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Journals Therapeutic Advances in Respir...

Therapeutic Advances in Respiratory Disease

https://read.qxmd.com/read/38073272/nebulization-versus-metered-dose-inhaler-and-spacer-in-bronchodilator-responsiveness-testing-a-retrospective-study
#41
JOURNAL ARTICLE
Rongli Lu, Ying Li, Chengping Hu, Pinhua Pan, Qiaohong Zhao, Ruoxi He
BACKGROUND: The recommended delivery mode for bronchodilators in bronchodilator responsiveness (BDR) testing remains controversial. OBJECTIVE: To compare the efficacy of salbutamol administration using a nebulizer versus a metered-dose inhaler (MDI) with spacer in BDR testing. DESIGN: A retrospective study. METHODS: This study examined the data of patients with chronic obstructive pulmonary disease who completed BDR testing between 1 December 2021 and 30 June 2022, at Xiangya Hospital, Central South University...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38069568/progress-in-diagnosis-and-treatment-of-difficult-to-treat-asthma-in-children
#42
REVIEW
Xuehua Zhou, Panpan Zhang, Hong Tan, Bo Dong, Zenghui Jing, Huajie Wu, Jianfeng Luo, Yao Zhang, Juan Zhang, Xin Sun
At present, medications containing inhaled corticosteroids (ICS-containing) are the keystones of asthma treatment. The majority of asthmatic children can significantly improve clinical outcomes with little worsening by standardized inhaled glucocorticoid treatment, but there is still a small proportion of children who are unable to achieve good symptom control even after the maximum standardized treatment, known as 'children with difficult-to-treat asthma (DA)'. The high heterogeneity of DA makes therapy challenging and expensive, which poses a serious risk to children's health and makes it extremely difficult for clinical physicians to accurately identify and treat children with DA...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38049958/preliminary-study-on-the-short-term-changes-of-pulmonary-perfusion-after-a-single-balloon-pulmonary-angioplasty-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#43
JOURNAL ARTICLE
Peng Hou, Hai-Ming Chen, Si-Yan Lin, Wen-Liang Guo, Peng-Hao Chen, Jie-Long Lin, Xiao-Feng Wu, Chun-Li Liu, Xin-Lu Wang, Cheng Hong
BACKGROUND: Little is known about immediate responses of blood perfusion to the balloon pulmonary angioplasty (BPA) procedure. OBJECTIVES: To investigate the changes in pulmonary perfusion of balloon-dilated vessels and untreated vessels with before, immediately after a single BPA and at follow-up. DESIGN: Retrospective single-center cohort study. METHODS: Patients who had chronic thromboembolic pulmonary hypertension (CTEPH) and completed the pulmonary perfusion single photon emission computed tomography (SPECT) imaging before, immediately after BPA and at follow-up were included...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38018405/comparison-of-clinical-outcomes-in-critically-ill-covid-19-patients-on-mechanical-ventilation-with-nosocomial-pneumonia-between-alpha-and-omicron-variants
#44
JOURNAL ARTICLE
Chuan-Yen Sun, Jhong-Ru Huang, Hsiao-Chin Shen, Ying-Ting Liao, Hung-Jui Ko, Chih-Jung Chang, Yuh-Min Chen, Jia-Yih Feng, Wei-Chih Chen, Kuang-Yao Yang
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a pandemic that has resulted in millions of deaths worldwide. Critically ill COVID-19 patients who require intubation and develop nosocomial pneumonia, commonly caused by gram-negative bacilli, have a higher mortality rate than those without nosocomial pneumonia. OBJECTIVES: The aim of this study is to compare the clinical characteristics and outcomes and associated risk factors of Alpha and Omicron SARS-CoV-2 variants in critically ill patients on mechanical ventilation (MV) with nosocomial pneumonia...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38018090/the-future-exacerbation-and-mortality-of-different-inhalation-therapies-among-patients-with-chronic-obstructive-pulmonary-disease-in-various-gold-groups-a-focus-on-the-gold-2017-and-gold-2023-reports
#45
MULTICENTER STUDY
Qing Song, Wei Cheng, Cong Liu, Xueshan Li, Ling Lin, Yating Peng, Yuqin Zeng, Rong Yi, Yi Liu, Xin Li, Yan Chen, Shan Cai, Ping Chen
