journal
https://read.qxmd.com/read/38605369/pysmooth-a-python-tool-for-the-removal-and-correction-of-genotyping-errors
#1
JOURNAL ARTICLE
Benjamin Soibam, Gregg Roman
In genetic mapping studies involving many individuals, genome-wide markers such as single nucleotide polymorphisms (SNPs) can be detected using different methods. However, it comes with some errors. Some SNPs associated with diseases can be in regions encoding long noncoding RNAs (lncRNAs). Therefore, identifying the errors in genotype file and correcting them is crucial for accurate genetic mapping studies. We develop a Python tool called PySmooth, that offers an easy-to-use command line interface for the removal and correction of genotyping errors...
April 11, 2024: BMC Research Notes
https://read.qxmd.com/read/38605312/the-inhibitory-effects-of-carvacrol-nystatin-and-their-combination-on-oral-candidiasis-isolates
#2
JOURNAL ARTICLE
Seyed Saeed Hosseini Balef, Seyed Sedigheh Hosseini, Negar Asgari, Ahmad Sohrabi, Nazanin Mortazavi
BACKGROUND: Candida, a common oral microbiota, can cause opportunistic fungal infections. With rising Candida infections and limited effective antifungals, new treatments are needed. This study investigates carvacrol essential oil's effect on oral candidiasis, alone and with nystatin, compared to nystatin alone. MATERIALS AND METHODS: In this study, oral samples were collected from dental clinic patients, especially denture users. The presence of Candida was confirmed and cultured from these samples...
April 11, 2024: BMC Research Notes
https://read.qxmd.com/read/38594730/strategies-for-improving-the-performance-of-prediction-models-for-response-to-immune-checkpoint-blockade-therapy-in-cancer
#3
JOURNAL ARTICLE
Tiantian Zeng, Jason Z Zhang, Arnold Stromberg, Jin Chen, Chi Wang
Immune checkpoint blockade (ICB) therapy holds promise for bringing long-lasting clinical gains for the treatment of cancer. However, studies show that only a fraction of patients respond to the treatment. In this regard, it is valuable to develop gene expression signatures based on RNA sequencing (RNAseq) data and machine learning methods to predict a patient's response to the ICB therapy, which contributes to more personalized treatment strategy and better management of cancer patients. However, due to the limited sample size of ICB trials with RNAseq data available and the vast number of candidate gene expression features, it is challenging to develop well-performed gene expression signatures...
April 9, 2024: BMC Research Notes
https://read.qxmd.com/read/38594711/associations-between-cognitive-function-and-lifestyle-in-community-living-older-people-a-correlational-study
#4
JOURNAL ARTICLE
Maryam Zarringhadam, Shirin Hasanvand, Mehdi Birjandi, Afsaneh Beiranvand
BACKGROUND: Previous studies have examined relationship between cognitive function and lifestyle; however, the nature of this relationship is expected to vary in diverse cultural and low-income setting where lifestyle practices differ from those in high-income countries. AIM: This study aims to investigate the correlation between lifestyle factors and cognitive function among individuals aged 60 years and older in 2021. METHODS: This cross-sectional, Community-based study involved 300 older adults from comprehensive urban health centers in Khorramabad, Iran, selected through stratified cluster sampling...
April 9, 2024: BMC Research Notes
https://read.qxmd.com/read/38589908/assessment-of-hypoxemia-among-young-adults-with-sickle-cell-anaemia-in-steady-state-in-southwestern-nigeria-a-crosssectional-study
#5
JOURNAL ARTICLE
Asafa M A, Ahmed I O, Afolabi M S, Bolarinwa R A, Ogunlade O
OBJECTIVES: Hypoxia is a known feature of sickle cell anaemia (SCA) which results from chronic anaemia and recurrent vaso-occlusive crisis (VOC) which can cause tissue ischaemia that leads to an end organ damage. The hallmark of SCA is chronic anaemia and recurrent vaso-occlusive crisis. The aim of this study is to compare the oxygen saturation of sickle cell anaemic individuals with the normal haemoglobin type (Hb AA) control and also to determine the prevalence of hypoxemia among SCA...
