journal
https://read.qxmd.com/read/38533651/toward-a-functional-cure-for-hepatitis-b
#1
REVIEW
Anna S F Lok
Current treatment of chronic hepatitis B virus (HBV) infection, pegylated interferon-α (pegIFN-α) and nucleos(t)ide analogue (NA), can suppress HBV replication, reverse liver inflammation and fibrosis, and decrease risks of cirrhosis and hepatocellular carcinoma, but hepatitis B surface antigen (HBsAg) loss is rare. Functional HBV cure is defined as undetectable HBsAg and unquantifiable serum HBV DNA for at least 24 weeks after a finite course of therapy. This requires suppression of HBV replication and viral protein production as well as restoration of immune response to HBV...
March 27, 2024: Gut and Liver
https://read.qxmd.com/read/38509701/combined-dna-methylation-and-gastric-microbiome-marker-predicts-helicobacter-pylori-negative-gastric-cancer
#2
JOURNAL ARTICLE
Min-Jeong Kim, Han-Na Kim, Jonathan P Jacobs, Hyo-Joon Yang
BACKGROUND/AIMS: While DNA methylation and gastric microbiome are each associated with gastric cancer (GC), their combined role in predicting GC remains unclear. This study investigated the potential of a combined DNA methylation and gastric microbiome signature to predict Helicobacter pylori -negative GC. METHODS: In this case-control study, we conducted quantitative methylation-specific polymerase chain reaction to measure the methylation levels of DKK3 , SFRP1 , EMX1 , NKX6-1 , MIR124-3 , and TWIST1 in the gastric mucosa from 75 H...
March 21, 2024: Gut and Liver
https://read.qxmd.com/read/38509700/risk-assessment-of-metachronous-gastric-neoplasm-after-endoscopic-resection-for-early-gastric-cancer-according-to-age-at-helicobacter-pylori-eradication
#3
JOURNAL ARTICLE
Seunghan Lee, Soo-Jeong Cho, Hyunsoo Chung, Bokyung Kim, Mi Jin Oh, Yun Suk Na, Jun Hee Lee, Jiyoon Kim, Sang Gyun Kim
BACKGROUND/AIMS: Helicobacter pylori eradication can reduce the incidence of metachronous gastric neoplasm (MGN) after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). This study evaluated the risk of developing MGN after ESD for EGC based on age at H. pylori eradication. METHODS: Data of patients who underwent curative ESD for EGC with H. pylori infection between 2005 and 2018 were retrospectively analyzed. The patients were allocated to four groups according to age at H...
March 21, 2024: Gut and Liver
https://read.qxmd.com/read/38468192/rebamipide-prevents-the-hemoglobin-drop-related-to-mucosal-damaging-agents-at-a-level-comparable-to-proton-pump-inhibitors
#4
JOURNAL ARTICLE
Ji Eun Kim, Yeong Chan Lee, Tae Se Kim, Eun Ran Kim, Sung Noh Hong, Young-Ho Kim, Kyunga Kim, Dong Kyung Chang
BACKGROUND/AIMS: : The effect of proton pump inhibitors (PPIs) on the lower gastrointestinal (GI) tract is uncertain, with potential to worsen damage. This study aimed to find the best method for protecting the entire GI tract from mucosal damage. METHODS: : A retrospective cohort study at Samsung Medical Center (2002-2019) included 195,817 patients prescribed GI mucosa-damaging agents. The primary goal was to assess the effectiveness of GI protective agents in preventing significant hemoglobin drops (>2 g/dL), indicating overall GI mucosal damage...
March 12, 2024: Gut and Liver
https://read.qxmd.com/read/38462478/quality-indicators-of-endoscopic-retrograde-cholangiopancreatography-in-korea
#5
REVIEW
Hyung Ku Chon, Ki-Hyun Kim, Tae Jun Song, Dong-Won Ahn, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Tae Joo Jeon, Chang Hwan Park, Kwang Bum Cho, Dong Wook Lee, Jin-Seok Park, Seung Bae Yoon, Kwang Hyun Chung, Jin Lee, Miyoung Choi
Endoscopic retrograde cholangiopancreatography (ERCP) is a procedure that requires significant experiences and skills and has various procedure-related complications, some of which can be severe and even result in the death of patients. Expanding ERCP availability has the advantage of increasing accessibility for patients. However, ERCP poses a substantial risk if performed without proper quality management. ERCP quality management is essential for both ensuring safe and successful procedures and meeting the social demands for enhanced healthcare competitiveness and quality assurance...
