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Archives of Osteoporosis

Dalisbor Marcelo Weber Silva, Marise Lazaretti-Castro, Cristiano Augusto de Freitas Zerbini, Vera Lúcia Szejnfeld, Sergio Ragi Eis, Victoria Zeghbi Cochenski Borba
INTRODUCTION: Osteoporosis is a very common disease, and data on its epidemiology is important for health care strategy implementation. Brazil is a developing country; its population is aging, leading to an expected increase in hip fractures and their undesirable consequences. OBJECTIVE: Assess the incidence of osteoporotic hip fractures and subsequent mortality in Southern Brazil as part of a large epidemiological study aiming to reinforce the data for FRAX Brazil...
April 16, 2019: Archives of Osteoporosis
Tânia Amorim, George S Metsios, Andreas D Flouris, Alan Nevill, Thayse N Gomes, Matthew Wyon, Franklim Marques, Luísa Nogueira, Nuno Adubeiro, Athanasios Z Jamurtas, José Maia, Yiannis Koutedakis
Less is known on bone mass gains in dancers involved in vocational dance training. The present study found that, as young vocational dancers progress on their professional training, their bone health remains consistently lower compared to non-exercising controls. Endocrine mechanisms do not seem to explain these findings. PURPOSE: Little is known on bone mass development in dancers involved in vocational training. The aim of the present study was to model bone mineral content (BMC) accruals and to determine whether circulating levels of oestrogens, growth hormone (GH), and insulin-like growth factor I (IGF-1) explain differences in bone mass gains between vocational dance students and matched controls...
April 9, 2019: Archives of Osteoporosis
Rosa Lauppe, Kristina E Åkesson, Östen Ljunggren, Anna Spångéus, Gustaf Ortsäter, Maurille Feudjo-Tepie, Oskar Ström
This study assesses the impact of risk factors for fracture in women aged 80+ and 60-79. The results suggest that risk assessment which fits younger women may not be suited for the 80+ strata as many common risk factors are less predictive in the older compared to the younger cohort. PURPOSE: This study assesses whether the impact of classical risk factors for fracture due to osteoporosis is different in women aged 80+ and women aged 60-79. Since most prior research on the contribution of risk factors is based on patients below 80 years of age, this study aims to fill this knowledge gap to increase the accuracy of risk assessment in the oldest old...
April 8, 2019: Archives of Osteoporosis
P C R van der Vet, J Q Kusen, M Rohner-Spengler, B C Link, R M Houwert, R Babst, C Henzen, L Schmid, F J P Beeres
INTRODUCTION: Minor trauma fractures (MTF) in the elderly are associated with an increase in mortality, morbidity, and the risk of subsequent fractures. Often, these patients who sustain MTF have an underlying bone disease, such as osteopenia or osteoporosis. Osteoporosis is known to be underdiagnosed and undertreated, and adequate treatment is essential to reduce the occurrence of MTFs. At our hospital, this has led to the implementation of Osteofit, a patient-education-based intervention targeted at improving screening and prevention of osteoporosis, with the goal to reduce the rate of subsequent MTF...
March 29, 2019: Archives of Osteoporosis
Xinbao Wu, Maoyi Tian, Jing Zhang, Minghui Yang, Xiaofeng Gong, Yishu Liu, Xian Li, Richard I Lindley, Melanie Anderson, Ke Peng, Jagnoor Jagnoor, Jiachao Ji, Manyi Wang, Rebecca Ivers, Wei Tian
Hip fracture becomes a major public health issue with the growing aging population. This study evaluated a multidisciplinary co-management program for older hip fracture patients and found it significantly improved the best practice indicators. It provided preliminary evidence to support the use of such intervention in hip fracture management. PURPOSE/INTRODUCTION: Hip fracture leads to high morbidity and mortality in older people. A previous study found a significant disparity in hip fracture management in Beijing Jishuitan Hospital (JSTH) compared to best practice care in the United Kingdom (UK)...
March 22, 2019: Archives of Osteoporosis
Pietro Donato, Jessica Pepe, Luciano Colangelo, Vittoria Danese, Veronica Cecchetti, Salvatore Minisola, Cristiana Cipriani
PURPOSE: The aim of the study was to evaluate the adherence to treatment with bisphosphonates in women with postmenopausal osteoporosis referred to a primary care clinic. METHODS: A total of 7257 outpatients were referred to the primary care service where the study was conducted. We retrieved data of postmenopausal women to which bisphosphonates have been prescribed in the period January 1, 2000-December 31, 2014, and analyzed the group of patients who had discontinued the drug...
