journal
https://read.qxmd.com/read/38308551/prognosis-of-peritoneal-dialysis-patients-with-different-peritoneal-transport-characteristics-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Yangyang Xia, Chunming Jiang, Ying Liu, Qingyan Zhang, Yuan Feng, Miao Zhang
INTRODUCTION: We aimed to examine the clinical characteristics of peritoneal dialysis (PD) patients with different baseline peritoneal transport characteristics and the effect of peritoneal transport characteristics on the prognosis of PD patients. METHODS: Patients who received PD for more than 3 months were included. Clinical characteristics, risk factors for high peritoneal transport, and risk factors for death and technique failure were examined. All patients were treated with glucose-containing peritoneal dialysis solution, and the peritoneal dialysis protocol was either day ambulatory peritoneal dialysis (DAPD) or continuous ambulatory peritoneal dialysis (CAPD)...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308550/promotion-of-inflammation-apoptosis-and-inhibition-of-autophagy-by-overexpression-of-lncrna-snhg12-in-acute-kidney-injury
#2
JOURNAL ARTICLE
Jiaqing Zhang, Liang Li, Yanhui Yu, Yan Fang, Jian Li, Jinji Li
UNLABELLED: \Introduction. There is a dispute regarding the roles of newly discovered lncRNAs in acute kidney injury (AKI). Therefore, this study discussed long non-coding RNA (lncRNA) small nuclear host gene 12 (SNHG12) in AKI and its molecular mechanism. METHODS: Lipopolysaccharide (LPS) induction was treated into renal tubular epithelial cells (HK-2 cells) to induce septic AKI in vitro. In the cell model, SNHG12, miR-1270, and tubulin beta class I (TUBB) expression patterns, along with p-p65, cleaved caspase-3, Beclin-1, p62, and autophagy related 7 (ATG7) protein expressions, were determined by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) and Western blot...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308549/clinical-efficacy-and-long-term-prognosis-of-high-flux-hemodialysis-combined-with-different-frequency-hemodiafiltration-in-the-treatment-of-middle-aged-and-elderly-patients-with-uremia
#3
JOURNAL ARTICLE
Xiaoyan Jiang, Fengjun Sun, Haiyan Huang
INTRODUCTION: To analyze the clinical efficacy and long-term prognosis of high flux hemodialysis (HFHD) combined with different frequency hemodiafiltration (HDF) in uremic patients. METHODS: 86 middle-aged and elderly patients with uremia were divided into the HF group (HFHD combined with high-frequency HDF) and the LF group (HFHD combined with low-frequency HDF). The changes between the two groups in various indicators after 12 months of dialysis and the survival rate at 5 years of follow-up were compared...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308548/association-of-anthropometric-indices-with-albumin-to-creatinine-ratio-and-glomerular-filtration-rate-as-indices-of-ckd-a-population-based-study
#4
JOURNAL ARTICLE
Firouzeh Moinzadeh, Media Babahajiani, Marjan Mansourian, Hourinaz Taghvaee
INTRODUCTION: This study was an attempt to detect the relationship between chronic kidney disease (CKD) and anthropometric indices in presence of confounding variables. METHODS: A cross-sectional study of 3375 participants was designed in Isfahan city. Waist-height ratio (WHtR), waist-hip ratio (WHR), body mass index (BMI) and waist circumference (WC) were measured. Participants were divided into CKD and non-CKD groups according to the calculated albumin to creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR)...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308547/inhibition-of-pyroptosis-of-renal-tubular-epithelial-cells-by-puerarin-via-regulation-of-lncrna-neat1-ameliorating-chronic-renal-failure
#5
JOURNAL ARTICLE
Jing Yang, Baochao Li, Jiangming Wang, Wenxing Fan
INTRODUCTION: Chronic kidney disease (CKD) is one of the major chronic human diseases worldwide. Puerarin, extensively used in traditional Chinese medicine, has shown favorable clinical effects in treating CKD. Here, we aimed to elucidate the mechanism by which puerarin alleviates CKD. METHODS: We constructed an animal model of CKD and intragastrically administered 400 mg/kg puerarin to the rat models. The extent of kidney injury was evaluated by performing hematoxylin and eosin staining...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308546/the-outcome-of-pauci-immune-crescentic-glomerulonephritis-and-its-prognostic-factors-a-single-center-case-series