March 11, 2024: Gut and Liver
https://read.qxmd.com/read/38409663/usefulness-of-direct-peroral-cholangioscopy-using-a-multibending-ultraslim-endoscope-for-the-management-of-intrahepatic-bile-duct-lesions-with-videos
#6
JOURNAL ARTICLE
Won Myung Lee, Jong Ho Moon, Yun Nah Lee, Chang Wook Min, Il Sang Shin, Jun Ho Myeong, Hee Kyung Kim, Jae Kook Yang, Tae Hoon Lee
BACKGROUND/AIMS: : Peroral cholangioscopy (POC) has been used to assess intrahepatic duct (IHD) lesions but with a limited role. A new multibending (MB) ultraslim endoscope has been designed to improve POC performance. We evaluated the usefulness of POC using the MB ultraslim endoscope for the management of IHD lesions. METHODS: : Between March 2017 and March 2020, 22 patients underwent direct POC using the MB ultraslim endoscope for IHD lesions documented by previous imaging or cholangiopancreatography...
February 27, 2024: Gut and Liver
https://read.qxmd.com/read/38388182/influence-of-cytokine-genetic-polymorphisms-in-helicobacter-pylori-associated-gastric-inflammation-according-to-sex-in-south-korea
#7
JOURNAL ARTICLE
Hee Jin Kim, Nayoung Kim, Jae Young Jang, Sihyun Kim, Jongchan Lee, Hyeon Jeong Oh
BACKGROUND/AIMS: : The relationship between genetic polymorphisms and gastric inflammation remains unclear. This study aimed to evaluate the impact of genetic polymorphisms on Helicobacter pylori (HP)-associated gastritis according to sex. METHODS: : Two hundred thirty-two male and 404 female subjects with current HP infection were prospectively enrolled. The genotyping of IL-1B-511 C/T, IL-1RN variable number of tandem repeats, IL-6-572 G/C, IL-8-251 A/T, IL-8-781 C/T, IL-10-1082 G/A, IL-10-592 C/A, TNF-A-308 G/A, and transforming growth factor ( TGF )- B-509 C/T, was determined by polymerase chain reaction-restriction fragment length polymorphism...
February 23, 2024: Gut and Liver
https://read.qxmd.com/read/38388181/daily-diet-and-nutrition-risk-factors-for-gastric-cancer-incidence-in-a-japanese-population
#8
JOURNAL ARTICLE
Ayaka Takasu, Takuji Gotoda, Sho Suzuki, Chika Kusano, Chiho Goto, Hideki Ishikawa, Hirofumi Kogure
BACKGROUND/AIMS: : Nutritional factors associated with gastric cancer (GC) are not completely understood. We aimed to determine the effect of nutrient intake on the incidence of GC. METHODS: : This was a post hoc analysis of a prospective trial that evaluated modalities for GC screening in participants aged 30 to 74 years living in high-risk areas for GC in Japan between June 2011 and March 2013. The patients were followed up for GC incidence for 6 years. All participants completed a self-administered food frequency questionnaire (FFQ) upon enrollment before GC screening...
February 23, 2024: Gut and Liver
https://read.qxmd.com/read/38384201/development-of-a-nomogram-to-predict-the-risk-for-acute-necrotizing-pancreatitis
#9
JOURNAL ARTICLE
Junchao Zhang, Xiaxia Weng
BACKGROUND/AIMS: : Necrotizing pancreatitis (NP) presents a more severe clinical trajectory and increased mortality compared to edematous pancreatitis. Prompt identification of NP is vital for patient prognosis. A risk prediction model for NP among Chinese patients has been developed and validated to aid in early detection. METHODS: : A retrospective analysis was performed on 218 patients with acute pancreatitis (AP) to examine the association of various clinical variables with NP...
