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Tissue Engineering. Part B, Reviews

Wenhai Zhang, Yue Guo, Mitchell Kuss, Wen Shi, Amy Aldrich, Jason Untrauer, Tammy Kielian, Bin Duan
The management and treatment of tissue infection, especially chronic infection, represents a significant challenge. Application of autologous platelet rich plasma (PRP) has emerged as a promising adjunct therapy for facilitating the healing of surgical wounds and tissue injuries. PRP is extracted from whole blood using a sequential centrifugation technique and when activated, can release a vast array of antimicrobial proteins, cytokines, and growth factors. These bioactive molecules are responsible for the ability of PRP to kill pathogens, resolve necrotic tissue, and promote wound healing...
February 2, 2019: Tissue Engineering. Part B, Reviews
Mohsen Setayeshmehr, Ebrahim Esfandiari, Mohammad Rafienia, Batool Hashemibeni, Asghar Taheri-Kafrani, Ali Samadikuchaksaraei, David L Kaplan, Lorenzo Moroni, Mohammad Joghataei
Cartilage consists of chondrocytes and a special extracellular matrix (ECM) having unique biochemical, biophysical, and biomechanical properties that play a critical role in the proliferation and differentiation of cells inherent to cartilage functions. Cartilage tissue engineering requires recreating these micro environmental physicochemical conditions to lead to chondrocytes differentiation from stem cells. ECM-derived hybrid scaffolds based on chondroitin sulphate, hyaluronic acid, collagen, and cartilage ECM analogs provide environments conducive to stem-cell proliferation...
January 16, 2019: Tissue Engineering. Part B, Reviews
Sarah Lepage, Naomi Robson, Hillary Gilmore, Ola Davis, Allyssa Hooper, Stephanie St John, Vashine Kamesan, Paul Gelis, Diana Carvajal, Mark Hurtig, Thomas Koch
Once believed to be limited to articular cartilage, osteoarthritis is now considered to be an organ disease of the "whole joint". Damage to the articular surface can lead to, be caused by, or occur in parallel with damage to other tissues in the joint. The relationship between cartilage and the underlying subchondral bone has particular importance when assessing joint health and determining treatment strategies. The articular cartilage is anchored to the subchondral bone via an interface of calcified cartilage, which as a whole makes up the "osteochondral unit"...
January 14, 2019: Tissue Engineering. Part B, Reviews
Nicole Hauptmann, Qilin Lian, Johanna Ludolph, Holger Rothe, Gerhard Hildebrand, Klaus Liefeith
Traditionally tissue engineering strategy relies on three components: cells, signaling systems (e.g. growth factors) and extracellular matrix (ECM). Nowadays the combination of cells, signaling systems, an artificial ECM and appropriate bioreactor systems has recently been defined as the "Tissue Engineering Quadriad"1 taking into consideration the fundamental role of the dynamic physiological environment. Not surprisingly, the establishment of an artificial ECM with the necessary flexibility seems to be a mission impossible without advanced materials and fabrication techniques...
January 11, 2019: Tissue Engineering. Part B, Reviews
Shi Shen, Mingxue Chen, Weimin Guo, Haojiang Li, Xu Li, Suqiong Huang, Xujiang Luo, Zhenyong Wang, Yang Wen, Zhiguo Yuan, Bin Zhang, Liqing Peng, Chao Gao, Naiqiang Zhuo, Shuyun Liu, Quanyi Guo
The regeneration of cartilage has made great progress in the past few decades, Previous techniques for constructing tissue-engineered cartilage scaffolds mainly include particulate-leaching, gas-foaming, freeze-drying and phase-separation techniques. Cartilage is heterogeneous, and it is difficult for traditional scaffolds to simulate such anisotropy. Therefore, the functional regeneration of cartilage is challenging. With advancements in additive manufacturing, it has become possible to prepare functional bionic scaffolds for structures and components by the codeposition of biological materials, cells and active biomolecules, thereby achieving functional cartilage regeneration...
January 4, 2019: Tissue Engineering. Part B, Reviews
Xiaojing Wang, Guowei Wang, Sarah Zingales, Baodong Zhao
Repairing bone defects poses a major orthopedic challenge because current treatments are constrained by the limited regenerative capacity of human bone tissue. Novel therapeutic strategies, such as stem cell therapy and tissue engineering, have the potential to enhance bone healing and regeneration, and hence may improve quality of life for millions of people. However, the ex vivo expansion of stem cells and their in vivo delivery pose technical difficulties that hamper clinical translation and commercial development...
