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JOURNAL ARTICLE
Piotr Eder, Bram Verstock, Emma Culver, Gabriele Dragoni, Lea Isabell Kredel, Joanna Wypych, Ana Garcia Garcia de Paredes, Magdalena Kaniewska, Haim Leibovitzh, Triana Lobaton, Marie Truyens, Grzegorz Oracz, Davide Giuseppe Ribaldone, Teresa Starzyńska, Abdenor Badaoui, Jean-Francois Rahier, Cristina Bezzio, Peter Bossuyt, Katherine Falloon, Daniela Pugliese, Catherine Frakes Vozzo, Tine Jess, Lone Larsen, Soren Olensen, Partha Pal, María Chaparro, Dikla Dror, Pierre Ellul, Iga Gromny, Maria Janiak, Katarzyna Maciejewska, Noam Peleg, Ariella Bar-Gil Shitrit, Łukasz Szwed, Renata Talar-Wojnarowska, Yifat Snir, Roni Weisshof, Eran Zittan, Izabela Miechowicz, Idan Goren
BACKGROUND: Autoimmune pancreatitis (AIP) is rarely associated with inflammatory bowel disease (IBD). Long-term outcomes of AIP and IBD in patients with AIP-IBD coexistence and predictors of complicated AIP course are scarcely known. METHODS: An ECCO COllaborative Network For Exceptionally Rare case reports project (ECCO-CONFER) collected cases of AIP diagnosed in patients with IBD. Complicated AIP was defined as a composite of endocrine and/or exocrine pancreatic insufficiency, and/or pancreatic cancer...
June 7, 2023: Journal of Crohn's & Colitis
#2
JOURNAL ARTICLE
Zhifu Sun, Manuel B Braga-Neto, Yuning Xiong, Adytia V Bhagwate, Hunter Gibbons, Mary Sagstetter, Feda H Hamdan, Saurabh Baheti, Jessica Friton, Asha Nair, Zhenqing Ye, William A Faubion
BACKGROUND: The development of Crohn's disease (CD) involves immune cell signaling pathways regulated by epigenetic modifications. Aberrant DNA methylation has been identified in peripheral blood and bulk intestinal tissue from CD patients. However, the DNA methylome of disease-associated intestinal CD4 + lymphocytes has not been evaluated. MATERIALS AND METHODS: Genome-wide DNA methylation sequencing was performed from terminal ileum CD4 + cells from 21 CD patients and 12 age and sex matched controls...
June 6, 2023: Journal of Crohn's & Colitis
#3
JOURNAL ARTICLE
J Sabino, L Tarassishin, C Eisele, K Hawkins, A Barré, N Nair, A Rendon, A Debebe, M Picker, M Agrawal, J Stone, J George, Peter Legnani, Elana Maser, Ching-Lynn Chen, Anne Thjømøe, Einar Mørk, M Dubinsky, J Hu, J F Colombel, I Peter, J Torres
BACKGROUND AND AIMS: Herein we analyzed the influence of early life factors, including breastmilk composition on the development of the intestinal microbiota of infants born to mothers with and without IBD. METHODS: The MECONIUM (Exploring MEChanisms Of disease traNsmission In Utero through the Microbiome) study is a prospective cohort study consisting of pregnant women with or without IBD and their infants. Longitudinal stool samples were collected from babies and analyzed using 16s rRNA sequencing and fecal calprotectin...
