Mert Döşkaya, Li Liang, Aarti Jain, Hüseyin Can, Sultan Gülçe İz, Philip Louis Felgner, Aysu Değirmenci Döşkaya, David Huw Davies, Adnan Yüksel Gürüz
No abstract text is available yet for this article.
May 30, 2024: Parasites & Vectors
Alvie Loufouma-Mbouaka, Tania Martín-Pérez, Martina Köhsler, Zeynep Danisman, Maya Schwarz, Rounik Mazumdar, Ascel Samba-Louaka, Julia Walochnik
BACKGROUND: Proteases produced by Acanthamoeba spp. play an important role in their virulence and may be the key to understanding Acanthamoeba pathogenesis; thus, increasing attention has been directed towards these proteins. The present study aimed to investigate the lytic factors produced by Acanthamoeba castellanii during the first hours of in vitro co-culture with human corneal epithelial cells (HCECs). METHODS: We used one old and one recent Acanthamoeba isolate, both from patients with severe keratitis, and subsets of these strains with enhanced pathogenic potential induced by sequential passaging over HCEC monolayers...
May 29, 2024: Parasites & Vectors
Yi-Lun Tsai, Wittawat Wechtaisong, Ting-Rong Lee, Chun-Hao Chang, Pin-Huan Yu, Mei-Hsiu Hwang
BACKGROUND: The endangered Formosan black bear (Ursus thibetanus formosanus) is the largest native carnivorous mammal in Taiwan. Diseases, poor management, illegal hunting, and habitat destruction are serious threats to the survival of bear populations. However, studies on the impact of diseases on bear populations are limited. Therefore, this study aimed to establish a database of the hematological and plasma profiles of free-ranging Formosan black bears and investigate the occurrence of ectoparasites, blood parasites, and vector-borne pathogens...
May 28, 2024: Parasites & Vectors
Wei-Zhong Kong, Hang-Ye Zhang, Yi-Fan Sun, Jing Song, Jian Jiang, Heng-Yuan Cui, Yu Zhang, Su Han, Yang Cheng
BACKGROUND: The spleen plays a critical role in the immune response against malaria parasite infection, where splenic fibroblasts (SFs) are abundantly present and contribute to immune function by secreting type I collagen (collagen I). The protein family is characterized by Plasmodium vivax tryptophan-rich antigens (PvTRAgs), comprising 40 members. PvTRAg23 has been reported to bind to human SFs (HSFs) and affect collagen I levels. Given the role of type I collagen in splenic immune function, it is important to investigate the functions of the other members within the PvTRAg protein family...
May 27, 2024: Parasites & Vectors
Dario E Elias, Marta V Cardinal, Natalia P Macchiaverna, Gustavo F Enriquez, Ricardo E Gürtler, M Sol Gaspe
BACKGROUND: Chagas disease, caused by Trypanosoma cruzi, is still a public health problem in Latin America and in the Southern Cone countries, where Triatoma infestans is the main vector. We evaluated the relationships among the density of green vegetation around rural houses, sociodemographic characteristics, and domestic (re)infestation with T. infestans while accounting for their spatial dependence in the municipality of Pampa del Indio between 2007 and 2016. METHODS: The study comprised sociodemographic and ecological variables from 734 rural houses with no missing data...
May 27, 2024: Parasites & Vectors
Lirong Lin, Yanjing Liu, Rui Liang, Yue Guo, Ruixue Xu, Ruoxi Fan, Zhiwei Jiao, Wenting Zhao, Lixia Yue, Mingke Lu, Shengfa Liu, Xin-Zhuan Su, Jian Li
BACKGROUND: Eukaryotic genes contain introns that are removed by the spliceosomal machinery during mRNA maturation. Introns impose a huge energetic burden on a cell; therefore, they must play an essential role in maintaining genome stability and/or regulating gene expression. Many genes (> 50%) in Plasmodium parasites contain predicted introns, including introns in 5' and 3' untranslated regions (UTR). However, the roles of UTR introns in the gene expression of malaria parasites remain unknown...
May 27, 2024: Parasites & Vectors
Gergő Keve, Tibor Csörgő, Dávid Kováts, Anikó Benke, Attila Tibor Bende, Hunor Ágoston, Attila Mórocz, Ákos Németh, Enikő Anna Tamás, Attila Huber, József Gyurácz, Gábor Keve, Jenő Kontschán, Anna Németh, Sándor Hornok
BACKGROUND: Louse flies (Diptera, Hippoboscidae) are important blood-sucking parasites of birds and mammals with a worldwide distribution. The aim of our study was to collect louse flies from birds across multiple sites in Hungary and evaluate the effects of avian traits on louse fly-host relationships. METHODS: Between 2015 and 2022, 237 louse flies were collected from birds at multiple locations in Hungary. The louse flies were identified to species level by morphological and molecular methods...
