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Journals Therapeutic Advances in Respir...

Therapeutic Advances in Respiratory Disease

https://read.qxmd.com/read/38183243/a-comparison-between-a-gastroesophageal-reflux-disease-questionnaire-based-algorithm-and-multichannel-intraluminal-impedance-ph-monitoring-for-the-treatment-of-gastroesophageal-reflux-induced-chronic-cough
#21
JOURNAL ARTICLE
Wanzhen Li, Tongyangzi Zhang, Wenhua Gu, Wenbo Shi, Shengyuan Wang, Yiqing Zhu, Cuiqin Shi, Li Yu, Xianghuai Xu
BACKGROUND: Empiric therapy with multichannel intraluminal impedance-pH monitoring (MII-pH) has been used for the initial treatment of gastroesophageal reflux-induced chronic cough (GERC). However, an algorithm based on the gastroesophageal reflux disease questionnaire (GerdQ) has the potential to achieve a simple, structured, and effective treatment approach for patients with GERC. OBJECTIVES: This study compared the efficacy of anti-reflux therapy based on GerdQ (new structured pathway, NSP) with medical treatment after MII-pH examination (ordinary clinical pathway, OCP) in the management of GERC...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38179676/liver-injury-due-to-endothelin-receptor-antagonists-a-real-world-study-based-on-post-marketing-drug-monitoring-data
#22
JOURNAL ARTICLE
Shichao Dong, Xiaofei Guo, Huayu Wang, Chuan Sun
BACKGROUND: Liver injury is the hallmark adverse reaction of endothelin receptor antagonist (ERA). Since the first drug, bosentan has been widely used in clinical practice, hepatotoxicity has been accompanied by the history of ERA. The new ERA has been proven to have a lower liver risk but the current research findings are inconsistent. ERA-based targeted drug combinations are commonly used in the treatment of pulmonary arterial hypertension, where the risk of liver injury is difficult to estimate...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38179653/referral-rates-and-barriers-to-lung-transplantation-based-on-pulmonary-function-criteria-in-interstitial-lung-diseases-a-retrospective-cohort-study
#23
JOURNAL ARTICLE
Ofir Deri, David Ovadia, Ella Huszti, Michael Peled, Milton Saute, Tammy Hod, Amir Onn, Lior Seluk, Nadav Furie, Inbal Shafran, Ronen Mass, Sumit Chatterji, Liran Levy
BACKGROUND: Interstitial lung diseases (ILD) unresponsive to medical therapy often require lung transplantation (LTx), which prolongs quality of life and survival. Ideal timing for referral for LTx remains challenging, with late referral associated with significant morbidity and mortality. Among other criteria, patients with ILD should be considered for LTx if forced vital capacity (FVC) is less than 80% or diffusion capacity for carbon monoxide (DLCO) is less than 40%. However, data on referral rates are lacking...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38159215/prone-positioning-during-cpap-therapy-in-sars-cov-2-pneumonia-a-concise-clinical-review
#24
REVIEW
Chiara Chiappero, Alessio Mattei, Luca Guidelli, Serena Millotti, Emiliano Ceccherini, Simon Oczkowski, Raffaele Scala
During the COVID-19 pandemic, the number of patients with hypoxemic acute respiratory failure (ARF) due to SARS-CoV-2 pneumonia threatened to overwhelm intensive care units. To reduce the need for invasive mechanical ventilation (IMV), clinicians tried noninvasive strategies to manage ARF, including the use of awake prone positioning (PP) with continuous positive airway pressure (CPAP). In this article, we review the patho-physiologic rationale, clinical effectiveness and practical issues of the use of PP during CPAP in non-intubated, spontaneously breathing patients affected by SARS-CoV-2 pneumonia with ARF...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38146618/disease-burden-of-copd-in-the-chinese-population-a-systematic-review
#25
REVIEW
Jiaxin Xu, Zile Ji, Peng Zhang, Tao Chen, Yang Xie, Jiansheng Li
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the main contributors to the global burden of disease. OBJECTIVES: This systematic review aimed to evaluate the disease burden of COPD in the Chinese population and to determine the factors influencing the economic burden of the disease. DESIGN: This is a systematic review study. DATA SOURCES AND METHODS: We searched PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, WANGFANG Data, and VIP databases for studies regarding the disease burden of COPD in mainland China published before 31 December 2022...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38146255/impact-of-the-covid-19-pandemic-on-adherence-to-positive-airway-pressure-treatment-in-patients-with-obstructive-sleep-apnea-systematic-review-and-meta-analysis
