journal
Journals Journal of Cardiovascular Tran...

Journal of Cardiovascular Translational Research

https://read.qxmd.com/read/39028366/a-novel-prediction-model-for-post-tavi-macce-based-on-extracellular-vesicles-concentration-analysis
#1
EDITORIAL
Shuqin Liu, Michail Spanos, Jing Wang, Junjie Xiao
No abstract text is available yet for this article.
July 19, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/39017912/prediction-of-left-ventricle-pressure-indices-via-a-machine-learning-approach-combining-ecg-pulse-oximetry-and-cardiac-sounds-a-preclinical-feasibility-study
#2
JOURNAL ARTICLE
Lorenzo Fassina, Francesco Paolo Lo Muzio, Leonhard Berboth, Jens Ötvös, Alessandro Faragli, Alessio Alogna
Heart failure (HF) is defined as the inability of the heart to meet body oxygen demand requiring an elevation in left ventricular filling pressures (LVP) to compensate. LVP increase can be assessed in the cardiac catheterization laboratory, but this procedure is invasive and time-consuming to the extent that physicians rather rely on non-invasive diagnostic tools. In this work, we assess the feasibility to develop a novel machine-learning (ML) approach to predict clinically relevant LVP indices. Synchronized invasive (pressure-volume tracings) and non-invasive signals (ECG, pulse oximetry, and cardiac sounds) were collected from anesthetized, closed-chest Göttingen minipigs...
July 17, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/39009945/cirbp-a-key-regulator-in-hypothermic-cardioprotection-of-aged-donor-hearts-during-transplantation
#3
EDITORIAL
Danni Meng, Michail Spanos, Junjie Xiao
No abstract text is available yet for this article.
July 15, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/39009944/short-term-s100a8-a9-blockade-promotes-cardiac-neovascularization-after-myocardial-infarction
#4
JOURNAL ARTICLE
Razvan Gheorghita Mares, Viorel Iulian Suica, Elena Uyy, Raluca Maria Boteanu, Luminita Ivan, Iuliu Gabriel Cocuz, Adrian Horatiu Sabau, Vikas Yadav, Istvan Adorjan Szabo, Ovidiu Simion Cotoi, Mihaela Elena Tomut, Gabriel Jakobsson, Maya Simionescu, Felicia Antohe, Alexandru Schiopu
Acute-phase inhibition of the pro-inflammatory alarmin S100A8/A9 improves cardiac function post-myocardial infarction (MI), but the mechanisms underlying the long-term benefits of this short-term treatment remain to be elucidated. Here, we assessed the effects of S100A8/A9 blockade with the small-molecule inhibitor ABR-238901 on myocardial neovascularization in mice with induced MI. The treatment significantly reduced S100A9 and increased neovascularization in the myocardium, assessed by CD31 staining. Proteomic analysis by mass-spectrometry showed strong myocardial upregulation of the pro-angiogenic proteins filamin A (~ 10-fold) and reticulon 4 (~ 5-fold), and downregulation of the anti-angiogenic proteins Ras homolog gene family member A (RhoA, ~ 4...
July 15, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/39009943/differential-expression-of-mrna-in-peripheral-blood-mononuclear-cells-may-predict-postoperative-atrial-fibrillation-in-coronary-artery-bypass-surgery-patients
#5
JOURNAL ARTICLE
Mingqi Tan, Xiankun Liu, Lianqun Wang, Nan Jiang, Yunpeng Bai, Zhigang Guo
Postoperative Atrial Fibrillation (POAF) frequently follows Coronary Artery Bypass Grafting (CABG) surgery. This prospective study investigates genes linked to POAF in CABG patients, aiming to create a predictive model. Employing differential gene and methylation analyses, the study identified four genes (WARS2, CKAP2, CHI3L1, HSD17B6) associated with POAF. Preoperative plasma samples and clinical data were collected from 139 CABG patients, categorized into POAF (+) (43) and POAF (-) (96). Real-time quantitative PCR assessed gene expression, and a predictive model using the LASSO method demonstrated robust performance, with AUC values of 0...
