journal
https://read.qxmd.com/read/29075356/jocb-bulletin
#1
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Journal of Chemical Biology
https://read.qxmd.com/read/29075355/design-synthesis-and-characterization-of-2-2-bis-2-4-dinitrophenyl-2-phosphonatomethylamino-acetate-as-a-herbicidal-and-biological-active-agent
#2
JOURNAL ARTICLE
Vijay Kumar, Simranjeet Singh, Rohit Singh, Niraj Upadhyay, Joginder Singh
The present study was designed to synthesize the bioactive molecule 2,2-bis(2,4-dinitrophenyl)-2-(phosphonatomethylamino)acetate ( 1 ), having excellent applications in the field of plant protection as a herbicide. Structure of newly synthesized molecule 1 was confirmed by using the elemental analysis, mass spectrometric, NMR, UV-visible, and FTIR spectroscopic techniques. To obtain better structural insights of molecule 1 , 3D molecular modeling was performed using the GAMESS programme. Microbial activities of 1 were checked against the pathogenic strains Aspergillus fumigatus (NCIM 902) and Salmonella typhimurium (NCIM 2501)...
October 2017: Journal of Chemical Biology
https://read.qxmd.com/read/29075354/design-and-synthesis-of-an-indol-derivative-as-antibacterial-agent-against-staphylococcus-aureus
#3
JOURNAL ARTICLE
Hau-Heredia Lenin, Figueroa-Valverde Lauro, Rosas-Nexticapa Marcela, Herrera-Meza Socorro, López-Ramos Maria, Díaz-Cedillo Francisco, García-Cervera Elodia, Pool-Gómez Eduardo, Paat-Estrella Josefa, Cauich-Carrillo Regina, Euan-Hau Saidy
Several indole derivatives with antibacterial activity have been prepared using different protocols; however, some require special reagents and conditions. The aim of this study involved the synthesis of some indole derivatives using estrone and OTBS-estrone as chemical tools. The synthesis of the indole derivatives involves reactions such as follows: (1) synthesis of two indol derivatives ( 4 or 5 ) by reaction of estrone or OTBS-estrone with phenylhydrazine in medium acid; (2) reaction of 4 or 5 with 6-cloro-1-hexyne in medium basic to form two hexynyl-indol ( 7 or 8 ); (3) preparation of indol-propargylic alcohol derivatives ( 10 or 11 ) by reaction of benzaldehyde with 7 or 8 in medium basic; (4) synthesis of indol-aldehydes ( 12 or 13 ) via oxidation of 10 or 11 with DMSO; (5) synthesis of indeno-indol-carbaldehyde ( 15 or 16 ) via alkynylation/cyclization of 12 or 13 with hexyne in presence of copper(II); (6) preparation indeno-indol-carbaldehyde complex ( 19 or 20 ) via alkynylation/cyclization of 12 or 13 with 1-(hex-5-yn-1-yl)-2-phenyl-1 H -imidazole...
October 2017: Journal of Chemical Biology
https://read.qxmd.com/read/29075353/last-issue-of-journal-of-chemical-biology
#4
EDITORIAL
Rudiger Woscholski, Banafshe Larijani
No abstract text is available yet for this article.
October 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28685001/jocb-bulletin
#5
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28685000/amphotericin-b-potentiates-the-anticancer-activity-of-doxorubicin-on-the-mcf-7-breast-cancer-cells
#6
JOURNAL ARTICLE
Farzaneh Tavangar, Hamid Sepehri, Marie Saghaeian Jazi, Jahanbakhsh Asadi
Despite the improvements in cancer treatment, breast cancer still remains the second most common cause of death from cancer in women. Doxorubicin (DOXO) is widely used for cancer treatment. However, drug resistance limits the treatment outcome. Here, we investigated the toxicity of DOXO in combination with an antifungal agent amphotericin B (AmB) against the MCF-7 breast cancer cell line. The cell viability was measured using MTT assay. The apoptosis was studied by caspase-8 and caspase-9 activity measurements and DNA fragmentation was investigated by TUNEL assay...
July 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28684999/mechanism-of-action-of-selective-inhibitors-of-il-6-induced-stat3-pathway-in-head-and-neck-cancer-cell-lines
#7
JOURNAL ARTICLE
Malabika Sen, Paul A Johnston, Netanya I Pollock, Kara DeGrave, Sonali C Joyce, Maria L Freilino, Yun Hua, Daniel P Camarco, David A Close, Donna M Huryn, Peter Wipf, Jennifer R Grandis
Studies indicate that elevated interleukin-6 (IL-6) levels engage IL6Rα-gp130 receptor complexes to activate signal transducer and activator of transcription 3 (STAT3) that is hyperactivated in many cancers including head and neck squamous cell carcinoma (HNSCC). Our previous HCS campaign identified several hits that selectively blocked IL-6-induced STAT3 activation. This study describes our investigation of the mechanism(s) of action of three of the four chemical series that progressed to lead activities: a triazolothiadiazine (864669), amino alcohol (856350), and an oxazole-piperazine (4248543)...
