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Early Intervention in Psychiatry

Satoshi Yamaguchi, Jerome C Foo, Asuka Nishida, Sayoko Ogawa, Fumiharu Togo, Tsukasa Sasaki
AIM: The prevalence of mental disorders increases sharply during adolescence. Therefore, school teachers are in a good position to provide initial assistance to students with mental health problems. Although effects of a number of mental health literacy programs aimed at teachers have been reported, they have not yet been reviewed in a systematic manner. This study conducted a systematic review of the effectiveness of mental health literacy programs for teachers. METHODS: PubMed, PsycINFO, CINAHL, ERIC, Web of Science and reference lists of included studies were searched in September 2018...
February 10, 2019: Early Intervention in Psychiatry
Sue M Cotton, Michael Berk, Henry Jackson, Greg Murray, Kate Filia, Melissa Hasty, Andrew Chanen, Christopher Davey, Barnaby Nelson, Aswin Ratheesh, Craig MacNeil
AIM: Young people with bipolar disorder (BD) commonly experience reduced quality of life, persistent symptoms and impaired functional recovery despite often superior school performance. Compromised long-term functioning can ensue. There is evidence that psychological therapies alongside pharmacology may be more efficacious earlier in the course of the disorder. Intervention in the early stages may thus reduce the burden and risk associated with BD and mitigate the impact of the disorder on normal developmental trajectories...
February 10, 2019: Early Intervention in Psychiatry
Jonathan Campion, Matthew J Taylor, David McDaid, A-La Park, David Shiers
AIM: Early Intervention Psychosis Services (EIPS) for people experiencing First Episode Psychosis (FEP) offer important clinical and non-clinical benefits over standard care. Similarly, intervention for Clinical High Risk for Psychosis state (CHR-P) can prevent psychosis, ameliorate symptoms and have non-clinical benefits. This study aimed to estimate associated local economic benefits of FEP and CHR-P services compared with standard care. METHODS: Across four south London boroughs, proportion of annual number of new cases of FEP and CHR-P seen by early intervention services was estimated...
February 10, 2019: Early Intervention in Psychiatry
Dan Turley, Richard Drake, Eoin Killackey, Alison R Yung
AIMS: Psychotic-like experiences (PLE) are sub-threshold, non-clinical forms of psychosis which can place an individual at greater risk of development of a psychotic disorder. Subtypes of PLE have also been shown to exist (bizarre experiences, persecutory ideation, perceptual abnormalities and magical thinking). Perceived stress relates to how two individuals may deal with the same objectively stressful event in different ways. The objective of our study was to investigate the extent to which perceived stress is associated with PLE in a community sample of adolescents, whether certain subtypes of PLE correlate more with perceived stress than others and to explore the role of depression with these associations...
February 3, 2019: Early Intervention in Psychiatry
Atipatsa C Kaminga, Wenjie Dai, Aizhong Liu, Japhet Myaba, Richard Banda, Shi W Wen
AIM: Long duration of untreated psychosis (DUP) is prevalent and has been shown to be associated with poorer prognosis. Thus, knowledge of its determinants may help to target early interventions to reduce DUP on the needed population. Previous studies seeking to understand determinants of DUP have been inconclusive. Therefore, this study aimed to investigate the effects of socio-demographic characteristics, premorbid functioning, and insight on DUP in patients with first-episode schizophrenia or schizophreniform disorder...
February 1, 2019: Early Intervention in Psychiatry
Laura Ortega, Itziar Montalvo, Rosa Monseny, Elisabet Vilella, Javier Labad
AIM: Quality of life (QoL) and social functioning have emerged as good predictors of the outcome of psychotic disorders. Poor QoL and social functioning are usually present before the onset of the first episode of psychosis. Our study aimed to explore the relationship between social adaptation and QoL in young people at risk of psychosis (ultra-high-risk, UHR) and healthy controls (HCs), and to investigate potential mediating effects of stress measures (perceived stress, stressful life events)...
January 28, 2019: Early Intervention in Psychiatry
Oliver D Robertson, Nieves G Coronado, Rickinder Sethi, Michael Berk, Seetal Dodd
AIM: Neuropsychiatric disorders including depression, bipolar and schizophrenia frequently exhibit a neuroprogressive course from prodrome to chronicity. There are a range of agents exhibiting capacity to attenuate biological mechanisms associated with neuroprogression. This review will update the evidence for putative neuroprotective agents including clinical efficacy, mechanisms of action and limitations in current assessment tools, and identify novel agents with neuroprotective potential...
