journal
https://read.qxmd.com/read/38845231/impacts-of-pi3k-protein-kinase-b-pathway-activation-in-reactive-astrocytes-from-detrimental-effects-to-protective-functions
#1
JOURNAL ARTICLE
Ramón Pérez-Núñez, María Fernanda González, Ana María Avalos, Lisette Leyton
Astrocytes are the most abundant type of glial cell In the central nervous system. Upon Injury and inflammation, astrocytes become reactive and undergo morphological and functional changes. Depending on their phenotypic classification as A1 or A2, reactive astrocytes contribute to both neurotoxic and neuroprotective responses, respectively. However, this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and injuries. Transcriptomic analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles, which emphasizes the heterogeneous nature of their reactivity...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845230/potassium-and-calcium-channels-in-different-nerve-cells-act-as-therapeutic-targets-in-neurological-disorders
#2
JOURNAL ARTICLE
Qing Qiu, Mengting Yang, Danfeng Gong, Haiying Liang, Tingting Chen
The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845228/polyethylene-glycol-fusion-repair-of-severed-rat-sciatic-nerves-reestablishes-axonal-continuity-and-reorganizes-sensory-terminal-fields-in-the-spinal-cord
#3
JOURNAL ARTICLE
Emily A Hibbard, Liwen Zhou, Cathy Z Yang, Karthik Venkudusamy, Yessenia Montoya, Alexa Olivarez, George D Bittner, Dale R Sengelaub
Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions; behavioral recovery is typically poor. We used a plasmalemmal fusogen, polyethylene glycol (PEG), to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic nerves. We have previously reported that sciatic nerve axons repaired by PEG- fusion do not undergo Wallerian degeneration, and PEG-fused animals exhibit rapid (within 2-6 weeks) and extensive locomotor recovery...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845225/the-potential-mechanism-and-clinical-application-value-of-remote-ischemic-conditioning-in-stroke
#4
JOURNAL ARTICLE
Yajun Zhu, Xiaoguo Li, Xingwei Lei, Liuyang Tang, Daochen Wen, Bo Zeng, Xiaofeng Zhang, Zichao Huang, Zongduo Guo
Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845224/complement-dependent-neuroinflammation-in-spinal-cord-injury-from-pathology-to-therapeutic-implications
#5
JOURNAL ARTICLE
Hassan Saad, Bachar El Baba, Ali Tfaily, Firas Kobeissy, Juanmarco Gutierrez Gonzalez, Daniel Refai, Gerald R Rodts, Christian Mustroph, David Gimbel, Jonathan Grossberg, Daniel L Barrow, Matthew F Gary, Ali M Alawieh
Spinal cord injury remains a major cause of disability in young adults, and beyond acute decompression and rehabilitation, there are no pharmacological treatments to limit the progression of injury and optimize recovery in this population. Following the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation, a similar role for complement in spinal neuroinflammation is a focus of ongoing research. In this work, we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins, triggers of complement activation, and role of effector functions in the pathology...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845223/combinatorial-therapies-for-spinal-cord-injury-repair
#6
JOURNAL ARTICLE
Carla S Sousa, Andreia Monteiro, António J Salgado, Nuno A Silva
Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845221/therapeutic-targeting-of-cellular-prion-protein-toward-the-development-of-dual-mechanism-anti-prion-compounds
#7
JOURNAL ARTICLE
Antonio Masone, Chiara Zucchelli, Enrico Caruso, Giovanna Musco, Roberto Chiesa
PrPSc, a misfolded, aggregation-prone isoform of the cellular prion protein (PrPC), is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other mammals. PrPSc can adopt different pathogenic conformations (prion strains), which can be resistant to potential drugs, or acquire drug resistance, posing challenges for the development of effective therapies. Since PrPC is the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity, it represents an attractive therapeutic target for prion diseases...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845220/role-of-the-globus-pallidus-in-motor-and-non-motor-symptoms-of-parkinson-s-disease
