Valeria Lombardi Fäh, Rosa Catarino, Sarah Castillo, Maria Badda, Sibel Gezer-Dickschat, Friederike Thieringer, Sibil Tschudin, Manuela Viviano, Michal Yaron
OBJECTIVE: To evaluate if daily oral 75 µg of Desogestrel (DSG) for 3 months prior to the insertion of etonogestrel-releasing contraceptive implant (ENG-IMPLANT) might help reduce its premature discontinuation. RESULTS: A total of 66 women were randomized in the ENG-IMPLANT group (26) and in the DSG + ENG-IMPLANT group (40), respectively, in the Geneva University Hospitals and Basel University Hospital, from August 15th, 2016 through September 30th, 2019...
March 13, 2023: BMC Research Notes
Canny Fung, Michael Ficklin, Chika C Okafor
OBJECTIVE: The aim of this study was to evaluate the association between meniscal lesions and severity of osteoarthritis (OA) among dogs that underwent Tibial Plateau Leveling Osteotomy (TPLO) for stabilization of cranial cruciate ligament rupture (CrCLR) at the University of Tennessee in 2011-2017. RESULTS: There were a total of 252 meniscal tears. Factors associated with diagnosis of medial meniscal tears (MMT) in dogs were severe OA in comparison to no OA (3...
March 13, 2023: BMC Research Notes
Jean Paul Muambangu Milambo, Peter S Nyasulu, John M Akudugu, James Ndirangu
PURPOSE: this study was conducted to assess the impact of AIs on body mass index and high sensitivity as prognostic predictors to be incorporated into point of care technology (POCT) testing in postmenopausal breast cancer women after a 24 month follow up in Africa. An observational cohort study was conducted; including 126 female BC patients with stages ranging from 0-III initially subjected to AIs and subsequently followed up for 24 months. Multiple imputation model was conducted to predict missing data...
March 13, 2023: BMC Research Notes
Wilmer J Santos, Alison M Hutchinson, Tamara Rader, Ian D Graham, Vanessa Watkins, Ligyana Korki de Candido, Megan Greenough, Janet E Squires
OBJECTIVES: To describe our experience with using a methodological outcomes measurement search filter (precise and sensitive versions of a filter designed to locate articles that report on psychometric properties of measurement tools) and citation searches to locate psychometric articles for tools that can be used to measure context attributes. To compare the precise filter when used alone and with reference list checking to citation searching according to number of records found, precision, and sensitivity...
March 11, 2023: BMC Research Notes
Hakayna Calegaro Salgado, Denise Gasparetti Drumond, Gabriel Duque Pannain, Louise Gracielle de Melo E Costa, Fernanda Souza Sampaio, Isabel Cristina Gonçalves Leite
OBJECTIVES: The main objective of the study was to describe and compare the feasibility of using fractional CO2 laser to the usual treatment with Clobetasol. Randomized clinical trials brought together 20 women from a Brazilian university hospital, 9 of them were submitted to Clobetasol treatment and 11 to laser therapy. Sociodemographic data were obtained and quality of life parameters, vulvar anatomy, self-perception and histopathological analysis of vulvar biopsies were evaluated. Evaluations were made before the beginning of the treatment, during its implementation, right after its completion (3 months), and 12 months after...
March 10, 2023: BMC Research Notes
Khushboo Singhal, Sonam Dhamija, Mitali Mukerji
OBJECTIVE: Alu repeats have gained huge importance in the creation and modification of regulatory networks. We previously reported a unique isoform of human CYP20A1 i.e. CYP20A1_Alu-LT with 23 Alu repeats exonized in its 9 kb long 3'UTR with 4742 potential binding sites for 994 miRNAs. The role of this transcript was hypothesized as a potential miRNA sponge in primary neurons as its expression correlated with that of 380 genes having shared miRNA sites and enriched in neuro-coagulopathy...
March 9, 2023: BMC Research Notes
Vilda Puji Dini Anita, Deden Derajat Matra, Ulfah Juniarti Siregar
OBJECTIVES: Falcataria moluccana, known locally as Sengon, is a fast-growing legume tree that is commonly planted in community forests of Java Island, Indonesia. However, the plantations face attacks of Boktor stem borer (Xystrocera festiva) and gall-rust disease (Uromycladium falcatariae) as major threats to its productivity. To control those pest and disease, it is necessary to grow resistant sengon clones, which are developed through tree improvement program, of which needs genetic and genomic information...
