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Autism Research: Official Journal of the International Society for Autism Research

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https://read.qxmd.com/read/30990248/using-latent-class-analysis-to-identify-treatment-use-subgroups-among-parents-of-children-with-autism-spectrum-disorder
#1
Sarah S Mire, Samuel McQuillin, Madeline Racine, Robin P Goin-Kochel
Among parents of 2,582 children (ages 4-17 years old) with autism spectrum disorder (ASD), we used latent class analysis to identify subgroups and profiles of treatment users and included annual household income in the specification of the models, then described characteristics of each subgroup. Based on three indicators of fit (Akaike's Information Criterion, Bayesian Information Criterion, and Lo-Mendell-Rubin), six latent classes of treatment users emerged. Subgroups included users of: (a) mostly private and school speech and occupational therapies; (b) nearly all treatment types; (c) mostly speech and occupational therapies, plus intensive behavioral and "other" treatments, but little medication use; (d) private therapies almost exclusively; (e) primarily psychotropic medications; and (f) mostly school-based therapies...
April 16, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30977597/enhanced-social-dominance-and-altered-neuronal-excitability-in-the-prefrontal-cortex-of-male-kcc2b-mutant-mice
#2
Allison M J Anacker, Jacqueline T Moran, Sara Santarelli, C Gunnar Forsberg, Tiffany D Rogers, Gregg D Stanwood, Benjamin J Hall, Eric Delpire, Jeremy Veenstra-VanderWeele, Michael D Saxe
The K-Cl cotransporter KCC2 is essential in the development of the "GABA switch" that produces a change in neuronal responses to GABA signaling from excitatory to inhibitory early in brain development, and alterations in this progression have previously been hypothesized to play a causal role in autism spectrum disorder (ASD). We investigated the KCC2b (Slc12a5) heterozygous knockout mouse using a battery of rodent behavioral tests relevant to core and comorbid ASD symptoms. Compared to wild-type littermates, KCC2+/- mice were normal in standard measures of locomotor activity, grooming and digging behaviors, and social, vocalization, and anxiety-like behaviors...
April 12, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30973210/early-processing-n170-of-infant-faces-in-mothers-of-children-with-autism-spectrum-disorder-and-its-association-with-maternal-sensitivity
#3
Carla Márquez, Humberto Nicolini, Michael J Crowley, Rodolfo Solís-Vivanco
Individuals with autism spectrum disorder (ASD) exhibit impaired adult facial processing, as shown by the N170 event-related potential. However, few studies explore such processing in mothers of children with ASD, and none has assessed the early processing of infant faces in these women. Moreover, whether processing of infant facial expressions in mothers of children with ASD is related to their response to their child's needs (maternal sensitivity [MS]) remains unknown. This study explored the N170 related to infant faces in a group of mothers of children with ASD (MA) and a reference group of mothers of children without ASD...
April 11, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30972967/reduced-heart-rate-variability-in-adults-with-autism-spectrum-disorder
#4
Rinku Thapa, Gail A Alvares, Tooba A Zaidi, Emma E Thomas, Ian B Hickie, Shin H Park, Adam J Guastella
A growing body of research has suggested heart rate variability (HRV) may be reduced in autism spectrum disorder (ASD) in comparison to neurotypical cohorts. While there have been several studies investigating HRV in children diagnosed with ASD, few studies have been conducted in adults. The objective of the current study was to investigate autonomic nervous system activity as assessed by HRV in adults diagnosed with ASD. We hypothesized that adults with ASD would show a reduction in HRV compared to neurotypical participants...
April 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30969478/academic-and-psychosocial-characteristics-of-incoming-college-freshmen-with-autism-spectrum-disorder-the-role-of-comorbidity-and-gender
#5
Alexandra Sturm, Connie Kasari
There is a pressing need to better characterize the college-bound population of individuals with autism spectrum disorder (ASD), as prior studies have included small samples, consisting of individuals who are either recruited due to diagnosis or are treatment seeking. As postsecondary institutions look to respond to the growing need for support services for individuals with ASD, insights derived from large, population-based samples is a necessity. The current study included a sample of over 2000 incoming postsecondary students who self-identified with ASD as a part of surveys distributed by institutions nationally...