#8
JOURNAL ARTICLE
Yimiao Jiang, Zengxin Qi, Huixian Zhu, Kangli Shen, Ruiqi Liu, Chenxin Fang, Weiwei Lou, Yifan Jiang, Wangrui Yuan, Xin Cao, Liang Chen, Qianxing Zhuang
The globus pallidus plays a pivotal role In the basal ganglia circuit. Parkinson's disease Is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845218/hypoxia-preconditioned-bone-marrow-derived-mesenchymal-stem-cells-protect-neurons-from-cardiac-arrest-induced-pyroptosis
#9
JOURNAL ARTICLE
Xiahong Tang, Nan Zheng, Qingming Lin, Yan You, Zheng Gong, Yangping Zhuang, Jiali Wu, Yu Wang, Hanlin Huang, Jun Ke, Feng Chen
Cardiac arrest can lead to severe neurological impairment as a result of inflammation, mitochondrial dysfunction, and post-cardiopulmonary resuscitation neurological damage. Hypoxic preconditioning has been shown to improve migration and survival of bone marrow-derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest, but the specific mechanisms by which hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect against brain injury after cardiac arrest are unknown. To this end, we established an in vitro co-culture model of bone marrow-derived mesenchymal stem cells and oxygen-glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis, possibly through inhibition of the MAPK and nuclear factor κB pathways...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845217/the-complex-roles-of-m6a-modifications-in-neural-stem-cell-proliferation-differentiation-and-self-renewal-and-implications-for-memory-and-neurodegenerative-diseases
#10
JOURNAL ARTICLE
Yanxi Li, Jing Xue, Yuejia Ma, Ke Ye, Xue Zhao, Fangliang Ge, Feifei Zheng, Lulu Liu, Xu Gao, Dayong Wang, Qing Xia
N6-methyladenosine (m6A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m6A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38845216/decreased-levels-of-phosphorylated-synuclein-in-plasma-are-correlated-with-poststroke-cognitive-impairment
#11
JOURNAL ARTICLE
Yi Wang, Yuning Li, Yakun Gu, Wei Ma, Yuying Guan, Mengyuan Guo, Qianqian Shao, Xunming Ji, Jia Liu
Poststroke cognitive impairment is a major secondary effect of ischemic stroke in many patients; however, few options are available for the early diagnosis and treatment of this condition. The aims of this study were to (1) determine the specific relationship between hypoxic and α-synuclein during the occur of poststroke cognitive impairment and (2) assess whether the serum phosphorylated α-synuclein level can be used as a biomarker for poststroke cognitive impairment. We found that the phosphorylated α-synuclein level was significantly increased and showed pathological aggregation around the cerebral infarct area in a mouse model of ischemic stroke...
June 3, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38886961/postnatal-development-of-rat-retina-a-continuous-observation-and-comparison-between-the-organotypic-retinal-explant-model-and-in-vivo-development
#12
JOURNAL ARTICLE
Baoqi Hu, Rui Wang, Hanyue Zhang, Xiou Wang, Sijia Zhou, Bo Ma, Yan Luan, Xin Wang, Xinlin Chen, Zhichao Zhang, Qianyan Kang
JOURNAL/nrgr/04.03/01300535-202503000-00033/figure1/v/2024-06-17T092413Z/r/image-tiff The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures. However, the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies. Thus, we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina...
March 1, 2025: Neural Regeneration Research
https://read.qxmd.com/read/38886960/salsolinol-as-an-rna-m6a-methylation-inducer-mediates-dopaminergic-neuronal-death-by-regulating-yap1-and-autophagy
#13
JOURNAL ARTICLE
Jianan Wang, Yuanyuan Ran, Zihan Li, Tianyuan Zhao, Fangfang Zhang, Juan Wang, Zongjian Liu, Xuechai Chen
JOURNAL/nrgr/04.03/01300535-202503000-00032/figure1/v/2024-06-17T092413Z/r/image-tiff Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin that causes Parkinson's disease. However, the mechanism by which Sal mediates dopaminergic neuronal death remains unclear. In this study, we found that Sal significantly enhanced the global level of N6-methyladenosine (m6A) RNA methylation in PC12 cells, mainly by inducing the downregulation of the expression of m6A demethylases fat mass and obesity-associated protein (FTO) and alkB homolog 5 (ALKBH5)...