March 21, 2019: Archives of Osteoporosis
Ye Seul Bae, Jooyoung Chang, Sang Min Park
Bisphosphonate use was not associated with the risk of female breast, ovarian, or cervical cancer. The results according to bisphosphonate type or concurrent drug uses were not associated with the cancer risk. The protective effect of bisphosphonate use on female breast cancer was significant in the low comorbidity group. PURPOSE: Despite the antitumor mechanisms, the effect of bisphosphonates on the risk of cancer is still unclear. We investigated the association between oral bisphosphonate use and the development of female breast, ovarian, and cervical cancer...
March 19, 2019: Archives of Osteoporosis
Tom Knauf, Benjamin Bücking, Mathias Bargello, Sebastian Ploch, Christopher Bliemel, Matthias Knobe, Steffen Ruchholtz, Daphne Eschbach
The incidence of hip fractures is increasing due to demographic transition. Data on long-term survival and influencing factors are sparse. Our prospective observational study with 395 patients shows a survival of 38% after 5 years. Significant risk factors were male gender, higher age, lower Barthel Index, lower Charlson Comorbidity Score, lower Mini-Mental State Examination, and delirium during hospitalization. PURPOSE: The incidence of hip fractures is increasing due to demographic transition...
March 16, 2019: Archives of Osteoporosis
Polyzois Makras, Athanasios D Anastasilakis, George Antypas, Efstathios Chronopoulos, Evangelia G Kaskani, Aikaterini Matsouka, Dimos K Patrikos, Konstantinos D Stathopoulos, Symeon Tournis, George Trovas, Christos Kosmidis
We report the updated guidelines for the management of osteoporosis in Greece, which include guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information, and national evidence from Greek clinical practice and the healthcare setting. PURPOSE: The purpose of this report was to update the Guidelines for the Management of Osteoporosis in Greece that was published in 2011. METHODS: In line with the GRADE system, the working group initially defined the main clinical questions that should be addressed when dealing with the diagnosis and management of osteoporosis in clinical practice in Greece...
March 15, 2019: Archives of Osteoporosis
Ricardo M Lima, Ricardo Jacó de Oliveira, Rafael Raposo, Silvia Gonçalves Ricci Neri, André Bonadias Gadelha
A better understanding of the relationship between osteoporosis and sarcopenia may help to develop effective preventive and therapeutic strategies. In the present study, the association between different stages of sarcopenia, BMD, and osteoporosis was examined. The salient findings indicate that a dose-response relationship exists between sarcopenia stages and bone-related phenotypes. PURPOSE: To assess the association between sarcopenia stages, bone mineral density (BMD), and the prevalence of osteoporosis in older women...
March 13, 2019: Archives of Osteoporosis
Minmin Chen, Yanhua Zhang, Yanping Du, Wei Hong, Wenjing Tang, Huilin Li, Songbai Zheng, Qun Cheng
In this study, we attempted to determine the epidemiology and clinical characteristics of hip fracture in the elderly. We find that elderly people with hip fracture have multiple comorbidities and suffer numerous complications. INTRODUCTION: We attempted to explore the epidemiology and clinical characteristics of hip fracture in the elderly. METHODS: One thousand five hundred thirty-nine patients aged over 65 years were included in the retrospective study. From the medical records, information was gathered about pre-fracture conditions, as well as fracture type, surgical details, laboratory indicators, postoperative complications, length of stay, outcomes, and costs of hospitalization...
March 12, 2019: Archives of Osteoporosis
Jiuzhou Jiang, Pengchen Qiu, Yiyun Wang, Chenchen Zhao, Shunwu Fan, Xianfeng Lin
This study was a cross-sectional study and enrolled 14,147 participants after excluding. We performed a large number of data analyses to indicate that HDL-C levels were related to bone health. A high HDL-C level is an independent risk factor for bone loss both in males and females. INTRODUCTION: Serum high-density lipoprotein cholesterol (HDL-C), usually called "good" cholesterol, is beneficial for preventing cardiovascular diseases. Previous studies have indicated that HDL-C levels may be related to bone mass...
March 9, 2019: Archives of Osteoporosis
Charat Thongprayoon, Prakrati Acharya, Narothama Reddy Aeddula, Aldo Torres-Ortiz, Tarun Bathini, Konika Sharma, Patompong Ungprasert, Kanramon Watthanasuntorn, Maria Lourdes Gonzalez Suarez, Sohail Abdul Salim, Wisit Kaewput, Jirat Chenbhanich, Michael A Mao, Wisit Cheungpasitporn
OBJECTIVE: The use of immunosuppressive agents, especially glucocorticoids, are associated with increased risks of bone loss in kidney transplant patients. Denosumab, a potent antiresorptive agent, has been shown to increase bone mineral density (BMD) in patients with CKD. However, its effects on bone metabolism and BMD in kidney transplant patients remain unclear. METHODS: A literature search was conducted using MEDLINE, EMBASE, and Cochrane Database from inception through April 2018 to identify studies evaluating denosumab's effect on changes in bone metabolism and BMD from baseline to post-treatment course in kidney transplant patients...
