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Iranian Journal of Kidney Diseases

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https://read.qxmd.com/read/30595569/sofosbuvir-and-daclatsvir-in-treatment-of-hepatitis-c-virus-related-membranoproliferative-glomerulonephritis-with-cryoglobulinemia-in-a-patient-with-hepatitis-c-genotype-4
#1
Ahmed Yahia Elmowafy, Hanzada Mohamed El Maghrabi, Mohamed Ahmed Zahab, Salwa Mahmoud Elwasif, Mohamed Adel Bakr
Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia. Treatment with interferon plus ribavirin, steroid, and cyclophosphamide was tried but failed. After introduction of a sofosbuvir-based regimen to the treatment, sustained virologic response was achieved and nephrotic syndrome remission was induced successfully...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30595568/c3-glomerulonephritis-with-multiple-mutations-in-complement-factor-h
#2
Nooshin Dalili, Babak Behnam, Farzaneh Vali, Mahmoud Parvin, Peyman Torbati, Nakisa Rasaii, Fariba Samadian, Pedram Ahmadpoor
Complement C3 glomerulopathy refers to a disease process in which abnormal control of complement activation or degradation results in predominant C3 fragment deposition within the glomerulus and causes glomerular damage. Abnormal control of the complement alternative pathway is a well-established risk factor for the occurrence of C3 glomerulonephritis. It is the first reported case in Iran with multiple mutations in complement factor H, with one of these mutations we have expected in hemolytic uremic syndrome rather than C3 glomerulopathy Genetic analysis showed that the molecular abnormalities of factor H led to complement factor H malfunction that were polymorphous and not restricted to the C-terminal domains of the protein...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30595567/downregulation-of-profibrotic-gene-expression-by-angiotensin-receptor-blockers
#3
Mohsen Nafar, Shiva Samavat, Elham Shahraki
INTRODUCTION: Chronic allograft nephropathy is characterized by interstitial fibrosis and tubular atrophy. The main players in the process of fibrosis are transforming growth factor-β (TGF-β) and miR-21 expression with a bidirectional interplay. This study aimed to evaluate the effects of angiotensin receptor type 1 antagonist, losartan, on peripheral blood and tissue expression of TGF-β and miR-21 and histologic findings in allograft biopsy in kidney transplant recipients. MATERIALS AND METHODS: In a randomized controlled trial, 54 patients were enrolled and divided randomly into 2 groups...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30595566/prevalence-of-pulmonary-hypertension-in-end-stage-renal-disease-patients-undergoing-hemodialysis-and-peritoneal-dialysis-at-a-referral-center-in-mashhad-iran-from-2015-to-2016
#4
Maryam Miri, Sepideh Hejazi, Forough Maghsoudlou, Mahnaz Ahmadi
INTRODUCTION: Pulmonary artery hypertension is a serious comorbidityof dialysis in patients with end-stage renal disease. The prevalence of dialysis-induced pulmonary artery hypertension is still a subject of debate. The aim of this study was to determine the prevalence of pulmonary artery hypertension in patients undergoing hemodialysis and peritoneal dialysis. MATERIALS AND METHODS: This cross-sectional study was conducted on patients undergoing either hemodialysis or peritoneal dialysis in Montaserieh Dialysis Center in Mashhad, Iran during 2015 and 2016...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30595565/treatment-effect-of-ergocalciferol-on-bone-metabolism-indexes-and-parathyroid-hormone-in-hemodialysis-patients
#5
Bahman Bashardoust, Anahita Zakeri, Nasrin Fouladi, Zeinab Izadi, Fariba Hosseini