July 15, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38995611/comprehensive-quality-analysis-of-conventional-and-novel-biomarkers-in-diagnosing-and-predicting-prognosis-of-coronary-artery-disease-acute-coronary-syndrome-and-heart-failure-a-comprehensive-literature-review
#6
REVIEW
Muhammad Abubakar, Umema Irfan, Ahmad Abdelkhalek, Izzah Javed, Muhammad Imran Khokhar, Fraz Shakil, Saud Raza, Siffat Saima Salim, Muhammad Mahran Altaf, Rizwan Habib, Simra Ahmed, Farea Ahmed
Coronary artery disease (CAD), acute coronary syndrome (ACS), and heart failure (HF) are major global health issues with high morbidity and mortality rates. Biomarkers like cardiac troponins (cTn) and natriuretic peptides (NPs) are crucial tools in cardiology, but numerous new biomarkers have emerged, proving increasingly valuable in CAD/ACS. These biomarkers are classified based on their mechanisms, such as fibrosis, metabolism, inflammation, and congestion. The integration of established and emerging biomarkers into clinical practice is an ongoing process, and recognizing their strengths and limitations is crucial for their accurate interpretation, incorporation into clinical settings, and improved management of CVD patients...
July 12, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38992315/inhibition-of-mettl4-targeting-a-methyltransferase-that-alleviates-heart-failure-by-modulating-excess-n6-methyladenine-in-mitochondrial-dna
#7
EDITORIAL
Jiaqi Wang, Michail Spanos, Yihua Bei
No abstract text is available yet for this article.
July 11, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38990461/silencing-dock2-attenuates-cardiac-fibrosis-following-myocardial-infarction-in-mice-via-targeting-pi3k-akt-and-wnt-%C3%AE-catenin-pathways
#8
JOURNAL ARTICLE
Guangquan Hu, Jin Chen, Min Chen, Kai Yang, Yuchen Wang, Ziyang Ma, Huangxin Bao, Xiaojie Ding
Cardiac fibrosis following myocardial infarction (MI) seriously affects the prognosis and survival rate of patients. This study aimed to determine the effect and regulation mechanism of the dedicator of cytokinesis 2 (DOCK2) during this process. Experiments were carried out in mice in vivo, and in Ang II treated cardiac fibroblasts (CFs) in vitro. DOCK2 was increased in mouse myocardial tissues after MI and Ang II-treated CFs. In MI mice, DOCK2 silencing improved cardiac function, and ameliorated cardiac fibrosis...
July 11, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38980655/morphological-features-of-the-vertebrobasilar-system-predict-ischemic-stroke-risk-in-spontaneous-vertebral-artery-dissection
#9
JOURNAL ARTICLE
Jiajia Bao, Mateng Bai, Muke Zhou, Jinghuan Fang, Yanbo Li, Jian Guo, Li He
The vertebral artery's morphological characteristics are crucial in spontaneous vertebral artery dissection (sVAD). We aimed to investigate morphologic features related to ischemic stroke (IS) and develop a novel prediction model. Out of 126 patients, 93 were finally analyzed. We constructed 3D models and morphological analyses. Patients were randomly classified into training and validation cohorts (3:1 ratio). Variables selected by LASSO - including five morphological features and five clinical characteristics - were used to develop prediction model in the training cohort...
July 9, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38980654/circulating-circ_0069094-is-correlated-with-the-present-and-endothelial-injury-of-acute-coronary-syndrome
#10
JOURNAL ARTICLE
Zhen Gao, Peng Wu, Hezhong Zhu, Jieqiong Chen, Wei Liu, Jiangtao Huo, Chaoyong He, Yang Duan, Jiajuan Chen
To investigate the impacts of circ_0069094 on acute coronary syndrome. Real-time polymerase chain reaction was used to detect the expression levels of circ_0069094, and its diagnostic performance was evaluated using ROC curve. Spearman's method was performed for correlation analysis. The levels of SOD, MDA, vWF in ACS rat models were assessed by commercial kits. The activities of H/R cell models were detected by CCK-8, Transwell, flow cytometry. The GO and KEGG were performed to analyze the function of targeted genes of miR-484...