March 9, 2019: Archives of Osteoporosis
Chanyang Min, Woo Jin Bang, Miyoung Kim, Dong Jun Oh, Hyo Geun Choi
The prevalence of hepatitis B was higher in osteoporosis patients than the control group, especially in females. However, the prevalence of hepatitis C was not different. The matching for various factors improved to have same conditions between osteoporosis patients and the control group. PURPOSE: Although chronic liver disease, including hepatitis B and hepatitis C, has been associated with osteoporosis in previous studies, the evidence was insufficient, and some findings were inconsistent...
March 9, 2019: Archives of Osteoporosis
Sarath Lekamwasam, Manju Chandran, Sewwandi Subasinghe
This paper revised the fixed intervention thresholds (ITs) based on the Sri Lankan fracture risk assessment tool (FRAX) published in 2013 and introduced new ITs, hybrid and two-tier, aiming to help clinicians in the management of postmenopausal osteoporosis. The hybrid and two-tier ITs have a better discriminatory power than age-dependent and revised fixed ITs. INTRODUCTION: This study revised the Sri Lankan FRAX®-based intervention thresholds (ITs) previously published in 2013. METHOD: Age-dependent ITs were estimated, from 50-80 years with 5-year intervals, using a Sri Lankan FRAX® algorithm for a woman with a BMI of 24...
March 9, 2019: Archives of Osteoporosis
Fan Yu, Weibo Xia
BACKGROUND: Osteoporosis has been one of the most common but largely under-diagnosed clinical problems among elderly population. The disease burden is even greater in China because of limited medical resources and large population size. This article is aimed to provide an overview of disease burden, secular trend, and management gap of osteoporosis and related fractures in China. METHODS: Based on the related studies published in English and Chinese from 1990 to 2017, we investigated the prevalence/incidence of osteoporosis and osteoporotic fracture in Chinese mainland, Hong Kong, and Taiwan, characterizing the secular trend and disease burden in different regions...
March 8, 2019: Archives of Osteoporosis
Xueli Zhang, Ting Hua, Jingqi Zhu, Kun Peng, Jun Yang, Sifeng Kang, Tingting Xu, Jian Hu, Guangyu Tang
The study was to investigate the correlation between body compositions and bone mineral density (BMD) and to evaluate the body composition contribution to BMD. In male, LM showed positive effect on BMD. In female, SAT showed positive, and FM and F/L showed negative effect on BMD. PURPOSE: The purpose of the study was to investigate the correlation between body compositions and bone mineral density (BMD) performed by quantitative computed tomography (QCT), and to evaluate the body composition contribution to BMD...
March 7, 2019: Archives of Osteoporosis
Riad A Sulimani
Vitamin D-deficient Saudi adolescent girls were screened for anti-tissue transglutaminase (IgA-tTG) antibodies to determine whether the presence of severe vitamin D deficiency was associated with celiac disease. All 9 participants who were positive for IgA-tTG antibodies had severe vitamin D deficiency (25(OH)D < 12.5 nmol/l), suggesting that this population should be screened for celiac disease. PURPOSE: The current cross-sectional study aimed to see if severe vitamin D deficiency is associated with celiac disease (CD) among Saudi adolescent girls...
March 4, 2019: Archives of Osteoporosis
Rajesh K Jain, Tamara Vokes
In an analysis of NHANES 2005-2006, older, but not younger, women and men with higher levels of physical activity had higher TBS, total hip T-score, and femoral neck T-score. Even modest levels of physical activity may be a crucial component of bone health maintenance. PURPOSE: Physical activity is associated with improved bone parameters in adolescence, but it is not clear if this persists into adulthood. Further, it is unclear how low levels of physical activity as measured by accelerometer may impact bone parameters...
March 2, 2019: Archives of Osteoporosis
Stijn C Voeten, Arend J Arends, Michel W J M Wouters, Bastiaan J Blom, Martin J Heetveld, Monique S Slee-Valentijn, Pieta Krijnen, Inger B Schipper, J H Han Hegeman
The nationwide Dutch Hip Fracture Audit (DHFA) is initiated to improve the quality of hip fracture care by providing insight into the actual quality of hip fracture care in daily practice. The baseline results demonstrate variance in practice, providing potential starting points to improve the quality of care. PURPOSE: The aim of this study is to describe the development and initiation of the DHFA. The secondary aim is to describe the hip fracture care in the Netherlands at the start of the audit and to assess whether there are differences in processes at baseline between hospitals...
March 1, 2019: Archives of Osteoporosis
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