June 6, 2023: Journal of Crohn's & Colitis
#4
JOURNAL ARTICLE
Kristina A Holten, Tomm Bernklev, Randi Opheim, Ingunn Johansen, Bjørn C Olsen, Charlotte Lund, Vibeke Strande, Asle W Medhus, Gøri Perminow, May-Bente Bengtson, Raziye Boyar Cetinkaya, Simen Vatn, Svein Oskar Frigstad, Tone B Aabrekk, Trond Espen Detlie, Øistein Hovde, Vendel A Kristensen, Småstuen Cvancarova Milada, Magne Henriksen, Gert Huppertz-Hauss, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen
BACKGROUND AND AIMS: Although fatigue is common in inflammatory bowel disease (IBD), its pathogenesis remains unclear. This study aimed to determine the prevalence of fatigue and its associated factors in a cohort of patients newly diagnosed with IBD. METHODS: Patients ≥18 years were recruited from the Inflammatory Bowel Disease South-Eastern Norway (IBSEN III) study, a population-based, observational inception cohort. Fatigue was assessed using the Fatigue Questionnaire and compared with data from a Norwegian general population...
June 5, 2023: Journal of Crohn's & Colitis
#5
JOURNAL ARTICLE
Nicola Pugliese, Arianna Dal Buono, Alessandro Armuzzi
No abstract text is available yet for this article.
May 30, 2023: Journal of Crohn's & Colitis
#6
JOURNAL ARTICLE
Carlijn E Bruggeling, Maarten Te Groen, Daniel R Garza, Famke van Heeckeren Tot Overlaer, Joyce P M Krekels, Basma-Chick Sulaiman, Davy Karel, Athreyu Rulof, Anne R Schaaphok, Daniel L A H Hornikx, Iris D Nagtegaal, Bas E Dutilh, Frank Hoentjen, Annemarie Boleij
BACKGROUND AND AIMS: Colonic bacterial biofilms are frequently present in ulcerative colitis (UC) and may increase dysplasia risk through pathogens expressing oncotraits. This prospective cohort study aimed to determine (1) the association of oncotraits and longitudinal biofilm presence with dysplasia risk in UC, and (2) the relation of bacterial composition with biofilms and dysplasia risk. METHODS: Feces and left- and right-sided colonic biopsies were collected from 80 UC patients and 35 controls...
May 27, 2023: Journal of Crohn's & Colitis
#7
JOURNAL ARTICLE
Kiran K Motwani, Jana G Hashash, Francis A Farraye, Michael D Kappelman, Kimberly N Weaver, Xian Zhang, Millie D Long, Raymond K Cross
BACKGROUND AND AIMS: The BNT162b2 and mRNA-1273 COVID-19 vaccines are efficacious in patients with inflammatory bowel disease; but there are a lack of data examining if holding immunosuppressive therapy around vaccination improves immune response. We studied the effect of holding IBD medications around the time of vaccination on antibody response and breakthrough COVID-19 infection. METHODS: Partnership to Report Effectiveness of Vaccination in populations Excluded from iNitial Trials of COVID is a prospective cohort of individuals with IBD receiving COVID-19 vaccination...
May 26, 2023: Journal of Crohn's & Colitis
#8
(no author information available yet)
No abstract text is available yet for this article.
May 24, 2023: Journal of Crohn's & Colitis
#9
JOURNAL ARTICLE
Laurent Peyrin-Biroulet, Ethan Arenson, David T Rubin, Corey A Siegel, Scott Lee, F Stephen Laroux, Wen Zhou, Tricia Finney-Hayward, Yuri Sanchez Gonzalez, Alan L Shields
BACKGROUND AND AIMS: To inform their future use in regulated clinical trials to evaluate treatment efficacy hypotheses, the measurement properties of three histologic indices, Geboes Score (GS), Robarts Histopathology Index (RHI), and Nancy Index (NI), were evaluated among patients with ulcerative colitis. METHODS: Analyses were conducted on data from a Phase 3 clinical trial of adalimumab (M14-033, n=491) and focused on evaluating the measurement properties of the GS, RHI, and NI...
May 24, 2023: Journal of Crohn's & Colitis
#10
JOURNAL ARTICLE
Sailish Honap, Anne Buisson, Silvio Danese, Beaugerie Laurent, Laurent Peyrin-Biroulet
Participatory research, also referred to as patient and public involvement, is an approach that involves collaborating with patients affected by the focus of the research, on the design, development, and delivery of research to improve outcomes. There are two broad justifications for this; firstly, that it enhances the quality and relevance of research, and secondly, that it satisfies the ethical argument of patient inclusion for decisions about them. This synergistic and collaborative effort, which bridges the divide between researchers and participants with the lived condition, is now a mainstream activity and widely accepted as best practice...