#26
REVIEW
Soomin Jo, Jaeyoung Cho
BACKGROUND: The adverse effects of the COVID-19 pandemic on sleep have been well studied. However, whether the COVID-19 pandemic impacted positive airway pressure (PAP) adherence in patients with obstructive sleep apnea (OSA) remains unclear. OBJECTIVES: To evaluate the impact of the COVID-19 pandemic on adherence to PAP therapy in patients with OSA. DESIGN: A retrospective cohort study, systematic review, and meta-analysis. DATA SOURCES AND METHODS: The retrospective study included adults with OSA who received PAP prescriptions within the year before and the year after the start date of COVID-19 social distancing (22 March 2020) in South Korea...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38140896/effects-of-external-diaphragm-pacing-combined-with-conventional-rehabilitation-therapies-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#27
JOURNAL ARTICLE
Linhong Jiang, Pingping Sun, Peijun Li, Weibing Wu, Zhenwei Wang, Xiaodan Liu
BACKGROUND: Numerous randomized controlled trials (RCTs) have reported the benefits of external diaphragm pacing combined with conventional rehabilitation therapies (EDP-CRTs) on pulmonary function and exercise capacity in patients with chronic obstructive pulmonary disease (COPD). However, evidence-based regarding its effects remains unclear. OBJECTIVES: This systematic review and meta-analysis aimed to evaluate the effects of EDP-CRTs versus CRTs on patients with COPD...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38131281/a-diagnostic-model-for-distinguishing-between-active-tuberculosis-and-latent-tuberculosis-infection-based-on-the-blood-expression-profiles-of-autophagy-related-genes
#28
JOURNAL ARTICLE
Chengbin Wang, Jie Hua, Xiaopu He, Liang Chen, Shuhan Lv
BACKGROUND: Autophagy is closely involved in the control of mycobacterial infection. OBJECTIVES: Here, a diagnostic model was developed using the levels of autophagy-related genes (ARGs) in the blood to differentiate active tuberculosis (ATB) and latent tuberculosis infection (LTBI). DESIGN: Secondary data analysis of three prospective cohorts. METHODS: The expression of ARGs in patients with ATB and LTBI were analyzed using the GSE37250, GSE19491, and GSE28623 datasets from the GEO database...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38108295/associations-between-depression-and-anxiety-index-and-frequency-of-acute-exacerbation-in-chronic-obstructive-pulmonary-disease
#29
JOURNAL ARTICLE
Yu Jin Hong, Youlim Kim, Ji-Yong Moon, Shinhee Park, Jung-Kyu Lee, Ki-Suck Jung, Kwang Ha Yoo, Yu-Il Kim, Joon Young Choi
BACKGROUND: Comorbidities of chronic obstructive pulmonary disease (COPD) influence clinical characteristics and prognosis. OBJECTIVES: This study compared the clinical characteristics and exacerbation rate of COPD according to the presence of depression or anxiety. DESIGN: This study used data from The Korea COPD Subgroup Study (KOCOSS) cohort, a nationwide prospective cohort from 54 medical centers, between April 2012 and 2019. METHODS: Depression and anxiety were diagnosed with the Beck Depression Inventory and Beck Anxiety Inventory...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38084849/value-of-human-epididymis-secretory-protein-4-in-differentiating-malignant-from-benign-pleural-effusion-an-analysis-of-two-cohorts
#30
JOURNAL ARTICLE
Qian Yang, Yan Niu, Jian-Xun Wen, Dan-Ni Yang, Yu-Ling Han, Xu-Hui Wen, Li Yan, Jin-Hong Huang, Hong Chen, Wen-Qi Zheng, Ting-Wang Jiang, Zhi-De Hu
BACKGROUND: Lung cancer is the most common cause of malignant pleural effusion (MPE). Serum human epididymis secretory protein 4 (HE4) is a useful diagnostic marker for lung cancer. OBJECTIVE: This study aimed to evaluate the diagnostic accuracy of pleural fluid HE4 for MPE. DESIGN: A prospective, double-blind diagnostic test accuracy study. METHODS: Patients with undiagnosed pleural effusion were enrolled in two cohorts (Hohhot and Changshu)...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38073301/a-prediction-model-for-risk-of-low-oxygen-saturation-in-patients-with-post-tuberculosis-tracheobronchial-stenosis-during-bronchoscopy