April 8, 2024: BMC Research Notes
https://read.qxmd.com/read/38566261/reference-intervals-of-complete-blood-count-parameters-in-the-adult-western-sudanese-population
#6
JOURNAL ARTICLE
Malak Ibrahim Mustafa, Ibrahim Abdelrhim Ali, Muaath Ahmed Mohammed, Elmutaz Hussien Taha, Kamal Mohamed Awad, Omer Abdelaziz Musa
BACKGROUND: A complete blood count (CBC) analysis is one of the most common conventional blood tests that physicians frequently prescribe. THE OBJECTIVE: of this study was to determine the reference intervals (RIs) of CBC parameters in the population of healthy adults living in the western Sudan region. METHODS: A cross-sectional study of healthy people residing in the western area of Sudan was carried out. We assessed the CBC RIs in samples taken from 153 individuals using an automated haematology analyser (Sysmex KX-21) and a modified Box-Cox transformation procedure to transform the data into a Gaussian distribution after eliminating outliers using the Dixon method...
April 2, 2024: BMC Research Notes
https://read.qxmd.com/read/38561830/first-record-of-psorophora-ferox-diptera-culicidae-infested-with-eggs-of-dermatobia-hominis-diptera-cuterebridae-in-ucayali-peru
#7
JOURNAL ARTICLE
Edwin Requena-Zúñiga, Fernando Chapilliquen-Alban, Walter Leon-Cueto, Fredy Bances-Juarez, Jorge Valle-Toledo, Jesús Rojas-Jaimes
INTRODUCTION: Dermatobia hominis belongs to the Cuterebridae family, Diptera order; These flies inhabit tropical regions where they are called "fly of death" since the larvae are capable of causing lesions in domestic animals, wild animals including humans, the adult females of D. hominis capture other dipteran to oviposit their eggs on them (phoresis), when hematophagous mosquitoes land on an animal and / or human in order to feed on their blood, the eggs hatch and the larvae immediately penetrate the skin where they will develop to later abandon the host, then in the soil and / or other moist substrate the pupal stage develops, finally new adult flies will emerge from the pupae...
April 2, 2024: BMC Research Notes
https://read.qxmd.com/read/38561805/resilience-and-mindfulness-among-radiological-personnel-in-norway-their-relationship-and-their-impact-on-quality-and-safety-a-questionnaire-study
#8
JOURNAL ARTICLE
Ann Mari Gransjøen
BACKGROUND: Stress and burnout are widespread problems among radiological personnel Individual and organizational resilience and mindfulness offer protection against burnout. AIM: To investigate the level of resilience and mindfulness among radiological personnel, the associations between organizational resilience, individual resilience, and mindfulness, and how these factors impact the quality of care provided in radiological departments. METHODS: An online questionnaire consisting of the Connor-Davidson Resilience Scale, the Mindful Attention Awareness Scale, the Benchmark Resilience Tool, and questions regarding burnout, and quality and safety was used...
April 1, 2024: BMC Research Notes
https://read.qxmd.com/read/38561785/re-evaluating-the-relationship-between-youth-with-hiv-and-bmi-in-an-age-of-increasing-rates-of-overweight-and-obese-youth
#9
JOURNAL ARTICLE
Samantha V Hill, Jiaying Hao, Mia Newlin-Bradner, Dustin M Long, Henna Budhwani, Tina Simpson
BACKGROUND: Newer antiretrivirals (ART) have shifted the metabolic experiences of people with HIV (PWH) from those of wasting syndrome to increases in body mass index (BMI). This study sought to examine the relationship between BMI and ART use among youth with HIV (YWH). METHODS: Charts from YWH ages 10-24 with at least two documented BMIs at least 6 months apart between 2017 and 2020 were included (N = 44). Statistical analyses were conducted in SAS 9...
April 1, 2024: BMC Research Notes
https://read.qxmd.com/read/38553773/from-voice-to-ink-vink-development-and-assessment-of-an-automated-free-of-charge-transcription-tool
#10
JOURNAL ARTICLE
Hannah Tolle, Maria Del Mar Castro, Jonas Wachinger, Agrin Zauyani Putri, Dominic Kempf, Claudia M Denkinger, Shannon A McMahon
BACKGROUND: Verbatim transcription of qualitative audio data is a cornerstone of analytic quality and rigor, yet the time and energy required for such transcription can drain resources, delay analysis, and hinder the timely dissemination of qualitative insights. In recent years, software programs have presented a promising mechanism to accelerate transcription, but the broad application of such programs has been constrained due to expensive licensing or "per-minute" fees, data protection concerns, and limited availability of such programs in many languages...