#6
JOURNAL ARTICLE
Neda Najafi, Sharzad Ossareh, Mitra Mehrazma, Mohsen Vahedi
INTRODUCTION: Pauci-immune crescentic glomerulonephritis (GN) is the most common cause of rapidly progressive GN in adults. The aim of this study was to determine the outcome of patients with pauci-immune crescentic GN and risk factors of the development of end-stage kidney disease (ESKD) in these patients. METHODS: This case series study was carried on 120 patients with pauci-immune crescentic GN biopsied in our center betwen 1998 and 2016. Inclusion criteria were age > 16 years, at least one crescentic glomerulus, maximally 1+ deposition of immunoglobulins and complement components at fluorescent microscopy, and at least 6 months follow-up...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308545/diabetic-kidney-disease-without-albuminuria-a-new-entity-in-diabetic-nephropathy
#7
JOURNAL ARTICLE
Nooshin Ahmadi, Atefeh Amouzegar
Non-albuminuric diabetic kidney disease (NA-DKD) is characterized by progressive loss of kidney function with an annual loss of estimated glomerular filtration rate (eGFR) more than 3 mL/ min/ 1.73m2 per year. NA-DKD is also associated with the late manifestation of diabetic kidney disease, characterized by reduced eGFR (< 60 mL/min/ 1.73m2), in the absence of albuminuria (urine albumin-to-creatinine ratio [UACR] less than 30 mg/g. The typical glomerular changes seen in diabetic nephropathy are less frequently observed in normoalbuminuric patients, while they predominantly show mesangial expansion and tubulointerstitial and vascular changes...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38043112/a-classical-phenotype-of-fabry-disease-with-novel-mutation-found-by-kidney-biopsy-a-case-report
#8
JOURNAL ARTICLE
Keiichiro Matsumoto, Marina Ishii, Masato Mizuta, Megumi Nakamura, Ryoko Matsumoto, Yuki Ikeda, Masatora Yamasaki, Makoto Fukuda, Motoaki Miyazono
Fabry disease (FD) is a multi-organ disorder caused by a deficiency of alpha-galactosidase (α-GLA) or reduced activity of the enzyme due to mutations in the GLA gene on the X chromosome, making it an X-linked hereditary disease. A 37-year-old man previously diagnosed with sudden deafness and cardiac hypertrophy was referred to our department after an abnormal urine finding during a public health checkup. A renal biopsy revealed characteristic findings, and he was diagnosed with FD with a novel GLA abnormality (c...
November 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38043111/abnormalities-of-the-serum-proteomic-in-thrombosis-after-cvc-catheterization-in-patients-with-end-stage-renal-disease
#9
JOURNAL ARTICLE
Li Wang, Xi Mei, Yangang Zhou, Jun Zeng, Ting Yang, Lumiu Liao, Man Xiong, Xiaoshan Zhao, Rui He
INTRODUCTION: This study utilized serum proteomics with tandem mass tags (TMT) to investigate potential biomarkers associated with femoral central venous catheter (CVC) thrombosis in endstage kidney disease (ESKD) patients. TMT proteomics analysis on serum samples was conducted to identify proteins with distinct expression levels that may be linked to thrombosis. The findings have important implications for enhancing anticoagulant procedures, catheter closure techniques, and determining optimal intervention timing for post-catheterization dialysis...
November 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38043110/role-and-mechanism-of-nup160-regulated-autophagy-in-pathogenesis-of-diabetic-nephropathy
#10
JOURNAL ARTICLE
Jiayong Xie, Ying Yuan, Gang Yao, Wenjuan Yu, Qiang Zhu
UNLABELLED: \Introduction. Diabetes mellitus (DM) is one of the most common chronic diseases worldwide, and diabetic nephropathy (DN) is the most significant complication of DM, which is highly prevalent and difficult to cure. This research project aims to investigate the role and mechanism of Nucleoporin 160kDa (NUP160)-regulated autophagy in the pathogenesis of DN. METHODS: NUP160 levels in diabetic and non-diabetic kidney tissues were measured by Western blot, and the connection between NUP160 and renal function of DN patients was analyzed...