#31
JOURNAL ARTICLE
Hui Chen, Sen Tian, Haidong Huang, Hui Wang, Zhenli Hu, Yuguang Yang, Wei Zhang, Yuchao Dong, Qin Wang, Chong Bai
BACKGROUND: Low oxygen saturation (LOS) is a frequent occurrence for patients with post-tuberculosis tracheobronchial stenosis (PTTS) during bronchoscopic procedures. However, there are currently no systematic assessment tools to predict LOS risk in PTTS patients during bronchoscopy. OBJECTIVES: This study aimed to develop an effective preoperative predictive model to guide clinical practice. DESIGN: Retrospective cohort study. METHODS: Data was retrospectively collected from PTTS patients who underwent bronchoscopic interventions between January 2017 and December 2022...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38073272/nebulization-versus-metered-dose-inhaler-and-spacer-in-bronchodilator-responsiveness-testing-a-retrospective-study
#32
JOURNAL ARTICLE
Rongli Lu, Ying Li, Chengping Hu, Pinhua Pan, Qiaohong Zhao, Ruoxi He
BACKGROUND: The recommended delivery mode for bronchodilators in bronchodilator responsiveness (BDR) testing remains controversial. OBJECTIVE: To compare the efficacy of salbutamol administration using a nebulizer versus a metered-dose inhaler (MDI) with spacer in BDR testing. DESIGN: A retrospective study. METHODS: This study examined the data of patients with chronic obstructive pulmonary disease who completed BDR testing between 1 December 2021 and 30 June 2022, at Xiangya Hospital, Central South University...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38069568/progress-in-diagnosis-and-treatment-of-difficult-to-treat-asthma-in-children
#33
REVIEW
Xuehua Zhou, Panpan Zhang, Hong Tan, Bo Dong, Zenghui Jing, Huajie Wu, Jianfeng Luo, Yao Zhang, Juan Zhang, Xin Sun
At present, medications containing inhaled corticosteroids (ICS-containing) are the keystones of asthma treatment. The majority of asthmatic children can significantly improve clinical outcomes with little worsening by standardized inhaled glucocorticoid treatment, but there is still a small proportion of children who are unable to achieve good symptom control even after the maximum standardized treatment, known as 'children with difficult-to-treat asthma (DA)'. The high heterogeneity of DA makes therapy challenging and expensive, which poses a serious risk to children's health and makes it extremely difficult for clinical physicians to accurately identify and treat children with DA...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38049958/preliminary-study-on-the-short-term-changes-of-pulmonary-perfusion-after-a-single-balloon-pulmonary-angioplasty-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#34
JOURNAL ARTICLE
Peng Hou, Hai-Ming Chen, Si-Yan Lin, Wen-Liang Guo, Peng-Hao Chen, Jie-Long Lin, Xiao-Feng Wu, Chun-Li Liu, Xin-Lu Wang, Cheng Hong
BACKGROUND: Little is known about immediate responses of blood perfusion to the balloon pulmonary angioplasty (BPA) procedure. OBJECTIVES: To investigate the changes in pulmonary perfusion of balloon-dilated vessels and untreated vessels with before, immediately after a single BPA and at follow-up. DESIGN: Retrospective single-center cohort study. METHODS: Patients who had chronic thromboembolic pulmonary hypertension (CTEPH) and completed the pulmonary perfusion single photon emission computed tomography (SPECT) imaging before, immediately after BPA and at follow-up were included...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38018405/comparison-of-clinical-outcomes-in-critically-ill-covid-19-patients-on-mechanical-ventilation-with-nosocomial-pneumonia-between-alpha-and-omicron-variants
#35
JOURNAL ARTICLE
Chuan-Yen Sun, Jhong-Ru Huang, Hsiao-Chin Shen, Ying-Ting Liao, Hung-Jui Ko, Chih-Jung Chang, Yuh-Min Chen, Jia-Yih Feng, Wei-Chih Chen, Kuang-Yao Yang
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a pandemic that has resulted in millions of deaths worldwide. Critically ill COVID-19 patients who require intubation and develop nosocomial pneumonia, commonly caused by gram-negative bacilli, have a higher mortality rate than those without nosocomial pneumonia. OBJECTIVES: The aim of this study is to compare the clinical characteristics and outcomes and associated risk factors of Alpha and Omicron SARS-CoV-2 variants in critically ill patients on mechanical ventilation (MV) with nosocomial pneumonia...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38018090/the-future-exacerbation-and-mortality-of-different-inhalation-therapies-among-patients-with-chronic-obstructive-pulmonary-disease-in-various-gold-groups-a-focus-on-the-gold-2017-and-gold-2023-reports