March 29, 2024: BMC Research Notes
https://read.qxmd.com/read/38553743/determinants-of-covid-19-vaccine-uptake-evidence-from-a-vulnerable-global-south-setting
#11
JOURNAL ARTICLE
John Oti Amoah, Susanna Aba Abraham, Charles Atanga Adongo, Deogratias Kaheeru Sekimpi, David Cudjoe Adukpo, Dorcas Obiri-Yeboah, David Teye Doku
OBJECTIVE: Studies are paying increasing attention to complex social determinants in explaining the variation in the rates COVID-19 vaccine uptake. This study examines the influence of various individual, contextual, and vaccine-related factors on COVID-19 vaccine uptake behaviour in a resource-scarce and vulnerable setting using a quantitative research approach. Using a multi-staged cluster sampling approach, 408 individuals from 204 households in Cape Coast, Ghana's tourism hub, were surveyed...
March 29, 2024: BMC Research Notes
https://read.qxmd.com/read/38549178/an-occupational-mechanical-job-exposure-index-based-on-five-norwegian-nationwide-surveys-of-living-conditions-on-work-environment
#12
JOURNAL ARTICLE
Åsmund Hermansen
OBJECTIVES: Nordic register data are not collected for research purposes, and various dimensions of working conditions are typically missing in register-based research. One way to address the issue of missing information on the work environment in register data is to utilize a job exposure matrix (JEM). The purpose of this paper is to document and provide access to a Mechanical Job Exposure Matrix (JEM) and a validated Occupational Mechanical Job Exposure Index based on the constructed JEM, allowing researchers to utilize the index in register-based research...
March 28, 2024: BMC Research Notes
https://read.qxmd.com/read/38549176/the-digital-divide-in-rural-and-regional-communities-a-survey-on-the-use-of-digital-health-technology-and-implications-for-supporting-technology-use
#13
JOURNAL ARTICLE
Hannah Jongebloed, Kate Anderson, Natalie Winter, Lemai Nguyen, Catherine E Huggins, Feby Savira, Paul Cooper, Eva Yuen, Anna Peeters, Bodil Rasmussen, Sandeep Reddy, Sarah Crowe, Rahul Bhoyroo, Imran Muhammad, Anna Ugalde
OBJECTIVE: A digital divide exists for people from rural and regional areas where they are less likely and confident to engage in digital health technologies. The aim of this study was to evaluate the digital health literacy and engagement of people from rural and regional communities, with a focus on identifying barriers and facilitators to using technology. RESULTS: Forty adults living in rural/regional areas completed a survey consisting of the eHealth Literacy Scale (eHEALS) with additional items surveying participants' experience with a range of digital health technologies...
March 28, 2024: BMC Research Notes
https://read.qxmd.com/read/38549130/have-we-bothered-to-ask-exploration-of-the-attitude-of-teachers-toward-participating-in-inclusive-education-research
#14
JOURNAL ARTICLE
Maxwell Peprah Opoku, William Nketsia, Mprah Kwadwo Wisdom, Michael Amponteng
OBJECTIVE: The importance of research cannot be overemphasized. Research findings serve as a guide for the enactment of development policies and legislation. However, not all members of the target population willingly participate in a study. The current study explored the reasons why some individuals refused to partake in inclusive education research in a developing country, Ghana. The journaling helped to capture the voices of 87 participants who refused to take part in a larger inclusive education survey study...
March 28, 2024: BMC Research Notes
https://read.qxmd.com/read/38549125/shower-dehumidification-to-reduce-nontuberculous-mycobacteria-aerosolization
#15
JOURNAL ARTICLE
Michael X Kostecki, Yvonne L Chan, Jennifer R Honda
OBJECTIVE: Nontuberculous mycobacteria (NTM) are environmentally acquired opportunistic pathogens that can cause recalcitrant lung disease. Prior reports have demonstrated links between shower use and infections, yet the aerosolization of NTM from showerheads, as well as the humidity levels that may modulate NTM aerosolization from showerheads is less studied. The objective of the current study was to investigate the role of humidity in NTM aerosolization among showers in homes located in a geographic area with high lung disease incidence, Hawai'i, and test whether deployment of a dehumidifier in well-ventilated bathrooms reduce NTM exposure...
