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Journals Therapeutic Advances in Respir...

Therapeutic Advances in Respiratory Disease

https://read.qxmd.com/read/38372128/a-real-world-study-of-quality-of-life-following-treatment-with-xylometazoline-hydrochloride-in-individuals-with-common-cold
#1
JOURNAL ARTICLE
Martina Hagen, Kim Clark, Pranab Kalita, Gessica Serra, Edwin Sanchez, Gabor Varbiro, Mathieu M Albasser
BACKGROUND: The common cold is a frequent, acute, and mild upper respiratory human disease. Nasal congestion has been considered the most bothersome symptom in the common cold, impacting quality of life (QoL). Topical decongestants containing steroids benefit QoL in allergic rhinitis, but no published research has assessed the impact of topical decongestants on QoL in the common cold. OBJECTIVE: To evaluate the effects of xylometazoline hydrochloride 0.1% (Otrivin, GSK Consumer Healthcare SARL, Switzerland) for up to 7 days on QoL in participants with nasal congestion associated with the common cold...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38357903/the-diagnostic-journey-of-pulmonary-arterial-hypertension-patients-results-from-a-multinational-real-world-survey
#2
JOURNAL ARTICLE
Mark Small, Loïc Perchenet, Alex Bennett, Jörg Linder
BACKGROUND: Pulmonary arterial hypertension (PAH) is a life-threatening, progressive disease often diagnosed late in its course. OBJECTIVES: To present patient-reported data that were captured within a large, multinational, point-in-time survey of PAH-treating physicians and their patients to better understand the diagnostic journey. DESIGN: Cross-sectional survey conducted in five European countries (EU5), Japan and the USA. METHODS: PAH-treating pulmonologists, cardiologists, rheumatologists or internists (USA only) completed a patient record form (PRF) for the next four consecutive adult PAH patients they saw; these patients filled in a patient self-completion (PSC) form on an anonymous, voluntary basis...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38357899/early-experience-of-endobronchial-ultrasound-guided-transbronchial-nodal-cryobiopsy-a-case-series-from-sabah-malaysia
#3
JOURNAL ARTICLE
Hema Yamini Ramarmuty, Nai-Chien Huan, Larry Ellee Nyanti, Teng Shin Khoo, Tamilarasi Renganathan, Ahmad Zaki Manoh, Nusaibah Azman, Kunji Kannan Sivaraman Kannan
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an established minimally invasive method for the diagnosis of benign and malignant conditions. Continuous efforts are underway to improve the material adequacy of EBUS-TBNA, including the introduction of a new technique called EBUS-guided transbronchial nodal cryobiopsy (EBUS-TBNC). This method allows for the retrieval of larger and well-preserved histologic samples from the mediastinum. We present a case series of four patients who underwent combined EBUS-TBNA and EBUS-TBNC procedures in our centre...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38343122/profile-of-cough-triggers-and-their-relationship-with-capsaicin-cough-sensitivity-in-chronic-cough
#4
JOURNAL ARTICLE
Tingting Xu, Zhiyin Chen, Chen Zhan, Wenzhi Zhan, Fang Yi, Kefang Lai
BACKGROUND: Cough hypersensitivity is an important part of the neurophysiology of cough, which presents with increased cough response to a lower level of stimuli or triggers. Classification of stimuli might bring about additional insight into the underlying mechanisms and management. OBJECTIVES: This study investigated the profile of cough triggers in chronic cough patients and their relationship with capsaicin cough sensitivity. DESIGN: This was a cross-sectional observational study...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38327061/video-assisted-thoracoscopic-surgery-for-non-cystic-fibrosis-bronchiectasis-in-children
#5
JOURNAL ARTICLE
Fengxia Ding, Zhengxia Pan, Chun Wu, Hongbo Li, Yonggang Li, Yong An, Jiangtao Dai, Gang Wang, Bo Liu
BACKGROUND: Pediatric bronchiectasis is a common respiratory disease in children. The use of video-assisted thoracoscopic surgery (VATS) for its treatment remains controversial. OBJECTIVES: The objective of our study was to compare and analyze the clinical efficacy of thoracoscopic surgery and thoracotomy in the treatment of pediatric bronchiectasis and summarize the surgical treatment experience of VATS in children with bronchiectasis. DESIGN: Retrospective single-center cohort study...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38235607/effects-of-omalizumab-on-lung-function-in-patients-with-moderate-to-severe-allergic-asthma-a-systematic-review-and-meta-analysis
#6
JOURNAL ARTICLE
Junyi Liao, Jia Tang, Yuanping Jiang, Youwen Wang, Jiali Ding, Yong He
