journal
https://read.qxmd.com/read/38904341/nighttime-blood-pressure-abnormalities-in-iranian-ckd-patients-necessity-to-perform-ambulatory-blood-pressure-monitoring
#1
JOURNAL ARTICLE
Mohammad Taghi Najafi, Mohammad Reza Abbasi, Seyed Mansour Gatmiri, Mohammad Reza Khatami, Atefeh Mokhtardokht, Mohammad Hossein Shojamoradi
INTRODUCTION: Ambulatory blood pressure monitoring (ABPM) is a valuable tool for detecting abnormalities in nighttime blood pressure (BP), including non-dipping and nighttime hypertension. These abnormalities are independent predictors of a poor prognosis in patients with chronic kidney disease (CKD). The aim of our study  was to analyze ABPM data and evaluate nighttime BP abnormalities in an Iranian CKD population. METHODS: This cross-sectional study was conducted on sixty two patients at stages III and IV of CKD who were referred to a nephrology clinic in Tehran, Iran...
May 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38904340/shenqi-pill-mitigates-renal-interstitial-fibrosis-through%C3%A2-weakening-notch1-jag1-pathway
#2
JOURNAL ARTICLE
Hongshu Chen, Yuanxiao Yang, Xiaojie Zhou, Yaorong Feng
INTRODUCTION: Shenqi pill (SQP) can be used to treat various kidney related diseases, but its exact mechanism of action remains unclear. We intended to analyze the role and mechanism of SQP on renal interstitial fibrosis (RIF). METHODS: After performing unilateral ureteral obstruction (UUO) surgery following the Institutional Animal Care and Use Committee guidelines, all rats were assigned into the sham group, UUO group, UUO + SQP 1.5 g/kg, UUO + SQP 3 g/kg, and UUO + SQP 6 g/kg groups...
May 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38904339/tacrolimus-intrapatient-variability-on-graft-outcomes-in%C3%A2-adherent-renal-transplantation-patients-a-cross-sectional%C3%A2-study
#3
JOURNAL ARTICLE
Mohsen Nafar, Sara Keshtkari, Shadi Ziaie, Ahmad Firouzan, Nasrin Borumandnia, Nooshin Dalili, Fatemeh Poorrezagholi, Fariba Samadian, Shiva Samavat
INTRODUCTION: Tacrolimus is the mainstem of immunosuppressive therapy in kidney transplant patients. It has high intrapatient variability (Tac-IPV), which has been reported to affect graft function by predisposing patients to rejection or nephrotoxicity. We conducted this study with the aim of assessing the influence of Tac-IPV on 2-year graft function, biopsy-proven rejection, and infections in compliant renal recipients. METHODS: In this single-center retrospective analytic cross-sectional study, 250 patients who underwent transplantation from March 21, 2018, to March 20, 2020 and had at least three outpatient tacrolimus trough levels on the same daily dose 6 to 12 months after transplantation were recruited...
May 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38904338/association-between-the-g82s-polymorphism-of-the%C3%A2-receptor-gene-for-advanced-glycation-end-products-and%C3%A2-soluble-serum-levels-rage-with-diabetic-nephropathy-in%C3%A2-the-white-asian-race
#4
JOURNAL ARTICLE
Asma Rezaei Arnesa, Sepideh Hajian, Saeede Salemi Bazargani, Iman Salahshourifar, Sahar Moghbelinejad, Zohreh Abdolvahabi, Hayedeh Yaghoobzadeh, Mojtaba Fathi, Hossein Piri
INTRODUCTION: Diabetic nephropathy is one of the most common severe symptoms of diabetes mellitus. Hyperglycemia can lead to tissue damage and inflammation due to mediators such as receptor for advanced glycation end-products (RAGE). Therefore, in this study, we aimed to investigate the association between the G82S polymorphism of the RAGE gene and diabetic nephropathy in diabetic patients. METHODS: In this case-control study, 356 participants (158 men and 198 women) of Asian race, aged 45 to 65 years, who were diagnosed with type 2 diabetes mellitus based on their fasting plasma glucose levels were enrolled...
