journal
https://read.qxmd.com/read/38505191/perioperative-treatment-with-rivaroxaban-and-dabigatran-on-changes-of-coagulation-and-platelet-activation-biomarkers-following-left-atrial-appendage-closure
#1
JOURNAL ARTICLE
Yao Yao, Yanli Li, Qinchun Jin, Xiaoye Li, Xiaochun Zhang, Qianzhou Lv
Insufficient data exist regarding the investigation of the impact of novel oral anticoagulants (NOACs) on coagulation activation biomarkers in the context of left atrial appendage closure (LAAC) and device-related thrombosis (DRT). The study was designed to investigate the changes and presence of coagulation activation biomarkers between different antithrombotic strategies following LAAC. A total of 120 nonvalvular atrial fibrillation patients intolerant of long-term anticoagulants, who underwent successful WATCHMAN closure implantation, were enrolled (rivaroxaban, n = 82; dabigatran, n = 38)...
2024: Cardiovascular Therapeutics
https://read.qxmd.com/read/38495810/dusp22-ameliorates-endothelial-to-mesenchymal-transition-in-huvecs-through-smad2-3-and-mapk-signaling-pathways
#2
JOURNAL ARTICLE
Lu Chen, Hongyu Su, Zekai Tao, Cui Liang, Zhongzhao Liu, Yiming Dong, Peipei Zheng, Yuan Liu
Endothelial-to-mesenchymal transition (EndMT) is the process by which endothelial cells lose their endothelial properties and acquire mesenchymal characteristics. Dual-specific protein phosphatase 22 (DUSP22) inactivates various protein kinases and transcription factors by dephosphorylating serine/threonine residues: hence, it plays a key role in many diseases. The aim of this study was to explore the functional role of DUSP22 in EndMT. In the transforming growth factor- β -induced EndMT model in human umbilical vein endothelial cells (HUVECs), we observed a downregulation of DUSP22 expression...
2024: Cardiovascular Therapeutics
https://read.qxmd.com/read/38449908/major-limitations-of-cardiovascular-risk-scores
#3
REVIEW
Ibtissam Talha, Noureddine Elkhoudri, Abderraouf Hilali
Background . Epidemiological studies conducted in extensive population cohorts have led to the creation of numerous cardiovascular risk predictor models. However, these tools have certain limitations that restrict its applicability. The aim behind the following work is to summarize today's best-known limitations of cardiovascular risk assessment models through presenting the critical analyses conducted in this area, with the intention of offering practitioners a comprehensive understanding of these restrictions...
2024: Cardiovascular Therapeutics
https://read.qxmd.com/read/38375358/-laminaria-japonica-aresch-derived-fucoidan-ameliorates-hyperlipidemia-by-upregulating-lxrs-and-suppressing-srebps
#4
JOURNAL ARTICLE
Yan Zhang, Tian Liu, Ze-Jie Qu, Xue Wang, Wen-Gang Song, Shou-Dong Guo
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, and hyperlipidemia is one major inducing factor of CVD. It is worthy to note that fucoidans are reported to have hypolipidemic activity with species specificity; however, the underlying mechanisms of action are far from clarification. This study is aimed at investigating the plasma lipid-lowering mechanisms of the fucoidan from L. japonica Aresch by detecting the levels of hepatic genes that are involved in lipid metabolism...
2024: Cardiovascular Therapeutics
https://read.qxmd.com/read/38234331/assessment-of-angiography-based-renal-quantitative-flow-ratio-measurement-in-patients-with-atherosclerotic-renal-artery-stenosis
#5
JOURNAL ARTICLE
Xiang Huang, Xiao-Lan Li, Heng Zhou, Xiao-Mei Li
BACKGROUND: Quantitative flow ratio (QFR) is an angiography-based fractional flow reserve measurement without pressure wire or induction of hyperemia. A recent innovation that uses combined geometrical data and hemodynamic boundary conditions to measure QFR from a single angiographic view has shown the potential to measure QFR of the renal artery-renal QFR (rQFR). OBJECTIVE: The aim of this pilot study was to assess the feasibility of rQFR measurement and the contribution of rQFR in selecting patients with atherosclerotic renal artery stenosis (ARAS) undergoing revascularization...
