Benard W Kulohoma, Sarah A O Wamwenje, Ibrahim I Wangwe, Nicodemus Masila, Caroline K Mirieri, Lillian Wambua
OBJECTIVE: Animal African trypanosomiasis (AAT) is a life-threatening vector-borne disease, caused by trypanosome parasites, which are principally transmitted by tsetse flies. In Kenya, the prevalence of drug-resistant trypanosomes in endemic regions remains poorly understood. The objective of this study was to establish AAT point prevalence, drug susceptibility of associated trypanosomes, and measure infectivity by multiple AAT mammalian hosts to tsetse flies in Shimba hills, a resource-poor region with high bovine trypanosomiasis prevalence and morbidity rates at the coast of Kenya...
April 29, 2020: BMC Research Notes
Tita Husnitawati Madjid, Jumadi, Raden Tina Dewi Judistiani, Bethy Suryawathy Hernowo, Ahmad Faried
OBJECTIVE: To explore the possibility of a new diagnostic approach of endometriosis based on immunocytochemistry scoring of Aromatase P450 expressions in endometrial cells collected from menstrual sloughing. This is a case control study. Immuncytochemistry scores vs. histopathological examination in one tertiary- and secondary-level hospital in Bandung; two secondary level hospital in Garut and Sumedang, West Java, Indonesia. Thirty-five patients with and without endometriosis were enrolled...
April 28, 2020: BMC Research Notes
Louisa Gibson, Melanie Porter
OBJECTIVES: Prenatal intake of alcohol and tobacco have been associated with negative outcomes in children. Consumption of alcohol while breastfeeding has also been associated with dose-dependent decreases in abstract reasoning ability and academic scores in children at later ages. Using longitudinal data from The Growing Up in Australia Study, the current study aimed to investigate whether intake of alcohol or tobacco while breastfeeding was related to later developmental health outcomes in children...
April 26, 2020: BMC Research Notes
Aklilu Abera Ayele, Kemal Ahmed Seid, Oumer Sada Muhammed
The authorship list on the original article [1] was incorrect and should instead show as Aklilu Abera Ayele, Kemal Ahmed Seid and Oumer Sada Muhammed. The authors apologise for this error.
April 24, 2020: BMC Research Notes
Muhamudu Kalange, Miriam Nansunga, Keneth Iceland Kasozi, Josephine Kasolo, Jackline Namulema, Jovile Kasande Atusiimirwe, Emanuel Tiyo Ayikobua, Fred Ssempijja, Edson Ireeta Munanura, Kevin Matama, Ibrahim Semuyaba, Gerald Zirintunda, Alfred Omachonu Okpanachi
OBJECTIVE: Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate-Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline)...
April 23, 2020: BMC Research Notes
Akash Gupta, Ethan Kung
OBJECTIVE: Operational details regarding the use of the adaptive meshing (AM) algorithm available in the SimVascular package are scarce despite its application in several studies. Lacking these details, novice users of the AM algorithm may experience undesirable outcomes post-adaptation such as increases in mesh error metrics, unpredictable increases in mesh size, and losses in geometric fidelity. Here we present a test case using our proposed iterative protocol that will help prevent these undesirable outcomes and enhance the utility of the AM algorithm...
April 22, 2020: BMC Research Notes
H N Ranasinghe, N Fernando, S Handunnetti, P N Weeratunga, P Katulanda, S Rajapakse, P Galappatthy, G R Constantine
OBJECTIVES: The objective was to assess the effect of propranolol on oxidative stress and anti-oxidant potential in patients with resistant hypertension as a secondary analysis of the APPROPRIATE trial. This randomized double blinded clinical trial recruited patients with resistant hypertension and allocated forty patients to propranolol and placebo in 1:1 ratio. The pro-oxidant state (nitrate and nitrite) was assessed using modified Griess assay. The total anti-oxidant capacity was measured using ABTS assay...
April 21, 2020: BMC Research Notes
Kanokporn Pinyopornpanish, Manee Pinyopornpanish, Nahathai Wongpakaran, Tinakon Wongpakaran, Atiwat Soontornpun, Pimolpun Kuntawong
Following the publication of the original article [1], the authors unfortunately became aware of the following errors in Table 3.