May 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38904337/mir-33a-overexpression-exacerbates-diabetic-nephropathy%C3%A2-through-sirt6-dependent-notch-signaling
#5
JOURNAL ARTICLE
Yingying Wang, Shasha Dai, Jing Yang, Jun Ma, Peng Wang, Xiaowei Zhao, Jua Liu, Ao Xiao, Yahui Song, Lipin Gao
INTRODUCTION: Diabetic nephropathy (DN) belongs to the major cause of end-stage kidney disease. We probed the functions of a microRNA miR-33a in inducing podocytes injury during childhood  DN (CDN). METHODS: Kidney samples were collected from 20 children with DN. Matrix deposition and glomerular basement membranes thickness were examined by periodic acid-Schiff staining. Immunofluorescence staining was performed to assess kidney function-related proteins. MicroRNA (MiR)-33a mimic together with miR-33a inhibitor was transfected into podocytes for determining the roles of miR-33a...
May 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38904336/trends-in-research-on-acute-kidney-injury-a-bibliometric%C3%A2-analysis-of-academic-journals-published-between-the-years%C3%A2-2000-and-2022
#6
JOURNAL ARTICLE
Yunxi Tao, Shenglong Xu, Xuhua Ge
Acute kidney injury (AKI) is a significant global health concern that was first recognized in 2004 and has subsequently affected more than thirteen million individuals each year, resulting in 1.7 million deaths. The present study explored the evolving of the research on AKI worldwide, specifically addressing the analysis of the  trends between the years 2000 and 2022 using the Web of Science Core Collection (WOSCC). CiteSpace software was employed to analyze 19,741 literature sources, which revealed shifts in keyword dynamics from foundational disease research to treatment prognosis and humanistic care...
May 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660700/attenuating-renal-interstitial-fibrosis-by-shenqi-pill-via%C3%A2-reducing-inflammation-response-regulated-by-nf-%C3%AE%C2%BAb%C3%A2-pathway-in-vitro-and-in-vivo
#7
JOURNAL ARTICLE
Hongshu Chen, Yuanxiao Yang, Xiaojie Zhou, Yaorong Feng
INTRODUCTION: One of the most significant clinical features of chronic  kidney disease is renal interstitial fibrosis (RIF). This study aimed  to investigate the role and mechanism of Shenqi Pill (SQP) on RIF. METHODS: RIF model was established by conducting unilateral  ureteral obstruction (UUO) surgery on rat or stimulating human  kidney-2 (HK-2) cell with transforming growth factor β1 (TGFβ1).  After modeling, the rats in the SQP low dose group (SQP-L), SQP  middle dose group (SQP-M) and SQP high dose group (SQP-H)  were treated with SQP at 1...
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660699/correlation-between-the-8-hydroxy-2-deoxyguanosine-level%C3%A2-in-the-peritoneal-solution-of-patients-undergoing-peritoneal%C3%A2-dialysis-and-the-peritoneal-equilibration-test-kt-v-ferritin-%C3%A2-and-albumin-levels
#8
JOURNAL ARTICLE
Hadi Khanifar, Leila Mahmoodnia
INTRODUCTION: Peritoneal dialysis (PD) is an effective treatment  modality for advanced kidney failure, offering patients a significant  degree of independence. However, the long-term use of PD is  limited due to the degeneration of the peritoneal membrane,  resulting in reduced dialysis adequacy. Evaluating the peritoneal  membrane condition in patients with advanced kidney failure  who are undergoing PD is challenging with existing methods.  Therefore, this study aimed to investigate the correlation between  8-hydroxy-2'-deoxyguanosine (8OHDG) levels in the peritoneal  solution of patients undergoing PD and various factors, such  as peritoneal equilibration test (PET), dialysis adequacy (Kt/V),  underlying diseases, serum ferritin, and albumin levels...
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660698/microvesicles-from-mesenchymal-stem-cells%C3%A2-overexpressing-mir-34a-ameliorate-renal-fibrosis-in-vivo
#9
JOURNAL ARTICLE
Yan Wang, Ping Hu, Yangping Li, Ruijuan Dong, Juan He
We recently discovered that microvesicles (MVs)  derived from mesenchymal stem cells (MSCs) overexpressing  miRNA-34a can alleviate experimental kidney injury in mice. In  this study, we further explored the effects of miR34a-MV on renal  fibrosis in the unilateral ureteral obstruction (UUO) models.  Methods. Bone marrow MSCs were modified by lentiviruses  overexpressing miR-34a, and MVs were collected from the  supernatants of MSCs. C57BL6/J mice were divided into control,  unilateral ureteral obstruction (UUO), UUO + MV, UUO + miR-34aMV and UUO + miR-34a-inhibitor-MV groups...