March 9, 2023: BMC Research Notes
Madeleine R Chalmers, JiHye Kim, Nam Chul Kim
OBJECTIVES: In 2012, Liu et al. reported that miR-34 is an age-related miRNA regulating age-associated events and long-term brain integrity in Drosophila. They demonstrated that modulating miR-34 and its downstream target, Eip74EF, showed beneficial effects on an age-related disease using a Drosophila model of Spinocerebellar ataxia type 3 expressing SCA3trQ78. These results imply that miR-34 could be a general genetic modifier and therapeutic candidate for age-related diseases. Thus, the goal of this study was to examine the effect of miR-34 and Eip47EF on another age-related Drosophila disease model...
March 6, 2023: BMC Research Notes
Marta B Lousada, J Edelkamp, T Lachnit, M Fehrholz, F Jimenez, R Paus
OBJECTIVE: Human hair follicles (HFs) are populated by a rich and diverse microbiome, traditionally evaluated by methods that inadvertently sample the skin microbiome and/or miss microbiota located in deeper HF regions. Thereby, these methods capture the human HF microbiome in a skewed and incomplete manner. This pilot study aimed to use laser-capture microdissection of human scalp HFs, coupled with 16S rRNA gene sequencing to sample the HF microbiome and overcome these methodological limitations...
March 6, 2023: BMC Research Notes
Afsaneh Mohsenzadeh, Mansoor Karimifar, Rasool Soltani, Valiollah Hajhashemi
OBJECTIVE: Pharmacological treatments of osteoarthritis (OA) have several side effects. Boswellia serrata resin (frankincense) is rich in boswellic acids that have antioxidant and anti-inflammatory effects; though, their oral bioavailability is low. The aim of this study was evaluation of the clinical effectiveness of frankincense extract in the treatment of knee OA. In a randomized double-blind placebo-controlled clinical trial, eligible patients with knee OA were randomly divided into two groups of drug (33 patients) and control (37 patients), to use oily solution of frankincense extract or placebo, respectively, on the involved knee three times daily for four weeks...
March 4, 2023: BMC Research Notes
Rabih Fares, Jean-Marc Rabil, Chadia Haddad, Sami Helwe, Joe Khalil, Carina Kasrine Al Halabi, Tiffany Abi Antoun, Georges Haddad, Souheil Hallit
PURPOSE: to evaluate the relationship between religious hallucinations and religious coping among Lebanese patients with schizophrenia. METHODS: We have studied the prevalence of religious hallucinations (RH) among 148 hospitalized Lebanese patients suffering from schizophrenia or schizoaffective disorder in November 2021 exhibiting religious delusions (RD), and their relationship with religious coping using the brief Religious Coping Scale (RCOPE). The PANSS scale was used to evaluate psychotic symptoms...
March 2, 2023: BMC Research Notes
Diego A Forero, Vaibhav Chand
In recent decades, advances in methods in molecular biology and genetics have revolutionized multiple areas of the life and health sciences. However, there remains a global need for the development of more refined and effective methods across these fields of research. In this current Collection, we aim to showcase articles presenting novel molecular biology and genetics techniques developed by scientists from around the world.
March 2, 2023: BMC Research Notes
Sümeyra Can, Özge Atilla, Didem Karaçetin
PURPOSE: In this study, it was aimed to evaluate the functionality to deliver different prescription dose except 20 Gy for the Xoft Axxent Ebt (electronic Brachytherapy) system and analyzing the system in terms of radiation dosimetry in water and 0.9% isotonic Sodium Chloride (NaCl) solution. MATERIALS AND METHODS: In the Xoft Axxent eBT, different prescription dose in single fraction were calculated for different balloon applicator volumes based on source position and irradiation times...
February 28, 2023: BMC Research Notes
Eman Bajamal, Samaa Al Anazi, Ola Esheaba, Neama Hantira
BACKGROUND: The current literature examining the impact of online learning on parents and their children, specifically in the time of COVID-19 are still lacking in Saudi Arabia. Therefore, the aim of the study to evaluate the psychometric properties of the Arabic version of the positive/negative experiences of online learning during COVID-19 Pandemic Assessment Scale. METHODS: A cross-sectional study approved by a university institutional review board was conducted among 184 participants in 2021...
