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European Annals of Allergy and Clinical Immunology

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https://read.qxmd.com/read/30702237/allergic-reactions-after-vaccination-translating-guidelines-into-clinical-practice
#1
REVIEW
A Radice, G Carli, D Macchia, A Farsi
Vaccination represents one of the most powerful medical interventions on global health. Despite being safe, sustainable, and effective against infectious and in some cases also non-infectious diseases, it's nowadays facing general opinion's hesitancy because of a false perceived risk of adverse events. Adverse reactions to vaccines are relatively rare, instead, and those recognizing a hypersensitivity mechanism are even rarer. The purpose of this review is to offer a practical approach to adverse events after vaccination, focusing on immune-mediated reactions with particular regard to their recognition, diagnosis and management...
January 31, 2019: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30702236/venom-immunotherapy-a-20-year-experience-with-an-ultra-rush-protocol-210-min
#2
J Cosme, A Spínola-Santos, M C Pereira-Santos, M Pereira-Barbosa
Background. Ultra-rush (UR) are induction protocols used in venom immunotherapy (VIT). Objectives: To evaluate the adverse reactions during a 210-minutes UR and determine possible risk factors. Methods: Retrospective study of 129 patients submitted to UR with VIT in the last 20 years. Results: In 114 (88.4%) patients the 101.1 μg maintenance dose was reached in 210 minutes. Systemic reactions (SR) occurred in 22% of patients (71% mild). There were no severe SR, late reactions or fatalities. Adrenaline was administered in 10% of all UR...
January 31, 2019: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30702235/the-growing-importance-of-real-life-studies-in-allergen-immunotherapy
#3
C Incorvaia, S Barberi, E Pastorello, G Ciprandi
Real-life studies offer the opportunity of obtaining outcomes suitable in clinical practice, as controlled trials do not mirror the real patients' population observed in clinical practice. This concept is particularly appropriate for allergen immunotherapy (AIT). Therefore, the current review will present and discuss the most recent and relevant studies published on this topic. Globally, 15 real-life studies on AIT efficacy are available until now, the total of patients amounts to 9090, with an average number of 699 patients per study...
January 31, 2019: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30702234/cross-elicitation-responses-to-2-methoxymethyl-p-phenylenediamine-in-p-phenylenediamine-highly-allergic-volunteers-using-allergy-alert-test-the-italian-experience
#4
A Tammaro, M Muscianese, C Chello, F R Parisella, S Persechino, C Goebel, A A Gaspari
Background. Allergic contact dermatitis after exposure to p-phenylenediamine (PPD)-containing hair dye products is a common and important clinical problem. Because there is a high rate of cross-elicitation of allergic contact dermatitis to other important hair dye products (such as p-toluene diamine [PTD] and other aminophenol hair dyes) in PPD allergic patients, safer alternative dyes with excellent hair coloring options are needed. We studied 2-methoxy methyl-PPD (Me-PPD), a chemical derivative of PPD for tolerance versus cross-elicitation in a cohort of eight PPD-allergic volunteers...
January 31, 2019: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30638358/allergic-bronchopulmonary-aspergillosis-screening-in-bronchiectasis-is-there-always-a-precise-answer-to-a-clear-question
#5
G Bonaiti, V Merati, A Pesci, P Faverio
No abstract text is available yet for this article.
January 2019: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30638357/uncovering-new-potential-culprits-in-drug-allergy-non-vitamin-k-oral-anticoagulants
#6
EDITORIAL
L Cecchi, G Carli, G Cortellini
No abstract text is available yet for this article.
January 2019: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30417637/hypersensitivity-reactions-to-non-vitamin-k-oral-anticoagulants-a-review-of-literature-and-diagnostic-work-up-proposal
#7
REVIEW
G Carli, A Farsi, F Chiarini, D Lippolis, G Cortellini
Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly being used in hospital and outpatient settings as safe alternatives to warfarin. Hypersensitivity reactions have been described for NOACs and can be classified according to Gell and Coombs. We reviewed case reports of possible drug hypersensitivity reactions, noticing a predominance of delayed reactions (both mild and severe) and the absence of cross-reactions to warfarin and low molecu-lar weight heparins. International experience on diagnostic tests is lacking...