April 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30969030/maternal-diabetes-and-hypertensive-disorders-in-association-with-autism-spectrum-disorder
#6
Christina Cordero, Gayle C Windham, Laura A Schieve, Margaret Daniele Fallin, Lisa A Croen, Anna Maria Siega-Riz, Stephanie M Engel, Amy H Herring, Alison M Stuebe, Catherine J Vladutiu, Julie L Daniels
Previous studies have shown complications of pregnancy, often examined in aggregate, to be associated with autism spectrum disorder (ASD). Results for specific complications, such as maternal diabetes and hypertension, have not been uniformly consistent and should be investigated independently in relation to ASD in a large community-based sample. The Study to Explore Early Development (SEED), a US multisite case-control study, enrolled children born in 2003-2006 at 2-5 years of age. Children were classified into three groups based on confirmation of ASD (n = 698), non-ASD developmental delay (DD; n = 887), or controls drawn from the general population (POP; n = 979)...
April 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30969026/sleep-determines-quality-of-life-in-autistic-adults-a-longitudinal-study
#7
Marie K Deserno, Denny Borsboom, Sander Begeer, Joost A Agelink van Rentergem, Kawita Mataw, Hilde M Geurts
Many individuals with autism report generally low quality of life (QoL). Identifying predictors for pathways underlying this outcome is an urgent priority. We aim to examine multivariate patterns that predict later subjective and objective QoL in autistic individuals. Autistic characteristics, comorbid complaints, aspects of daily functioning, and demographics were assessed online in a 2-year longitudinal study with 598 autistic adults. Regression trees were fitted to baseline data to identify factors that could predict QoL at follow-up...
April 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30964233/parent-reported-prevalence-of-food-allergies-in-children-with-autism-spectrum-disorder-national-health-interview-survey-2011-2015
#8
Yuling Tan, Shiny Thomas, Brian K Lee
Food allergies are frequently reported to co-occur with autism spectrum disorder (ASD), but the prevalence of this co-occurrence remains uncertain. In the present study, we examined parent-reported prevalence of co-occurring food allergy and ASD in a nationally representative sample of US children ages 2-17 in the National Health Interview Survey, study years 2011-2015. All analyses used survey weights to account for the complex sampling design. In the analytic sample of 53,365 children ages 2-17, there were 905 children with parent-reported ASD (prevalence of 1...
April 9, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30919599/short-report-relationships-between-sensory-processing-repetitive-behaviors-anxiety-and-intolerance-of-uncertainty-in-autism-spectrum-disorder-and-williams-syndrome
#9
Magdalena Glod, Deborah M Riby, Jacqui Rodgers
Autism spectrum disorder (ASD) and Williams syndrome (WS) share psychopathology relating to sensory processing and repetitive behaviors. The relationships between the sensory features and repetitive behaviors in both disorders, and the mechanisms underlying these relationships are not well understood. The aim of this study was to examine the relationships between sensory processing, repetitive behaviors, anxiety, and intolerance of uncertainty in children with ASD and those with WS to better understand the complexity of psychopathology in these disorders...
March 28, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30912315/flourishing-in-children-with-autism-spectrum-disorders
#10
Claudia L Hilton, Karen Ratcliff, Diane M Collins, Joanne Flanagan, Ickpyo Hong
Flourishing is an indicator of positive mental health and is important for children's development and well-being. We used variables from the National Survey of Children's Health 2016 as indicators of flourishing (difficulty making friends, is bullied, bullies others, shares ideas with family, argues, finishes tasks, does all homework, shows curiosity, stays calm, and cares about doing well in school) to compare differences in parent perceptions of their children with and without autism spectrum disorder (ASD)...