December 2018: Tissue Engineering. Part B, Reviews
Hong Zhang, Meng-Fei Liu, Ri-Chun Liu, Wei-Liang Shen, Zi Yin, Xiao Chen
Tendon injuries are common musculoskeletal system disorders, but the tendons have poor regeneration ability. To address this issue, tendon tissue engineering provides potential strategies for future therapeutic treatment. Elements of the physical microenvironment, such as the mechanical force and surface topography, play a vital role in regulating stem cell fate, enhancing the differentiation efficiency of seed cells in tendon tissue engineering. Various inducible scaffolds have been widely explored for tendon regeneration, and scaffold-enhancing modifications have been extensively studied...
December 2018: Tissue Engineering. Part B, Reviews
Denver Khoo, Owen Ung, Daniela Blomberger, Dietmar Werner Hutmacher
Nipple-areola complex reconstruction is a common procedure that often accompanies breast reconstruction. Historically, local skin flaps were utilised for nipple reconstruction, with more recent techniques exploring the addition of implanted material. Tissue engineering and regenerative medicine (TE&RM) represents a potential source of stable and biocompatible implantable tissue which may have a positive effect on cosmetic outcomes. Conventional TE&RM techniques involve seeding a scaffold with the patients' own cells and using growth factors to promote survival...
October 31, 2018: Tissue Engineering. Part B, Reviews
Ziba Roveimiab, Francis Lin, Judy E Anderson
The essential interactions between and among cells in the three types of muscle tissue in development, wound healing, and regeneration of tissues, are underpinned by the ability of cardiac, smooth, and skeletal muscle cells to migrate in maintaining functional capacity after pathologies such as myocardial infarction, tissue grafting, and traumatic and postsurgical injury. Microfluidics-based devices now offer significant enhancement over conventional approaches to studying cell chemotaxis and haptotaxis that are inherent in migration...
October 31, 2018: Tissue Engineering. Part B, Reviews
Dimitrios Kouroupis, Clara Sanjurjo-Rodriguez, Elena Jones, Diego Correa
To date, the therapeutic efficacy of human mesenchymal stem cells (hMSCs) has been investigated in various clinical trials with moderate or, in some cases, inconsistent results. The still elusive reproducibility relates, in part, with constitutive differences in the cell preparation, translated into variable "cell potencies." Other factors include poor cell homing and survival, and age-/disease-associated host tissue impairment. It is well accepted that within in vivo niches, MSCs exist as heterogeneous cell populations with different stemness propensities and supportive functions...
October 27, 2018: Tissue Engineering. Part B, Reviews
Amani M Basudan, Marwa Y Shaheen, Rob B de Vries, Jeroen J J P van den Beucken, John A Jansen, Hamdan S Alghamdi
This meta-analysis was to systematically investigate all preclinical researches on the possible benefits of antiosteoporotic drugs on titanium implants. Also, we performed a subgroup analysis to examine if the methods of drug delivery (systemic vs. local vs. surface coatings) or the types of antiosteoporotic drug (anticatabolic vs. anabolic) have more effect on bone-to-implant regeneration. A total of 116 articles (animal studies) were included. Poor reporting was assessed in the majority of the included studies...
October 26, 2018: Tissue Engineering. Part B, Reviews
Abdul Razzaq Farooqi, Rainer Bader, Ursula van Rienen
Hyaline cartilage undergoes many substantial age-related physiochemical and biomechanical changes that reduce its ability to overcome the effects of mechanical stress and injury. In quest of therapeutic options, magnetic stimulation and electrical stimulation have been proposed for improving tissue engineering approaches for the repair of articular cartilage. The aim of the current study is to summarize <i>in silico</i> investigations involving induced electrical properties of cartilage tissue due to various biophysical stimuli along their respective mathematical descriptions...
October 23, 2018: Tissue Engineering. Part B, Reviews
Shigeo Ichihashi, Alicia Fernández-Colino, Frederic Wolf, Diana M M Rojas González, Kimihiko Kichikawa, Stefan Jockenhoevel, Thomas Schmitz-Rode, Petra Mela
Endovascular treatment using bare metal stents or drug eluting stents is routinely performed to restore the blood flow in the coronary and peripheral arteries; however, intimal hyperplasia and late stent thrombosis are still major issues leading to stent failure and often to the need for re-intervention. Covered stents have emerged as an alternative approach to avoid intimal hyperplasia. They are characterized by the presence of a membrane that spans the struts of the stent and acts as a physical barrier to block the ingrowth of the neointimal tissue into the lumen...