2024: Cardiovascular Therapeutics
https://read.qxmd.com/read/38146531/improving-health-outcomes-in-coronary-artery-disease-patients-with-short-term-protocols-of-high-intensity-interval-training-and-moderate-intensity-continuous-training-a-community-based-randomized-controlled-trial
#6
JOURNAL ARTICLE
Catarina Gonçalves, Jorge Bravo, João Pais, Ana Abreu, Armando Raimundo
Studies have shown that the higher the aerobic capacity, the lower the risk of cardiovascular mortality and morbidity. In the case of cardiac patients, high-intensity interval training (HIIT) seems to be more effective than moderate-intensity continuous training (MICT) in improving aerobic capacity. The aim of this study was to investigate the effects of two community-based exercise programs using two short-term protocols (HIIT and MICT) on physical fitness and physical activity (PA) levels in coronary artery disease (CAD) patients...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/38125704/valsartan-attenuated-homocysteine-induced-impaired-autophagy-and-er-stress-in-human-umbilical-vein-endothelial-cells
#7
JOURNAL ARTICLE
Xinyan Wu, Ani Wang, Long Xu, Meng Li, Qingxian Zhai, Weidong Wang, Chunling Li, Lizi Jin
Hyperhomocysteinemia is a risk factor for various cardiovascular diseases. However, the mechanism underlying homocysteine- (Hcy-) induced vascular injury remains unclear. The purpose of the present study was to examine a potential mechanism by which Hcy induced injury in human umbilical vascular endothelial cells (HUVEC). The protein abundance of autophagy-related markers was markedly decreased after Hcy treatment, which was associated with endoplasmic reticulum (ER) stress and apoptosis in HUVECs. Protein expression level of angiotensin II type 1 receptor (AT1 receptor) was dramatically increased in response to Hcy...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/38125703/relationship-between-%C3%AE-1-aa-and-at1-aa-and-cardiac-function-in-patients-with-hypertension-complicated-with-left-ventricular-diastolic-function-limitation
#8
JOURNAL ARTICLE
Liang Wang, Xue-Bai Lv, Yu-Ting Yuan, Ning Wang, Hong-Ying Yao, Wen-Chao Zhang, Peng-Fei Yin, Xiao-Hui Liu
OBJECTIVE: To investigate the association between β 1 adrenergic receptor autoantibodies ( β 1-AA) and angiotensin II type-1 receptor autoantibodies (AT1-AA) and cardiac function in patients with hypertension complicated with left ventricular diastolic function limitation. METHODS: A total of 120 patients with essential hypertension who were not taking drug treatment and were hospitalised in the Department of Cardiology at the authors' hospital from April 2018 to December 2018 were enrolled in this study and divided into a diastolic dysfunction group (65 cases) and a normal diastolic group (55 cases) according to their left ventricular diastolic function...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/38125702/ginkgolide-b-blocks-vascular-remodeling-after-vascular-injury-via-regulating-tgf-%C3%AE-1-smad-signaling-pathway
#9
JOURNAL ARTICLE
Quan Wang, Shuai Ni, Li Ling, Siqi Wang, Hanbin Xie, Zhanhong Ren
Coronary artery disease (CAD) is the most prevalent cardiovascular disease worldwide, resulting in myocardial infarction (MI) and even sudden death. Following percutaneous coronary intervention (PCI), restenosis caused by vascular remodeling is always formed at the stent implantation site. Here, we show that Ginkgolide B (GB), a naturally occurring terpene lactone, effectively suppresses vascular remodeling and subsequent restenosis in wild-type mice following left carotid artery (LCA) injury. Additional experiments reveal that GB exerts a protective effect on vascular remodeling and further restenosis through modulation of the Tgf β 1/Smad signaling pathway in vivo and in human vascular smooth muscle cells (HVSMAs) but not in human umbilical vein endothelial cells (HUVECs) in vitro ...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/38045109/frequencies-of-vkorc1-1639g-a-and-rs397509427-in-patients-on-warfarin-and-healthy-syrian-subjects
#10
JOURNAL ARTICLE
Yara Altawil, Lama A Youssef
BACKGROUND: Vitamin K epoxide reductase complex subunit 1 ( VKORC1 ) gene encodes a key enzyme with multiple cellular activities, namely, the reduction of vitamin K to its active form. VKORC1 -1639G>A (rs9923231) is a common single nucleotide polymorphism with a crucial impact on warfarin dosing and possibly other physiological functions. This study aimed at investigating the frequencies of VKORC1 -1639G>A alleles and genotypes in Syrian healthy subjects and patients on warfarin for different indications...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/38024105/role-of-k-and-ca-2-channels-in-the-vasodilator-effects-of-plectranthus-barbatus-brazilian-boldo-in-hypertensive-rats