March 26, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30896090/assessing-a-hyperarousal-hypothesis-of-insomnia-in-adults-with-autism-spectrum-disorder
#11
Emma K Baker, Amanda L Richdale, Agnes Hazi, Luke A Prendergast
This study aimed to investigate the relationship between sleep, psychopathology (anxiety, depression and presleep arousal) symptoms, and cortisol in adults with autism spectrum disorder (ASD). The sample composed of 29 adults with ASD (51.7% males) and 29 control adults (51.7% males) aged 21-44 years. Thirteen adults with ASD were medicated for a comorbid diagnosis of anxiety and/or depression (ASD-Med), while the remaining 16 adults with ASD were not medicated for such diagnoses (ASD-Only). Participants completed a questionnaire battery, 14-day sleep/wake diary and 14-day actigraphy assessment...
March 21, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30892834/meeting-the-24-hr-movement-guidelines-an-update-on-us-youth-with-autism-spectrum-disorder-from-the-2016-national-survey-of-children-s-health
#12
Seán Healy, Carrie J Aigner, Justin A Haegele, Freda Patterson
The purpose of this study was to examine how adherence to the physical activity (PA), screen-time (ST), and sleep duration guidelines differ between youth with autism spectrum disorder (ASD) and youth with typical development (TD). A secondary objective was to assess how PA, ST, and sleep duration varied among youth with ASD by age and ASD severity. Utilizing the 2016 National Survey of Children's Health data, parental reports of time spent by youth in PA, ST, and sleep were used to determine adherence to the 24-hr movement guidelines for 1008 youth with ASD and 34 489 youth with TD...
March 20, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30891960/the-use-of-eye-tracking-as-a-biomarker-of-treatment-outcome-in-a-pilot-randomized-clinical-trial-for-young-children-with-autism
#13
Jessica Bradshaw, Frederick Shic, Anahita N Holden, Erin J Horowitz, Amy C Barrett, Tamsin C German, Ty W Vernon
There is a pressing need for objective, quantifiable outcome measures in intervention trials for children with autism spectrum disorder (ASD). The current study investigated the use of eye tracking as a biomarker of treatment response in the context of a pilot randomized clinical trial of treatment for young children with ASD. Participants included 28 children with ASD, aged 18-48 months, who were randomized to one of two conditions: Pivotal Response Intervention for Social Motivation (PRISM) or community treatment as usual (TAU)...
March 20, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30883046/newborn-vitamin-d-levels-in-relation-to-autism-spectrum-disorders-and-intellectual-disability-a-case-control-study-in-california
#14
Gayle C Windham, Michelle Pearl, Meredith C Anderson, Victor Poon, Darryl Eyles, Karen L Jones, Kristen Lyall, Martin Kharrazi, Lisa A Croen
Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already diagnosed, but a few examined levels during perinatal development, the more likely susceptibility period. Therefore, we examined newborn vitamin D levels in a case-control study conducted among births in 2000-2003 in southern California. Children with ASD (N = 563) or intellectual disability (ID) (N = 190) were identified from the Department of Developmental Services and compared to population controls (N = 436) identified from birth certificates...
March 18, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30852853/association-between-breastfeeding-initiation-and-duration-and-autism-spectrum-disorder-in-preschool-children-enrolled-in-the-study-to-explore-early-development
#15
Gnakub N Soke, Matthew Maenner, Gayle Windham, Eric Moody, Jamie Kaczaniuk, Carolyn DiGuiseppi, Laura A Schieve
Studies report inconsistent findings on the relationship between ASD and breastfeeding. We explored associations between ASD and breastfeeding initiation (yes/no) and duration (months categorized in tertiles) in the Study to Explore Early Development, a community-based case-control study in six sites in the Unites States. We adjusted for various child and mother demographic and pregnancy factors. Breastfeeding initiation was reported in 85.7% of mothers of children with ASD and 90.6% of mothers of controls...