November 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38043109/identification-of-phactr4-as-a-new-biomarker-for-diabetic-nephropathy-and-its-correlation-with-glomerular-endothelial-dysfunction-and-immune-infiltration
#11
JOURNAL ARTICLE
Baixue Yu, Mei Meng, Tingting Li, Yi Shi
INTRODUCTION: The pathophysiology of diabetic nephropathy (DN) is fundamentally dependent on glomerular endothelial cells (GECs), which are a crucial portion of the glomerular filtration barrier. This study aimed to identify biomarker candidates associated with GECs dysfunction in DN by combining microarray and single-cell sequencing dataset analysis. METHODS: Microarray dataset GSE30528 was downloaded from the Gene expression omnibus (GEO) database. Key gene sets for diabetic kidney disease (DKD) were selected by using weighted gene co-expression network analysis (WGCNA)...
November 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38043108/simple-memorable-formulas-for-screening-hypertension-in-children-based-on-the-new-american-academy-of-pediatrics-guideline
#12
JOURNAL ARTICLE
Afagh Hassanzadeh Rad, Jahangir Kamalpour, Behrad Badeli, Daniel Badeli, Hamidreza Badeli
INTRODUCTION: Hypertension (HTN), also known as high blood pressure (BP), is a major global risk factor for cardiovascular and kidney diseases. Although annual BP screenings for children over three years of age are recommended, underdiagnosis of HTN in children is common. To address this issue, the American Academy of Pediatrics updated its guideline for screening and managing high BP in children in 2017, which can be cumbersome to implement in clinical practice due to the numerous cut-off points and tables...
November 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38043107/role-of-farnesoid-receptors-and-nrf2-mediated-genes-in-gentamicin-induced-nephrotoxicity-in-rat-a-time-course-study
#13
JOURNAL ARTICLE
Mohammad Reza Ashrafi, Azadeh Khalili, Seyed Ali Hashemi, Roham Mazloom, Saeed Changizi-Ashtiyani, Gholamreza Bayat
INTRODUCTION: Farnesoid-X-activated receptor (FXR) is considered as an upstream controller which could influence the other key regulatory genes encoding cellular antioxidant defense system. METHODS: Thirty-five male Wistar rats (240 ± 20 g) were randomly allocated into five groups: 1) control, 2) received gentamicin (100 mg/kg/d) for three days (GM-3d), 3) seven days (GM-7d), 4) 10 days (GM-10d), and 5) 14 consecutive days (GM-14d). Biochemical measurements of BUN and serum creatinine (SCr), histological assessment of renal samples as well as molecular analysis using real-time qRT-PCR were used to investigate the pattern of changes in different levels...
November 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38043106/general-principles-of-vaccination-of-pediatric-candidates-of-kidney-transplant-in-iran
#14
JOURNAL ARTICLE
Shirin Sayyahfar, Masoumeh Mohkam, Nakysa Hooman, Foroozan Faress
Pediatric organ transplantation, specifically kidney transplant, has improved considerably in recent decades in Iran. Since infections are the most common cause of morbidity and mortality among transplanted children, pre-transplant vaccination is an effective preventive tool in this regard. In addition, administration of some vaccines is contraindicated in post- transplant period and the efficacy and immunogenicity of authorized vaccines may also be suboptimal in comparison to normal population. Therefore, pre-transplant period offers an outstanding chance to boost the immunization of this population...
November 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/37838938/a-hematopoietic-stem-cell-transplant-recipient-with-nephrotic-syndrome-and-immune-complex-deposits-in-tubular-basement-membrane-a-rare-case-report
#15
JOURNAL ARTICLE
Niloofar Nematollahi, Monir Sadat Hakemi, Farnaz Tavakoli, Fatemeh Nili
Following allogenic hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD) may develop which may affect several organs. Although the presence of nephrotic syndrome after HSCT is rare, sometimes it occurs in the setting of GVHD. The most common histological finding on kidney biopsy of patients with proteinuria owing to GVHD is membranous glomerulonephritis (MGN). However, reports of immune complex deposition in the tubular basement membrane (TBM) and glomerular basement membrane (GBM) are extremely rare...