#11
JOURNAL ARTICLE
Jeniffer Cristóvão Moser, Rita de Cássia Vilhena da Silva, Philipe Costa, Luisa Mota da Silva, Nadla Soares Cassemiro, Arquimedes Gasparotto Junior, Denise Brentan Silva, Priscila de Souza
Plectranthus barbatus , popularly known as Brazilian boldo, is used in Brazilian folk medicine to treat cardiovascular disorders including hypertension. This study investigated the chemical profile by UFLC-DAD-MS and the relaxant effect by using an isolated organ bath of the hydroethanolic extract of P. barbatus (HEPB) leaves on the aorta of spontaneously hypertensive rats (SHR). A total of nineteen compounds were annotated from HEPB, and the main metabolite classes found were flavonoids, diterpenoids, cinnamic acid derivatives, and organic acids...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/38024104/circulating-fabp-4-levels-in-patients-with-atherosclerosis-or-coronary-artery-disease-a-comprehensive-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Narges Jalilian, Reza Pakzad, Mahdi Shahbazi, Seyyed-Reza Edrisi, Karimeh Haghani, Mohsen Jalilian, Salar Bakhtiyari
BACKGROUND: Cardiovascular diseases (CDs), notably coronary artery disease (CAD) due to atherosclerosis, impose substantial global health and economic burdens. Fatty acid-binding proteins (FABPs), including FABP-4, have been recently linked to CDs. This study conducted a systematic review and meta-analysis to examine FABP-4 levels in CAD and atherosclerosis patients, exploring their potential links to these conditions. METHODS: A systematic review and meta-analysis were done based on the PRISMA guideline...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/38024103/effect-of-thrombolysis-on-circulating-microparticles-in-patients-with-st-segment-elevation-myocardial-infarction
#13
JOURNAL ARTICLE
Zhe Li, Wei Zhang, Qun-Rang Wang, Yu-Juan Yang, Xin-Hong Liu, Gong Cheng, Feng-Jun Chang
OBJECTIVE: We demonstrated that circulating microparticles (MPs) are increased in patients with coronary heart disease (both chronic coronary syndrome (CCS) and acute coronary syndrome). Whether thrombolysis affects MPs in patients with ST-segment elevation myocardial infarction (STEMI) with or without percutaneous coronary intervention (PCI) is unknown. METHODS: This study was divided into three groups: STEMI patients with thrombolysis ( n = 18) were group T, patients with chronic coronary syndrome ( n = 20) were group CCS, and healthy volunteers ( n = 20) were the control group...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/37719172/identifying-factors-for-low-risk-participation-in-alternative-cardiac-rehabilitation-models-for-patients-with-coronary-heart-disease-using-mi-s-scorepad
#14
REVIEW
Eric J Brandt, Joshua Garfein, Chih-Wen Pai, Joseph Bryant, Eva Kline-Rogers, Samantha Fink, Melvyn Rubenfire
INTRODUCTION: Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is appropriate for low- and moderate-risk patients, there are no paradigms to define such individuals with coronary heart disease. METHODS: We reviewed a decade of data from all patients with coronary heart disease enrolled in a single CR center (University of Michigan) to identify the prevalence of low-risk factors, which may inform on consideration for participation in alternative models of CR...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/37705934/elevated-serum-total-bilirubin-might-indicate-poor-coronary-conditions-for-unstable-angina-pectoris-patients-beyond-as-a-cardiovascular-protector
#15
JOURNAL ARTICLE
Qi Liang, Yongjian Zhang, Jin Liang
BACKGROUNDS: Serum total bilirubin (STB) is recently more regarded as an antioxidant with vascular protective effects. However, we noticed that elevated STB appeared in unstable angina pectoris (UAP) patients with diffused coronary lesions. We aimed to explore STB's roles in UAP patients, which have not been reported by articles. METHODS AND RESULTS: 1120 UAP patients were retrospectively screened, and 296 patients were finally enrolled. They were grouped by Canadian Cardiovascular Society (CCS) angina grades...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/37645544/left-bundle-branch-area-pacing-versus-right-ventricular-pacing-in-patients-with-atrioventricular-block-an-observational-cohort-study