November 12, 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30417636/cost-effectiveness-of-the-sq-hdm-slit-tablet-for-the-treatment-of-allergic-asthma-in-three-eastern-european-countries
#8
W Green, J McMaster, R Babela, S Buchs
Background. The standardized quality (SQ®) house dust mite (HDM) sublingual immunotherapy (SLIT)-tablet (acarizax®, ALK-Abelló A/S, Hørsholm, Denmark) is an allergy immunotherapy tablet for people with allergic respiratory disease. This analysis aims to assess the cost-effectiveness of the SQ HDM SLIT-tablet from the perspective of three Eastern European countries: Czech Republic, Poland and Slovakia. Methods. A cost-utility model per country was developed, which compared the SQ HDM SLIT-tablet as add-on to pharmacotherapy with pharmacotherapy alone in patients with HDM allergic asthma (AA) over a five year time horizon...
November 12, 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30417635/infectious-etiology-of-chronic-diarrhea-in-patients-with-primary-immunodeficiency-diseases
#9
L Parvaneh, N Sharifi, G Azizi, L Sharifi, A Mohebbi, E Bahraminia, S Delavari, M Alebouyeh, E Tajeddin, S R Mohebbi, R Yazdani, N Behniafard, A Aghamohammadi
Background. Primary immunodeficiency diseases (PIDs) are life-threatening disorders, which manifest commonly with gastrointestinal (GI) signs, mainly as chronic diarrhea. Objective. To investigate and compare infectious etiology of chronic diarrhea in different PIDs. Patients and methods. Assessing clinical features, obtaining immunological profiles, as well as characterizing infectious etiology of diarrhea were performed in 38 PID patients with chronic diarrhea. Stool samples and/or biopsy specimens were checked using culture, microscopic examination, RT-PCR, and PCR, as appropriate...
November 12, 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30618228/spontaneous-disappearance-of-severe-latex-allergy-in-an-adult
#10
R Asero
No abstract text is available yet for this article.
November 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30067000/impact-of-allergy-on-children-with-attention-deficit-hyperactivity-disorder
#11
Z B Abd El-Hamid, M M Refaat, H H El-Shahawy, A M Eissa, M M El-Sheikh, A S Abdel-Rehim, S A Elgaaly, M H Abd El-Moneam, N A Mohamed, O M Abdel Latif
Background. Attention deficit hyperactivity disorder (ADHD) is commonly present worldwide, causing serious problems to those affected. ADHD was suggested to be secondary to allergic disorder or its medication. Both ADHD and allergy depend on complex environmental and genetic interaction, and they meet the hypersensitivity criteria. Objective. Detect the percentage of allergy in ADHD children, the common allergic disorders and allergens, and the effect of allergy on symptom and severity of ADHD. Material and methods...
November 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/29384118/paediatric-case-series-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-12-year-experience-at-a-single-referral-centre-in-hong-kong-and-the-first-reported-use-of-infliximab
#12
G T Chua, J S Rosa Duque, P C Y Chong, P P W Lee, Y L Lau, M H K Ho
DRESS (drug reaction with eosinophilia and systemic symptoms) is a rare but potentially life-threatening disorder characterized by fever, skin eruption, haematological abnormalities and multi-organ dysfunction after drug exposure. The pathophysiology is thought to be related to interactions between culprit drugs, viral reactivation and T-lymphocytes activation. We report 4 paediatric patients with DRESS who were treated at our centre over the past 12 years. Most cases improved after corticosteroids. Other immunosuppressive medications were attempted in refractory cases with varied outcomes...
November 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30318869/the-role-of-mobile-apps-in-allergic-respiratory-diseases-an-italian-multicentre-survey-report
#13
C Lombardi, M Bonini, G Passalacqua
We performed a multicentre survey about the role of mobile apps in allergic respiratory diseases. The main objective was to investigate the current use and usefulness of mobile phone apps in the management of allergic respiratory disease. An original questionnaire including 12 multiple-choice questions was administered to 360 participants (153 male and 207 female subjects). Of notice, 290 subjects owned a smartphone, 120 a personal computer and 68 a tablet (multiple answers were possible). 123 subjects reported to be regular mobile-apps users, 209 were occasional users and 76 has never downloaded an app...
October 15, 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30246512/bet-v-1-sensitization-modulates-allergenic-molecular-1-immune-response
#14
G Ciprandi, M Silvestri, A Pistorio, R Olcese, P Del Barba, M A Tosca
Background Allergy is characterized by allergen-specific IgE production. Molecular-based allergy diagnostic allows to define the precise sensitization profile. Bet v 1 is the major allergen of the PR-10 family. It has been reported that pan-allergens could affect the sensitization panel in adults. This study aimed to evaluate the impact of Bet v 1 sensitization on sensitization pattern in a large sample of children. Methods Serum IgE molecular components were assessed by ISAC method. Sera from 1,205 children, 708 males (58...
