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Journals Therapeutic Advances in Cardio...

Therapeutic Advances in Cardiovascular Disease

https://read.qxmd.com/read/38819836/inhibitory-effect-of-microrna-21-on-pathways-and-mechanisms-involved-in-cardiac-fibrosis-development
#1
REVIEW
Amirreza Khalaji, Saba Mehrtabar, Armin Jabraeilipour, Nadia Doustar, Hamed Rahmani Youshanlouei, Amir Tahavvori, Payam Fattahi, Seyed Mohammad Amin Alavi, Seyed Reza Taha, Andarz Fazlollahpour-Naghibi, Mahdieh Shariat Zadeh
Cardiac fibrosis is a pivotal cardiovascular disease (CVD) process and represents a notable health concern worldwide. While the complex mechanisms underlying CVD have been widely investigated, recent research has highlighted microRNA-21's (miR-21) role in cardiac fibrosis pathogenesis. In this narrative review, we explore the molecular interactions, focusing on the role of miR-21 in contributing to cardiac fibrosis. Various signaling pathways, such as the RAAS, TGF-β, IL-6, IL-1, ERK, PI3K-Akt, and PTEN pathways, besides dysregulation in fibroblast activity, matrix metalloproteinases (MMPs), and tissue inhibitors of MMPs cause cardiac fibrosis...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38801157/gene-polymorphism-as-a-cause-of-hemorrhagic-complications-in-patients-with-non-valvular-atrial-fibrillation-treated-with-oral-vitamin-k-independent-anticoagulants
#2
REVIEW
Ayan Abdrakhmanov, Aizhana Shaimerdinova, Zhanasyl Suleimen, Svetlana Abildinova, Rustam Albayev, Gulnar Tuyakova, Elena Rib, Akmaral Beysenbayeva, Gulden Kabduyeva, Makhabbat Bekbossynova
Atrial fibrillation (AF) accounts for 40% of all cardiac arrhythmias and is associated with a high risk of stroke and systemic thromboembolic complications. Dabigatran, rivaroxaban, apixaban, and edoxaban are direct oral anticoagulants (DOACs) that have been proven to prevent stroke in patients with non-valvular AF. This review summarizes the pharmacokinetics, pharmacodynamics, and drug interactions of DOACs, as well as new data from pharmacogenetic studies of these drugs. This review is aimed at analyzing the scientific literature on the gene polymorphisms involved in the metabolism of DOACs...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38708947/use-of-coronary-artery-calcium-score-and-coronary-ct-angiography-to-guide-cardiovascular-prevention-and-treatment
#3
REVIEW
Maria Rita Lima, Pedro M Lopes, António M Ferreira
Currently, cardiovascular risk stratification to guide preventive therapy relies on clinical scores based on cardiovascular risk factors. However, the discriminative power of these scores is relatively modest. The use of coronary artery calcium score (CACS) and coronary CT angiography (CCTA) has surfaced as methods for enhancing the estimation of risk and potentially providing insights for personalized treatment in individual patients. CACS improves overall cardiovascular risk prediction and may be used to improve the yield of statin therapy in primary prevention, and possibly identify patients with a favorable risk/benefit relationship for antiplatelet therapies...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38523335/disparities-in-heart-failure-between-white-black-and-hispanic-young-adults-insights-from-the-national-health-and-nutrition-examination-survey
#4
JOURNAL ARTICLE
Khawaja M Talha, Talal Almas, Abdul Mannan Khan Minhas, Husam Salah, Adeena Jamil, Heather M Johnson, Vardhmaan Jain, Steve Antoine, Sadiya S Khan, Muhammad Shahzeb Khan
BACKGROUND: The prevalence of heart failure (HF) is increasing among young adults in the United States with pervasive racial and ethnic differences in this population. OBJECTIVE: To evaluate contemporary associations between race and ethnicity, clinical comorbidities, and outcomes among young to middle-aged adults with HF. METHODS: A retrospective analysis was performed using the National Health and Nutrition Examination Survey. All participants with a self-report of HF aged 20-64 years from 2005 to 2018 were included and stratified by race and ethnicity [non-Hispanic (NH) Whites, NH Blacks, and Hispanics]...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38415471/association-between-dietary-calcium-intake-and-severe-abdominal-aorta-calcification-among-american-adults-a-cross-sectional-analysis-of-the-national-health-and-nutrition-examination-survey
#5
JOURNAL ARTICLE
Kai Zhang, Fangming Gu, Yu Han, Tianyi Cai, Zhaoxuan Gu, Jianguo Chen, Bowen Chen, Min Gao, Zhengyan Hou, Xiaoqi Yu, JiaYu Zhao, Yafang Gao, Jinyu Xie, Rui Hu, Tianzhou Liu, Bo Li