October 12, 2018: Tissue Engineering. Part B, Reviews
Dongxu Ke, Sean V Murphy
Bioprinting is a recently developed technology that has great potential to manufacture artificial tissues and organs for transplantation. Recent studies have demonstrated promising results of small-scale bioprinted tissues with vascular structure and signs of their particular tissue functions. However, the recreation of a complex and multifunctional vascular network and the limitation of oxygen and nutrient diffusion in a human-scale tissue are still challenges in the current stage of this technology. Bioprinting technology has evolved different approaches to better create vascular networks in a small scale and high resolution...
October 12, 2018: Tissue Engineering. Part B, Reviews
Charlène Kichenbrand, Emilie Velot, Patrick Menu, Vanessa Moby
Mesenchymal stem cells (MSC) have a lot of potential in regenerative medicine, and MSC-based therapies are currently explored in numerous research fields. Among these cells, deciduous or permanent dental pulp-MSC represent a promising option in tissue engineering. This expectation is based on their capacity to self-renew, to repair various damaged tissues and organs due to their multipotency, as well as their ability to modulate immune system. They present other advantages such as the harvesting by a simple, painless, and noninvasive procedure and the absence of ethical considerations...
October 9, 2018: Tissue Engineering. Part B, Reviews
Sara Catarina Nunes da Silva Santos, Ólafur Eysteinn Sigurjonsson, Catarina de Almeida Custódio, João Filipe Colardelle da Luz Mano
Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors (GFs) and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own GFs...
October 5, 2018: Tissue Engineering. Part B, Reviews
Misako Nakashima, Koichiro Iohara, Marco Bottino, Ashraf F Fouad, Jacques E Nor, George Huang
Rapid progress has been made in the last decade related to stem cell-mediated pulp-dentin regeneration, from characterization of dental pulp stem cells (DPSCs) to the first-ever reported clinical case in humans. However, many challenges still need to be addressed before such technology can become a common clinical practice; therefore, further rigorous research is needed. Animal study models are very important to test new ideas, concepts, and technologies. This review summarizes and discusses several key animal models that have been utilized to investigate pulp-dentin regeneration...
October 4, 2018: Tissue Engineering. Part B, Reviews
Mingxue Chen, Weimin Guo, Shunag Gao, Chunxiang Hao, Shi Shen, Zengzeng Zhang, Zehao Wang, Xu Li, Xiaoguang Jing, Xueliang Zhang, Zhiguo Yuan, Mingjie Wang, Yu Zhang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Shuyun Liu, Quanyi Guo
Meniscus injuries are very common in the knee joint. Treating a damaged meniscus continues to be a scientific challenge in sport medicine because of its poor self-healing potential and few clinical therapeutic options. Tissue engineering strategies are very promising solutions for repairing and regenerating a damaged meniscus. Meniscus is exposed to a complex biomechanical microenvironment, and it plays a crucial role in meniscal development, growth, and repairing. Over the past decades, increasing attention has been focused on the use of biomechanical stimulus to enhance biomechanical properties of the engineered meniscus...
October 2018: Tissue Engineering. Part B, Reviews
Molly N Pantelic, Lisa M Larkin
Volumetric muscle loss (VML) is a debilitating condition wherein muscle loss overwhelms the body's normal physiological repair mechanism. VML is particularly common among military service members who have sustained war injuries. Because of the high social and medical cost associated with VML and suboptimal current surgical treatments, there is great interest in developing better VML therapies. Skeletal muscle tissue engineering (SMTE) is a promising alternative to traditional VML surgical treatments that use autogenic tissue grafts, and rather uses isolated stem cells with myogenic potential to generate de novo skeletal muscle tissues to treat VML...
October 2018: Tissue Engineering. Part B, Reviews
Kyung Min Park, Young Min Shin, Kyobum Kim, Heungsoo Shin
In 2017, a new paradigm change caused by artificial intelligence and big data analysis resulted in innovation in each field of science and technology, and also significantly influenced progress in tissue engineering and regenerative medicine (TERM). TERM has continued to make technological advances based on interdisciplinary approaches and has contributed to the overall field of biomedical technology, including cancer biology, personalized medicine, development biology, and cell-based therapeutics. While researchers are aware that there is still a long way to go until TERM reaches the ultimate goal of patient treatment through clinical translation, the rapid progress in convergence studies led by technological improvements in TERM has been encouraging...
October 2018: Tissue Engineering. Part B, Reviews
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