May 23, 2023: Journal of Crohn's & Colitis
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JOURNAL ARTICLE
Joana Revés, André Mascarenhas, Maria José Temido, Bárbara Morão, Catarina Neto Nascimento, Ana Rita Franco, Raquel R Mendes, Carolina Palmela, Cristina Chagas, Pedro Narra Figueiredo, Luísa Glória, Francisco Portela, Joana Torres
BACKGROUND: Early biological therapy within the first 18-24 months after diagnosis is associated with improved clinical outcomes in Crohn's disease (CD). However, the definition of the best time to initiate biological therapy remains unclear. We aimed to assess if there is an optimal timing for early biological therapy initiation. METHODS: Multicentre retrospective cohort study including newly diagnosed CD patients who started anti-TNF therapy within 24 months from diagnosis...
May 23, 2023: Journal of Crohn's & Colitis
#12
JOURNAL ARTICLE
Nicolas Pierre, Sophie Vieujean, Laurent Peyrin-Biroulet, Marie-Alice Meuwis, Edouard Louis
In Crohn's disease, the treat-to-target strategy has been highly encouraged and became a standard of care. In this context, defining the target (remission) constitutes a major stake which fuels the literature. Currently, clinical remission (symptoms control) is no longer the only objective of treatments since it does not allow to well control inflammation-induced tissue damage. The introduction of endoscopic remission as a therapeutic target was clearly a progress but this examination remains invasive, costly, not well accepted by patients and does not allow a tight control of disease activity...
May 19, 2023: Journal of Crohn's & Colitis
#13
JOURNAL ARTICLE
Lisa Lou Schulze, Emily Becker, Mark Dedden, Li-Juan Liu, Chiara van Passen, Mariam Mohamed Abdou, Tanja M Müller, Maximilian Wiendl, Karen A-M Ullrich, Imke Atreya, Moritz Leppkes, Arif B Ekici, Philipp Kirchner, Michael Stürzl, Dan Sexton, Deborah Palliser, Raja Atreya, Britta Siegmund, Markus F Neurath, Sebastian Zundler
BACKGROUND AND AIMS: The anti-MAdCAM-1 antibody ontamalimab demonstrated efficacy in a phase II trial in UC and results of early terminated phase III trials are pending, but its precise mechanisms of action are still unclear. Thus, we explored the mechanisms of ontamalimab and compared it to the anti-α4β7 antibody vedolizumab. METHODS: We studied MAdCAM-1 expression with RNA sequencing and immunohistochemistry. The mechanisms of ontamalimab were assessed with fluorescence microscopy, dynamic adhesion and rolling assays...
May 19, 2023: Journal of Crohn's & Colitis
#14
(no author information available yet)
No abstract text is available yet for this article.
May 19, 2023: Journal of Crohn's & Colitis
#15
JOURNAL ARTICLE
Imogen S Stafford, James J Ashton, Enrico Mossotto, Guo Cheng, R Mark Beattie, Sarah Ennis
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with two main subtypes: Crohn's disease (CD) and Ulcerative Colitis (UC). Prompt subtype diagnosis enables the correct treatment to be administered. Using genomic data, we aimed to assess machine learning (ML) to classify patients according to IBD subtype. METHODS: Whole exome sequencing from paediatric/adult IBD patients was processed using an in-house bioinformatics pipeline. This data was condensed into the per-gene, per-individual genomic burden score, GenePy...
