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Recent Patents on Drug Delivery & Formulation

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https://read.qxmd.com/read/30848224/scientific-papers-and-patents-on-substances-with-unproven-effects
#1
Sergei V Jargin
It is evident from reviewing of scientific literature that the quality of argumentation in some areas of medical research has deteriorated during last decades. Publication of series of questionable reliability have been continued without making references to the published criticism; examples are discussed in this review. Another tendency is that drugs without proven efficiency are advertised, corresponding products patented and marketed as evidence-based medications. Professional publications are required to register drugs and dietary supplements to obtain permissions for the practical use; and such papers appeared, sometimes being of questionable reliability...
March 7, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30848223/pharmaceutical-cocrystal-a-novel-approach-to-tailor-the-biopharmaceutical-properties-of-a-poorly-water-soluble-drug
#2
Dipti Srivastava, Zeeshan Fatima, Chanchal Deep Kaur, Sachin L Tulsankar, Sanap Sachin Nashik
AIM AND BACKGROUND: The present study reports the formation of a cocrystal of candesartan with the coformer methyl paraben,its characterization and determination of its bioavailability.Candesartan is a poorly water soluble drug having an anti-hypertensive activity. The recent patents on the cocrystals of the drugs Progesterone (US9982007B2), Epalrestat (EP2326632B1), Gefitinib (WO2015170345A1), Valsartan(CN102702118B) for enhancement of solubility helped in selection of the drug for this work...
March 6, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30836929/synthesis-and-characterization-of-valcyclovir-hcl-hybrid-solid-lipid-nanoparticles-by-using-natural-oils
#3
C Archana, M J Newton Amaldoss
BACKGROUND: The Jojoba Simmondsia Chinensis oil is used as one of the main ingredients which have an antioxidant, moisturizing and stabilizing activity. Likewise, grape seed (Vitis vinifera) oil is also used in this preparation which also has some remarkable medicinal properties such as antioxidant, astringent and as a moisturizer. The Valacyclovir solid lipid nanoparticles (SLN) were prepared in combination. OBJECTIVE: The prime objective of the study is to prepare a nano dispersion with good stability indicating zeta potential...
March 4, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30827275/bilayer-tablet-based-chronotherapeutics-in-the-management-of-nocturnal-asthma-an-overview
#4
Sourav Thakur, Bhupendra Singh, Vijay Mishra, Nishika Yadav, Namita Giri, Pardeep Sharma, Ankit Saini, Lavi Kumar Garg
BACKGROUND AND AIM: Asthma is a common ailment having larger circadian difference. The nocturnal asthma (NA) is inconstant exacerbation of asthma condition related to the rises in warning sign at night and there is need for treatment, air route alertness, and/or falling of lung role. These symptoms are linked to sleep or known as circadian events. Chronotherapeutics is a management system which consists of in-vivo drug accessibility programmed to check rhythms of ailment in direction to improve the therapeutic outcomes by suppressing the side effects...
February 27, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30806332/progress-in-drug-and-formulation-development-for-chemoprevention-of-oral-squamous-cell-carcinoma-a-review
#5
Himangshu Sarma, Taslima Jahan, Hemanta Kr Sharma
BACKGROUND: Cancer is a life-threatening global problem with high incidence rates. Prioritizing the prevention of cancer, chemopreventive agents have drawn much attention from the researchers. OBJECTIVE: This review focuses on discussion of the progress in the development of chemopreventive agents and formulations related to the prevention of oral cancer. METHODS: In this perspective, an extensive literature survey was carried out to understand the mechanism, control and chemoprevention of oral cancer...
February 22, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30767755/nanocarriers-for-vaginal-drug-delivery
#6
Zeenat Iqbal, Fahima Dilnawaz
BACKGROUND: Vaginal drug delivery approach represents one of the imperative strategies for local and systemic delivery of drugs. The peculiar dense vascular networks, mucus permeability, range of physiological characteristics of the vaginal cavity have been exploited for therapeutic benefit. Furthermore, the vaginal drug delivery has been curtailed due to the influence of different physiological factors like acidic pH, constant cervical secretion, microflora, cyclic changes during periods along with turnover of mucus of varying thickness...
February 15, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30747090/a-review-on-enteric-coated-pellets-composed-of-core-pellets-prepared-by-extrusion-spheronization
#7
Hetal Patel, Mukesh Gohel
Enteric coated dosage form bypasses the stomach and releases the drug into the small intestine. Advantages of enteric coated pellets in comparison with enteric coated tablets are a) Pellets provide rapid onset of action and faster drug release due to the smaller size than tablets and b) Pellets exhibits less residence time of acid-labile drugs in the stomach compared to tablets. Dosage form coat can be damaged by longer resistance time in the stomach. The present review summarizes the current state of enteric coated pellets where core pellets are prepared by extrusion-spheronization technique and the enteric coating is applied in a fluidized bed processor...