September 24, 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30039693/severe-asthma-in-adolescents-and-adults-a-national-multicenter-registry-in-real-life
#15
C Micheletto, M B Bilò, L Antonicelli, M Bresciani, G D'Amato, E De Benedictis, F De Michele, S Gasparini, M Giovannini, A Musarra, A Vaghi
The number of patients with uncontrolled asthma is growing especially in young people. Although current therapies improve the disease management, the heterogeneity of clinical outcomes results in patients whose asthma is refractory to standard therapies. To understand not responsive phenotypes, we instituted a web-registry aimed to collect real life data of adolescent and adult patients. One-hundred and five Italian medical Centers are part of the network. Participants above 14 years and affected by severe asthma will be included in the study...
September 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30039692/an-atlas-of-ige-sensitization-patterns-in-different-italian-areas-a-multicenter-cross-sectional-study
#16
E Scala, D Villalta, C G Uasuf, P Pignatti, L Pirrotta, E C Guerra, M Locanto, G Meneguzzi, M Giani, L Cecchi, D Abeni, R Asero
Background. The development of recombinant technology supported the allergy diagnostic work-up in the daily clinical practice, representing a useful tool for epidemiological studies. Methods. An atlas of the IgE sensitization profiles found throughout Italy was prepared from a nationwide, multicenter, cross-sectional study. Results. 6052 unselected consecutive individuals, belonging to North-West [NW], North-East [NE], Centre [C], South [S], and Islands subset [Is] were evaluated by means of the ImmunoCAP ISAC test...
September 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/30028111/drug-induced-anaphylaxis-seven-year-single-center-survey
#17
I Mota, Â Gaspar, F Benito-Garcia, M Correia, M Chambel, M Morais-Almeida
Background and Objective. Drug-induced anaphylaxis (DIA) is the most common cause of fatal anaphylaxis. We aimed to characterize patients with DIA and their allergological workup. Methods. Systematic review of patients with history of DIA referred to our center over 7 years. Results. Included 125 patients (10% pediatric age), being 36 years the median age of first episode (from 1 to 74 years). The main culprits were nonsteroidal anti-inflammatory drugs (NSAIDs) (43%), antibiotics (42%) and anesthetic agents (6%)...
September 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/29533055/effect-of-industrial-processing-on-the-ige-reactivity-of-three-commonly-consumed-mo-roccan-fish-species-in-fez-region
#18
N Mejrhit, O Azdad, L Aarab
Objectives. The aim of this work was to study the effect of industrial processing on the allergenicity of three commonly consumed Moroccan fish species in Fez region (sardine, common pandora, and shrimp). Methods. This work was conducted by a sera-bank obtained from 1248 patients recruited from Fez Hospitals. Their sera were analyzed for specific IgE binding to raw fish extracts. Among them, 60 patients with higher specific IgE levels were selected, and used to estimate the binding variation of IgE to these products under several processing (frying, cooking, canning, marinade, and fermentation) using ELISA analysis...
September 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/29384114/freshly-squeezed-anaphylaxis-caused-by-drone-larvae-juice
#19
J Stoevesandt, A Trautmann
Drone larvae are mostly considered a by-product of beekeeping, but have recently been advo-cated as a high-protein source of food. There are as yet no data concerning their allergenic potential. We report on a 29-year old bee keeper who experienced an anaphylactic reaction following the consumption of a freshly prepared beverage from raw drone larvae. Larvae-specific sensitization was confirmed by prick-to-prick and basophil activation testing. Bee stings and classical bee products including honey and royal jelly were tolerated...
September 2018: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/29384108/patch-testing-in-a-case-of-eslicarbazepine-and-carbamazepine-induced-cutaneous-reaction
#20
E Finelli, P Custódio, O Porovska, S Prates, P Leiria-Pinto
Anticonvulsants are among the drugs most commonly involved in cutaneous adverse drug reactions (CADRs). Eslicarbazepine is a new anti-epileptic drug, chemically related to carbamazepine but with a more favorable safety profile. We report the clinical case of a woman who developed a skin rash on day 10 of eslicarbazepine with further exacerbation with eosinophilia on day 2 of carbamazepine. Epicutaneous tests were positive with eslicarbazepine.
September 2018: European Annals of Allergy and Clinical Immunology
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