#36
MULTICENTER STUDY
Qing Song, Wei Cheng, Cong Liu, Xueshan Li, Ling Lin, Yating Peng, Yuqin Zeng, Rong Yi, Yi Liu, Xin Li, Yan Chen, Shan Cai, Ping Chen
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 report revised the combined assessment, merged the C and D groups into the E group, and revised the initial inhalation therapy recommendation. OBJECTIVES: This study aimed to analyze the future exacerbation and mortality of different inhalation therapies among patients with chronic obstructive pulmonary disease (COPD) in various groups based on the GOLD 2017 and GOLD 2023 reports...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37997884/hyperinflation-and-reduced-diffusing-capacity-predict-prognosis-in-sclc-value-of-extended-pre-therapeutic-lung-function-testing
#37
JOURNAL ARTICLE
Kathrin Kahnert, Lilli Maria Lempert, J├╝rgen Behr, Laura Elsner, Toki Bolt, Amanda Tufman, Diego Kauffmann-Guerrero
BACKGROUND: Small cell lung cancer (SCLC) is characterized by aggressive growth and poor prognosis. Although SCLC affects nearly exclusively heavy smokers and leads to frequent respiratory symptoms, the impact of pre-therapeutic lung function testing in SCLC is sparely investigated until now. Therefore, we sought to examine whether we could find prognostic markers in pre-therapeutic lung function testing of SCLC patients. PATIENTS AND METHODS: We retrospectively analysed a cohort of 205 patients with the diagnosis of SCLC between 2010 and 2018...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37993998/ultrasonography-a-novel-auxiliary-interpretive-approach-for-tuberculin-purified-pure-protein-derivative-skin-test-a-comparative-study
#38
JOURNAL ARTICLE
Weijie Jiao, Yi Huang, Ying Lei, Jun Zhang, Ming Yu
BACKGROUND: The tuberculin-purified protein derivative (PPD) test is commonly used as a screening tool for tuberculosis (TB). However, the traditional judgment standard of the PPD test is influenced by subjective factors, which can lead to less accurate and intuitive test results. OBJECTIVES: To evaluate the accuracy of ultrasonography as a novel auxiliary judgment method for the tuberculin-PPD test and its clinical application. DESIGN: This study was designed as a comparative study following the STROBE guidance...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37991015/factors-for-progressive-pulmonary-fibrosis-in-connective-tissue-disease-related-interstitial-lung-disease
#39
JOURNAL ARTICLE
Kyuhwan Kim, Jongmin Lee, Yong Suk Jo
BACKGROUND: Progressive fibrosis can occur in connective tissue disease (CTD)-related interstitial lung disease (ILD) and make the prognosis worse. OBJECTIVES: This study aimed to investigate factors related to progressive pulmonary fibrosis (PPF) phenotype in CTD-ILDs. DESIGN: Medical records of patients diagnosed as CTD and ILD at a single, tertiary hospital in South Korea were retrospectively reviewed. METHODS: Patients whose lung functions were followed up for more than a year were included in analysis...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37970818/clinical-characteristics-and-outcomes-of-hypersensitivity-pneumonitis-in-south-korea
#40
JOURNAL ARTICLE
Sungmin Zo, Man Pyo Chung, Hak Young Yoo, Kyung Soo Lee, Joungho Han, Myung Jin Chung, Hongseok Yoo
BACKGROUND: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that results from an immune-mediated reaction involving various antigens in susceptible individuals. However, the clinical characteristics and outcomes of HP in South Korea are not well understood. OBJECTIVES: This study was conducted to identify the clinical characteristics and outcomes of HP in South Korea. DESIGN: This is a retrospective observational study investigating patients with pathologically confirmed HP at our center, along with a comprehensive review of published HP cases in the Republic of Korea...
2023: Therapeutic Advances in Respiratory Disease
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