Hans Christian Kiilgaard, Anne Helene Køllund Nissen, Chandrakumar Balaratnasingam, Enrico Borrelli, Mark P Breazzano, Elon H C van Dijk, Mehmet Orkun Sevik, Jakob Grauslund, Yousif Subhi
Identifying macular neovascularization (MNV) in eyes with central serous chorioretinopathy (CSC) has important implications for its management. Optical coherence tomography angiography (OCTA) is increasingly used for this purpose. Here, we systematically reviewed the literature and conducted meta-analysis to determine the diagnostic accuracy of OCTA for detecting MNV in eyes with CSC. We systematically searched the literature in 12 databases for relevant studies from database inception until 18 November 2023...
July 11, 2024: Acta Ophthalmologica
Ingemar Gustafsson, Thorbjörg Olafsdotttir, Olof Neumann, Per Johansson, Dimitrios Bizios, Anders Ivarsen, Jesper Ø Hjortdal
PURPOSE: To present baseline characteristics and to present the perioperative corneal thickness during corneal crosslinking (CXL) treatment for progressive keratoconus and to describe how the addition of sterile water (SW) efficaciously can maintain the corneal thickness. The treatment efficacy will be evaluated when the 1-year follow-up is complete. METHODS: A randomised clinical study using epithelium-off CXL with continuous UVA irradiation (9 mW/cm2 ) and two kinds of riboflavin solutions: (i) isoosmolar dextran-based riboflavin (n = 27) and (ii) hypoosmolar dextran-free riboflavin (n = 27)...
July 5, 2024: Acta Ophthalmologica
Elli Joukainen, Jaakko Antonen, Sanna Leinonen
PURPOSE: To evaluate possible risk factors for uveitis among Finnish sarcoidosis patients. METHODS: Patient charts of patients with sarcoidosis, with (n = 97) or without (n = 255) uveitis, and with a comprehensive eye examination from January 2014 to January 2021 at Tays Eye Centre, Tampere University Hospital, Finland were studied. RESULTS: Sarcoidosis patients with uveitis had higher rate of lymphocytopenia (43% vs...
July 4, 2024: Acta Ophthalmologica
Josefine Freiberg, Roshan Welikala, Jens Rovelt, Sarah A Barman, Christopher G Owen, Alicja R Rudnicka, Miriam Kolko
PURPOSE: To characterise the retinal vasculometry of a Danish eye and vision cohort and examine associations with systolic blood pressure (BP), diastolic BP, mean arterial BP, and intraocular pressure (IOP). DESIGN: Longitudinal study. METHODS: The retinal vasculature of fundus images from the FOREVER (Finding Ophthalmic Risks and Evaluating the Value of Eye exams and their predictive Reliability) cohort was analysed using a fully automated image analysis program...
July 2, 2024: Acta Ophthalmologica
R O B de Keizer, J S Suwandi, J C van Limpt, C Kluis, G Hötte, A P Nagtegaal, D Paridaens
BACKGROUND/AIMS: Data regarding the effectiveness of prophylactic systemic antibiotics (PSA) in lacrimal surgery is scarce. Therefore, we determined the postoperative surgical site infection (SSI) rate in lacrimal surgery without PSA. METHODS: We retrospectively analysed files of patients who underwent external (extDCR) or endoscopic endonasal dacryocystorhinostomy (endoDCR). We excluded patients with incomplete data (n = 68), acute a priori infection with the need for antibiotics (n = 15) and PSA post-operatively for other reasons (n = 28)...
July 2, 2024: Acta Ophthalmologica
André Schulz, Thorsten Knoll, Tino Jaeger, Ronan Le Harzic, Frank Stracke, Sascha L Wien, Yves Olsommer, Ina Meiser, Sylvia Wagner, Michael Rammensee, Oliver Kurz, Stephan Klesy, Loic Sermeus, Henrike Julich-Haertel, Yanick Schweitzer, Kai Januschowski, Thomas Velten, Peter Szurman
PURPOSE: To develop and evaluate a photovoltaic, wireless wide-field epiretinal prosthesis for the treatment of retinitis pigmentosa. METHODS: A mosaic array of thinned silicon-based photodiodes with integrated thin-film stimulation electrodes was fabricated with a flexible polyimide substrate film to form a film-based miniaturized electronic system with wireless optical power and signal transmission and integrated electrostimulation. Manufactured implants were characterized with respect to their optoelectronic performance and biocompatibility following DIN EN ISO 10993...