February 22, 2024: Gut and Liver
https://read.qxmd.com/read/38384200/real-world-risk-of-gastrointestinal-bleeding-for-direct-oral-anticoagulants-and-warfarin-users-a-distributed-network-analysis-using-a-common-data-model
#10
JOURNAL ARTICLE
Jae Myung Cha, Myoungsuk Kim, Hyeong Ho Jo, Won-Woo Seo, Sang Youl Rhee, Ji Hyun Kim, Gwang Ha Kim, Junseok Park
BACKGROUND/AIMS: : Early studies on direct oral anticoagulants (DOACs) reported a higher risk of gastrointestinal bleeding (GIB) compared with warfarin; however, recent studies have reported a reduced risk. Therefore, this study was designed to evaluate the risk of GIB in users of DOAC and warfarin. METHODS: : Using a common data model, we investigated the comparative risk of GIB in subjects from eight hospitals who were newly prescribed DOACs or warfarin. We excluded subjects who had a prior history of GIB or had been prescribed both medications...
February 22, 2024: Gut and Liver
https://read.qxmd.com/read/38384199/the-association-between-educational-attainment-and-the-risk-of-nonalcoholic-fatty-liver-disease-among-chinese-adults-findings-from-the-reaction-study
#11
JOURNAL ARTICLE
Yuanyue Zhu, Long Wang, Lin Lin, Yanan Huo, Qin Wan, Yingfen Qin, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Guijun Qin, Xulei Tang, Gang Chen, Shuangyuan Wang, Hong Lin, Xueyan Wu, Chunyan Hu, Mian Li, Min Xu, Yu Xu, Tiange Wang, Zhiyun Zhao, Zhengnan Gao, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, Li Chen, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Lulu Chen, Tianshu Zeng, Jiajun Zhao, Yiming Mu, Weiqing Wang, Guang Ning, Yufang Bi, Yuhong Chen, Jieli Lu
BACKGROUND/AIMS: : Low educational attainment is a well-established risk factor for nonalcoholic fatty liver disease (NAFLD) in developed areas. However, the association between educational attainment and the risk of NAFLD is less clear in China. METHODS: : A cross-sectional study including over 200,000 Chinese adults across mainland China was conducted. Information on education level and lifestyle factors were obtained through standard questionnaires, while NAFLD and advanced fibrosis were diagnosed using validated formulas...
February 22, 2024: Gut and Liver
https://read.qxmd.com/read/38384181/tumor-derived-exosomal-circular-rna-pinin-induces-fgf13-expression-to-promote-colorectal-cancer-progression-through-mir-1225-5p
#12
JOURNAL ARTICLE
Xianghui Liao, Tuhua Li, Li Yang, Haiwen Li, Weiru Li, Yuting Liu, Zhong Xie
BACKGROUND/AIMS: : Colorectal cancer (CRC) is a common malignant tumor, and circular RNAs (circRNAs) are abnormally expressed in CRC. However, the function and underlying mechanism of circRNA pinin (circ-PNN; hsa_circ_0101802) in CRC remain unclear. METHODS: : Exosomes were isolated from the plasma of CRC patients and identified by transmission electron microscopy and Western blotting. The RNA expression levels of circ-PNN, miR-1225-5p, and fibroblast growth factor 13 (FGF13) were measured by quantitative real-time polymerase chain reaction...
February 22, 2024: Gut and Liver
https://read.qxmd.com/read/38384180/the-effect-of-tegoprazan-on-the-treatment-of-endoscopic-resection-induced-artificial-ulcers-a-multicenter-randomized-active-controlled-study
#13
JOURNAL ARTICLE
Byung-Wook Kim, Jong Jae Park, Hee Seok Moon, Wan Sik Lee, Ki-Nam Shim, Gwang Ho Baik, Yun Jeong Lim, Hang Lak Lee, Young Hoon Youn, Jun Chul Park, In-Kyung Sung, Hyunsoo Chung, Jeong Seop Moon, Gwang Ha Kim, Su Jin Hong, Hyuk Soon Choi
BACKGROUND/AIMS: : Tegoprazan is a novel potassium-competitive acid blocker that has beneficial effects on acid-related disorders such as gastroesophageal reflux and peptic ulcer diseases. This study aimed to validate the effect of tegoprazan on endoscopic submucosal dissection (ESD)-induced artificial ulcers. METHODS: : Patients from 16 centers in Korea who underwent ESD for gastric neoplasia were enrolled. After ESD, pantoprazole was administered intravenously for 48 hours...
