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Journal of Cardiovascular Translational Research

Wei Lu, Xiaoying He, Le Su, Junying Miao
Atherosclerosis is predicted to be the primary cause of death in the world by 2020. Changes in atherosclerotic plaque composition will lead to acute coronary syndromes. Although the studies on the molecular mechanisms of long noncoding RNA (lncRNA) are in-depth in molecular and cell levels, the in vivo research which studied the knowledge about lncRNAs in the regulation of plaque composition is still sparse. In this study, in order to investigate how a new lncRNA, CERNA1, regulates the composition of atherosclerotic plaques, we overexpressed CERNA1 in apolipoprotein E-/- (Apo E-/- ) mice and analyzed the role of CERNA1 in atherosclerotic plaque stabilization...
March 19, 2019: Journal of Cardiovascular Translational Research
Yu Li, Xin Quan, Xialing Li, Yu Pan, Tao Zhang, Zhuo Liang, Yunlong Wang
Molecular events involved in acute myocardial infarction (AMI) still remain unclear. A rat AMI model and cardiomyocytes cultured in vitro were used to mimic hypoxic conditions, and the profiles of histone methylation-related gene expression were explored. The demethylase Kdm6a expression was significantly upregulated in the rat AMI model and in hypoxia induction. The apoptosis rate of cardiomyocytes was significantly exacerbated when Kdm6a was knocked down. The expression of the Na+ /Ca2+ exchanger (Ncx) was significantly upregulated in cardiomyocytes under hypoxia...
March 18, 2019: Journal of Cardiovascular Translational Research
Natalia Briceno, Kalpa De Silva, Matthew Ryan, Tiffany Patterson, Kevin O'Gallagher, Howard Ellis, Simone Rivolo, Jack Lee, Simon Redwood, Ajay M Shah, Michael Marber, Divaka Perera
The effect of intra-aortic balloon counterpulsation (IABC) varies, and it is unknown whether this is due to a heterogeneous coronary physiological response. This study aimed to characterise the coronary and left ventricular (LV) effects of IABC and define responders in terms of their invasive physiology. Twenty-seven patients (LVEF 31 ± 9%) underwent coronary pressure and Doppler flow measurements in the target vessel and acquisition of LV pressure volume loops after IABC supported PCI, with and without IABC assistance...
March 15, 2019: Journal of Cardiovascular Translational Research
Nynke H M Kooistra, Freek Nijhoff, Masieh Abawi, Pierfrancesco Agostoni, Daniël M Araya Roos, Sjoerd van Tuijl, Niels Blanken, Michiel Voskuil, Pieter A F M Doevendans, Pieter R Stella, Tim Leiner
Accuracy of aortic regurgitation (AR) quantification by magnetic resonance (MR) imaging in the presence of a transcatheter heart valve (THV) remains to be established. We evaluated the accuracy of cardiac MR velocity mapping for quantification of antegrade flow (AF) and retrograde flow (RF) across a THV and the optimal slice position to use in cardiac MR imaging. In a systematic and fully controlled laboratory ex vivo setting, two THVs (Edwards SAPIEN XT, Medtronic CoreValve) were tested in a porcine model (n = 1) under steady flow conditions...
March 15, 2019: Journal of Cardiovascular Translational Research
Hubert Gufler, Sabine Niefeldt, Johannes Boltze, Stephanie Prietz, Christian Klopsch, Sabine Wagner, Brigitte Vollmar, Can Yerebakan
This experimental study describes the adaptive processes of the right ventricular (RV) myocardium after pulmonary artery banding (PAB) evaluated by cine cardiac magnetic resonance (CMR), phase-contrast CMR (PC-CMR), and conductance catheter. Seven sheep were subjected to CMR 3 months after PAB. Conductance catheter measurements were performed before and 3 months after PAB. Four nonoperated, healthy, age-matched animals served as controls. Higher RV masses (p < 0.01), elevated RV end-systolic volumes (p < 0...