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660697/case-of-igg4-related-disease-with-crescentic%C3%A2-glomerulonephritis-an-unusual-presentation-of-the-disease
#10
JOURNAL ARTICLE
Azin Ghaffari, Mitra Mehrazma, Shahrzad Ossareh
IgG4-related disease (IgG4-RD) is a chronic systemic inflammatory  disease, characterized by tissue infiltration of lymphocytes and  IgG4-secreting plasma cells, presenting by fibrosis of different  tissues, which is usually responsive only to oral steroids therapy.  Kidneys are the most commonly involved organs, exhibiting renal  insufficiency, tubulointerstitial nephritis, and glomerulonephritis.  Here, we describe a patient with acute renal insufficiency who  was presented with edema, weakness, anemia and multiple  lymphadenopathies...
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660696/risk-factors-and-clinical-characterization-of-cardiovascularand-cerebrovascular-events-in-elderly-hemodialysis-patients
#11
JOURNAL ARTICLE
Wei Liu, Hong Ze Wang, Ying Shi, Weiqiang Shen, Mingyan Dai
INTRODUCTION: The purpose of this study was to assess the risk factors and clinical characteristics of cardiovascular and cerebrovascular events in elderly hemodialysis patients. METHODS: Elderly patients undergoing hemodialysis (HD) at Deqing County People's Hospital in Zhejiang, China, from May 2020 to May 2023 were enrolled in this study. They were divided into two groups depending on the occurrence of cardiovascular or cerebrovascular events: the case group and the control group...
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660695/risk-factors-analysis-of-aki-in-patients-with-primary-non-small-cell-lung-cancer-treated-with-pd-1-pd-l1-inhibitor
#12
JOURNAL ARTICLE
Jiong-Ming Ying, Feng Yan
INTRODUCTION: To investigate the risk factors of Programmed Cell Death Protein 1 (PD-1), Programmed Cell Death Ligand 1(PD-L1) inhibitor associated acute kidney injury (AKI) in patients with primary non-small cell lung cancer (NSCLC) and construct a predictive model. METHODS: 120 NSCLC patients were selected as the research subjects and their clinical data were collected. Patients were divided into AKI and Non-AKI (N-AKI) group based on the development of AKI. Exploring the risk factors of PD-1P/D-L1 inhibitor related AKI in NSCLC patients using multivariate logistic regression analysis and visualized the logistic regression analysis to obtain a nomogram model...
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660694/conceptual-approach-to-body-fluids-and-edema-education%C3%A2-determines-clinical-outcomes-in-heart-failure
#13
JOURNAL ARTICLE
Mohammad A Shafiee, Amireza Goli, Pouyan Shaker, Vishal Sharma, Yasmin Shahideh, Khrystyna Maryniak, Behrooz Broumand
In this brief communication, we reemphasize the importance of critical thinking in clinical practice using the example of edema. The common practice of thinking and inquiry by practicing clinicians has beneficial implications for healthcare by improving outcomes and patient care while alleviating the burden of misconceptions in practice. We provide an in-depth and interactive investigation of physiological concepts as a foundation for understanding body fluid dynamics. Finally, we offer a new classification of symptoms of heart failure...
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660693/erratum
#14
JOURNAL ARTICLE
Admin Admin
No Abstract. </p><p>DOI: <a href="https://dx.doi.org/10.52547/ijkd.8206" target="_blank">10.52547/ijkd.8206</a></p>.
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38660692/mind-the-gap-in-kidney-care-translating-what-we-know%C3%A2-into-what-we-do
#15
JOURNAL ARTICLE
Valerie A Luyckx, Katherine R Tuttle, Dina Abdellatif, Ricardo Correa-Rotter, Winston W S Fung, Agnès Haris, Li-Li Hsiao, Makram Khalife, Latha A Kumaraswami, Fiona Loud, Vasundhara Raghavan, Stefanos Roumeliotis, Marianella Sierra, Ifeoma Ulasi, Bill Wang, Siu-Fai Lui, Vassilios Liakopoulos, Alessandro Balducci, Or The World Kidney Day Joint Steering Committee
Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target...