BACKGROUND: Evidence regarding the relationship between dietary calcium intake and severe abdominal aortic calcification (AAC) is limited. Therefore, this study aimed to investigate the association between dietary calcium intake and severe AAC in American adults based on data from the National Health and Nutrition Examination Survey (NHANES). METHODS: The present cross-sectional study utilized data from the NHANES 2013-2014, a population-based dataset. Dietary calcium intake was assessed using two 24-h dietary recall interviews...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38400698/percutaneous-image-guided-management-of-a-misplaced-pericardiocentesis-catheter-into-the-inferior-vena-cava
#6
JOURNAL ARTICLE
Haytham Derbel, Mahdi Krichen, Youssef Zaarour, Salim Jazzar, Mario Ghosn, Vania Tacher, Hicham Kobeiter
Misplacement of pericardiocentesis catheter in central veins is a rare complication that can be managed with several methods. In this case, we report a percutaneous image-guided plug-assisted management of a misplaced pericardiocentesis catheter into the inferior vena cava through a transhepatic tract successfully occluded. This minimally invasive technique was not previously described in this setting and had a favorable long-term outcome.
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38396350/safety-and-potential-usefulness-of-sequential-intracoronary-acetylcholine-and-ergonovine-administration-for-spasm-provocation-testing
#7
JOURNAL ARTICLE
Yasusuke Kinoshita, Yuichi Saito, Yuetsu Kikuta, Katsumasa Sato, Masahito Taniguchi, Kenji Goto, Hideo Takebayashi, Seiichi Haruta, Yoshio Kobayashi
BACKGROUND: Although guidelines recommend intracoronary acetylcholine (ACh) and ergonovine (ER) provocation testing for diagnosis of vasospastic angina, the feasibility and safety of sequential (combined) use of both pharmacological agents during the same catheterization session remain unclear. OBJECTIVES: In this study, we investigated the feasibility and safety of sequential intracoronary ACh and ER administration for coronary spasm provocation testing. METHODS: The study included 235 patients who showed positive results on ACh and ER provocation testing...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38343041/vasospastic-angina-a-review-on-diagnostic-approach-and-management
#8
REVIEW
Kenny Jenkins, Graziella Pompei, Nandine Ganzorig, Sarah Brown, John Beltrame, Vijay Kunadian
Vasospastic angina (VSA) refers to chest pain experienced as a consequence of myocardial ischaemia caused by epicardial coronary spasm, a sudden narrowing of the vessels responsible for an inadequate supply of blood and oxygen. Coronary artery spasm is a heterogeneous phenomenon that can occur in patients with non-obstructive coronary arteries and obstructive coronary artery disease, with transient spasm causing chest pain and persistent spasm potentially leading to acute myocardial infarction (MI). VSA was originally described as Prinzmetal angina or variant angina, classically presenting at rest, unlike most cases of angina (though in some patients, vasospasm may be triggered by exertion, emotional, mental or physical stress), and associated with transient electrocardiographic changes (transient ST-segment elevation, depression and/or T-wave changes)...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38305256/the-impact-of-platelet-to-lymphocyte-ratio-on-clinical-outcomes-in-heart-failure-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Mehrbod Vakhshoori, Niloofar Bondariyan, Sadeq Sabouhi, Keivan Kiani, Nazanin Alaei Faradonbeh, Sayed Ali Emami, Mehrnaz Shakarami, Farbod Khanizadeh, Shahin Sanaei, Niloofaralsadat Motamedi, Davood Shafie
BACKGROUND: Inflammation has been suggested to play a role in heart failure (HF) pathogenesis. However, the role of platelet-to-lymphocyte ratio (PLR), as a novel biomarker, to assess HF prognosis needs to be investigated. We sought to evaluate the impact of PLR on HF clinical outcomes. METHODS: English-published records in PubMed/Medline, Scopus, and Web-of-science databases were screened until December 2023. Relevant articles evaluated PLR with clinical outcomes (including mortality, rehospitalization, HF worsening, and HF detection) were recruited, with PLR difference analysis based on death/survival status in total and HF with reduced ejection fraction (HFrEF) patients...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38183273/evolocumab-use-in-clinical-practice-in-switzerland-final-data-of-the-observational-heymans-cohort-study