March 7, 2019: Journal of Cardiovascular Translational Research
Jan Fiedler, Da-Hee Park, Lisa Hobuß, Parnian Kalbasi Anaraki, Angelika Pfanne, Annette Just, Saskia Mitzka, Inna Dumler, Frank Weidemann, Andres Hilfiker, Thomas Thum
Calcification of aortic valves leads to aortic stenosis mainly in elderly individuals, but the underlying molecular mechanisms are still not understood. Here, we studied microRNA (miR, miRNA) expression and function in healthy and stenotic human aortic valves. We identified miR-21, miR-24, and miR-143 to be highly upregulated in stenotic aortic valves. Using luciferase reporter systems, we found direct binding of miR-143 to the 3'UTR region of the matrix gla protein (MGP), which in turn is a key factor to sustain homeostasis in aortic valves...
March 6, 2019: Journal of Cardiovascular Translational Research
Mohan Satish, Shailendra K Saxena, Devendra K Agrawal
Adipokine dysregulation and insulin resistance are two hallmark sequelae attributed to the current clinical definition of metabolic syndrome (MetS) that are also linked to atherosclerotic vascular disease. Here, we critically discuss the underlying pathophysiological mechanisms and the interplay between the two sequelae. Adipokine dysregulation is involved with decreased nitric oxide, vascular inflammation, and insulin resistance in itself to promote atherosclerosis. Insulin resistance is involved with endothelial dysfunction by direct and indirect mechanisms that also promote vascular inflammation and atherosclerosis...
March 5, 2019: Journal of Cardiovascular Translational Research
Shunchang Li, Min Liang, Derun Gao, Quansheng Su, Ismail Laher
Diastolic dysfunction is a common complication that occurs early in diabetes mellitus. Titin and collagen are two important regulators of myocardial passive tension, which contributes to diabetic myocardial diastolic dysfunction. Exercise therapy significantly improves the impaired diabetic cardiac function, but its benefits appear to depend on the type of exercise used. We investigated the effect of aerobic and resistance exercise on cardiac diastolic function in diabetic rats induced by high-fat diet combined with low-dose streptozotocin injection...
February 28, 2019: Journal of Cardiovascular Translational Research
Thiruvelselvan Ponnusamy, Srikanth Komarulu Venkatachala, Manjunatha Ramanujappa, Lakshmi Mundkur
The pathogenic roles of inflammatory T cells and monocytes subsets have not been explored in different manifestations of coronary artery disease. We studied the frequency of these cells, their response to autoantigens, regulatory cell functional assay, foam cell formation and macrophage differentiation in 181 patients (stable angina, ST-elevated myocardial infarction (STEMI), NSTEMI, and unstable angina), and 34 controls and in samples collected during recurrent cardiac events and from patients showing clinical improvement...
February 27, 2019: Journal of Cardiovascular Translational Research
Wei Zhou, J Martijn Bos, Dan Ye, David J Tester, Sybil Hrstka, Joseph J Maleszewski, Steve R Ommen, Rick A Nishimura, Hartzell V Schaff, Chang Sung Kim, Michael J Ackerman
Hypertrophic cardiomyopathy (HCM), characterized by unexplained left ventricular hypertrophy, is one of the most common heritable cardiovascular diseases. The myosin regulatory light chain (MYL2) mutation R58Q has been associated with severe cardiac hypertrophy and sudden cardiac death (SCD). Herein, we provide the first patient-specific, induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of MYL2-R58Q. The MYL2-R58Q iPSC-CMs were nearly 30% larger than control iPSC-CMs at day 60. The percentage of myofibrillar disarray and cells with irregular beating in MYL2-R58Q iPSC-CMs was significantly higher than that in control cells...
February 22, 2019: Journal of Cardiovascular Translational Research
Chi-Sheng Lu, Yi-Nan Lee, Shin-Wei Wang, Yih-Jer Wu, Cheng-Huang Su, Chin-Ling Hsieh, Ting Yi Tien, Bo-Jeng Wang, Min-Che Chen, Chun-Wei Chen, Hung-I Yeh
Desmogleins (Dsg2) are the major components of desmosomes. Dsg2 has five extracellular tandem cadherin domains (EC1-EC5) for cell-cell interaction. We had previously confirmed the Dsg2 antibody and its epitope (named KC21) derived from EC2 domain suppressing epithelial-mesenchymal transition and invasion in human cancer cell lines. Here, we screened six peptide fragments derived from EC2 domain and found that KR20, the parental peptide of KC21, was the most potent one on suppressing endothelial colony-forming cell (ECFC) tube-like structure formation...