March 28, 2024: BMC Research Notes
https://read.qxmd.com/read/38539217/an-in-silico-analysis-of-ogt-gene-association-with-diabetes-mellitus
#16
JOURNAL ARTICLE
Abigail O Ayodele, Brenda Udosen, Olugbenga O Oluwagbemi, Elijah K Oladipo, Idowu Omotuyi, Itunuoluwa Isewon, Oyekanmi Nash, Opeyemi Soremekun, Segun Fatumo
O-GlcNAcylation is a nutrient-sensing post-translational modification process. This cycling process involves two primary proteins: the O-linked N-acetylglucosamine transferase (OGT) catalysing the addition, and the glycoside hydrolase OGA (O-GlcNAcase) catalysing the removal of the O-GlCNAc moiety on nucleocytoplasmic proteins. This process is necessary for various critical cellular functions. The O-linked N-acetylglucosamine transferase (OGT) gene produces the OGT protein. Several studies have shown the overexpression of this protein to have biological implications in metabolic diseases like cancer and diabetes mellitus (DM)...
March 27, 2024: BMC Research Notes
https://read.qxmd.com/read/38532408/heterogeneity-of-clinical-symptomatology-in-pediatric-patients-at-clinical-high-risk-for-psychosis
#17
JOURNAL ARTICLE
L Sophia Rintell, Devon Carroll, Meghan Wales, Joseph Gonzalez-Heydrich, Eugene D'Angelo
OBJECTIVE: Widespread use of diagnostic tools like the Structured Interview for Prodromal Symptoms (SIPS) has highlighted that youth at Clinical High Risk for Psychosis (CHR-P) present with heterogeneous symptomatology. This pilot study aims to highlight the range of clinical characteristics of CHR-P youth, investigate the role of the non-positive (negative, disorganization, and general) symptoms in risk assessment, and determine if specific profiles are associated with severe symptomatology...
March 26, 2024: BMC Research Notes
https://read.qxmd.com/read/38515162/zika-virus-prevention-behaviors-and-knowledge-among-male-partners-of-pregnant-people-and-lack-of-condom-use-as-a-prevention-behavior-from-the-zika-en-embarazadas-y-ni%C3%A3-os-zen-prospective-cohort-study-colombia
#18
JOURNAL ARTICLE
Christina L Sancken, Ayzsa Tannis, Sandra A Amouzou, Veronica Burkel, Jeffrey M Carlson, Suzanne Newton, Suzanne M Gilboa, Maritza Gonzalez, Diana Valencia, Van T Tong, Martha Ospina
OBJECTIVE: Zika virus (ZIKV) infection in pregnancy can cause brain and eye abnormalities and neurodevelopmental sequelae. In the absence of medical countermeasures, behavioral interventions were recommended to prevent mosquito bites and sexual transmission of ZIKV. This report uses data from the Zika en Embarazadas y Niños (ZEN) prospective cohort study in Colombia to describe the knowledge, attitudes, and behaviors (KAB) related to ZIKV prevention in male partners compared to those of their pregnant partners at study enrollment during February 2017-2018...
March 21, 2024: BMC Research Notes
https://read.qxmd.com/read/38509599/long-term-outcome-of-combined-radiologic-and-surgical-strategy-for-the-management-of-biliary-complications-after-pediatric-liver-transplantation
#19
JOURNAL ARTICLE
Ana M Calinescu, Sébastien Monluc, Stephanie Franchi-Abella, Dalila Habes, Gabrielle Weber, Marion F Almes, Jerome Waguet, Emmanuel Jacquemin, Virginie Fouquet, Jordi Miatello, Geraldine Hery, Catherine Baujard, Emmanuel Gonzales, Sophie Branchereau, Florent Guérin
OBJECTIVES: We aimed to analyze the risk factors for management failure of BC after pediatric liver transplantation (pLT) by retrospectively analyzing primary pLT performed between 1997 and 2018 (n = 620 patients). RESULTS: In all, 117/620 patients (19%) developed BC. The median (range) follow-up was 9 (1.4-21) years. Patient survival at 1, 5 and 10 years was 88.9%, 85.7%, 84.4% and liver graft survival was 82.4%, 77.4%, and 74.3% respectively...
March 20, 2024: BMC Research Notes
https://read.qxmd.com/read/38504380/a-gender-specific-geodatabase-of-five-cancer-types-with-the-highest-frequency-of-occurrence-in-iran
#20
JOURNAL ARTICLE
Sharareh Faramarzi, Behzad Kiani, Mohammedreza Hoseinkhani, Neda Firouraghi
OBJECTIVES: Cancer is a global health challenge with complex characteristics. Despite progress in research and treatment, a universally effective prevention strategy is lacking. Access to reliable information, especially on occurrence rates, is vital for cancer management. This study aims to create a database containing individual and spatially integrated data on commonly diagnosed cancers in Iran from 2014 to 2017, serving as a valuable resource for spatial-epidemiological approaches...
March 19, 2024: BMC Research Notes
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