June 23, 2024: Acta Ophthalmologica
Chandrakumar Balaratnasingam, Christine A Curcio, William H Morgan, Elon H C van Dijk
Central serous chorioretinopathy (CSC) is a frequently occurring chorioretinal disease, that is commonly associated with subretinal fluid accumulation in a generally young population. Even though choroidal abnormalities have been found to be of importance, the exact pathogenesis of CSC is still being learned. The origin of pigment epithelial detachments, seen in many CSC patients, is also unclear. Based on the follow-up of a CSC patient for more than 5 years, we hypothesize that intraocular pressure and, by extension, the pressure gradient across the Bruch's membrane, may be one factor in the pathogenesis of pigment epithelial detachments in CSC, which might very well have implications for the occurrence of and possible ways to prevent subretinal fluid in CSC...
June 11, 2024: Acta Ophthalmologica
Benjamin Sommer Thinggaard, Frederik Pedersen, Ryo Kawasaki, Jimmi Wied, Yousif Subhi, Jakob Grauslund, Lonny Stokholm
PURPOSE: To report the incidence of post-injection endophthalmitis (PIE) and the cumulative risk associated with repeated injections of intravitreal anti-vascular endothelial growth factor (anti-VEGF). METHODS: We employed nationwide registries in Denmark to include all individuals aged ≥40 years who received at least one intravitreal anti-VEGF injection in 2007-2022. Our primary endpoint PIE was identified using specific diagnostic codes for endophthalmitis and procedure codes for vitreous biopsy within 10 days prior to and 120 days post-injection...
June 3, 2024: Acta Ophthalmologica
Diana Chabané Schmidt, Daniella Bach-Holm, Line Kessel
PURPOSE: To investigate visual development and long-term complications after cataract surgery in childhood. METHODS: This cross-sectional study included patients from a family with Marner's hereditary cataracts who had cataract surgery before 18 years of age. The study was conducted from 1 January 2022 until 31 December 2022. The patients contributed to their medical files and participated in an updated ophthalmologic examination. RESULTS: We included 52 patients (101 eyes, 34 females)...
June 3, 2024: Acta Ophthalmologica
Mukharram M Bikbov, Gyulli M Kazakbaeva, Ellina M Rakhimova, Songhomitra Panda-Jonas, Albina A Fakhretdinova, Azaliia M Tuliakova, Iulia A Rusakova, Jost B Jonas
PURPOSE: To assess associations between atrial fibrillation/atrial flutter (AF) and ocular parameters and diseases. METHODS: The population-based Ural Eye and Medical Study (UEMS) and the Ural Very Old Study (UVOS) included 4894 individuals (age: 40+ years) and 835 individuals (age: 85+ years), respectively. RESULTS: In the UEMS, AF prevalence (80/4894; 1.6%; 95% CI: 1.3, 2.0) increased from 1/1029 (0.1%) in the age group of 40 to <50 years to 29/619 (4...
June 1, 2024: Acta Ophthalmologica
Fredrik Fineide, Morten Magnø, Kristian Dahlø, Miriam Kolko, Steffen Heegaard, Jelle Vehof, Tor Paaske Utheim
One of the most common causes of blindness on a global scale is glaucoma. There is a strong association between glaucoma and increased intraocular pressure (IOP). Because of this, adequate IOP-lowering is the most important treatment strategy, mostly through topical eyedrops. Well-functioning meibomian glands are paramount for maintaining a stable tear film, and their dysfunction is the most common cause of dry eye disease. There is a growing concern that both topical glaucoma medications themselves and their added preservatives damage the meibomian glands, and consequently, the ocular surface...
June 1, 2024: Acta Ophthalmologica
Lars Christian Boberg-Ans, Daniel Ethan Hutter, Morten La Cour, Lars Konge, Anton Le, Andreas Vangsted, Ann Sofia Skou Thomsen
PURPOSE: To compare Manual Small Incision Cataract Surgery (MSICS) microsurgical performance in course participants who received virtual reality simulation-based training by either a surgical expert or a non-ophthalmologist instructor. SETTING: Copenhagen Academy for Medical Education and Simulation, Copenhagen, Denmark. DESIGN: Randomized controlled trial. METHODS: Residents and specialists in ophthalmology with no prior MSICS experience were included to receive virtual reality simulation training in MSICS using the HelpMeSee simulator...
May 31, 2024: Acta Ophthalmologica
Anna P M Jørgensen, Maarit Kulmala, Dordi Austeng, Kari Anne I Evensen, Eero Kajantie, Anna Majander, Tora Sund Morken
PURPOSE: To explore foveal and parafoveal thickness in adults born preterm with very low birth weight (VLBW) and its association with best-corrected visual acuity (BCVA) and gestational age (GA) compared to adults born at term. METHODS: In a joint study of the Helsinki Study of Very Low Birth Weight Adults (Finland) and the NTNU Low Birth Weight Life study (Norway), 106 VLBW and 143 term-born controls were examined with spectral-domain optical coherence tomography and BCVA at age 31-43 years...