BACKGROUND: With the rise of targeted treatments for asthma, treatment with omalizumab is a new option. OBJECTIVES: To assess the improvement of pulmonary function with additional omalizumab treatment in patients (⩾6 years old) with moderate-to-severe allergic asthma. DATA SOURCES AND METHODS: Observational studies of randomized controlled trials of add-on omalizumab for the treatment of patients with moderate-to-severe allergic asthma, published from the establishment till August 2022, were retrieved from WAN FANG DATA, PubMed, CNKI, Embase, Cochrane, and Web of Science databases...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38230522/comparison-between-high-flow-nasal-cannula-and-conventional-oxygen-therapy-in-covid-19-patients-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Jian-Chao Wang, Yun Peng, Bing Dai, Hai-Jia Hou, Hong-Wen Zhao, Wei Wang, Wei Tan
BACKGROUND: High-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) are important respiratory support strategies for acute hypoxemic respiratory failure (AHRF) in coronavirus disease 2019 (COVID-19) patients. However, the results are conflicting for the risk of intubation with HFNC as compared to COT. OBJECTIVES: We systematically synthesized the outcomes of HFNC relative to COT in COVID-19 patients with AHRF and evaluated these outcomes in relevant subpopulations...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38205629/the-significance-of-dynamic-monitoring-plasma-tmao-level-in-pulmonary-arterial-hypertension-a-cohort-study
#8
JOURNAL ARTICLE
Yicheng Yang, Xin Li, Peizhi Wang, Songren Shu, Bingyang Liu, Yanru Liang, Beilan Yang, Zhihui Zhao, Qin Luo, Zhihong Liu, Lemin Zheng, Qixian Zeng, Changming Xiong
BACKGROUND: Gut microbiota assumes an essential role in the development and progression of pulmonary arterial hypertension (PAH). Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite, is correlated with the prognosis of patients with PAH. However, the correlation between changes in TMAO (ΔTMAO) and the prognosis of PAH remains elusive. OBJECTIVES: To investigate the association between ΔTMAO and prognosis of PAH, and explore whether dynamic assessment of TMAO level was superior to measurement at a single time point in predicting prognosis...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38189269/pleural-fluid-carbohydrate-antigen-72-4-and-malignant-pleural-effusion-a-diagnostic-test-accuracy-study
#9
JOURNAL ARTICLE
Xi-Shan Cao, Li Yan, Ting-Wang Jiang, Jin-Hong Huang, Hong Chen, José M Porcel, Wen-Qi Zheng, Zhi-De Hu
BACKGROUND: The prognosis of malignant pleural effusion (MPE) is poor. A timely and accurate diagnosis is the prerequisite for managing MPE patients. Carbohydrate antigen 72-4 (CA72-4) is a diagnostic tool for MPE. OBJECTIVE: We aimed to evaluate the diagnostic accuracy of pleural fluid CA72-4 for MPE. DESIGN: A prospective, preregistered, and double-blind diagnostic test accuracy study. METHODS: We prospectively enrolled participants with undiagnosed pleural effusions from two centers in China (Hohhot and Changshu)...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38189181/a-simple-and-efficient-clinical-prediction-scoring-system-to-identify-malignant-pleural-effusion
#10
JOURNAL ARTICLE
Shuyan Wang, Jing An, Xueru Hu, Tingting Zeng, Ping Li, Jiangyue Qin, Yongchun Shen, Tao Wang, Fuqiang Wen
BACKGROUND: Early diagnosis of malignant pleural effusion (MPE) is of great significance. Current prediction models are not simple enough to be widely used in heavy clinical work. OBJECTIVES: We aimed to develop a simple and efficient clinical prediction scoring system to distinguish MPE from benign pleural effusion (BPE). DESIGN: This retrospective study involved patients with MPE or BPE who were admitted in West China Hospital from December 2010 to September 2016...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38183263/post-reflux-swallow-induced-peristaltic-wave-index-a-new-parameter-for-the-identification-of-non-acid-gastroesophageal-reflux-related-chronic-cough
#11
JOURNAL ARTICLE
Bingxian Sha, Wanzhen Li, Haodong Bai, Tongyangzi Zhang, Shengyuan Wang, Linyang Wu, Wenbo Shi, Yiqing Zhu, Li Yu, Xianghuai Xu
BACKGROUND: The current available diagnostic criteria for gastroesophageal reflux-related chronic cough (GERC) dominated by non-acid reflux is imperfect. The post-reflux swallow-induced peristaltic wave index (PSPWI) is a parameter reflecting esophageal clearance function. OBJECTIVES: This study aims to investigate its diagnostic value for non-acid GERC. DESIGN: This study sought to compare the diagnostic value of PSPWI in different types of GERC, particularly non-acid GERC, and explore the clinical significance of PSPWI in the diagnosis of non-acid GERC through diagnostic experiments...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38183243/a-comparison-between-a-gastroesophageal-reflux-disease-questionnaire-based-algorithm-and-multichannel-intraluminal-impedance-ph-monitoring-for-the-treatment-of-gastroesophageal-reflux-induced-chronic-cough
#12
JOURNAL ARTICLE
