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Acta Ophthalmologica

Yue Yin, Lan Gong
PURPOSE: To propose and to evaluate a quantitative measuring method of meibomian gland (MG) vagueness. METHODS: A total of 47 patients (32 female and 15 male, 39.21 ± 11.07 years) with meibomian gland dysfunction (MGD) were recruited to the MGD group, and 47 healthy volunteers were recruited to the control group matched in age and gender. The clinical examinations included ocular surface evaluation, MG function indexes and MG morphological indexes (including MG vagueness value)...
February 14, 2019: Acta Ophthalmologica
Anca Pantalon, Martin Pfister, Valentin Aranha Dos Santos, Sabina Sapeta, Angelika Unterhuber, Niklas Pircher, Gerald Schmidinger, Gerhard Garhöfer, Doreen Schmidl, Leopold Schmetterer, René M Werkmeister
PURPOSE: To employ ultrahigh-resolution (UHR) optical coherence tomography (OCT) for investigation of the early wound healing process in corneal epithelium. METHODS: A custom-built UHR-OCT system assessed epithelial healing in human keratoconic cornea after epi-off crosslinking (CXL) procedure and a wound healing model in rabbits with iatrogenic corneal injury. 3D OCT data sets enhanced obtaining epithelial thickness maps and evaluation of reepithelization stage...
February 14, 2019: Acta Ophthalmologica
Pekko Hujanen, Anja Tuulonen, Hannele Uusitalo-Järvinen
No abstract text is available yet for this article.
February 14, 2019: Acta Ophthalmologica
Felix Tonagel, Carina Kelbsch, Christoph Kernstock
No abstract text is available yet for this article.
February 13, 2019: Acta Ophthalmologica
Ahmed M Abu El-Asrar, Nele Berghmans, Saleh A Al-Obeidan, Priscilla W Gikandi, Ghislain Opdenakker, Jo Van Damme, Sofie Struyf
PURPOSE: Evidence exists that the interleukin (IL)-10 family of cytokines is involved in autoimmune diseases. The aim of this study was to analyse the levels of the IL-10 family cytokines IL-10, IL-19, IL-20, IL-22, IL-26, IL-28A and IL-29 in aqueous humour (AH) samples from patients with specific uveitic entities. In addition, we correlated their levels with the levels of the proinflammatory cytokines tumour necrosis factor-α (TNF-α) and IL-1β. METHODS: Aqueous humour (AH) samples from patients with active uveitis associated with Behçet's disease (BD; n = 13), sarcoidosis (n = 8), human leucocyte antigen (HLA)-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12) and control subjects (n = 9) were assayed with the use of a multiplex assay...
February 13, 2019: Acta Ophthalmologica
Romain Deschamps, Vivien Vasseur, Natalia Shor, Catherine Vignal, Laurence Salomon, Olivier Gout, Martine Mauget-Faÿsse
BACKGROUND: Acute optic neuritis (AON) is a common optic nerve disease leading to retrograde degeneration of optic nerve axons, reflected by thinning of the inner retinal layers on optical coherence tomography. On the contrary, acute macular neuroretinopathy (AMN) type 2 is a rare outer retinal disorder that leads to thinning of the outer nuclear layers and is diagnosed by multimodal imaging. The aim of this study was to report a new association between these two diseases. METHODS: Patients with a first episode of optic neuritis were invited to participate in a study that involved optical coherence tomography evaluation at baseline and the following 1, 3, 6 and 12 months...
February 13, 2019: Acta Ophthalmologica
Alban Comet, Pierre Gascon, Lauren Sauvan, Benjamin Donnadieu, Frédéric Matonti
No abstract text is available yet for this article.