April 20, 2020: BMC Research Notes
Hianga Fayssa Fernandes Siqueira, Jorge Luiz de Almeida Teixeira, Reginaldo da Silva Lessa Filho, Evânia Curvelo Hora, Filipe Ferreira Brasileiro, Kênya de Souza Borges, Érika de Abreu Costa Brito, Marcela Sampaio Lima, Adriane Dórea Marques, Alex Rodrigues Moura, Tarcizo Costa Figueiredo Júnior, Thiago Costa de Oliveira, Ana Alice Santana Vasconcelos, Carlos Anselmo Lima
OBJECTIVES: This study was conducted aiming to assess the quality of life and satisfaction of women who had mastectomy treated with and without breast reconstruction. RESULTS: A total of 81 women who had mastectomy were included, of whom 53 (65.4%) underwent breast reconstruction. Quality of life was not significantly better in the reconstruction group than the nonreconstruction group. Satisfaction with the surgically operated breast, whether reconstructed or not, was positively correlated with quality of life (p = 0...
April 19, 2020: BMC Research Notes
Agnes Bwanika Naggirinya, Andrew Mujugira, David B Meya, Irene Andia Biraro, Ezekiel Mupere, William Worodria, Yukari C Manabe
OBJECTIVE: Tuberculosis (TB) is the leading cause of adrenal insufficiency in resource-limited settings. The adrenal gland is the most commonly affected endocrine organ in TB infection. We assessed factors associated with functional adrenal insufficiency (FAI) among TB-HIV patients with and without drug-resistance in Uganda. Patients with drug-sensitive and drug-resistant TB were enrolled and examined for clinical signs and symptoms of FAI with an early morning serum cortisol level obtained...
April 19, 2020: BMC Research Notes
Shaian Tavakolian, Hossein Goudarzi, Ebrahim Faghihloo
OBJECTIVE: It has been indicated that there is a tight association between cancer and different factors, such as environment and genetics, including aberrantly expressed microRNAs. The crucial role of microRNAs in the regulation of diverse signaling pathways in gastrointestinal cancer has been established in several studies. In this study, we aimed to evaluate the expression of microRNA-9 and -192 in colon and gastric cancers. After extracting the RNA from tissues and serum samples of patients, suffering from colon and gastric cancer, cDNA was synthesized...
April 19, 2020: BMC Research Notes
Sanne Van Campenhout, Agustina A M B Hastuti, Sander Lefere, Hans Van Vlierberghe, Frank Vanhaecke, Marta Costas-Rodríguez, Lindsey Devisscher
OBJECTIVE: The occurrence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. To challenge the current incidence of NAFLD, non-invasive markers that could identify patients at risk or monitor disease progression are an important need. Copper intake and organ copper concentrations have earlier been linked to NAFLD progression, but serum copper does not adequately represent the disease state. Cu atoms occur under the form of two stable isotopes, 63 Cu and 65 Cu, and the ratio of both (expressed as δ65 Cu, in  ‰) in blood serum has been shown to be altered in chronic liver disease...
April 19, 2020: BMC Research Notes
Bandar Saad Assakran, Abdullah Homood Alromaih, Abdulrahman Haitham Alashkar, Fatimah Salem AlGhasham, Mansur Suliman Alqunai
OBJECTIVE: Laparoscopic sleeve gastrectomy (LSG) is one of the most commonly performed bariatric procedures. Some surgeons still perform routine post-sleeve gastrografin (RSG) study believing that it would detect post-LSG complications, especially leak. In this study, we aimed to evaluate the cost-effectiveness of RSG by considering the cost of the study, length of hospital stay and complications-related costs RSG could prevent. RESULTS: A total of 98 eligible patients were included...
April 16, 2020: BMC Research Notes
Zahra Yari, Makan Cheraghpour, Vahideh Aghamohammadi, Meysam Alipour, Nila Ghanei, Azita Hekmatdoost
OBJECTIVE: The purpose of the present study was to determine the association between energy-dense nutrient-poor snacks intake and the risk of non-alcoholic fatty liver disease (NAFLD) in Iranian adults. For this purpose, a total of 143 cases with a newly confirmed diagnosis of NAFLD and 471 controls free of the disease were studied. Dietary intake was assessed using a food frequency questionnaire. RESULTS: The percentage of calories from total energy-dense nutrient-poor snacks was 6...