INTRODUCTION: Vitamin D deficiency is a common problem in end-stage renal disease patients under hemodialysis. Both active and nutritional vitamin D supplementation have been recommended for its treatment. In this study we aimed to evaluate the effects of treatment with ergocalciferol on bone metabolism indexes in hemodialysis patients. MATERIALS AND METHODS: In a randomized controlled trial, 40 hemodialysis patients were randomly allocated to the intervention (n = 20) and placebo (n = 20) groups...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30595564/molecular-genetic-analysis-of-pkhd1-mutations-in-pedigrees-with-autosomal-recessive-polycystic-kidney-disease
#6
Fatemeh Bitarafan, Masoud Garshasbi
INTRODUCTION: A wide variety of mutations are spread throughout the PKHD1 gene, which encodes a 4074-bp amino acid protein, namely fibrocystin/polyductin, and is responsible for all features of autosomal recessive polycystic kidney disease (ARPKD). Autosomal recessive polycystic kidney disease is a hereditary early-onset form of polycystic kidney disease characterized by fusiform dilation of collecting ducts and congenital hepatic fibrosis. The highest level of PKDH1 expression is in the kidneys of fetus and adults, suggesting the functionally importance of the gene in the mature kidney in addition to its role in kidney development...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30595563/trpc6-mutational-analysis-in-iranian-children-with-focal-segmental-glomerulosclerosis
#7
Alaleh Gheissari, Rokhsareh Meamar, Majid Kheirollahi, Maedeh Rouigari, Moein Dehbashi, Leila Dehghani, Amin Abedini
INTRODUCTION: Focal segmental glomerulosclerosis (FSGS) ranks among nephrotic syndromes. Research shows that FSGS is brought about by several genes including transient receptor potential cation channel subfamily c member 6 (TRPC6). This study aimed to investigate TRPC6 gene in Iranian FSGS children. MATERIALS AND METHODS: Twenty-six FSGS patients were included. They were all under 16 years old. Polymerase chain reaction amplification and sequencing were performed to examine exons 2 and 13 of TRPC6 gene...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30595562/brachial-artery-flow-mediated-dilatation-and-carotid-intima-media-thickness-in-children-with-idiopathic-nephrotic-syndrome
#8
Doaa Mohammed Youssef, Mohamed Abdelsalam Gomaa, Ahmed El-Akhras, Sabry Abdel Rahman Tolba, Ghada Mohamed Abd Allah, Osama Daoud, Sameh Saber
INTRODUCTION: Disturbances of lipid metabolism has been reported in nephrotic syndrome (NS) and may predispose to atherosclerosis. This study aimed to investigate the correlation between cardiovascular risk factors and carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilatation in patients with idiopathic NS. MATERIALS AND METHODS: This case-control study included 31 patients with NS and 31 healthy individuals as the control group. All patients were subjected to full clinical examination; laboratory investigations in the form of lipid profile, kidney function tests, serum protein, serum albumin, C-reactive protein, and ferritin; carotid ultrasonography, and brachial artery flow-mediated dilatation...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30595561/cyclosporine-in-pediatric-nephrology
#9
Seçil Arslansoyu Camlar, Alper Soylu, Salih Kavukçu
Cyclosporine began to be used as one of the immunosuppressive agents in transplantation in the beginning of the 1980s, and in the treatment of nephrotic syndrome in the pediatric nephrology. Therapeutic area of cyclosporine is narrow and its side effects limit its usage. Preference for cyclosporine and tacrolimus as a calcineurin inhibitor is left for the choice of the department. There are still countries with preferred-cyclosporine use because of economic reasons. Cyclosporine is currently being used in the treatment of nephrotic syndrome, but due to its high relapse rates in a short-term use, and nephrotoxicity in long-term use, search for new drugs with fewer side effects keeps continuing...