February 11, 2019: Acta Ophthalmologica
Ingen Shu, Hiroto Ishikawa, Hiroki Nishikawa, Shohei Morikawa, Fumiki Okamoto, Taiji Sakamoto, Masahiko Sugimoto, Mineo Kondo, Masanori Iwasaki, Takamasa Kinoshita, Toshi Toibana, Yoshinori Mitamura, Yoshihiro Takamura, Ryosuke Motohashi, Masahiko Shimura, Yutaka Sakurai, Masaru Takeuchi, Fumi Gomi
PURPOSE: To evaluate real-world evidence for young Japanese patients with rhegmatogenous retinal detachment (RRD) by retrospectively examining surgical procedures and clinical outcomes in the Japan Clinical Retina Study group. METHODS: This was a multicentre retrospective study of the medical records of 562 young patients (384 males and 178 females; mean age: 33.0 ± 11.8 years) who had been diagnosed with RRD and who underwent surgical procedures in participating centres during the period between April 2013 and August 2016...
February 11, 2019: Acta Ophthalmologica
Xi Wang, Wenqiu Zhang, Bingjie Chen, Meng Liao, Longqian Liu
PURPOSE: To compare the clinical outcomes of bilateral medial rectus plication and resection for the treatment of convergence insufficiency (CI)-type intermittent exotropia (IXT). METHODS: Fifty-five patients with CI-type IXT were included in this prospective study and were followed for 6 months. The patients were randomized into two groups: the bilateral medial rectus plication (BMRP) group (n = 27) and the bilateral medial rectus resection (BMRR) group (n = 28)...
February 11, 2019: Acta Ophthalmologica
Kimberly Spooner, Thomas Hong, Rashmi Nair, Nicholas Chian Chiang Chow, Geoffrey K Broadhead, Wijeyanthy Wijeyakumar, Andrew A Chang
PURPOSE: To report 4-year outcomes following the switch to aflibercept in treatment-resistant neovascular age-related macular degeneration (nAMD). METHODS: In this prospective, open-label, non-controlled, clinical trial, 49 patients with treatment-resistant nAMD received 2 mg intravitreal aflibercept as three loading doses every 4 weeks, followed by injections every 8 weeks for the first 48 weeks, then an individualized regimen for a further 36 months, following previous treatment with ranibizumab and/or bevacizumab...
February 11, 2019: Acta Ophthalmologica
Laura Armonaite, Stefan Löfgren, Anders Behndig
PURPOSE: To evaluate the efficacy and safety of iris suture fixation of out-of-the-bag dislocated three-piece intraocular lenses (IOL). METHODS: In a retrospective interventional consecutive case series, a chart review was performed in two groups of patients: fourteen patients with a dislocated out-of-the-bag three-piece IOL that underwent IOL fixation to the iris using the Siepser sliding knot technique (Iris group) and 18 patients with in-the-bag dislocation that underwent IOL exchange with a new scleral-sutured IOL (Exchange group)...
February 7, 2019: Acta Ophthalmologica
Annemiek D Barsingerhorn, F Nienke Boonstra, Jeroen Goossens
PURPOSE: We determined the latencies of orienting responses during a preferential looking task in children with normal vision and in children with visual impairments between 6 and 12 years old, and assessed the feasibility of scoring grating detection in these populations with video-based eye tracking. METHODS: Children performed a computerized preferential looking test, while a remote eye tracker measured the children's eye movements. The stimuli consisted of a 2 × 2 grid, with three uniform grey fields and one target field consisting of a black-and-white square wave grating...
February 7, 2019: Acta Ophthalmologica
Sanne E Detiger, A Faiz Karim, Robert M Verdijk, P Martin van Hagen, Jan A M van Laar, Dion Paridaens
IgG4-related disease (IgG4-RD) is an immune-mediated systemic fibro inflammatory disease. Treatment of IgG4-related orbital disease (IgG4-ROD) is often indicated to relieve the symptoms and to prevent complications. For IgG4-ROD, no international formal treatment guidelines are available and the optimal treatment strategy is uncertain. In this systematic review, we describe the efficacy of conventional and biologic disease-modifying antirheumatic drugs (DMARDs) in IgG4-ROD. A systematic search of Embase, Medline, Web-of-Science, PubMed publisher, Cochrane and Google Scholar was performed for treatment outcomes in IgG4-ROD...
February 7, 2019: Acta Ophthalmologica
Andreas Schatz, Anna-Maria Seuthe, Kai Januschowski
BACKGROUND: The scope of the study was the functional assessment of possible effects of intravitreally injected ocriplasmin using electroretinographical (ERG) examinations. METHODS: Seven subjects suffered from pathologies within the label of ocriplasmin (Jetrea® ) were examined in the study. An extended international society for clinical electrophysiology of vision ERG protocol was used for baseline recordings (before treatment) and was repeated for comparison 3 months after treatment with intravitreally injected ocriplasmin...