July 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28684998/bioactive-m-ii-complexes-of-amino-acid-based-n-3-o-donor-mixed-ligand-in-vitro-and-in-silico-dna-binding-studies
#8
JOURNAL ARTICLE
T Daniel Prakash, V Violet Dhayabaran
Three novel mixed ligand M(II) complexes, namely [CoL1 L2 Cl2 ] ( 1 ), [CuL1 L2 Cl2 ] ( 2 ), and [ZnL1 L2 Cl2 ] ( 3 ), were synthesized using 1,4-naphthoquinone, L-histidine, and 1,10-phenanthroline as ligands. The ligand framework and the corresponding structural changes on complexation were ascertained based on the results of elemental analysis, conductivity measurements, magnetic behavior, FT-IR, UV-visible, 1 H NMR, 13 C NMR, ESR spectral studies, and ESI mass spectrometry. The biological action of the ligand ( L ) and complexes 1 - 3 such as DNA binding and cleaving ability were studied...
July 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28684997/synthesis-of-tert-butyl-substituted-benzamido-phenylcarbamate-derivatives-anti-inflammatory-activity-and-docking-studies
#9
JOURNAL ARTICLE
Shankar Bhookya, Jalapathi Pochampally, Anil Valeru, Vianala Sunitha, Saikrishna Balabadra, Vijjulatha Manga, Karunakar Rao Kudle
A series of new tert -butyl 2-(substituted benzamido) phenylcarbamate (4a - 4j) were synthesized by the condensation of tert -butyl 2-amino phenylcarbamate ( 3 ) with various substituted carboxylic acid in the presence of EDCI and HOBt as coupling reagent, obtain in excellent yields. The structures of all newly synthesized compounds were characterized spectroscopically and evaluated for in vivo anti-inflammatory activity compared to the standard drug, indomethacin, by using the carrageenan-induced rat paw edema protocol...
July 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28684996/molecular-docking-pass-analysis-bioactivity-score-prediction-synthesis-characterization-and-biological-activity-evaluation-of-a-functionalized-2-butanone-thiosemicarbazone-ligand-and-its-complexes
#10
JOURNAL ARTICLE
Tahmeena Khan, Shalini Dixit, Rumana Ahmad, Saman Raza, Iqbal Azad, Seema Joshi, Abdul Rahman Khan
2-Butanone thiosemicarbazone ligand was prepared by condensation reaction between thiosemicarbazide and butanone. The ligand was characterized by 1 H NMR, 13 C NMR, FT-IR, mass spectrometry and UV spectroscopic studies. Docking studies were performed to study inhibitory action against topoisomerase II (Topo II) and ribonucleoside diphosphate reductase (RR) enzymes. Inhibition constants ( K i ) of the ligand were 437.87 and 327.4 μM for the two enzymes, respectively. The ligand was tested for its potential anticancer activity against two cancer cell lines MDA-MB-231 and A549 using MTT assay and was found to exhibit good activity at higher doses with an IC50  = 80 μM against human breast cancer cell line MDA-MB-231...
July 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28405242/jocb-bulletin
#11
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28405241/design-and-synthesis-of-a-new-steroid-macrocyclic-derivative-with-biological-activity
#12
JOURNAL ARTICLE
Maria López-Ramos, Lauro Figueroa-Valverde, Socorro Herrera-Meza, Marcela Rosas-Nexticapa, Francisco Díaz-Cedillo, Elodia García-Cervera, Eduardo Pool-Gómez, Regina Cahuich-Carrillo
The aims of this study were to evaluate the positive inotropic effect of a new macrocyclic derivative (compound 11 ) and characterize the molecular mechanism involved in its biological activity. The first step was achieved by synthesis of a macrocyclic derivative involving a series of reactions for the preparation of several steroid derivatives such as (a) steroid-pyrimidinone ( 3 and 4 ), (b) steroid-amino ( 5 ), (c) steroid-imino ( 6 ), (d) ester-steroid ( 7 and 8 ), and (e) amido-steroid ( 9 and 10 ). Finally, 11 was prepared by removing the tert -butyldimethylsilane fragment of 10 ...
April 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28405240/targeting-the-ubiquitin-conjugating-enzyme-e2d4-for-cancer-drug-discovery-a-structure-based-approach
#13
JOURNAL ARTICLE
Vishwanath Ramatenki, Ramakrishna Dumpati, Rajender Vadija, Santhiprada Vellanki, Sarita Rajender Potlapally, Rohini Rondla, Uma Vuruputuri
Cancer progression is a global burden. The incidence and mortality now reach 30 million deaths per year. Several pathways of cancer are under investigation for the discovery of effective therapeutics. The present study highlights the structural details of the ubiquitin protein 'Ubiquitin-conjugating enzyme E2D4' (UBE2D4) for the novel lead structure identification in cancer drug discovery process. The evaluation of 3D structure of UBE2D4 was carried out using homology modelling techniques. The optimized structure was validated by standard computational protocols...