February 28, 2023: BMC Research Notes
Rabeah Y Rawashdeh, Ghassan Qabaja, Borhan Aldeen Albiss
OBJECTIVE: Because of the need to extensively study the synergistic activity of metallic nanoparticles, this study aimed to evaluate the antibacterial activity of mixed metallic nanoparticles, made by differing the weight mixing ratio. We prepared multi-metallic nanorods (NRs) by chemical reduction method, with different ratio combinations of silver Ag and copper Cu, two main batches of nanorods were produced: bimetallic mix made only of Ag-Cu, and trimetallic mix made of Ag-Cu and lithium Li, AgCu NRs and AgCuLi NRs respectively...
February 28, 2023: BMC Research Notes
Alejandro Llanos-Cuentas, Alvaro Schwalb, Juan Luis Quintana, Brian Delfin, Fiorela Alvarez, César Ugarte-Gil, Rosio I Guerra Gronerth, Aldo Lucchetti, Max Grogl, Eduardo Gotuzzo
OBJECTIVE: To assess the effectiveness and safety of hydroxychloroquine (HCQ) prophylaxis for the prevention of SARS-CoV-2 infection in healthcare workers (HCW) on duty during the COVID-19 pandemic. RESULTS: A total of 68 HCWs met the eligibility criteria were randomly allocated to receive HCQ (n = 36) or not (n = 32). There were no significant differences between groups in respects to age, gender, or medical history. Eight participants met the primary efficacy endpoint of SAR-CoV-2 infection during the study period; there was no difference in incidence of SARS-CoV-2 infections between both study arms (HCQ: 5 vs Control: 3, p = 0...
February 28, 2023: BMC Research Notes
Samira Sadeghi, Maryam Delphan, Masoumeh Shams, Fataneh Esmaeili, Mahsa Shanaki-Bavarsad, Mehrnoosh Shanaki
OBJECTIVE: Targeting autophagy is a new therapeutic strategy for the complications of diabetes,such as diabetic cardiomyopathy (DCM). During diabetes, increased or insufficient autophagic activity causes aberrations in cellular homeostasis. Regarding the conflicting and unclear results regarding the effect of HIIT and curcumin supplementation on the expression of genes associated to autophagy, this study aimed to assess whether 4-week high-intensity interval training (HIIT) and curcumin supplementation are able to influence the expression of autophagy-related genes in myocardial cells of diabetic rats...
February 25, 2023: BMC Research Notes
Jack McCoy, Natalia Martínez-Ainsworth, Vivian Bernau, Hannah Scheppler, Grant Hedblom, Achuyt Adhikari, Anna McCormick, Michael Kantar, Leah McHale, Lev Jardón-Barbolla, Kristin L Mercer, David Baumler
BACKGROUND: Peppers, bell and chile, are a culturally and economically important worldwide. Domesticated Capsicum spp. are distributed globally and represent a complex of valuable genetic resources. OBJECTIVES: Explore population structure and diversity in a collection of 467 peppers representing eight species, spanning the spectrum from highly domesticated to wild using 22,916 SNP markers distributed across the twelve chromosomes of pepper. RESULTS: These species contained varied levels of genetic diversity, which also varied across chromosomes; the species also differ in the size of genetic bottlenecks they have experienced...
February 25, 2023: BMC Research Notes
Mariela E Srednik, Claudia A Perea, Gabriela I Giacoboni, Jessica A Hicks, Linda K Schlater
Staphylococcus pseudintermedius is an opportunistic pathogen commonly associated with skin infections in dogs. Twenty-three methicillin-resistant S. pseudintermedius (MRSP) isolated in Argentina from dogs with pyoderma were analyzed using whole genome sequencing (WGS) and classified into sequence types (ST) by multilocus sequence typing (MLST) and staphylococcal chromosome cassette mec (SCCmec) types.Based on the WGS analysis, MLST, and SCCmec type results, we report for the first time in Argentina two MRSP strains, one each, belonging to ST71-SCCmec III and ST45-ΨSCCmec57395 from dogs with pyoderma...
February 23, 2023: BMC Research Notes
Evelyn Sakeah, Ayaga A Bawah, Irene Kuwolamo, Maria Anyorikeya, Patrick O Asuming, Raymond Akawire Aborigo
BACKGROUND: Maternal mortality is still a burden worldwide, and Ghana's maternal and child mortalities are still high. Incentive schemes have been effective in improving health workers' performance thereby reducing maternal and child deaths. The efficiency of public health services in most developing countries has been linked to the provision of incentives. Thus, financial packages for Community Health Volunteers (CHVs) serve as enablers for them to be focused and committed to their work...
February 20, 2023: BMC Research Notes
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