May 19, 2023: Journal of Crohn's & Colitis
#16
JOURNAL ARTICLE
Misha Kabir, Siwan Thomas-Gibson, Phil J Tozer, Janindra Warusavitarne, Omar Faiz, Ailsa Hart, Lisa Allison, Austin G Acheson, Semra Demirli Atici, Pearl Avery, Mantaj Brar, Michele Carvello, Matthew C Choy, Robin J Dart, Justin Davies, Anjan Dhar, Shahida Din, Bu'Hussain Hayee, Kesavan Kandiah, Konstantinos H Katsanos, Christopher Andrew Lamb, Jimmy K Limdi, Richard E Lovegrove, Pär Myrelid, Nurulamin Noor, Ioannis Papaconstantinou, Dafina Petrova, Polychronis Pavlidis, Thomas Pinkney, David Proud, Shellie Radford, Rohit Rao, Shaji Sebastian, Jonathan P Segal, Christian Selinger, Antonino Spinelli, Kathryn Thomas, Albert Wolthuis, Ana Wilson
BACKGROUND AND AIMS: Inflammatory Bowel Disease colitis-associated dysplasia is managed with either enhanced surveillance and endoscopic resection or prophylactic surgery. The rate of progression to cancer after a dysplasia diagnosis remains uncertain in many cases and patients have high thresholds for accepting proctocolectomy. Individualised discussion of management options is encouraged to take place between patients and their multidisciplinary teams for best outcomes. We aimed to develop a toolkit to support a structured, multidisciplinary and shared decision-making approach to discussions about dysplasia management options between clinicians and their patients...
May 12, 2023: Journal of Crohn's & Colitis
#17
JOURNAL ARTICLE
Steven Itzkowitz, Francis A Farraye, Paul Limburg, Zubin Gagrat, Marilyn C Olson, Julia Zella, John Kisiel
BACKGROUND & AIMS: The FDA-approved multitarget stool-DNA (mt-sDNA) test is a successful colorectal cancer (CRC) screening tool in average-risk individuals but is not indicated for patients with inflammatory bowel disease (IBD). We determined the performance of the mt-sDNA assay without the hemoglobin component (mt-sDNA Hgb-) in patients with IBD, while measuring sensitivity for colorectal cancer and advanced colorectal neoplasia (ACRN). METHODS: This was a multi-center, proof-of-concept investigation in persons aged 18-84 years with a diagnosis of IBD, or primary sclerosing cholangitis (PSC) with IBD...
May 11, 2023: Journal of Crohn's & Colitis
#18
JOURNAL ARTICLE
H Öhlmann, L R Lanters, N Theysohn, J Langhorst, H Engler, A Icenhour, S Elsenbruch
BACKGROUND AND AIMS: Despite relevance to pain chronicity, disease burden, and treatment, mechanisms of pain perception for different types of acute pain remain incompletely understood in patients with inflammatory bowel disease (IBD). Building on experimental research across pain modalities, we herein addressed behavioral and neural correlates of visceral versus somatic pain processing in women with quiescent ulcerative colitis (UC) compared to irritable bowel syndrome (IBS) as a patient control group, and healthy women (HC)...
May 10, 2023: Journal of Crohn's & Colitis
#19
JOURNAL ARTICLE
Emma Druvefors, Pär Myrelid, Roland E Andersson, Kalle Landerholm
BACKGROUND AND AIMS: Colectomy and reconstruction in patients with inflammatory bowel disease (IBD) may adversely affect fertility, but few population-based studies are available. METHODS: Fertility was assessed in 2,989 women and 3,771 men with IBD and prior colectomy 1964-2014, identified from the Swedish National Patient Register, and 35,092 matched individuals. RESULTS: Reconstruction with ileoanal pouch anastomosis (IPAA) was as common as ileorectal anastomosis (IRA) in ulcerative colitis (UC) and IBD-unclassified (IBD-U) while rare in Crohn's disease (CD)...
May 9, 2023: Journal of Crohn's & Colitis
#20
EDITORIAL
Peter M Irving
No abstract text is available yet for this article.
May 4, 2023: Journal of Crohn's & Colitis
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