January 28, 2019: Early Intervention in Psychiatry
Alice Thomson, Helen Griffiths, Rebecca Fisher, Robert McCabe, Sue Abbott-Smith, Matthias Schwannauer
AIM: Compared with adult onset psychosis, adolescent psychosis has been associated with poorer outcomes in terms of social and cognitive functioning and negative symptoms. Young people experiencing first episode psychosis have developmental needs that frequently pre-date and are compounded by psychosis onset (a previous study). There is a lack of published studies of adolescent onset psychosis and further information is needed so that developmentally appropriate interventions can be developed...
January 28, 2019: Early Intervention in Psychiatry
Andrew M Chanen, Jennifer Betts, Henry Jackson, Patrick McGorry, Barnaby Nelson, Sue M Cotton, Cali Bartholomeusz, Martina Jovev, Aswin Ratheesh, Christopher Davey, Christos Pantelis, Louise McCutcheon, Shona Francey, Amit Bhaduri, Danielle Lowe, Victoria Rayner, Katherine Thompson
AIM: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically indistinguishable from those in schizophrenia, occur early in the course of the disorder, and are enduring, distressing and disabling. In clinical practice, this symptom is widely assumed to be unresponsive to treatment with antipsychotic medication and early intervention is rarely offered. The Verbal Experiences Response in Borderline personality disorder to Aripiprazole TrIal Medication (VERBATIM) study aims to be the first controlled trial to investigate the effectiveness of conventional pharmacotherapy for this symptom in this patient group...
January 28, 2019: Early Intervention in Psychiatry
Ava A John-Baptiste, Lihua Li, Wanrudee Isaranuwatchai, Elizabeth Osuch, Kelly K Anderson
AIM: The First Episode Mood and Anxiety Disorder Program (FEMAP) provides treatment to emerging adults with mood and anxiety disorders in an accessible, youth-friendly environment. We sought to investigate FEMAP's impact on the costs of care. METHODS: We conducted a retrospective observational study of one-year health service costs using linked administrative datasets to compare emerging adults treated at FEMAP (FEMAP users) to propensity-score matched controls (non-users)...
January 27, 2019: Early Intervention in Psychiatry
Suzie Lavoie, Andrea R Polari, Sherilyn Goldstone, Barnaby Nelson, Patrick D McGorry
AIM: Clinical staging in psychiatry aims to classify patients according to the severity of their symptoms, from stage 0 (increased risk, asymptomatic) to stage 4 (severe illness), enabling adapted treatment at each stage of the illness. The staging model would gain specificity if one or more quantifiable biological markers could be identified. Several biomarkers reflecting possible causal mechanisms and/or consequences of the pathophysiology are candidates for integration into the clinical staging model of psychiatric illnesses...
January 27, 2019: Early Intervention in Psychiatry
Theresa K Haidl, Mauro Seves, Susanne Eggers, Ayda Rostamzadeh, Anna Genske, Saskia Jünger, Christiane Woopen, Frank Jessen, Ruhrmann Stephan, Kai Vogeley
OBJECTIVE: Numerous studies suggest that health literacy (HL) plays a crucial role in maintaining and improving individual health. Empirical findings highlight the relation between levels of a person's HL and her/his clinical outcome. To date, the role of HL in persons at-risk for psychosis has not been systematically reviewed. METHODS: We conducted a systematic review using a mixed-methods approach to analyse a variety of study types. Peer-reviewed publications were systematically searched in PUBMED, Cochrane Library, PsycINFO and Web of Science...
January 27, 2019: Early Intervention in Psychiatry
Jean Addington, Lu Liu, Benjamin I Goldstein, Jianli Wang, Sidney H Kennedy, Signe Bray, Catherine Lebel, Jacqueline Stowkowy, Glenda MacQueen
AIM: The first aim of this project was to identify a sample of youth who met different stages of risk for the development of a serious mental illness (SMI) based on a published clinical staging model. The second aim was to determine whether participants allocated to the different stages were a good fit to the model by comparing these groups on a range of clinical measures. METHODS: This two-site longitudinal study recruited 243 youth, ages 12 to 25. The sample included (a) 42 healthy controls, (b) 43 non-help seeking individuals with no mental illness but with some risk of SMI, such as having a first-degree relative with a SMI (stage 0), (c) 52 help-seeking youth experiencing distress and possibly mild symptoms of anxiety or depression (stage 1a) and (d) 108 youth with attenuated symptoms of SMI, such as bipolar disorder or psychosis (stage 1b)...
January 22, 2019: Early Intervention in Psychiatry
Franco Mascayano, Ilana Nossel, Iruma Bello, Thomas Smith, Hong Ngo, Sarah Piscitelli, Igor Malinovsky, Ezra Susser, Lisa Dixon
AIM: Consistent evidence shows that early interventions for individuals with psychosis lead to improvements in symptoms, social functioning and treatment satisfaction. These results, combined with the allocation of specific funds for early psychosis services, have contributed to the emergence and dissemination of coordinated specialty care for early psychosis in the United States. Despite the rapid growth of such services across the country over the last 5 years, implementation processes are not yet well understood...