#16
JOURNAL ARTICLE
Zhongxiu Chen, Yuanning Xu, Lingyun Jiang, Ran Zhang, Hongsen Zhao, Ran Liu, Lei Zhang, Yajiao Li, Xingbin Liu
OBJECTIVE: We aim to conduct a comparison of the safety and effectiveness performance between left bundle branch area pacing (LBBAP) and right ventricular pacing (RVP) regimens for patients with atrioventricular block (AVB). METHODS: This observational cohort study included patients who underwent pacemaker implantations with LBBAP or RVP for AVB indications from the 1st of January 2018 to the 18th of November 2021 at West China Hospital. The primary composite outcome included all-cause mortality, lead failure, or heart failure hospitalization (HFH)...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/37636560/comparison-of-different-chronic-maintenance-antithrombotic-strategies-in-patients-with-coronary-artery-disease-a-systematic-review-and-network-meta-analysis
#17
REVIEW
Junyan Zhang, Zhongxiu Chen, Yujia Cai, Chen Li, Yong He
BACKGROUND: Optimal antithrombotic therapy during the chronic maintenance period in patients with coronary artery disease (CAD) is unknown. We compared five kinds of mainstream chronic maintenance antithrombotic strategies at least one year after the acute phase: aspirin alone, clopidogrel alone, ticagrelor alone, continued dual antiplatelet therapy (DAPT) for a period of time, and maintenance with aspirin combined with a low-dose anticoagulant such as rivaroxaban. METHODS: Ten randomized, controlled trials were selected using PubMed, Ovid MEDLINE, Embase, and Cochrane library through February 2023...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/37588774/drug-coated-balloon-only-strategy-for-de-novo-coronary-artery-disease-a-meta-analysis-of-randomized-clinical-trials
#18
JOURNAL ARTICLE
Wenyi Zhang, Mingduo Zhang, Jinfan Tian, Min Zhang, Yuan Zhou, Xiantao Song
BACKGROUNDS: Many clinical trials have demonstrated the value of drug-coated balloons (DCB) for in-stent restenosis. However, their role in de novo lesions is not well documented. The aim of this study is to evaluate the safety and efficacy of the DCB-only strategy compared to other percutaneous coronary intervention strategies for de novo coronary lesions. METHODS: The PubMed, Embase, Web of Science, and Cochrane Library Central Register of Controlled Trials (CENTRAL) electronic databases were searched for randomized controlled trials published up to May 6, 2023...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/37496726/heart-failure-with-preserved-left-ventricular-ejection-fraction-a-complex-conundrum-simply-not-limited-to-diastolic-dysfunction
#19
REVIEW
Angel Lopez-Candales, Talal Asif, Khalid Sawalha, Nicholas B Norgard
Over the last two decades, the changing paradigm of heart failure with preserved ejection fraction (HFpEF) has transformed our understanding not only of the pathophysiology of this clinical entity but also the diagnostic and therapeutic approaches aimed at treating this complex patient population. No longer HFpEF should be seen as simply left ventricular diastolic dysfunction but as a group of that in addition of having small and thick left ventricles with abnormal diastolic filling patterns as their main pathophysiologic abnormality; they also have whole host of different abnormalities...
2023: Cardiovascular Therapeutics
https://read.qxmd.com/read/37404774/water-based-exercises-on-peak-oxygen-consumption-exercise-time-and-muscle-strength-in-patients-with-coronary-artery-disease-a-systematic-review-with-meta-analysis
#20
REVIEW
Alana Lalucha Andrade Guimarães, Mansueto Gomes-Neto, Lino Sérgio Rocha Conceição, Micheli Bernardone Saquetto, Caroline Oliveira Gois, Vitor Oliveira Carvalho
BACKGROUND: There is a growing use of water-based exercises in cardiac rehabilitation programs. However, there is little data concerning the effects of water-based exercise on the exercise capacity of coronary artery disease (CAD) patients. OBJECTIVE: To perform a systematic review to investigate the effects of water-based exercise on peak oxygen consumption, exercise time, and muscle strength in patients with CAD. METHODS: Five databases were searched to find randomized controlled trials that evaluated the effects of water-based exercise for coronary artery disease patients...
2023: Cardiovascular Therapeutics
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