February 21, 2019: Journal of Cardiovascular Translational Research
Valeria Raparelli, Marco Proietti, Andrea Lenzi, Stefania Basili
The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74] rather than the 4-item Morisky Medication Adherence Scale.
February 12, 2019: Journal of Cardiovascular Translational Research
Benyamin Rahmani, Christopher McGregor, Guerard Byrne, Gaetano Burriesci
Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0.6% glutaraldehyde, and used to develop a new surgical valve design. The valves underwent in vitro hydrodynamic test in a pulse duplicator and high-cycled accelerated wear testing and were evaluated for acute haemodynamics and thrombogenicity in a juvenile sheep implant study for 48 h...
February 12, 2019: Journal of Cardiovascular Translational Research
Jasmine A Luzum, Joseph D English, Umair S Ahmad, Jessie W Sun, Benjamin D Canan, Wolfgang Sadee, Joseph P Kitzmiller, Philip F Binkley
Two common genetic polymorphisms in the beta-1 adrenergic receptor (ADRB1 Ser49Gly [rs1801252] and Arg389Gly [rs1801253]) significantly affect receptor function in vitro. The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure. Patients with heart failure and baseline LVEF ≤ 40% were genotyped (n = 98), and retrospective chart review assessed the primary outcome of LVEF recovery to ≥ 40%...
February 12, 2019: Journal of Cardiovascular Translational Research
Xiaohong Liu, Liuqing Yang, Dongmin Kwak, Lei Hou, Ruru Shang, Carolyn Meyer, Angela Panoskaltsis-Mortari, Xin Xu, Edward Kenneth Weir, Yingjie Chen
Dyspnea is a major symptom of heart failure (HF). Here, we have studied the lung remodeling and airway resistance in HF mice. We demonstrated that aortic banding-induced HF caused a dramatic decrease of lung compliance and an increase of lung airway resistance. The decrease of lung compliance was correlated with the increased lung weight in a linear fashion (γ2  = 0.824). An HF-induced increase of lung airway resistance and a decrease of lung compliance were almost identical in anesthetized mice and in the isolated lungs from these mice...
January 24, 2019: Journal of Cardiovascular Translational Research
Jerry Curran, Daniel Burkhoff, Robert A Kloner
Heart failure is a major cause of morbidity and mortality around the world, and myocardial infarction is its leading cause. Myocardial infarction destroys viable myocardium, and this dead tissue is replaced by a non-contractile scar that results in impaired cardiac function and a significantly increased likelihood of the patient developing heart failure. Limiting infarct scar size has been the target of pre-clinical and clinical investigations for decades. However, beyond reperfusion, few therapies have translated into the clinic that limit its formation...
January 22, 2019: Journal of Cardiovascular Translational Research
Stefan M Sattler, Anniek F Lubberding, Lasse Skibsbye, Reza Jabbari, Reza Wakili, Thomas Jespersen, Jacob Tfelt-Hansen
Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. AMI was induced by ligation of the mid-left anterior descending artery for 120 min followed by 60 min of reperfusion...
January 7, 2019: Journal of Cardiovascular Translational Research
Jing Wang, Chenglin Zhao, Junjie Xiao
No abstract text is available yet for this article.
January 7, 2019: Journal of Cardiovascular Translational Research
Zhongrong Zhang, Yi Duan, Yihua Bei
No abstract text is available yet for this article.
January 4, 2019: Journal of Cardiovascular Translational Research
Haifa Abdulla Al-Muhtaresh, Abdel Halim Salem, Ghada Al-Kafaji
Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated their association with the risk of CAD risk and their potential as biomarkers. The two miRNAs were upregulated in patients with T2D and CAD compared with controls, associated with CAD risk and remained significant after adjustment for multiple confounders...
January 4, 2019: Journal of Cardiovascular Translational Research
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