma...
March 12, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30845975/the-iap-antagonist-birinapant-potentiates-bortezomib-anti-myeloma-activity-in-vitro-and-in-vivo
#13
Liang Zhou, Yu Zhang, Yun Leng, Yun Dai, Maciej Kmieciak, Lora Kramer, Kanika Sharma, Yan Wang, William Craun, Steven Grant
BACKGROUND: Mechanisms by which Smac mimetics (SMs) interact with proteasome inhibitors (e.g., bortezomib) are largely unknown, particularly in multiple myeloma (MM), a disease in which bortezomib represents a mainstay of therapy. METHODS: Interactions between the clinically relevant IAP (inhibitor of apoptosis protein) antagonist birinapant (TL32711) and the proteasome inhibitor bortezomib were investigated in multiple myeloma (MM) cell lines and primary cells, as well as in vivo models...
March 7, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30845955/platelet-integrin-%C3%AE-iib%C3%AE-3-signal-transduction-regulation-and-its-therapeutic-targeting
#14
REVIEW
Jiansong Huang, Xia Li, Xiaofeng Shi, Mark Zhu, Jinghan Wang, Shujuan Huang, Xin Huang, Huafeng Wang, Ling Li, Huan Deng, Yulan Zhou, Jianhua Mao, Zhangbiao Long, Zhixin Ma, Wenle Ye, Jiajia Pan, Xiaodong Xi, Jie Jin
Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a high level in platelets and their progenitors, where it plays a central role in platelet functions, hemostasis, and arterial thrombosis. Integrin αIIbβ3 also participates in cancer progression, such as tumor cell proliferation and metastasis. In resting platelets, integrin αIIbβ3 adopts an inactive conformation. Upon agonist stimulation, the transduction of inside-out signals leads integrin αIIbβ3 to switch from a low- to high-affinity state for fibrinogen and other ligands...
March 7, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30836977/correction-to-minimal-residual-disease-and-graft-vs-host-disease-guided-multiple-consolidation-chemotherapy-and-donor-lymphocyte-infusion-prevent-second-acute-leukemia-relapse-after-allotransplant
#15
Chen-Hua Yan, Yu Wang, Jing-Zhi Wang, Yu-Hong Chen, Yao Chen, Feng-Rong Wang, Yu-Qian Sun, Xiao-Dong Mo, Wei Han, Huan Chen, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang
The original article [1] contains two errors in the MRD Testing sub-section of the Methods.
March 5, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30832702/mortality-of-lymphoma-and-myeloma-in-china-2004-2017-an-observational-study
#16
Weiping Liu, Jiangmei Liu, Yuqin Song, Xiaopei Wang, Maigeng Zhou, Lijun Wang, Jun Ma, Jun Zhu
BACKGROUND: There is a dearth of accurate information about patterns of mortality of lymphoid neoplasms and temporal trends in China. In this nationwide mortality study, we aimed to assess the mortality of lymphoma and myeloma in 2017 and the changes in the trend from 2004 to 2016. METHODS: Death certificate data obtained from the Chinese Center for Disease Control and Prevention's disease surveillance points system (CDC-DSP) and population data from the National Bureau of Statistics of China were used in this study...
March 4, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30832692/downregulation-of-rnf128-activates-wnt-%C3%AE-catenin-signaling-to-induce-cellular-emt-and-stemness-via-cd44-and-cttn-ubiquitination-in-melanoma
#17
Chuan-Yuan Wei, Meng-Xuan Zhu, Yan-Wen Yang, Peng-Fei Zhang, Xuan Yang, Rui Peng, Chao Gao, Jia-Cheng Lu, Lu Wang, Xin-Yi Deng, Nan-Hang Lu, Fa-Zhi Qi, Jian-Ying Gu
BACKGROUND: Ring finger proteins (RNFs) were involved in carcinogenesis. Here, we aimed to explore the detailed mechanism of RNF128 in the progression of melanoma. METHODS: We reanalyzed several gene expression profiles from the Gene Expression Omnibus (GEO) database and obtained the overlapped differential expressed RNF genes. Among them, RNF128 was selected to further explore its expression, the biological significance, and the underlying molecular mechanism, as well as the clinical relevance in melanoma patients...
March 4, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30832689/transcriptional-factor-six2-promotes-the-competitive-endogenous-rna-network-between-cyp4z1-and-pseudogene-cyp4z2p-responsible-for-maintaining-the-stemness-of-breast-cancer-cells
#18
Lufeng Zheng, Qianqian Guo, Chenxi Xiang, Shijia Liu, Yuzhang Jiang, Lanlan Gao, Haiwei Ni, Ting Wang, Qiong Zhao, Hai Liu, Yingying Xing, Yaohui Wang, Xiaoman Li, Tao Xi
BACKGROUND: The expression of CYP4Z1 and the pseudogene CYP4Z2P has been shown to be specifically increased in breast cancer by our group and others. Additionally, we previously revealed the roles of the competitive endogenous RNA (ceRNA) network mediated by these genes (ceRNET_CC) in breast cancer angiogenesis, apoptosis, and tamoxifen resistance. However, the roles of ceRNET_CC in regulating the stemness of breast cancer cells and the mechanisms through which ceRNET_CC is regulated remain unclear...
March 4, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30808369/mir-195-5p-notch2-mediated-emt-modulates-il-4-secretion-in-colorectal-cancer-to-affect-m2-like-tam-polarization
#19
Xiaobin Lin, Shuyi Wang, Min Sun, Chunxiao Zhang, Chen Wei, Chaogang Yang, Rongzhang Dou, Qing Liu, Bin Xiong
BACKGROUND: Tumor microenvironment (TME) is a complex environment containing tumor cells, tumor-associated macrophages (TAMs), interstitial cells, and non-cellular components. Epithelial-mesenchymal transition (EMT), as a major actor in cancer tumorigenicity and metastasis, was involved in the interaction between TAMs and tumor cells. However, the potential mechanisms of EMT and how EMT-programmed tumor cells affect M2-like TAMs still need further exploration. METHODS: An integrated analysis of nine CRC miRNA expression datasets was performed...
February 26, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30795783/linck-contributes-to-breast-tumorigenesis-by-promoting-proliferation-and-epithelial-to-mesenchymal-transition
#20
Jing Li, Yajing Hao, Wenzhe Mao, Xiaowei Xue, Pengchao Xu, Lihui Liu, Jiao Yuan, Dongdong Zhang, Na Li, Hua Chen, Lin Zhao, Zhao Sun, Jianjun Luo, Runsheng Chen, Robert Chunhua Zhao
BACKGROUND: Increasing evidence has demonstrated that mesenchymal stem cells (MSCs) play a role in the construction of tumor microenvironments. Co-culture between tumor cells and MSCs provides an easy and useful platform for mimicking tumor microenvironments and identifying the important members involved in tumor progress. The long non-coding RNAs (lncRNAs) have been shown to regulate different tumorigenic processes. In this study, we aimed to examine functional lncRNA deregulations associated with breast cancer malignancy instigated by MSC-MCF-7 co-culture...
February 22, 2019: Journal of Hematology & Oncology
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