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 report revised the combined assessment, merged the C and D groups into the E group, and revised the initial inhalation therapy recommendation. OBJECTIVES: This study aimed to analyze the future exacerbation and mortality of different inhalation therapies among patients with chronic obstructive pulmonary disease (COPD) in various groups based on the GOLD 2017 and GOLD 2023 reports...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37997884/hyperinflation-and-reduced-diffusing-capacity-predict-prognosis-in-sclc-value-of-extended-pre-therapeutic-lung-function-testing
#46
JOURNAL ARTICLE
Kathrin Kahnert, Lilli Maria Lempert, Jürgen Behr, Laura Elsner, Toki Bolt, Amanda Tufman, Diego Kauffmann-Guerrero
BACKGROUND: Small cell lung cancer (SCLC) is characterized by aggressive growth and poor prognosis. Although SCLC affects nearly exclusively heavy smokers and leads to frequent respiratory symptoms, the impact of pre-therapeutic lung function testing in SCLC is sparely investigated until now. Therefore, we sought to examine whether we could find prognostic markers in pre-therapeutic lung function testing of SCLC patients. PATIENTS AND METHODS: We retrospectively analysed a cohort of 205 patients with the diagnosis of SCLC between 2010 and 2018...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37993998/ultrasonography-a-novel-auxiliary-interpretive-approach-for-tuberculin-purified-pure-protein-derivative-skin-test-a-comparative-study
#47
JOURNAL ARTICLE
Weijie Jiao, Yi Huang, Ying Lei, Jun Zhang, Ming Yu
BACKGROUND: The tuberculin-purified protein derivative (PPD) test is commonly used as a screening tool for tuberculosis (TB). However, the traditional judgment standard of the PPD test is influenced by subjective factors, which can lead to less accurate and intuitive test results. OBJECTIVES: To evaluate the accuracy of ultrasonography as a novel auxiliary judgment method for the tuberculin-PPD test and its clinical application. DESIGN: This study was designed as a comparative study following the STROBE guidance...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37991015/factors-for-progressive-pulmonary-fibrosis-in-connective-tissue-disease-related-interstitial-lung-disease
#48
JOURNAL ARTICLE
Kyuhwan Kim, Jongmin Lee, Yong Suk Jo
BACKGROUND: Progressive fibrosis can occur in connective tissue disease (CTD)-related interstitial lung disease (ILD) and make the prognosis worse. OBJECTIVES: This study aimed to investigate factors related to progressive pulmonary fibrosis (PPF) phenotype in CTD-ILDs. DESIGN: Medical records of patients diagnosed as CTD and ILD at a single, tertiary hospital in South Korea were retrospectively reviewed. METHODS: Patients whose lung functions were followed up for more than a year were included in analysis...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37970818/clinical-characteristics-and-outcomes-of-hypersensitivity-pneumonitis-in-south-korea
#49
JOURNAL ARTICLE
Sungmin Zo, Man Pyo Chung, Hak Young Yoo, Kyung Soo Lee, Joungho Han, Myung Jin Chung, Hongseok Yoo
BACKGROUND: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that results from an immune-mediated reaction involving various antigens in susceptible individuals. However, the clinical characteristics and outcomes of HP in South Korea are not well understood. OBJECTIVES: This study was conducted to identify the clinical characteristics and outcomes of HP in South Korea. DESIGN: This is a retrospective observational study investigating patients with pathologically confirmed HP at our center, along with a comprehensive review of published HP cases in the Republic of Korea...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37966017/role-of-nrf2-and-exercise-in-alleviating-copd-induced-skeletal-muscle-dysfunction
#50
REVIEW
Meiling Jiang, Peijun Li, Yingqi Wang, Yuanyuan Cao, Xiaoyu Han, Linhong Jiang, Xiaodan Liu, Weibing Wu
Chronic obstructive pulmonary disease (COPD) is a complex chronic respiratory disease with cumulative impacts on multiple systems, exhibiting significant extrapulmonary impacts, and posing a serious public health problem. Skeletal muscle dysfunction is one of the most pronounced extrapulmonary effects in patients with COPD, which severely affects patient prognosis and mortality primarily through reduced productivity resulting from muscle structural and functional alterations. Although the detailed pathogenesis of COPD has not been fully determined, some researchers agree that oxidative stress plays a significant role...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37966015/improvement-in-severe-asthma-patients-receiving-biologics-and-factors-associated-with-persistent-insufficient-control-a-real-life-national-study