January 22, 2019: Early Intervention in Psychiatry
Matthew Loughlin, Katherine Berry, Joanna Brooks, Sandra Bucci
AIM: Early intervention for psychosis services (EIS) has been established worldwide and is offered to individuals experiencing a first episode of psychosis. Engagement with EIS typically lasts for 3 years, after which point, service users are either transferred to primary care or community mental health teams, according to perceived needs. Although UK National Institute for Clinical Excellence (NICE) guidelines recommend transfer of care should be arranged in conjunction with the receiving service, there exists little, if any, practical guidance as to how this should actually be managed...
January 22, 2019: Early Intervention in Psychiatry
Maria Ferrara, Enrico Tedeschini, Flavia Baccari, Vincenzo Musella, Francesca Vacca, Fausto Mazzi, Mila Ferri, Vinod Srihari, Fabrizio Starace
AIM: To report on the development of an early intervention service in Modena, Italy, with information relevant to the first 4 years of implementation. METHODS: The 2-year service was offered to people aged 18-35 with psychotic manifestations, within 2 years from psychosis onset/or naïve to antipsychotics, by teams placed within community mental health Centres, according to a "specialist within generalist" model. Treatment included pharmacological consultation, psychoeducation and social inclusion programs...
January 22, 2019: Early Intervention in Psychiatry
Mary Jane Tacchi, Jorn Heggelund, Jan Scott
AIM: To systematically review evidence that objectively assessed level of physical fitness is associated with future risk of adverse mental health outcomes during the peak age range for onset of adult mental disorders. METHODS: Searches of Electronic databases (EBSCOhost, SPORTDISCUS, EMBASE, MedLINE, Cochrane database, CINAHL, PsychInfo, and Dissertation Abstracts), supplemented by hand searches of journals, conference proceedings and citations. Random-effects meta-analysis models were used to pool the intervention effects...
January 21, 2019: Early Intervention in Psychiatry
Craig Macneil, Frances Foster, Amanda Nicoll, Richard Monfries, Lucas Coulson, Helen Osman, Michelle Grainger, Sue Cotton
AIM: For early psychosis services to be effective, it is essential to have staff that are trained in evidence-based interventions in this area. In this paper, we report on research undertaken by The Early Psychosis Prevention and Intervention Centre's Statewide Services (ESW) team. The focus was on assessing knowledge acquisition in early psychosis clinicians that had attended ESW's specialist training. METHODS: Between October 2012 and October 2017, data were collected from a large cohort of clinicians that had attended 46 ESW workshops covering topics identified in international guidelines as key components of early psychosis service provision...
January 21, 2019: Early Intervention in Psychiatry
Nicholas J K Breitborde, Jacob G Pine, Aubrey M Moe
AIM: Self-determination theory (SDT) has demonstrated that human well-being is associated with the satisfaction of three basic psychological needs (ie, autonomy, competence and relatedness)-with more recent research highlighting the applicability of SDT to individuals with first-episode psychosis (FEP). These findings suggest that satisfaction of basic psychological need may be an important treatment target for specialized clinical programs for FEP. METHODS: We examined the effects of participation in specialized, multi-component care for FEP on basic psychological need satisfaction...
January 15, 2019: Early Intervention in Psychiatry
Matteo Tonna, Paolo Ossola, Carlo Marchesi, Elena Bettini, Antonio Lasalvia, Chiara Bonetto, Jacopo Lenzi, Paola Rucci, Laura Iozzino, Massimo Cellini, Carla Comacchio, Doriana Cristofalo, Armando D'Agostino, Giovanni de Girolamo, Katia De Santi, Daniela Ghigi, Emanuela Leuci, Maurizio Miceli, Anna Meneghelli, Francesca Pileggi, Silvio Scarone, Paolo Santonastaso, Stefano Torresani, Sarah Tosato, Angela Veronese, Angelo Fioritti, Mirella Ruggeri
AIM: Current diagnostic systems, DSM-5 and ICD-10, still adopt a categorical approach to classify psychotic disorders. The present study was aimed at investigating the structure of psychotic symptomatology in both affective and non-affective psychosis from a dimensional approach. METHODS: Participants with a first episode psychosis (FEP) were recruited from a cluster-randomized controlled trial (GET-UP PIANO TRIAL), offered to all Community Mental Health Centres (CMHCs) located across two northern Italian regions...
January 15, 2019: Early Intervention in Psychiatry
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