May 27, 2024: Parasites & Vectors
Justine C Shiau, Nathan Garcia-Diaz, Dennis E Kyle, Ashutosh K Pathak
BACKGROUND: Like other oviparous organisms, the gonotrophic cycle of mosquitoes is not complete until they have selected a suitable habitat to oviposit. In addition to the evolutionary constraints associated with selective oviposition behavior, the physiological demands relative to an organism's oviposition status also influence their nutrient requirement from the environment. Yet, studies that measure transmission potential (vectorial capacity or competence) of mosquito-borne parasites rarely consider whether the rates of parasite replication and development could be influenced by these constraints resulting from whether mosquitoes have completed their gonotrophic cycle...
May 23, 2024: Parasites & Vectors
Aidi Galus Lugenge, Olukayode G Odufuwa, Jilly Jackson Mseti, Johnson Kyeba Swai, Ole Skovmand, Sarah Jane Moore
BACKGROUND: "Regeneration time" (RT) denotes the time required to obtain a stable mortality rate for mosquitoes exposed to insecticide-treated nets (ITNs) after three consecutive washes of a net in a day. The RT informs the wash interval used to artificially age ITNs to simulate their lifetime performance under user conditions (20 washes). RT was estimated following World Health Organization (WHO) longitudinal method (LM) procedures. Longitudinal evaluation may introduce heterogeneity due to mosquito batch variability, complicating RT determination...
May 22, 2024: Parasites & Vectors
Aspire Mudavanhu, Ruben Schols, Emilie Goossens, Tamuka Nhiwatiwa, Tawanda Manyangadze, Luc Brendonck, Tine Huyse
BACKGROUND: Snail-borne trematodes afflict humans, livestock, and wildlife. Recognizing their zoonotic potential and possible hybridization, a One Health approach is essential for effective control. Given the dearth of knowledge on African trematodes, this study aimed to map snail and trematode diversity, focusing on (i) characterizing gastropod snail species and their trematode parasites, (ii) determining infection rates of snail species as intermediate hosts for medically, veterinary, and ecologically significant trematodes, and (iii) comparing their diversity across endemic regions...
May 22, 2024: Parasites & Vectors
Atikah Fitria Muharromah, Thaddeus M Carvajal, Maria Angenica F Regilme, Kozo Watanabe
BACKGROUND: The adaptive divergence of Aedes aegypti populations to heterogeneous environments can be a driving force behind the recent expansion of their habitat distribution and outbreaks of dengue disease in urbanized areas. In this study, we investigated the population genomics of Ae. aegypti at a regional scale in Metropolitan Manila, Philippines. METHODS: We used the Pool-Seq double digestion restriction-site association DNA sequencing (ddRAD-Seq) approach to generate a high number of single nucleotide polymorphisms (SNPs), with the aim to determine local adaptation and compare the population structure with 11 microsatellite markers...
May 21, 2024: Parasites & Vectors
Ziyun Huang, Xingzhuo Liu, Shiguang Huang, Fangli Lu
BACKGROUND: Schistosoma japonicum eggs lodge in the liver and induce a fibrotic granulomatous immune response in the liver of host. Galectin 3 (Gal-3) is a protein implicated in fibrosis in multiple organs. However, the pathology and molecular mechanisms promoting hepatic granuloma formation remain poorly understood. METHODS: To investigate the effect of blocking galectin-receptor interactions by α-lactose on liver immunopathology in mice with S. japonicum infection, C57BL/6 mice were infected with S...
May 20, 2024: Parasites & Vectors
Joel O Odero, Ismail H Nambunga, John P Masalu, Gustav Mkandawile, Hamis Bwanary, Emmanuel E Hape, Rukiyah M Njalambaha, Patrick Tungu, Halfan S Ngowo, Emmanuel W Kaindoa, Salum A Mapua, Najat F Kahamba, Luca Nelli, Charles Wondji, Lizette L Koekemoer, David Weetman, Heather M Ferguson, Francesco Baldini, Fredros O Okumu
BACKGROUND: Anopheles funestus is a leading vector of malaria in most parts of East and Southern Africa, yet its ecology and responses to vector control remain poorly understood compared with other vectors such as Anopheles gambiae and Anopheles arabiensis. This study presents the first large-scale survey of the genetic and phenotypic expression of insecticide resistance in An. funestus populations in Tanzania. METHODS: We performed insecticide susceptibility bioassays on An...
