Simon M Rice, Barnaby Nelson, G Paul Amminger, Shona M Francey, Lisa J Phillips, Magenta B Simmons, Margaret Ross, Hok Pan Yuen, Alison R Yung, Kieran O'Gorman, Patrick D McGorry, Stephen J Wood, Gregor E Berger
AIM: Lithium, even at low doses, appears to offer neuroprotection against a wide variety of insults. In this controlled pilot, we examined the safety (i.e., side-effect profile) of lithium in a sample of young people identified at ultra-high risk (UHR) for psychosis. The secondary aim was to explore whether lithium provided a signal of clinical efficacy in reducing transition to psychosis compared with treatment as usual (TAU). METHODS: Young people attending the PACE clinic at Orygen, Melbourne, were prescribed a fixed dose (450 mg) of lithium (n = 25) or received TAU (n = 78)...
April 10, 2024: Early Intervention in Psychiatry