April 16, 2020: BMC Research Notes
Andra Tilgase, Lita Grīne, Ilze Blāķe, Mārtiņs Borodušķis, Agnija Rasa, Pēteris Alberts
OBJECTIVE: Uveal melanoma is a rare intraocular malignancy. Half of the patients diagnosed will develop metastases within 10 to 30 years, most commonly in the liver. Although there has been a significant development in the treatment of melanoma, no effective treatment to prevent or treat metastases of uveal melanoma is available. Oncolytic viruses are now being studied for various types of cancers and show promising results. Preclinical results show cytolytic activity of enteric cytopathic human orphan virus type 7 (ECHO-7) strain Rigvir in human melanoma, rhabdomyosarcoma, gastric adenocarcinoma, lung carcinoma and pancreas adenocarcinoma cell lines...
April 16, 2020: BMC Research Notes
Blessing A Afolabi, Olawande C Olagoke
OBJECTIVE: Monosodium glutamate (MSG) is a food additive that has been shown to be toxic to rodents at high concentrations. The available studies in Drosophila melanogaster suggest that MSG toxicity depends on concentration and gender, thus the safety of MSG as a food enhancer still requires further investigation. We have documented impaired locomotor activity and altered oxidative stress markers in cockroaches co-exposed to methylmercury and monosodium glutamate (MSG). We herein examined the susceptibility of Nauphoeta cinerea to high and low concentrations (4% and 1%) of MSG, while monitoring the activities of acetylcholinesterase (AChE), as well as markers of oxidative stress and antioxidant activity over 30 days...
April 16, 2020: BMC Research Notes
Helda Tutunchi, Maryam Saghafi-Asl, Mohammad Asghari-Jafarabadi, Alireza Ostadrahimi
OBJECTIVES: This study aimed to examine the relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults. In this cross-sectional study, a total of 95 subjects aged > 20 years newly diagnosed with NAFLD were recruited. NAFLD was diagnosed using ultrasonography by a single expert radiologist in a fasting state. RESULTS: The mean age of the patients was 49.27 (SD 9.7) years, with 53.68% males and 46.32% females. Most patients had grade I NAFLD (72...
April 16, 2020: BMC Research Notes
Christopher Angiro, Patrick P'Odyek Abila, Timothy Omara
OBJECTIVE: Kampala Industrial and Business Park (KIBP) is one of the premier and the most successful Ugandan industrial complexes that impact the inner Murchison bay of Lake Victoria. The current study aimed at evaluating the effect of industrial effluents on the physicochemical and microbiological quality of water taken from four different sites along Namanve stream in KIBP, Wakiso district, Uganda. RESULTS: All the water quality parameters were below WHO maximum permissible limits except turbidity, electrical conductivity and Escherichia coli count...
April 16, 2020: BMC Research Notes
Ruvindu Hasamal Waidyasekera, Umesh Jayarajah, Dharmabandhu Nandadeva Samarasekera
OBJECTIVE: Flexible sigmoidoscopy is useful to look for an underlying aetiology in fistula-in-ano. This study was aimed to assess the yield of routine flexible sigmoidoscopy in patients presenting with fistula-in-ano. A retrospective analysis of 159 consecutive patients with fistula-in-ano who underwent routine flexible sigmoidoscopy was performed. Sigmoidoscopy findings were recorded on a standard uniform format using a computer database. Those with a known aetiology were excluded. RESULTS: The median age was 39 (range: 14-74) years and the majority were males (n = 128, 80...
April 16, 2020: BMC Research Notes
Narges Sadeghi, Mohadeseh Fahiminia, Mehdi Teimouri
OBJECTIVES: File fragment classification of video file formats is a topic of interest in network forensics. There are some publicly available datasets for file fragments of various file types such as textual, audio, and image file formats. However, there is no public dataset for file fragments of video file formats. So, in order to evaluate and compare the performance of the classification methods, a challenge is the need to have such datasets. DATA DESCRIPTION: In this study, we present a dataset that contains file fragments of 10 video file formats: 3GP, AVI, ASF, FLV, MKV, MOV, MP4, WebM, OGV, and RMVB...
April 15, 2020: BMC Research Notes
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