May 17, 2024: Parasites & Vectors
Lesley Bell-Sakyi, Lee R Haines, Giovanni Petrucci, Alexandra Beliavskaia, Catherine Hartley, Jing Jing Khoo, Benjamin L Makepeace, Adly M M Abd-Alla, Alistair C Darby
BACKGROUND: Insect cell lines play a vital role in many aspects of research on disease vectors and agricultural pests. The tsetse fly Glossina morsitans morsitans is an important vector of salivarian trypanosomes in sub-Saharan Africa and, as such, is a major constraint on human health and agricultural development in the region. METHODS: Here, we report establishment and partial characterisation of a cell line, GMA/LULS61, derived from tissues of adult female G...
May 17, 2024: Parasites & Vectors
A L Joyce, Miguel Moreno, Leonel Palomo, Raul O'Connor, Denis Escobar
BACKGROUND: This study examined population genetics of Aedes aegypti in El Salvador and Honduras, two adjacent countries in Central America. Aedes aegypti is associated with yellow fever, dengue, chikungunya, and Zika. Each year, thousands of cases of dengue are typically reported in El Salvador and Honduras. METHODS: In El Salvador, collections were obtained from five Departments. In Honduras, samples were obtained from six municipalities in four Departments. Mitochondrial DNA cytochrome oxidase I (COI) was sequenced, and consensus sequences were combined with available sequences from El Salvador to determine haplotype number, haplotype diversity, nucleotide diversity, and Tajima's D...
May 16, 2024: Parasites & Vectors
Ben P Jones, Kezia Kozel, Allen Jethro I Alonte, Kennesa Klariz R Llanes, Alexandra Juhász, Umer Chaudhry, Sara Roose, Peter Geldhof, Vicente Y Belizario, Peter Nejsum, J Russell Stothard, E James LaCourse, Arnoud H M van Vliet, Vachel Gay V Paller, Martha Betson
BACKGROUND: The giant roundworm Ascaris is an intestinal nematode, causing ascariasis by infecting humans and pigs worldwide. Recent estimates suggest that Ascaris infects over half a billion people, with chronic infections leading to reduced growth and cognitive ability. Ascariasis affects innumerable pigs worldwide and is known to reduce production yields via decreased growth and condemnation of livers. The predominant anthelminthic drugs used to treat ascariasis are the benzimidazoles...
May 16, 2024: Parasites & Vectors
Marcos Antonio Bezerra-Santos, Giovanni Benelli, Giacinto Salvatore Germinara, Petr Volf, Domenico Otranto
Volatile organic compounds (VOCs) are chemicals emitted as products of cell metabolism, which reflects the physiological and pathological conditions of any living organisms. These compounds play a key role as olfactory cues for arthropod vectors such as mosquitoes, sand flies, and ticks, which act in the transmission of pathogens to many animal species, including humans. Some VOCs may influence arthropod behaviour, e.g., host preference and oviposition site selection for gravid females. Furthermore, deadly vector-borne pathogens such as Plasmodium falciparum and Leishmania infantum are suggested to manipulate the VOCs profile of the host to make them more attractive to mosquitoes and sand fly vectors, respectively...
May 16, 2024: Parasites & Vectors
Monique A M Shepherd-Gorringe, Marie W Pettit, Frances M Hawkes
BACKGROUND: Ivermectin is a well-tolerated anthelminthic drug with wide clinical and veterinary applications. It also has lethal and sublethal effects on mosquitoes. Mass drug administration with ivermectin has therefore been suggested as an innovative vector control tool in efforts to curb emerging insecticide resistance and reduce residual malaria transition. To support assessments of the feasibility and efficacy of current and future formulations of ivermectin for vector control, we sought to establish the relationship between ivermectin concentration and its lethal and sublethal impacts in a primary malaria vector...
May 16, 2024: Parasites & Vectors
Richard Thomas, Adriana Santodomingo, Liliana Saboya-Acosta, Julian F Quintero-Galvis, Lucila Moreno, Juan E Uribe, Sebastián Muñoz-Leal
No abstract text is available yet for this article.
May 16, 2024: Parasites & Vectors
Pattarapon Khemrattrakool, Thitipong Hongsuwong, Phornpimon Tipthara, Rattawan Kullasakboonsri, Theerawit Phanphoowong, Patchara Sriwichai, Borimas Hanboonkunupakarn, Podjanee Jittamala, Joel Tarning, Kevin C Kobylinski
BACKGROUND: Ivermectin mass drug administration to humans or livestock is a potential vector control tool for malaria elimination. Racemic ivermectin is composed of two components, namely a major component (> 80%; ivermectin B1a ), which has an ethyl group at C-26, and a minor component (< 20%; ivermectin B1b ), which has a methyl group at C-26. There is no difference between the efficacy of ivermectin B1a and ivermectin B1b efficacy in nematodes, but only ivermectin B1b has been reported to be lethal to snails...
May 15, 2024: Parasites & Vectors
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.