May 29, 2024: Acta Ophthalmologica
Koen A van Overdam, Marc Veckeneer, Anass Hajjaj, Emine Kilic, Jennifer S N Verhoekx
No abstract text is available yet for this article.
May 26, 2024: Acta Ophthalmologica
Birgitte Romme Nielsen, Mark Alberti, Morten Lyng Høgild, Toke Bek, Benjamin Sommer Thinggaard, Jakob Grauslund, Ulrik Christensen, Morten la Cour
PURPOSE: To investigate changes in the incidence rate of primary rhegmatogenous retinal detachment (RRD) surgery over time and to determine to what extent these changes can be attributed to pseudophakia. METHODS: This nationwide cohort study was based on national patient registries. The study population comprised individuals at risk of RRD aged 40 years and above from 2006 to 2021 in Denmark. The primary outcome was RRD incidence, and the exposure was phacoemulsification surgery...
May 24, 2024: Acta Ophthalmologica
Athanasia Skriapa-Manta, Abinaya Priya Venkataraman, Monica Olsson, Maria Nilsson, Kristina Teär Fahnehjelm
PURPOSE: The purpose of this study was to evaluate the optic disc and macula in a large cohort of patients with different severity of optic nerve hypoplasia (ONH) using high-resolution spectral domain optical coherence tomography (SD-OCT). METHODS: In total, 36 patients (52 ONH eyes and 17 fellow eyes in unilateral cases) and 45 healthy right eyes from 45 controls were evaluated. All patients underwent an examination to confirm the diagnosis. SD-OCT images of the disc and macula were obtained and analysed both quantitatively and qualitatively...
May 23, 2024: Acta Ophthalmologica
Olena Al-Shymali, Mario Cantó, Jorge L Alió Del Barrio, Colm McAlinden, Pilar Yebana, Jorge L Alio
PURPOSE: To manage patient dissatisfaction following multifocal intraocular lens (MF-IOL) implantation by IOL exchange with either a monofocal or an alternative MF-IOL, and to compare outcomes in these two groups. METHODS: MF-IOL exchange was performed in 32 patients (64 eyes) with neuroadaptation failure. The MF-to-MF group involved patients who had a MF-IOL exchanged with another MF-IOL of a different optical profile and the MF-to-MO group involved patients who had a MF-IOL exchanged to a monofocal IOL...
May 23, 2024: Acta Ophthalmologica
Lien Alluyn, Laure Dequeker, Siska Dhaese, Alejandra Consejo, Julie De Zaeytijd, Bart P Leroy, Julie De Backer, Elke O Kreps
PURPOSE: To investigate the anterior scleral thickness (AST) in patients with Marfan syndrome (MFS). METHODS: A prospective, cross-sectional study was conducted at the Department of Ophthalmology, Ghent University Hospital, Ghent, including patients with a genetically confirmed clinical diagnosis of MFS and age-, gender- and axial length-matched controls. Subjects with known corneal, conjunctival or scleral pathology and a history of ocular surgery, including pars plana vitrectomy, recent contact lens use or high-grade astigmatism were excluded...
May 21, 2024: Acta Ophthalmologica
Adam Sendecki, Daniel Ledwoń, Julia Nycz, Anna Wąsowska, Anna Boguszewska-Chachulska, Andrzej W Mitas, Edward Wylęgała, Sławomir Teper
PURPOSE: Age-related macular degeneration (AMD) is a complex eye disorder affecting millions worldwide. This article uses deep learning techniques to investigate the relationship between AMD, genetics and optical coherence tomography (OCT) scans. METHODS: The cohort consisted of 332 patients, of which 235 were diagnosed with AMD and 97 were controls with no signs of AMD. The genome-wide association studies summary statistics utilized to establish the polygenic risk score (PRS) in relation to AMD were derived from the GERA European study...
May 18, 2024: Acta Ophthalmologica
Lonny Stokholm, Frederik Nørregaard Pedersen, Nis Andersen, Jens Andresen, Toke Bek, Sebastian Dinesen, Javad Hajari, Steffen Heegaard, Kurt Højlund, Caroline Schmidt Laugesen, Ryo Kawasaki, Sören Möller, Katja Christina Schielke, Yousif Subhi, Anne Suhr Thykjær, Jakob Grauslund
PURPOSE: To evaluate the five-year incidence of diabetic retinopathy (DR) and associated risk markers in patients with type 1 diabetes in the national Danish DR-screening programme. METHODS: Based on national data, we included all 16 999 patients with type 1 diabetes in the Danish Registry of Diabetic Retinopathy, who attended the national screening programme in the period 2013-2018. According to the worse eye at first screening, DR was classified (levels 0-4) and linked with various national health registries to retrieve information on diabetes duration, systemic comorbidity, and medication...
May 18, 2024: Acta Ophthalmologica
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