Thomas H Schindler, William F Fearon, Matthieu Pelletier-Galarneau, Giuseppe Ambrosio, Udo Sechtem, Terrence D Ruddy, Krishna K Patel, Deepak L Bhatt, Timothy M Bateman, Henry Gewirtz, Jamshid Shirani, Juhani Knuuti, Robert J Gropler, Panithaya Chareonthaitawee, Riemer H J A Slart, Stephan Windecker, Philipp A Kaufmann, Maria R Abraham, Viviany R Taqueti, Thomas J Ford, Paolo G Camici, Heinrich R Schelbert, Vasken Dilsizian
Angina pectoris and dyspnea in patients with normal or nonobstructive coronary vessels remains a diagnostic challenge. Invasive coronary angiography may identify up to 60% of patients with nonobstructive coronary artery disease (CAD), of whom nearly two-thirds may, in fact, have coronary microvascular dysfunction (CMD) that may account for their symptoms. Positron emission tomography (PET) determined absolute quantitative myocardial blood flow (MBF) at rest and during hyperemic vasodilation with subsequent derivation of myocardial flow reserve (MFR) affords the noninvasive detection and delineation of CMD...
January 11, 2023: JACC. Cardiovascular Imaging