November 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367025/successful-treatment-of-posttransplant-recurrent-complement-c3-glomerulopathy-with-eculizumab
#10
Hatice Sahin, Ebru Gok Oguz, Hadim Akoglu, Gokhan Atilgan, Gulay Ulusal Okyay, Guner Karaveli Gursoy, Tugba Kip Teymur, Dilek Ertoy, Basol Canbakan, Mehmet Deniz Ayli
Two-thirds of complement C3 glomerulopathy (C3G) recur after transplantation and commonly cause graft loss. There is not a standard treatment protocol for these cases. We present a kidney transplant patient with recurrent C3G who was successfully treated with eculizumab. Nephrotic proteinuria and hematuria occurred and creatinine levels increased after transplantation. A graft biopsy revealed recurrent C3G. The patient was administered 250 mg pulse methylprednisolone for 3 days and had 9 sessions of plasmapheresis...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367024/cutaneous-infection-with-mycobacterium-haemophilum-in-an-immunocompromised-patient
#11
Sara Abolghasemi, Fatemeh Abbasi, Shabnam Tehrani, Mohsen Nafar, Mohammad Javad Nasiri
Mycobacterium haemophilum is a fastidious nontuberculosis Mycobacterium that must be considered in the differential diagnosis of infections in immunocompromised patients. Mycobacterium haemophilum typically is a pathogen of the cutaneous or subcutaneous tissue and also presents as septic arthritis, osteomyelitis, pulmonary disease, and lymphadenitis. We report a 32-year-old man with past medical history of kidney transplantation, endocarditis, gastrointestinal bleeding, and hypertension, complaining of multiple painful nodular lesions since 3 months earlier...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367023/association-of-forkhead-box-p3-gene-polymorphisms-with-allograft-rejection-episodes-in-kidney-transplant-patients-a-study-from-kashmir-north-india
#12
Zubair Khuja, Manzoor Parry, Roohi Rasool, Abdul Rashid Reshi
INTRODUCTION: The forkhead box P3 (FOXP3) gene is important for regulation and development of T cells, which are mediators of kidney allograft rejection. The FOXP3 gene polymorphism may be associated with the rejection of kidney transplants. This study was designed to determine the association of FOXP3 polymorphism with kidney transplant rejection. MATERIALS AND METHODS: A total of 118 kidney transplant patients were included in this study and were grouped into rejection (n = 31) and nonrejection (n = 87) groups...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367022/serum-matrix-metalloproteinase-9-tissue-inhibitor-of-metalloproteinase-1-and-matrix-metalloproteinase-9-neutrophil-gelatinase-associated-lipocalin-complex-levels-in-patients-with-early-stage-diabetic-nephropathy
#13
Gokhan Cakirca, Faruk Hilmi Turgut
INTRODUCTION: This study was aimed to investigate the efficacy of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the neutrophil gelatinase-associated lipocalin (NGAL)-bound form of MMP-9 (MMP-9/NGAL complex) markers in the determination of early nephropathy in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Twenty-five type 2 diabetic patients with normoalbuminuria, 27 type 2 diabetic patients with microalbuminuria, and 23 healthy controls were recruited...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367021/myocardial-function-in-egyptian-pediatric-patients-with-acute-nephritic-syndrome
#14
Mohamed N El-Gamasy, Walid Ahmed El-Shehaby
INTRODUCTION: Acute nephritic syndrome (ANS) is the most common cause of hypertensive heart failure in pediatric population. There are few publications on myocardial evaluation using electrocardiographic and echocardiographic data in pediatric patients with ANS. This study aimed to evaluate myocardial function by electrocardiography and 2-dimensional echocardiography in Egyptian pediatric patients with ANS. MATERIALS AND METHODS: Sixty children with ANS were included and subjected to clinical, laboratory, electrocardiography for corrected QT interval, and 2-dimensional echocardiographic study on admission, and repeated at 6 and 12 weeks to measure left ventricular ejection fraction, left atrium-aorta ratio, and the ratio of peak early filling (E wave) to late diastolic filling (A wave) velocities (E/A ratio)...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367020/efficacy-and-safety-of-mycophenolate-mofetil-versus-intravenous-pulse-cyclophosphamide-as-induction-therapy-in-proliferative-lupus-nephritis
#15
Leyla Gadakchi, Mehrzad Hajialilo, Mohammad-Reza Nakhjavani, Sima Abedi Azar, Sousan Kolahi, Morteza Gojazadeh, Ali-Asghar Ebrahimi, Aida Malek Mahdavi, Hamid Noshad, Alireza Khabbazi