March 9, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30825364/social-and-nonsocial-reward-moderate-the-relation-between-autism-symptoms-and-loneliness-in-adults-with-asd-depression-and-controls
#16
Gloria T Han, Andrew J Tomarken, Katherine O Gotham
Individuals with autism spectrum disorder (ASD) report high levels of co-occurring mood disorders. Previous work suggests that people with ASD also experience aberrant responses to social reward compared to typically developing (TD) peers. In the TD population, aberrant reward processing has been linked to anhedonia (i.e., loss of pleasure), which is a hallmark feature of depression. This study examined the interplay between self-reported pleasure from social and nonsocial rewards, autism symptom severity, loneliness, and depressive symptoms across adults with autism spectrum disorder (ASD; N = 49), TD currently depressed adults (TD-dep; N = 30), and TD never depressed controls (TD-con; N = 28)...
March 2, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30816644/social-and-delay-discounting-in-autism-spectrum-disorder
#17
Katherine Rice Warnell, Sydney Maniscalco, Sydney Baker, Richard Yi, Elizabeth Redcay
Current literature is divided over whether and how processes such as perspective taking and reward sensitivity differ between individuals with autism spectrum disorder (ASD) versus neurotypical individuals. Discounting tasks may provide novel insight into how these processes operate. In delay discounting tasks, participants choose between smaller immediate rewards and larger delayed rewards, and in social discounting tasks, participants choose between a smaller monetary rewards for themselves versus a larger reward for partners of varied social distance (e...
February 28, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30803153/autism-prevalence-and-outcomes-in-older-adults
#18
John Elder Robison
Recent studies of mortality, illness, and suicide among autistic adults paint an alarming picture. Autistic people appear to die much earlier than the general population, and they seem to be far more vulnerable to a surprising range of medical problems. Suicide and depression seem far more common than in the general population. If correct, that suggests an older autistic population in silent crisis, with few if any supports. If so, older autistic people should be a focus for public health and human service agencies...
February 25, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30802365/social-and-nonsocial-visual-prediction-errors-in-autism-spectrum-disorder
#19
Rachel K Greene, Shuting Zheng, Jessica L Kinard, Maya G Mosner, Christopher A Wiesen, Daniel P Kennedy, Gabriel S Dichter
Impaired predictive coding has been proposed as a framework to explain discrepancies between expectations and outcomes in autism spectrum disorder (ASD) that may contribute to core symptoms of the disorder. However, no eye tracking study has directly addressed this framework in the context of visual predictions of social and nonsocial stimuli. The current study used eye tracking to examine violations of learned visual associations of both social and nonsocial stimuli. Twenty-six adolescents with ASD and 18 typically developing control (TDC) adolescents completed an outcome expectation eye tracking task in which predictive cues correctly (80% of trials) or incorrectly (20% of trials) indicated the location (left or right) of forthcoming social or nonsocial stimuli...
February 25, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/30802364/mortality-and-cause-of-death-of-australians-on-the-autism-spectrum
#20
Ye In Jane Hwang, Preeyaporn Srasuebkul, Kitty-Rose Foley, Samuel Arnold, Julian N Trollor
Focused investigations regarding mortality rates, risk factors, and cause of death in autistic populations remain scarce. The present study used large linked datasets spanning 2001-2015 to report the rates and risk factors for mortality and cause of death in individuals on the autism spectrum (n = 35,929 age range 5-64) with and without concurrent intellectual disability (ID) in New South Wales, Australia. Mortality rates for those on the autism spectrum were 2.06 times that of the general population. Concurrent ID, epilepsy, mental health conditions, and chronic physical health conditions were associated with a higher risk of death for those on the spectrum, whereas demographic variables such as gender and socioeconomic status were not...
February 25, 2019: Autism Research: Official Journal of the International Society for Autism Research
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