February 11, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30706830/design-development-and-in-vitro-ex-vivo-evaluation-of-mucoadhesive-buccal-film-of-benzydamine-hydrochloride-for-the-effective-treatment-of-aphthous-stomatitis
#8
Deepak Sharma, Amit Sharma, Rajeev Garg
BACKGROUND: During the recent two decades the development of mucoadhesive drug delivery system has been gained tremendous importance to cure many recurrent diseases of oral cavity. The drug delivery through the buccal route is quite challenging due to limited absorption area, movements of the target region and regular flow of saliva leads to the sub-therapeutic drug level in the buccal region. OBJECTIVE: The aim is to develop unidirectional release mucoadhesive buccal film for the transmucosal delivery of Benzydamine Hydrochloride (WO2016126217Al, EP0812193B1) and evaluate the effects of different grade of HPMC polymer (US5980942A) with presumption to prolong the residence time and therapeutic effectiveness at the target site...
January 28, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30674269/nanocapsules-for-drug-delivery-an-updated-review-of-the-last-decade
#9
Nazlıı Erdoğar, Erem Bilensoy, Safiye Akkın
OBJECTIVE: It is known that nanoparticulate drug delivery systems comprise a wide variety of dosage forms including nanospheres, micelles, solid lipid nanoparticles, nanoliposomes, dendrimers, magnetic nanoparticles, and nanocapsules. METHODS: This review describes nanocapsule preparation techniques and their applications for the treatment of several diseases using patents and examples from the literature. RESULTS: Nanocapsules are vesicular systems consisting of an inner liquid core (aqueous/oily) surrounded by a polymeric wall that have immense potential as drug carriers because of the many advantages like improving poor aqueous solubility, stabilizing drugs by protecting the molecule from the environment, providing the desired pharmacokinetic profile, allowing controlled release, as well as facilitating oral administration...
January 23, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30605066/review-of-recent-patents-and-developments-in-skeletal-muscle-regeneration
#10
J Wang, G Q Wang, H Wang, Q M Chen, F J Burczynski
Skeletal muscle is a highly-specialized tissue that is capable of contractile function and able to withstand and adapt to daily mechanical and physiological stress. Musculoskeletal disorders, including muscular dystrophies, result in chronic pain and disability, reduced quality of life, burden on family, and increased healthcare costs. Although several mechanisms have been identified for muscle injury and regeneration, mechanisms of these diseases are poorly understood, and targeted and effective pharmacologic treatment(s) not available...
January 1, 2019: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30539707/montelukast-sodium-formulation-containing-green-tea-extract-to-reduce-the-oxidative-stress-in-guinea-pig-model-of-chronic-allergic-asthma
#11
Neelam Singh, Giriraj T Kulkarni, Yatendra Kumar
AIM AND BACKGROUND: The rationale of this study is that, treatment of asthmatic Guinea pig with combined administration of Montelukast sodium and green tea extract (GTE) as a single capsule will mitigate the inflammatory injury in the airways and weaken the asthmatic response. Recent patents for the treatment of asthma researched a polyphenolic alternatives for antiasthmatic combination therapy, especially for those patients who remains unresponsive or poorly responsive for current asthma therapy (US7232585B2)...
December 11, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30501606/mesoporous-silica-nanoparticles-a-versatile-platform-for-biomedical-applications
#12
Pooja Jain, Nazia Hassan, Zeenat Iqbal, Fahima Dilnawaz
BACKGROUND: Nanotechnology based drug delivery approach has emerged as a promising field, where different kinds of formulations are developed for therapeutic applications. Inflowing of nanomedicine developed through various biomaterials appears to be a game changer in the domain of pharmaceutical and biotechnological industries. Nanomedicines propose to overcome the major constraints of conventional medicine of low solubility and stability, and non-adequate pharmacokinetic profiles and side effects...
December 3, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30430950/the-unprecedented-role-of-gold-nonmaterial-in-diabetes-management
#13
Simpal Kumari, Vipan Kumar Kamboj, Diksha Rajpoot, Anil Teotia, Prabhakar Kumar Verma, Gyanendra Nath Singh
BACKGROUND: Gold nanoparticles possess unique mechanical, chemical, photo-optical and biological properties and have been an interesting field of research and development in life sciences. Research efforts in this area have resulted in innovative nanodevices and nanostructures useful in the diagnostics, biosensing, therapeutics, and targeted drug delivery. OBJECTIVE: In this review, the unique potential aspects of gold nanoparticles/ nanoformulations/ or devices related to diabetes management have been discussed together with the recent patent on the gold nanoparticles / or developed for diabetes management...