INTRODUCTION: Lupus nephritis is a common and severe manifestation of systemic lupus erythematosus that can lead to end-stage renal disease and death. The aim of this study was to compare the efficacy and safety of mycophenolate mofetil (MMF) and cyclophosphamide as induction therapy and subsequently as maintenance therapy for lupus nephritis. MATERIALS AND METHODS: In this retrospective case-control study, 67 patients with proliferative lupus nephritis who were treated with MMF (n = 45) and pulse of intravenous cyclophosphamide (n = 22) were included...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367019/effect-of-sevelamer-on-serum-levels-of-klotho-and-soluble-tumor-necrosis-factor-like-weak-inducer-of-apoptosis-in-rats-with-adenine-induced-chronic-kidney-disease
#16
Zahra Golmohamadi, Hassan Argani, Amir Ghorbanihaghjo, Nadereh Rashtchizadeh, Nasrin Bargahi, Mehran Mesgari, Davoud Sanajou
INTRODUCTION: Nontraditional risk factors for cardiovascular disease (CVD), including mineral disorder, high fibroblast growth factor 23 (FGF23), low klotho, and low soluble TWEAK could predict the incipient risk of CVD in chronic kidney disease (CKD). The present study evaluates the effect of sevelamer on soluble tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and klotho levels in adenine-induced CKD rats. METHODS AND MATERIALS: Normal control rats without sevelamer were compared with 3 groups of adenine-induced CKD rats, including CKD rats without sevelamer, CKD rats treated with 3% sevelamer, and rats receiving adenine and 3% sevelamer concurrently...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367018/association-of-vitamin-d-deficiency-with-increased-pulse-wave-velocity-and-augmentation-index-in-children-with-chronic-kidney-disease
#17
Seçil Conkar, Sevgi Mir, Eser Dogan, Zulal Ülger Tutar
INTRODUCTION: It is known that in children with chronic kidney disease (CKD), cardiovascular damage starts in the form of arterial stiffness. There are risk factors other than the traditional ones such as arterial stiffness hypertension, obesity, hypercholesterolemia, and insulin resistance. Vitamin D deficiency is rather common in CKD, and it was introduced as a risk factor for atherosclerosis; however, its relationship with arterial stiffness is not known completely. The purpose of this study was to research the relationship between 25-hydroxyvitamin D levels and arterial stiffness...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367017/prevalence-and-associated-factors-of-chronic-kidney-disease-among-patients-infected-with-human-immunodeficiency-virus-in-cameroon
#18
Halle Marie Patrice, Oumarou Moussa, Kaze Francois, Mapoure Yacouba, Mbatchou Hugo, Luma Henry
INTRODUCTION: Chronic kidney disease (CKD) is frequent amongst human immunodeficiency virus (HIV)-positive patients, and screening is not routinely performed in Sub-Saharan Africa due to resource constraints. We aimed to determine the prevalence of CKD and associated factors in HIV-infected patients in Cameroon. MATERIALS AND METHODS: A cross-sectional study in Northern Cameroon included HIV-positive patients who attended the HIV clinic. Patients with an estimated glomerular filtration rate less than 60 mL/min/1...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367016/acute-kidney-injury-risk-recognition-in-resource-sufficient-versus-resource-limited-regions
#19
Nooshin Dalili, Kianoush Kashani
Acute kidney injury is a very common complication of acute illnesses with dire consequences. There are significant differences in incidence, etiology, severity, and clinical impact of acute kidney injury between resource-sufficient and resource-limited regions. Awareness of such differences would potentially allow clinicians and policymakers to devise and provide region-specific interventions to decrease the incidence of acute kidney injury and mitigate its complications. In this review article, we describe the similarities and differences of acute kidney injury risk factors and risk stratifications based on the level of resource availability in different regions...
October 2018: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/30367015/potential-adverse-effects-of-creatine-supplement-on-the-kidney-in-athletes-and-bodybuilders
#20
Dorna Davani-Davari, Iman Karimzadeh, Shahrokh Ezzatzadegan-Jahromi, Mohammad Mahdi Sagheb
INTRODUCTION: Nowadays, creatine is one of the most common oral supplements used by professional athletes for boosting their strength and muscle mass. In this review, we collect available experimental and clinical data about renal safety of both short-term and long-term use of creatine. MATERIALS AND METHODS: Scientific literature was critically searched by keywords "creatine," "renal insufficiency," and "renal dysfunction" and their synonyms in medical databases (Scopus, MEDLINE, EMBase, and ISI Web of Knowledge)...
October 2018: Iranian Journal of Kidney Diseases
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