February 7, 2019: Acta Ophthalmologica
Meng Tian, Christoph Tappeiner, Martin S Zinkernagel, Sebastian Wolf, Marion R Munk
PURPOSE: To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept-source optical coherence tomography angiography (OCTA). METHODS: In this study consecutive patients with intermediate uveitis ± vasculitis and healthy age-matched controls were evaluated using central 3 × 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 × 3 scans and wide field OCTA were evaluated...
February 6, 2019: Acta Ophthalmologica
Xiaoxiao Liu, Xiangui He, Yao Yin, Bo Zhang, Sifei Sun, Jianfeng Zhu, Haidong Zou, Ling Wang, Xun Xu
PURPOSE: The aim of the present study was to investigate age-specific normative retinal oxygen saturation values and explore the associated factors in healthy Chinese school-aged children with different refractive statuses. DESIGN: Population-based observational cross-sectional study. METHODS: Children aged 7-19 years were enrolled. Each participant underwent a series of comprehensive ocular examinations, including axial length (AL), cycloplegic refraction and Oxymap T1 imagery following cycloplegia...
February 3, 2019: Acta Ophthalmologica
Marcos Muñoz, Alfonso Anton, Marta Castany, Alfonso Gil, Alberto Martinez, Francisco J Muñoz-Negrete, Jose Urcelay, Javier Moreno-Montañes
PURPOSE: To report 1-year treatment outcomes of P50 EX-PRESS implant versus nonpenetrating deep sclerectomy (NPDS) with Esnoper V2000 combined with phacoemulsification. DESIGN: Randomized, prospective and multicentre clinical trial. METHODS: Settings: Six clinical centres. POPULATION: Patients 54-89 years of age without previous filtering surgery with cataract and glaucoma who required lower levels of intraocular pressure (IOP)...
February 3, 2019: Acta Ophthalmologica
Zohar Habot-Wilner, Glenn Noronha, Charles C Wykoff
Delivery of pharmaceuticals to the posterior segment presents challenges that arise from the anatomy and clearance pharmacokinetics of the eye. Systemic and several local administration options [topical, periocular, intravitreal (IVT) and subretinal] are in clinical use, each with a unique benefit to risk profile shaped by factors including the administered agent, frequency of dosing, achievable pharmaceutical concentrations within posterior segment structures versus elsewhere in the eye or the body, invasiveness of the procedure and the inherent challenges with some administration methods...
January 31, 2019: Acta Ophthalmologica
Olavi Pärssinen, Markku Kauppinen, Ulrich Halekoh, Jaakko Kaprio, Taina Rantanen
PURPOSE: To examine genetic influences on interocular similarities in ocular refraction and components of refraction among elderly female twins. METHODS: Refraction was assessed in 94 monozygotic (MZ) and 74 dizygotic (DZ) female twins aged 66-78 years. Absolute values of interocular differences (Aniso variables) in spherical refraction (SR), refractive astigmatism (AST), spherical equivalent (SE), corneal refractive power (CR), corneal astigmatism (CAST), anterior chamber depth (ACD) and axial length (AL) were calculated...
January 31, 2019: Acta Ophthalmologica
Eva Karlén, Lollo Milestad, Tony Pansell
PURPOSE: Albinism degrades visual function due to developmental disorders of the eye and visual pathways, larger refractive errors, absent binocularity and poor fixation control. Reading spectacles is commonly prescribed in our clinic and well tolerated. The purpose was to evaluate whether the accommodative response is typical or affected in comparison to a reference group. METHODS: Twenty-two children with albinism (median: 13.5 years) and 12 controls (median: 13 years) underwent a full optometric examination and an objective accommodation measurement (WAM-5500 @ 6 Hz; Grand Seiko) in response to minus-lens-blur (-1, -2 and -3 D) and to a prolonged near viewing task (20 cm) for 5 min...
January 31, 2019: Acta Ophthalmologica
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