#10
JOURNAL ARTICLE
Isabella Sudano, Stephan Krähenbühl, François Mach, Anne Anstett, Nafeesa Dhalwani, Ian Bridges, Mahendra Sibartie, Kausik K Ray
AIMS: The HEYMANS study observed patients receiving evolocumab as part of routine clinical hyperlipidemia management. It was designed to capture data on clinical parameters relevant to health authorities and physicians. METHODS: This was a European multi-country observational cohort serial chart review study; data on the Swiss cohort are reported here. Patients were prescribed evolocumab as per the Swiss reimbursement criteria in force at the time and were invited chronologically...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38115784/methotrexate-and-cardiovascular-prevention-an-appraisal-of-the-current-evidence
#11
REVIEW
Arduino A Mangoni, Salvatore Sotgia, Angelo Zinellu, Ciriaco Carru, Gianfranco Pintus, Giovanni Damiani, Gian Luca Erre, Sara Tommasi
New evidence continues to accumulate regarding a significant association between excessive inflammation and dysregulated immunity (local and systemic) and the risk of cardiovascular events in different patient cohorts. Whilst research has sought to identify novel atheroprotective therapies targeting inflammation and immunity, several marketed drugs for rheumatological conditions may serve a similar purpose. One such drug, methotrexate, has been used since 1948 for treating cancer and, more recently, for a wide range of dysimmune conditions...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38099406/the-importance-of-pathways-to-facilitate-early-diagnosis-and-treatment-of-patients-with-cardiac-amyloidosis
#12
REVIEW
Chun Shing Kwok, William E Moody
Cardiac amyloidosis (CA) is a condition caused by extracellular deposition of amyloid fibrils in the heart. It is an underdiagnosed disease entity which can present with a variety of cardiac and non-cardiac manifestations. Diagnosis usually follows an initial suspicion based on clinical evaluation or imaging findings before confirmation with subsequent imaging (echocardiography, cardiac magnetic resonance imaging, 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy) in combination with biochemical screening for monoclonal dyscrasia (serum free light chains and serum and urine electrophoresis) and/or histology (bone marrow trephine, fat or endomyocardial biopsy)...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38069578/a-comprehensive-review-of-the-novel-therapeutic-targets-for-the-treatment-of-diabetic-cardiomyopathy
#13
REVIEW
Arti Dhar, Jegadheeswari Venkadakrishnan, Utsa Roy, Sahithi Vedam, Nikita Lalwani, Kenneth S Ramos, Tej K Pandita, Audesh Bhat
Diabetic cardiomyopathy (DCM) is characterized by structural and functional abnormalities in the myocardium affecting people with diabetes. Treatment of DCM focuses on glucose control, blood pressure management, lipid-lowering, and lifestyle changes. Due to limited therapeutic options, DCM remains a significant cause of morbidity and mortality in patients with diabetes, thus emphasizing the need to develop new therapeutic strategies. Ongoing research is aimed at understanding the underlying molecular mechanism(s) involved in the development and progression of DCM, including oxidative stress, inflammation, and metabolic dysregulation...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/37991005/non-selective-del-nido-and-st-thomas-cardioplegia-in-adults-analysis-of-early-clinical-experience-using-propensity-matching
#14
JOURNAL ARTICLE
Faizus Sazzad, Zhi Xian Ong, Geok Seen Ong, Hai Dong Luo, Si Guim Goh, Theo Kofidis, Sorokin Vitaly
BACKGROUND: Del Nido cardioplegia (DNC) is a single-dose, high potassium, low-volume cardioplegia solution that has grown in favor recently. However, the use of DNC in the Asian population may be associated with certain challenges. METHODS: Between January 2017 and April 2022, DNC was used for myocardial protection in this single-center retrospective study. In total, 5731 patients underwent open heart surgeries, where 310 patients received DNC for single or multiple procedures...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/37772698/the-usage-of-sglt-2-inhibitors-in-the-management-of-heart-failure-in-rural-africa-mitigating-the-barriers-to-the-optimal-adoption-of-a-novel-adjuvant-therapeutic-agent-in-the-management-of-heart-failure
#15
LETTER
Patrick Ashinze, Toufik Abdul-Rahman, Andrew Awuah Wireko
No abstract text is available yet for this article.