March 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308551/prognosis-of-peritoneal-dialysis-patients-with-different-peritoneal-transport-characteristics-a-retrospective-cohort-study
#16
JOURNAL ARTICLE
Yangyang Xia, Chunming Jiang, Ying Liu, Qingyan Zhang, Yuan Feng, Miao Zhang
INTRODUCTION: We aimed to examine the clinical characteristics of peritoneal dialysis (PD) patients with different baseline peritoneal transport characteristics and the effect of peritoneal transport characteristics on the prognosis of PD patients. METHODS: Patients who received PD for more than 3 months were included. Clinical characteristics, risk factors for high peritoneal transport, and risk factors for death and technique failure were examined. All patients were treated with glucose-containing peritoneal dialysis solution, and the peritoneal dialysis protocol was either day ambulatory peritoneal dialysis (DAPD) or continuous ambulatory peritoneal dialysis (CAPD)...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308550/promotion-of-inflammation-apoptosis-and-inhibition-of-autophagy-by-overexpression-of-lncrna-snhg12-in-acute-kidney-injury
#17
JOURNAL ARTICLE
Jiaqing Zhang, Liang Li, Yanhui Yu, Yan Fang, Jian Li, Jinji Li
UNLABELLED: \Introduction. There is a dispute regarding the roles of newly discovered lncRNAs in acute kidney injury (AKI). Therefore, this study discussed long non-coding RNA (lncRNA) small nuclear host gene 12 (SNHG12) in AKI and its molecular mechanism. METHODS: Lipopolysaccharide (LPS) induction was treated into renal tubular epithelial cells (HK-2 cells) to induce septic AKI in vitro. In the cell model, SNHG12, miR-1270, and tubulin beta class I (TUBB) expression patterns, along with p-p65, cleaved caspase-3, Beclin-1, p62, and autophagy related 7 (ATG7) protein expressions, were determined by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) and Western blot...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308549/clinical-efficacy-and-long-term-prognosis-of-high-flux-hemodialysis-combined-with-different-frequency-hemodiafiltration-in-the-treatment-of-middle-aged-and-elderly-patients-with-uremia
#18
JOURNAL ARTICLE
Xiaoyan Jiang, Fengjun Sun, Haiyan Huang
INTRODUCTION: To analyze the clinical efficacy and long-term prognosis of high flux hemodialysis (HFHD) combined with different frequency hemodiafiltration (HDF) in uremic patients. METHODS: 86 middle-aged and elderly patients with uremia were divided into the HF group (HFHD combined with high-frequency HDF) and the LF group (HFHD combined with low-frequency HDF). The changes between the two groups in various indicators after 12 months of dialysis and the survival rate at 5 years of follow-up were compared...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308548/association-of-anthropometric-indices-with-albumin-to-creatinine-ratio-and-glomerular-filtration-rate-as-indices-of-ckd-a-population-based-study
#19
JOURNAL ARTICLE
Firouzeh Moinzadeh, Media Babahajiani, Marjan Mansourian, Hourinaz Taghvaee
INTRODUCTION: This study was an attempt to detect the relationship between chronic kidney disease (CKD) and anthropometric indices in presence of confounding variables. METHODS: A cross-sectional study of 3375 participants was designed in Isfahan city. Waist-height ratio (WHtR), waist-hip ratio (WHR), body mass index (BMI) and waist circumference (WC) were measured. Participants were divided into CKD and non-CKD groups according to the calculated albumin to creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR)...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38308547/inhibition-of-pyroptosis-of-renal-tubular-epithelial-cells-by-puerarin-via-regulation-of-lncrna-neat1-ameliorating-chronic-renal-failure
#20
JOURNAL ARTICLE
Jing Yang, Baochao Li, Jiangming Wang, Wenxing Fan
INTRODUCTION: Chronic kidney disease (CKD) is one of the major chronic human diseases worldwide. Puerarin, extensively used in traditional Chinese medicine, has shown favorable clinical effects in treating CKD. Here, we aimed to elucidate the mechanism by which puerarin alleviates CKD. METHODS: We constructed an animal model of CKD and intragastrically administered 400 mg/kg puerarin to the rat models. The extent of kidney injury was evaluated by performing hematoxylin and eosin staining...
January 2024: Iranian Journal of Kidney Diseases
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