#51
JOURNAL ARTICLE
Laurent Guilleminault, Claire Camus, Chantal Raherison-Semjen, Audrey Capdepon, Arnaud Bourdin, Philippe Bonniaud, Stéphanie Fry, Gilles Devouassoux, François-Xavier Blanc, Christophe Pison, Clairelyne Dupin, Naji Khayath, Joelle Courdeau, Judith Valcke-Brossollet, Cécilia Nocent-Ejnaini, Fabien Rolland, Carmen Lamandi, Alain Proust, Anaig Ozier, Laurent Portel, Wanda Gaspard, Pauline Roux-Claude, Antoine Beurnier, Stéphanie Martinez, Jean-Marc Dot, Florence Hennegrave, Guillaume Vignal, Etienne Auvray, Nicolas Paleiron, Nicolas Just, Jean Miltgen, Maud Russier, Cécile Olivier, Camille Taillé, Alain Didier
BACKGROUND: Biological therapies have revolutionized the treatment of severe asthma with type 2 inflammation. Although such treatments are very effective in reducing exacerbation and the dose of oral steroids, little is known about the persistence of symptoms in severe asthma patients treated with biologics. PURPOSE: We aim to describe asthma control and healthcare consumption of severe asthma patients treated with biologics. DESIGN: The Second Souffle study is a real-life prospective observational study endorsed by the Clinical Research Initiative in Severe Asthma: a Lever for Innovation & Science Network...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37949827/analysis-of-the-effect-of-cytomegalovirus-infection-in-clinical-outcomes-and-prolonged-duration-of-sars-cov-2-shedding-in-intensive-care-unit-patients-with-covid-19-pneumonia
#52
JOURNAL ARTICLE
Hsiao-Chin Shen, Jia-Yih Feng, Chuan-Yen Sun, Jhong-Ru Huang, Yuh-Min Chen, Wei-Chih Chen, Kuang-Yao Yang
BACKGROUND: Coronavirus disease 2019 (COVID-19) is a global outbreak disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Cytomegalovirus (CMV) infection can occur in critical COVID-19 patients and is associated with adverse clinical outcomes. OBJECTIVE: The aim of this study was to explore the clinical characteristics and outcome of CMV infection in critical COVID-19 patients. DESIGN: This was a retrospective cohort study...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37947059/ferroptosis-triggers-airway-inflammation-in-asthma
#53
REVIEW
Minming Li, Min Li, Yunjiao Hou, Huilin He, Ruonan Jiang, Chu Wang, Shibo Sun
Ferroptosis is a regulatory cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress. Many signaling pathways such as iron metabolism, lipid metabolism, and amino acid metabolism precisely regulate the process of ferroptosis. Ferroptosis is involved in a variety of lung diseases, such as acute lung injury, chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Increasing studies suggest that ferroptosis is involved in the development of asthma...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37941347/development-and-validation-of-a-machine-learning-model-for-differential-diagnosis-of-malignant-pleural-effusion-using-routine-laboratory-data
#54
RANDOMIZED CONTROLLED TRIAL
Ting-Ting Wei, Jia-Feng Zhang, Zhuo Cheng, Lei Jiang, Jiang-Yan Li, Lin Zhou
BACKGROUND: The differential diagnosis of malignant pleural effusion (MPE) and benign pleural effusion (BPE) presents a clinical challenge. In recent years, the use of artificial intelligence (AI) machine learning models for disease diagnosis has increased. OBJECTIVE: This study aimed to develop and validate a diagnostic model for early differentiation between MPE and BPE based on routine laboratory data. DESIGN: This was a retrospective observational cohort study...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37936408/clinical-factors-linked-to-the-type-of-respiratory-medication-in-copd-results-from-the-cosyconet-cohort
#55
JOURNAL ARTICLE
Peter Alter, Kathrin Kahnert, Franziska C Trudzinski, Robert Bals, Henrik Watz, Tim Speicher, Sandra Söhler, Tobias Welte, Klaus F Rabe, Emiel F M Wouters, Claus F Vogelmeier, Rudolf A Jörres
BACKGROUND: The use of maintenance medication in patients with chronic obstructive pulmonary disease (COPD) in real life is known to deviate from recommendations in guidelines, which are largely based on randomized controlled trials and selected populations. OBJECTIVES: We used the COSYCONET (<u>CO</u>PD and <u>Sy</u>stemic Consequences - <u>Co</u>morbidities <u>Net</u>work) cohort to analyze factors linked to the use of COPD drugs under non-interventional circumstances...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37936381/stepwise-management-of-copd-what-is-next-after-bronchodilation