September 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/37838937/impact-of-nanographene-oxide-on-cisplatin-induced-acute-kidney-injury-managed-by-stem-cells-therapy
#16
JOURNAL ARTICLE
Parvin Karimzadeh, Tahereh Foroutan, Mohsen Nafar, Sahar Kalavati
INTRODUCTION: Graphene-based nanomaterials have shown some degrees of stem cell protection against cell death. Due to their distinctive function, the kidneys are exposed to many toxic substances. On the other hand, minor and trivial effects of stem cells have been reported for the treatment of acute kidney injury (AKI). Here, we explain the use of Graphene oxide (GO) for improving the efficacy of mesenchymal stem cells (MSCs) in the treatment of Cisplatin-induced AKI. METHODS: In this study, GO particles were synthesized in our lab...
September 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/37838936/a-study-of-the-effectiveness-of-mobile-health-application-in-a-self-management-intervention-for-kidney-transplant-patients
#17
JOURNAL ARTICLE
Xiuyuan Xie, Xuejing Wang, Anqi Li, Yanhong Yan, Ting Lu, Yue Wu, Zheng Lin
INTRODUCTION: With the development of information technology in medical treatment, mobile medical treatment has become a new way to seek treatment, follow-up, extended care, popular science, disease prevention and access to disease expertise. The application of mobile medical treatment is relatively mature in the management of chronic diseases. Currently, mobile medical intervention is also introduced in the self-management of patients after Renal Transplantation. Compared with traditional intervention methods, mobile medical treatment has the advantages of convenience, speed, low cost and no geographical restriction, and it is easy to be used by KT recipients in self-management and has good feasibility...
September 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/37838935/covid-19-associated-acute-kidney-injury-the-incidence-and-associated-factors-in-different-kdigo-stages-among-the-hospitalized-patients
#18
JOURNAL ARTICLE
Jamshid Roozbeh, Anahid Hamidianjahromi, Aida Doostkam, Leila Malekmakan, Abolfazl Dorraninejad
INTRODUCTION: Acute kidney injury (AKI) is the most common reported renal complication associated with COVID-19. In this study, we evaluated the frequency of AKI, the predisposing factors, and its impact on the patient's outcomes in COVID-19. METHODS: By collecting retrospective data, we conducted a crosssectional study on hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients in a COVID-19- designated hospital in Shiraz, Iran, from March 2020 to June 2020...
September 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/37838934/the-effect-of-moringa-isothiocyanate-1-on-renal-damage-in-diabetic-nephropathy
#19
JOURNAL ARTICLE
Lijing Chen, Deyong Fan, Fei Guo, Jiuhong Deng, Linlin Fu
INTRODUCTION: Diabetic nephropathy (DN) is the most common clinical complication of diabetes mellitus. Moringa isothiocyanate-1 (MIC-1) is effective in the treatment of diabetes mellitus, but its mechanism of action in DN remains obscure. This research specifically probed the role of MIC-1 in modulating renal injury in DN. METHODS: Six db/m mice were assigned to control group and twelve db/db mice were randomly allocated to the db/db and db/db + MIC-1 groups. The body and kidney weights of the mice were monitored...
September 2023: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/37838933/long-term-outcomes-in-patients-with-membranous-nephropathy-a-retrospective-cohort-study-in-iran
#20
JOURNAL ARTICLE
Seyed Mehdi Hoseini, Neda Najafi, Mitra Mehrazma, Reihane Chegini, Mandana Rahimi, Mohsen Vahedi, Shahrzad Ossareh
INTRODUCTION: Membranous nephropathy (MN) has variable clinical outcomes, ranging from spontaneous remission to slow progression to kidney failure. Since the clinical outcomes of MN have not been studied in a large sample size in Iran, this study was designed to evaluate the outcome of patients diagnosed with MN at Hasheminejad Kidney Center (HKC), Tehran. METHODS: In this retrospective cohort study, 1086 patients with a diagnosis of MN who were biopsied between 1998 and 2018 in HKC were evaluated through a review of medical records for baseline clinical and laboratory characteristics at the time of biopsy and through a review of follow-up charts and phone calls for the evaluation of clinical outcomes...
September 2023: Iranian Journal of Kidney Diseases
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