July 9, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38980653/tmao-impairs-mouse-aortic-vasodilation-by-inhibiting-trpv4-channels-in-endothelial-cells
#11
JOURNAL ARTICLE
Ning Zhang, Liangju Liu, Xiaowang Lv, Yixuan Wang, Wei Zhang, Xin Wen, Fan Yu, Tingting Zhou
Trimethylamine oxide (TMAO) is an intestinal flora metabolite associated with risk of cardiovascular diseases. Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+ -permeable ion channel that is essential for vasodilation and endothelial function. Currently, there are few studies on the effect of TMAO on TRPV4 channels. In the present study, Ca2+ imaging of vascular tissue showed that TMAO inhibited TRPV4-mediated Ca2+ influx into aortic endothelial cells in a dose-dependent manner. Furthermore, a whole-cell patch clamp assay showed that TMAO blocked TRPV4-mediated cation currents...
July 9, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38971921/plasma-biomarker-screening-based-on-proteomic-signature-of-patients-with-resistant-hypertension
#12
JOURNAL ARTICLE
Jianmin Du, Xiaoqian Yu, Wenyu Zhang, Xinghai Zhang, Hengli Zhao, Rui Xu, Qing Wen
Resistant hypertension (RH) poses a significant health challenge, yet its underlying pathogenesis remains unclear. This study employs untargeted proteomic techniques to analyze the plasma of patients with RH and controlled hypertension (CH), identifying 157 differentially expressed proteins, with TGFB1 emerging as a key candidate. Through gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, Protein-Protein Interaction Networks (PPI) topological analysis, TGFB1's differential regulation in RH is established...
July 6, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38971920/high-intensity-focused-ultrasound-a-new-choice-to-conduct-pulmonary-artery-denervation
#13
JOURNAL ARTICLE
Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu, Zhenghui Xiao, Zhou Yang, Yunbin Xiao
This research aimed to explore whether high-intensity focused ultrasound (HIFU) could conduct pulmonary artery denervation (PADN). HIFU was performed in pulmonary arteries of 6 normotensive rabbits at dose of 250W, 6 times for each rabbit, and an additional 6 rabbits served as controls. Then ATEPH was induced in both groups by intravenous infusion of autogeneic thrombus. Hemodynamics and ultrasonography parameters were measured by right heart catheter and echocardiography pre- and post-establishment of ATEPH models in both groups...
July 6, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38969912/blood-pressure-variability-after-non-invasive-low-level-tragus-stimulation-in-acute-heart-failure
#14
JOURNAL ARTICLE
Michiaki Nagai, Keigo Dote, Masaya Kato, Shota Sasaki, Noboru Oda, Sunny S Po, Tarun W Dasari
Higher blood pressure (BP) variability (BPV) was shown to be strong predictors of poor cardiovascular outcomes in heart failure (HF). It is currently unknown if low-level tragus stimulation (LLTS) would lead to improvement in BPV in acute HF (AHF). The 22 patients with AHF (median 80 yrs, males 60%) were randomly assigned to active or sham group using an ear clip attached to the tragus (active group) or the earlobe (sham group) for 1 h daily over 5 days. In the active group, standard deviation (SD), coefficient of variation (CV) and δ in SBP were significantly decreased after LLTS (all p < 0...
July 5, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38913293/gut-microbiota-as-predictive-biomarker-for-chronic-heart-failure-in-patients-with-different-nutritional-risk
#15
JOURNAL ARTICLE
Chen Yang, Xiaopeng Li, Miaomiao Hu, Ting Li, Li Jiang, Yong Zhang
To examine the relationship between gut microbiota and disease development in chronic heart failure patients with different nutritional risk. The study analyzed stool samples from 62 CHF patients and 21 healthy peoples using 16S rRNA gene sequencing. CHF patients were separated into risk (n = 30) and non-risk group (n = 32) based on NRS2002 scores. Analysis methods used were LEfSe, random forest regression model, ROC curves, BugBase, PICRUSt2, metagenomeSeq. Risk group includes 11 cases of HFrEF, 6 cases of HFpEF, and 13 cases of HFmrEF...