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/37731284/neointimal-characteristic-changes-following-drug-coated-balloons-in-lesions-with-repeated-revascularization
#16
JOURNAL ARTICLE
Yosuke Takei, Hiroyoshi Mori, Takahiro Tezuka, Ayumi Omura, Daisuke Wada, Hiromoto Sone, Kazuma Tashiro, Masahiro Sasai, Tokutada Sato, Hiroshi Suzuki
BACKGROUND: Since their emergence, drug-coated balloons (DCBs) have been used widely to treat in-stent lesions with coronary artery disease (CAD). However, despite their superior efficacy to balloon angioplasty, how DCBs affect neointimal characteristics is poorly understood. OBJECTIVES: We aimed to assess the neointimal characteristic changes following DCB treatment. METHODS: Using optical frequency domain imaging (OFDI), we serially observed the in-stent lesion site just after and 1 year after DCB angioplasty in 12 lesions of 11 patients with repeated revascularization...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/37724558/transient-left-bundle-branch-block-associated-with-very-high-coronary-artery-calcium-a-case-report
#17
JOURNAL ARTICLE
Alexander C Razavi, Sindhu Prabakaran, Mariem Sawan, Lakshmi Tummala, Ifeoma Onuorah, Sagar B Amin, Marly van Assen, Carlo N De Cecco, Arshed A Quyyumi, Seamus P Whelton, Laurence S Sperling, Francois G Rollin
Coronary artery calcium (CAC) is the measure of subclinical coronary artery atherosclerosis most strongly associated with atherosclerotic cardiovascular disease (ASCVD) risk. However, CAC is rarely reported in the inpatient setting to guide chest pain management. We present a case of very high CAC in a 64-year-old woman with hypertension, type 2 diabetes, and hyperlipidemia presenting with dyspnea. Initial electrocardiogram (ECG) demonstrated normal conduction with a heart rate of 76 beats/min, but new T-wave inversions in V1-V4 and a high-sensitivity troponin-I (hsTnI) value of 6 ng/L (normal < 6 ng/L)...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/37724539/the-therapeutic-potential-of-targeting-cardiac-rgs4
#18
REVIEW
Giselle Del Calvo, Teresa Baggio Lopez, Anastasios Lymperopoulos
G protein-coupled receptors (GPCRs) play pivotal roles in regulation of cardiac function and homeostasis. To function properly, every cell needs these receptors to be stimulated only when a specific extracellular stimulus is present, and to be silenced the moment that stimulus is removed. The regulator of G protein signaling (RGS) proteins are crucial for the latter to occur at the cell membrane, where the GPCR normally resides. Perturbations in both activation and termination of G protein signaling underlie numerous heart pathologies...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/37697803/assessment-of-atrial-septal-defects-using-3-dimensional-transthoracic-echocardiography-prior-to-percutaneous-device-closure-first-report-from-bangladesh
#19
JOURNAL ARTICLE
Santosh Kumar Saha, Chaudhury Meshkat Ahmed, Tuhin Haque, Mohammad Abdullah Al Mamun, Mohd Zahid Hussain
BACKGROUND: Secundum atrial septal defect (ASD) is treated following trans-catheter closure in alternative to surgical treatment. Per-intervention selection of device size with balloon occlusive diameter (BOD) often cause tearing or enlarging, causing arrhythmias and hypotension. We assessed the suitability of percutaneous device closure for ASD using 3-dimensional transthoracic echocardiography (3DTTE). OBJECTIVES: This study was conducted to investigate if 3DTTE could be an alternative of balloon sizing for selection of device size in atrial septal defect device closure...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/37655749/carotid-total-plaque-area-as-an-independent-predictor-of-short-term-subclinical-polyvascular-atherosclerosis-progression-and-major-adverse-cardiac-and-cerebrovascular-events
#20
JOURNAL ARTICLE
Vadim Genkel, Alla Kuznetsova, Evgeniy Lebedev, Alexey Salashenko, Albina Savochkina, Karina Nikushkina, Lubov Pykhova, Veronika Sumerkina, Igor Shaposhnik
BACKGROUND: The use of ultrasound-based methods for imaging of subclinical atherosclerosis, including measurement of carotid plaque burden (cPB), is a promising direction for further improvement of major adverse cardiac and cerebrovascular events (MACCE) prediction. OBJECTIVES: The aim of the study was to research the prognostic values' significance of cPB indicators with regard to the short-term progression of polyvascular subclinical atherosclerosis and the long-term onset of MACCE...
2023: Therapeutic Advances in Cardiovascular Disease
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