February 22, 2024: Gut and Liver
https://read.qxmd.com/read/38384179/molecular-activity-of-inflammation-and-epithelial-mesenchymal-transition-in-the-microenvironment-of-ulcerative-colitis
#14
JOURNAL ARTICLE
Yu Kyung Jun, Nayoung Kim, Hyuk Yoon, Ji Hyun Park, Hyung Kyung Kim, Yonghoon Choi, Ji Ae Lee, Cheol Min Shin, Young Soo Park, Dong Ho Lee
BACKGROUND/AIMS: : The genetic expression in the active inflammatory regions is increased in ulcerative colitis (UC) with endoscopic activity. The aim of this study was to investigate the molecular activity of inflammation and tissue remodeling markers in endoscopically inflamed and uninflamed regions of UC. METHODS: : Patients with UC (n=47) and controls (n=20) were prospectively enrolled at the Seoul National University Bundang Hospital. Inflamed tissue was obtained at the most active lesion, and uninflamed tissue was collected from approximately 15 cm above the upper end of the active lesion via colonoscopic biopsies...
February 22, 2024: Gut and Liver
https://read.qxmd.com/read/38356344/immune-enhancing-treatment-among-acute-necrotizing-pancreatitis-patients-with-metabolic-abnormalities-a-post-hoc-analysis-of-a-randomized-clinical-trial
#15
JOURNAL ARTICLE
Xiaofei Huang, Wenjian Mao, Xingxing Hu, Fengxia Qin, Hui Zhao, Aiping Zhang, Xinyu Wang, Christian Stoppe, Dandan Zhou, Lu Ke, Haibin Ni
BACKGROUND/AIMS: : Metabolic syndrome is common in patients with acute pancreatitis and its components have been reported to be associated with infectious complications. In this post hoc analysis, we aimed to evaluate whether metabolic abnormalities impact the effect of immune-enhancing thymosin alpha-1 (Tα1) therapy in acute necrotizing pancreatitis (ANP) patients. METHODS: : All data were obtained from the database for a multicenter randomized clinical trial that evaluated the efficacy of Tα1 in ANP patients...
February 15, 2024: Gut and Liver
https://read.qxmd.com/read/38213189/noninferiority-outcomes-of-besifovir-compared-to-tenofovir-alafenamide-in-treatment-na%C3%A3-ve-patients-with-chronic-hepatitis-b
#16
JOURNAL ARTICLE
Tae Hyung Kim, Ji Hoon Kim, Hyung Joon Yim, Yeon Seok Seo, Sun Young Yim, Young-Sun Lee, Young Kul Jung, Jong Eun Yeon, Soon Ho Um, Kwan Soo Byun
BACKGROUND/AIMS: : Besifovir dipivoxil maleate (BSV) and tenofovir alafenamide fumarate (TAF) have been recently approved in Korea as the initial antiviral agents for chronic hepatitis B (CHB). However, the real-world outcome data for these drugs remain limited. Therefore, we conducted a noninferiority analysis using real-world data to compare the clinical outcomes of the two nucleotide analogs in treatment-naïve patients with CHB. METHODS: : We retrospectively investigated a cohort of patients with CHB who received BSV or TAF as first-line antiviral agents...
January 12, 2024: Gut and Liver
https://read.qxmd.com/read/38481278/optimal-follow-up-of-incidental-pancreatic-cystic-lesions-without-worrisome-features-the-follow-up-strategy-is-still-evolving
#17
EDITORIAL
Tae Yoon Lee
No abstract text is available yet for this article.
March 15, 2024: Gut and Liver
https://read.qxmd.com/read/38481277/three-step-algorithm-for-screening-high-risk-group-of-metabolic-dysfunction-associated-steatotic-liver-disease-in-general-population
#18
EDITORIAL
Joo Hyun Oh, Dae Won Jun
No abstract text is available yet for this article.
March 15, 2024: Gut and Liver
https://read.qxmd.com/read/38481276/meaning-of-better-scoring-system-for-the-patients-with-cancer-bleeding-in-the-upper-gastrointestinal-tract
#19
EDITORIAL
Ji Yong Ahn
No abstract text is available yet for this article.
March 15, 2024: Gut and Liver
https://read.qxmd.com/read/38221817/non-contrast-abbreviated-magnetic-resonance-imaging-a-cost-effective-rookie-in-hepatocellular-carcinoma-surveillance-for-cirrhotic-patients
#20
EDITORIAL
Subin Heo, Won-Mook Choi
No abstract text is available yet for this article.
January 15, 2024: Gut and Liver
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