June 24, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38886316/vaccarin-ameliorates-doxorubicin-induced-cardiotoxicity-via-inhibition-of-p38-mapk-mediated-mitochondrial-dysfunction
#16
JOURNAL ARTICLE
Xin Shi, Yang Cao, Hongyu Wang, Qi Zhao, Cong Yan, Shengzhu Li, Ling Jing
Doxorubicin is a frequently used chemotherapeutic agent for treating various malignancies. However, it leads to severe cardiotoxic side effects, such as heart failure, and elevates the risk of sudden cardiac death among cancer patients. While oxidative stress has been identified as the primary cause of doxorubicin-induced cardiotoxicity, therapeutic antioxidant approaches have yielded unsatisfactory outcomes. The aim of this study is to explore the therapeutic potential of vaccarin, an active flavonoid glycoside extracted from traditional Chinese herbal agent Semen Vaccariae, in doxorubicin-induced cardiotoxicity...
June 17, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38858339/modulating-the-expression-of-exercise-induced-lncrnas-implications-for-cardiovascular-disease-progression
#17
REVIEW
Li-Hua Yu, Ge-Lin Zhang
Recent research shows exercise is good for heart health, emphasizing the importance of physical activity. Sedentary behavior increases the risk of cardiovascular disease, while exercise can help prevent and treat it. Additionally, physical exercise can modulate the expression of lncRNAs, influencing cardiovascular disease progression. Therefore, understanding this relationship could help identify prospective biomarkers and therapeutic targets pertaining to cardiovascular ailments. This review has underscored recent advancements concerning the potential biomarkers of lncRNAs in cardiovascular diseases, while also summarizing existing knowledge regarding dysregulated lncRNAs and their plausible molecular mechanisms...
June 10, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38856882/crispr-cas9-mediated-deletion-of-the-uox-gene-generates-a-mouse-model-of-hyperuricemia-with-multiple-complications
#18
JOURNAL ARTICLE
Linzi Zeng, Shalaimaiti Shali, Yabiao Gao, Xingchen Du, Xiaoxia Zhu, Lin Li, Yuxiang Dai, Ping Zhou
Hyperuricemia is a common metabolic disorder with severe complications. We aimed to develop a mouse model for spontaneous hyperuricemia. Uox-/- mouse model was generated on C57BL/6J background by deleting exon 2-4 of Uox using the CRISPR/Cas9 system. The prototypic Uox -/- mice had 5.5-fold increased serum uric acid (1351.04±276.58μmol/L) as compared to the wild type mice (P<0.0001), but died by 4 weeks. After allopurinol (3ug/g) intervention, they all survived > 8 weeks. The serum uric acid was 612...
June 10, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38848015/novel-genetic-variants-associated-with-primary-myocardial-fibrosis-in-sudden-cardiac-death-victims
#19
JOURNAL ARTICLE
Sini Skarp, Anne Doedens, Lauri Holmström, Valerio Izzi, Samu Saarimäki, Eeva Sliz, Johannes Kettunen, Lasse Pakanen, Risto Kerkelä, Katri Pylkäs, Heikki V Huikuri, Robert J Myerburg, Juhani Junttila
Myocardial fibrosis is a common finding in victims of sudden cardiac death (SCD). Whole exome sequencing was performed in 127 victims of SCD with primary myocardial fibrosis as the only pathological finding. These cases are derived from the Fingesture study which has collected data from autopsy-verified SCD victims in Northern Finland. A computational approach was used to identify protein interactions in cardiomyocytes. Associations of the identified variants with cardiac disease endpoints were investigated in the Finnish national genetic study (FinnGen) dataset...
June 7, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38807004/mitochondria-associated-organelle-crosstalk-in-myocardial-ischemia-reperfusion-injury
#20
REVIEW
Hui Yao, Yuxin Xie, Chaoquan Li, Wanting Liu, Guanghui Yi
Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury. This damage often leads to disruption of endoplasmic reticulum protein regulatory programs and dysfunction of mitochondrial energy metabolism. Mitochondria and endoplasmic reticulum are seamlessly connected through the mitochondrial-associated endoplasmic reticulum membrane (MAM), which serves as a crucial site for the exchange of organelles and metabolites. However, there is a lack of reports regarding the communication of information and metabolites between mitochondria and related organelles, which is a crucial factor in triggering myocardial I/R damage...
May 28, 2024: Journal of Cardiovascular Translational Research
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