April 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28101254/jocb-bulletin
#14
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28101253/2-chromon-3-yl-imidazole-derivatives-as-potential-antimicrobial-agents-synthesis-biological-evaluation-and-molecular-docking-studies
#15
JOURNAL ARTICLE
Shweta Sharma, Vishal Sharma, Gurpreet Singh, Harpreet Kaur, Shubham Srivastava, Mohan Paul S Ishar
A series of novel 2-(chromon-3-yl)-4,5-diphenyl-1H-imidazoles (4a-h) were synthesized by one pot condensation of substituted 3-formylchromones (1a-h), benzil (2) and ammonium acetate (3) in refluxing acetic acid at 110 °C under N2 atmosphere. Allylation of compounds 4a-h with allyl bromide in the presence of fused K2CO3 furnished N-allyl-2-(chromon-3-yl)-4,5-diphenyl-1H-imidazoles (6a-h). The synthesized compounds were characterized spectroscopically and evaluated for in vitro antimicrobial activity against various pathogenic bacterial and fungal strains by disc diffusion method...
January 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28101252/identification-of-proteins-from-wild-cardoon-flowers-cynara-cardunculus-l-by-a-proteomic-approach
#16
JOURNAL ARTICLE
Amal Ben Amira, Julien Bauwens, Edwin De Pauw, Souhail Besbes, Hamadi Attia, Frédéric Francis, Christophe Blecker
Proteomic approach was applied to identify total proteins, particularly the enzymatic content, from wild cardoon flowers. As the selection of an appropriate sample preparation method is the key for getting reliable results, two different extraction/precipitation methods (trichloroacetic acid and phenol/ammonium acetate) were tested on fresh and lyophilized flowers. After two-dimensional electrophoresis (2D-E) separations, a better protein pattern was obtained after phenol extraction from lyophilized flowers...
January 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28101251/antifungal-and-anthelmintic-activity-of-novel-benzofuran-derivatives-containing-thiazolo-benzimidazole-nucleus-an-in-vitro-evaluation
#17
JOURNAL ARTICLE
R Kenchappa, Yadav D Bodke, Sandeep Telkar, M Aruna Sindhe
A novel series of thiazolo[3,2-a]benzimidazole derivatives containing benzofuran nucleus (5a-l) have been synthesized. The key intermediate, substituted benzimidazol-sulfanyl benzofuran ethanone (3a-d) was prepared by refluxing the mixture of substituted 2-acetyl benzofuran and substituted 2-mercaptobenzimidazole in acetic acid. The cyclisation of compounds (3a-d) using polyphosphoric acid furnished the corresponding 6-substituted benzofuran thiazolo[3,2-a]benzimidazoles (4a-d). Further, the cyclized compounds (4a-d) were subjected for Mannich reaction to give corresponding Mannich bases (5a-l)...
January 2017: Journal of Chemical Biology
https://read.qxmd.com/read/28101250/is-phosphatidylglycerol-essential-for-terrestrial-life
#18
REVIEW
Samuel Furse
Lipids are of increasing importance in understanding biological systems. Lipids carrying an anionic charge are noted in particular for their electrostatic interactions with both proteins and divalent cations. However, the biological, analytical, chemical and biophysical data of such species are rarely considered together, limiting our ability to assess the true role of such lipids in vivo. In this review, evidence from a range of studies about the lipid phosphatidylglycerol is considered. This evidence supports the conclusions that this lipid is ubiquitous in living systems and generally of low abundance but probably fundamental for terrestrial life...
January 2017: Journal of Chemical Biology
https://read.qxmd.com/read/27698951/jocb-bulletin
#19
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Journal of Chemical Biology
https://read.qxmd.com/read/27698950/the-removal-of-mercury-ii-from-water-by-ag-supported-on-nanomesoporous-silica
#20
JOURNAL ARTICLE
Mohammad Ali Azizi Ganzagh, Mardali Yousefpour, Zahra Taherian
In this study, the synthesis of SBA-15/Ag nanocomposite materials with different amounts of silver (2.5, 5, and 10 %) has been investigated under acidic conditions by using P123 as a template via the direct method. The nanocomposites of SBA-15 were synthesized by the same method and by the addition of silver salt. Finally, the nanocomposite materials were examined for the removal of mercury ions from wastewater as an adsorbent by the reverse titration method. Characterization was carried out through x-ray diffraction analysis (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and N2 adsorption-desorption (Brunauer-Emmett-Teller)...
October 2016: Journal of Chemical Biology
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