March 1, 2025: Neural Regeneration Research
https://read.qxmd.com/read/38886959/pro-resolving-lipid-mediator-reduces-amyloid-%C3%AE-42-induced-gene-expression-in-human-monocyte-derived-microglia
#14
JOURNAL ARTICLE
Ying Wang, Xiang Zhang, Henrik Biverstål, Nicolas G Bazan, Shuai Tan, Nailin Li, Makiko Ohshima, Marianne Schultzberg, Xiaofei Li
JOURNAL/nrgr/04.03/01300535-202503000-00031/figure1/v/2024-06-17T092413Z/r/image-tiff Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte-derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42-induced Alzheimer's disease-like inflammation...
March 1, 2025: Neural Regeneration Research
https://read.qxmd.com/read/38886958/inhibiting-shp2-reduces-glycolysis-promotes-microglial-m1-polarization-and-alleviates-secondary-inflammation-following-spinal-cord-injury-in-a-mouse-model
#15
JOURNAL ARTICLE
Xintian Ding, Chun Chen, Heng Zhao, Bin Dai, Lei Ye, Tao Song, Shuai Huang, Jia Wang, Tao You
JOURNAL/nrgr/04.03/01300535-202503000-00030/figure1/v/2024-06-17T092413Z/r/image-tiff Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2 (SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear...
March 1, 2025: Neural Regeneration Research
https://read.qxmd.com/read/38886957/maintaining-moderate-levels-of-hypochlorous-acid-promotes-neural-stem-cell-proliferation-and-differentiation-in-the-recovery-phase-of-stroke
#16
JOURNAL ARTICLE
Lin-Yan Huang, Yi-De Zhang, Jie Chen, Hai-Di Fan, Wan Wang, Bin Wang, Ju-Yun Ma, Peng-Peng Li, Hai-Wei Pu, Xin-Yian Guo, Jian-Gang Shen, Su-Hua Qi
JOURNAL/nrgr/04.03/01300535-202503000-00029/figure1/v/2024-06-17T092413Z/r/image-tiff It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late stroke. Indeed, previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain tissue. Our previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke, but its specific role and mechanism are currently unclear...
March 1, 2025: Neural Regeneration Research
https://read.qxmd.com/read/38886956/enhancement-of-motor-functional-recovery-in-thoracic-spinal-cord-injury-voluntary-wheel-running-versus-forced-treadmill-exercise
#17
JOURNAL ARTICLE
Do-Hun Lee, Dan Cao, Younghye Moon, Chen Chen, Nai-Kui Liu, Xiao-Ming Xu, Wei Wu
JOURNAL/nrgr/04.03/01300535-202503000-00028/figure1/v/2024-06-17T092413Z/r/image-tiff Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group (10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group...
March 1, 2025: Neural Regeneration Research
https://read.qxmd.com/read/38886955/repetitive-traumatic-brain-injury-induced-complement-c1-related-inflammation-impairs-long-term-hippocampal-neurogenesis
#18
JOURNAL ARTICLE
Jing Wang, Bing Zhang, Lanfang Li, Xiaomei Tang, Jinyu Zeng, Yige Song, Chao Xu, Kai Zhao, Guoqiang Liu, Youming Lu, Xinyan Li, Kai Shu
JOURNAL/nrgr/04.03/01300535-202503000-00027/figure1/v/2024-06-17T092413Z/r/image-tiff Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus, leading to long-term cognitive impairment. However, the mechanism underlying this neurogenesis impairment remains unknown. In this study, we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain injury...
March 1, 2025: Neural Regeneration Research
https://read.qxmd.com/read/38886954/neuroprotection-by-resveratrol-glucuronide-and-quercetin-glucuronide-via-binding-to-polyphenol-and-glycosaminoglycan-binding-sites-in-the-laminin-receptor
#19
JOURNAL ARTICLE
Rayudu Gopalakrishna, Jennifer Aguilar, Emily Lee, William J Mack
No abstract text is available yet for this article.
March 1, 2025: Neural Regeneration Research
https://read.qxmd.com/read/38886953/neuroinflammation-as-a-therapeutic-target-in-huntington-s-disease
#20
JOURNAL ARTICLE
Andrea Kwakowsky, Thulani H Palpagama
No abstract text is available yet for this article.
March 1, 2025: Neural Regeneration Research
journal
journal
41745
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.