#56
REVIEW
Marc Miravitlles, Kazuto Matsunaga, Michael Dreher
Inhaled bronchodilator therapy with long-acting muscarinic antagonists (LAMAs) and long-acting β2 -agonists (LABAs) in combination is currently the mainstay of treatment for chronic obstructive pulmonary disease (COPD). Treatment guidelines recommend the addition of inhaled corticosteroids (ICS) to LABA/LAMA only in patients with a history of frequent/severe exacerbations and high blood eosinophil counts, or in those with concomitant asthma. Despite this, real-world data suggest that clinicians are not adhering to this guidance and that ICS are frequently overused...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37886829/an-unexpected-encounter-and-outcome-between-endobronchial-lipoma-and-carcinoma-a-case-report-and-literature-review
#57
JOURNAL ARTICLE
Yang Yang, Jun Liu, Songkuan Chen, Guangzhao Yang, Guoqun Mao, Xiaoyu Han, Jian Wang
Bronchial lipoma is a rare benign tumor of the lung, which is often misdiagnosed due to concomitant pulmonary diseases. In addition, the coexistence of endobronchial lipoma and lung cancer is extremely unusual. To date, no related computed tomography (CT) images have been reported. The patient was a 53-year-old man, who was admitted to our hospital with cough, yellow phlegm, and fever for 1 week. The CT image showed an irregular mass in the medial segment of the right middle lobe (B4a ) with surrounding ground glass opacity, and another solid nodule in the right lower lobe (B6b )...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37855117/associations-of-medication-regimen-complexity-with-medication-adherence-and-clinical-outcomes-in-patients-with-chronic-obstructive-pulmonary-disease-a-prospective-study
#58
JOURNAL ARTICLE
Ruoxi He, Ye Wang, Xiaoxia Ren, Ke Huang, Jieping Lei, Hongtao Niu, Wei Li, Fen Dong, Baicun Li, Ting Yang, Chen Wang
BACKGROUND: High medication burdens are common in patients with chronic obstructive pulmonary disease (COPD). This study aimed to explore the associations of medication regimen complexity index (MRCI) with medication adherence and clinical outcomes among patients with acute exacerbations of COPD (AECOPD) after hospital discharge. METHODS: Data were obtained from a nationwide cohort study of inpatients with AECOPD in China. MRCI scores were calculated using the medication list 30 days after discharge and separated into COPD-specific and non-COPD MRCI scores...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37822218/all-cause-readmission-rate-and-risk-factors-of-30-and-90-day-after-discharge-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#59
JOURNAL ARTICLE
Huanrong Ruan, Hulei Zhao, Jiajia Wang, Hailong Zhang, Jiansheng Li
BACKGROUND: The readmission rate following hospitalization for chronic obstructive pulmonary disease (COPD) is surprisingly high, and frequent readmissions represent a higher risk of mortality and a heavy economic burden. However, information on all-cause readmissions in patients with COPD is limited. OBJECTIVE: This study aimed to systematically summarize all-cause COPD readmission rates within 30 and 90 days after discharge and their underlying risk factors...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37795626/long-term-impact-of-add-on-sequential-triple-combination-therapy-in-pulmonary-arterial-hypertension-real-world-experience
#60
JOURNAL ARTICLE
Himanshu Deshwal, Tatiana Weinstein, Rachel Salyer, Jesse Thompson, Frank Cefali, Rebecca Fenton, Eric Bondarsky, Roxana Sulica
BACKGROUND: Sequential triple combination therapy is recommended for pulmonary arterial hypertension (PAH) patients who are not at therapeutic goal on dual therapy, but long-term data on efficacy and safety is scarce. OBJECTIVE: To assess the long-term impact of sequential triple combination therapy in patients with PAH who are not at goal on dual combination therapy. STUDY DESIGN AND METHODS: We performed a retrospective observational study in a racially/ethnically diverse cohort of consecutive PAH patients on a stable dual therapy regimen who remained in intermediate- or high-risk category and were subsequently initiated on sequential triple combination therapy...
2023: Therapeutic Advances in Respiratory Disease
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