November 14, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30345934/self-emulsifying-drug-delivery-system-of-simvastatin-formulation-development-optimization-by-box-behnken-design-in-vitro-and-in-situ-single-pass-intestinal-perfusion-spip-studies
#14
Madhu Verma, Arun Nanda, Yatendra Kumar
PURPOSE: The purpose of the study was formulation development, optimization and evaluation of a Self-Emulsifying Drug Delivery System (SEDDS) of Simvastatin (SIM) for improvement in dissolution and bioavailability of SIM. Solubility enhancement of Biopharmaceutical Classification System (BCS) Class-II drugs is a burning topic and attracting various publications and patents regarding different strategies employed for improvement of dissolution viz., USOO5340591A (Solid dispersion), US005472954A, US005646131A (complexation), USOO5858410A (Nanosuspensions), USOO5874029A (micronization) US 2008...
October 22, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30295193/role-of-porous-carriers-in-the-biopharmaceutical-performance-of-solid-self-microemulsion-preconcentrates-of-canagliflozin1
#15
Dilpreet Singh, Ashok K Tiwary, Neena Bedi
OBJECTIVE: The aim of the present investigation entails the development of solid SMEDDS for improving the oral bioavailability of canagliflozin using porous carriers. The previous patent (WO2017046730A1) was based on enhanced of solubility of canagliflozin through co-crystal formation. METHODS: Preconcentrates were prepared by employing Lauroglycol (80 mg), Tween 80 (300 mg) and Transcutol P (120 mg) and successfully adsorbed onto various hydrophilic and hydrophobic carriers...
October 8, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30039767/antibacterial-and-in-vitro-growth-inhibition-study-of-struvite-urinary-stones-using-oxalis-corniculata-linn-leaf-extract-and-its-biofabricated-silver-nanoparticles
#16
Poppy Das, Kiran Kumar, Arunai Nambiraj, Rajendra Awasthi, Kamal Dua, Himaja Malipeddi
BACKGROUND: Herbal drugs are gaining exponential scientific recognition due to their distinct advantages. In the last 2-3 decades, a gradual increase in worldwide patents on herbal nano-formulations has been noted to address the solubility and bioavailability issues of phytoceuticals. Struvite or ammonium magnesium phosphate hexahydrate (NH4MgPO4.6H2O) is among the important urinary infection stones causing painful urological ailment. These smaller stones may bind together to form a bigger staghorn calculi...
July 23, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30019653/clinical-application-of-polysialylated-therapeutic-proteins
#17
He Meng, Curtis Lockshin, Sanjay Jain, Umesh Shaligram, Joseph Martinez, Dmitry Genkin, David B Hill, Camille Ehre, Dana Clark, Henry Hoppe
While protein therapeutics are invaluable in managing numerous diseases, many require frequent injections to maintain therapeutically effective concentrations, due to their short half-life in circulation. PolyXen™, a platform technology employing biodegradable, non-immunogenic and hydrophilic polysialic acids (PSA) for drug delivery, is being utilized to overcome such limitations, thereby enabling the clinical utility of a broad range of protein therapeutics. Here, we report the recent progress on two development candidates, polysialylated erythropoietin (PSA-EPO) and polysialylated deoxyribonuclease I (PSA-DNase)...
July 17, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/30003863/preparation-characterization-and-in-vivo-assessment-of-repaglinide-nanosuspension-for-oral-bioavailability-improvement
#18
Laxmikant R Zawar, Sanjay B Bari
AIM AND BACKGROUND: The objective of the study was to improve the bioavailability of poorly soluble repaglinide (RPG) by preparing nanosuspension with poloxamer 188 using high pressure homogenization (HPH). The recent patents on nanocrystals (US20150337006A1) facilitated selection of drug and polymer. METHODS: Suspensions containing dissimilar sized particles were prepared by ultrasonication and HPH. The prepared aqueous suspensions were lyophilized and then characterized...
July 12, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/29952275/comparative-study-on-photodynamic-activation-of-ortho-toluidine-blue-and-methylene-blue-loaded-mesoporous-silica-nanoparticles-against-resistant-microorganisms
#19
Ashka Amina, Deepali V Kaduskar
AIMS AND BACKGROUND: Number of pathogenic microorganisms have been increasing over the years, and so as these microorganisms been developing resistance against various antibiotics. Antimicrobial photodynamic therapy (aPDT), also called photodynamic inactivation, is emerging as a promising alternative to treatments based on conventional antibiotics. Recent patents on structured silver mesoporous silica nanoparticles having antimicrobial activity (WO2010/071831 A2), photosensitiser modified core-shell structure nanocomposites (CN 103536935(A)), and Chitosan-coated magnetic mesoporous silica nanoparticles (CN 104785214(A)) helped in selecting method of synthesis of MSN and photosensitizers...
June 26, 2018: Recent Patents on Drug Delivery & Formulation
https://read.qxmd.com/read/29359680/withdrawn-novel-ternary-polymeric-blends-for-controlled-release-matrices-containing-weakly-basic-model-drug
#20
(no author information available yet)
No abstract text is available yet for this article.
January 23, 2018: Recent Patents on Drug Delivery & Formulation
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