Cynthia Van der Hauwaert, Grégoire Savary, Claire Pinçon, Viviane Gnemmi, Christian Noël, Franck Broly, Myriam Labalette, Michaël Perrais, Nicolas Pottier, François Glowacki, Christelle Cauffiez
BACKGROUND: Identification of the culprit genes underlying multifactorial diseases is one of the most important current challenges of molecular genetics. While recent advances in genomics research have accelerated the discovery of susceptibility genes, much remains to be learned about the functions of disease-associated genetic variants. Recently, Moore and co-workers identified, in the donor genome, an association between a common genetic variant (rs4730751) in the gene encoding caveolin-1 (CAV1), a major structural component of caveolae, and long-term allograft survival...
2015: Fibrogenesis & Tissue Repair