Wanzhen Li, Tongyangzi Zhang, Wenhua Gu, Wenbo Shi, Shengyuan Wang, Yiqing Zhu, Cuiqin Shi, Li Yu, Xianghuai Xu
BACKGROUND: Empiric therapy with multichannel intraluminal impedance-pH monitoring (MII-pH) has been used for the initial treatment of gastroesophageal reflux-induced chronic cough (GERC). However, an algorithm based on the gastroesophageal reflux disease questionnaire (GerdQ) has the potential to achieve a simple, structured, and effective treatment approach for patients with GERC. OBJECTIVES: This study compared the efficacy of anti-reflux therapy based on GerdQ (new structured pathway, NSP) with medical treatment after MII-pH examination (ordinary clinical pathway, OCP) in the management of GERC...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38179676/liver-injury-due-to-endothelin-receptor-antagonists-a-real-world-study-based-on-post-marketing-drug-monitoring-data
#13
JOURNAL ARTICLE
Shichao Dong, Xiaofei Guo, Huayu Wang, Chuan Sun
BACKGROUND: Liver injury is the hallmark adverse reaction of endothelin receptor antagonist (ERA). Since the first drug, bosentan has been widely used in clinical practice, hepatotoxicity has been accompanied by the history of ERA. The new ERA has been proven to have a lower liver risk but the current research findings are inconsistent. ERA-based targeted drug combinations are commonly used in the treatment of pulmonary arterial hypertension, where the risk of liver injury is difficult to estimate...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38179653/referral-rates-and-barriers-to-lung-transplantation-based-on-pulmonary-function-criteria-in-interstitial-lung-diseases-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
Ofir Deri, David Ovadia, Ella Huszti, Michael Peled, Milton Saute, Tammy Hod, Amir Onn, Lior Seluk, Nadav Furie, Inbal Shafran, Ronen Mass, Sumit Chatterji, Liran Levy
BACKGROUND: Interstitial lung diseases (ILD) unresponsive to medical therapy often require lung transplantation (LTx), which prolongs quality of life and survival. Ideal timing for referral for LTx remains challenging, with late referral associated with significant morbidity and mortality. Among other criteria, patients with ILD should be considered for LTx if forced vital capacity (FVC) is less than 80% or diffusion capacity for carbon monoxide (DLCO) is less than 40%. However, data on referral rates are lacking...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38159215/prone-positioning-during-cpap-therapy-in-sars-cov-2-pneumonia-a-concise-clinical-review
#15
REVIEW
Chiara Chiappero, Alessio Mattei, Luca Guidelli, Serena Millotti, Emiliano Ceccherini, Simon Oczkowski, Raffaele Scala
During the COVID-19 pandemic, the number of patients with hypoxemic acute respiratory failure (ARF) due to SARS-CoV-2 pneumonia threatened to overwhelm intensive care units. To reduce the need for invasive mechanical ventilation (IMV), clinicians tried noninvasive strategies to manage ARF, including the use of awake prone positioning (PP) with continuous positive airway pressure (CPAP). In this article, we review the patho-physiologic rationale, clinical effectiveness and practical issues of the use of PP during CPAP in non-intubated, spontaneously breathing patients affected by SARS-CoV-2 pneumonia with ARF...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38146618/disease-burden-of-copd-in-the-chinese-population-a-systematic-review
#16
REVIEW
Jiaxin Xu, Zile Ji, Peng Zhang, Tao Chen, Yang Xie, Jiansheng Li
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the main contributors to the global burden of disease. OBJECTIVES: This systematic review aimed to evaluate the disease burden of COPD in the Chinese population and to determine the factors influencing the economic burden of the disease. DESIGN: This is a systematic review study. DATA SOURCES AND METHODS: We searched PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, WANGFANG Data, and VIP databases for studies regarding the disease burden of COPD in mainland China published before 31 December 2022...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38146255/impact-of-the-covid-19-pandemic-on-adherence-to-positive-airway-pressure-treatment-in-patients-with-obstructive-sleep-apnea-systematic-review-and-meta-analysis
#17
REVIEW
Soomin Jo, Jaeyoung Cho
BACKGROUND: The adverse effects of the COVID-19 pandemic on sleep have been well studied. However, whether the COVID-19 pandemic impacted positive airway pressure (PAP) adherence in patients with obstructive sleep apnea (OSA) remains unclear. OBJECTIVES: To evaluate the impact of the COVID-19 pandemic on adherence to PAP therapy in patients with OSA. DESIGN: A retrospective cohort study, systematic review, and meta-analysis. DATA SOURCES AND METHODS: The retrospective study included adults with OSA who received PAP prescriptions within the year before and the year after the start date of COVID-19 social distancing (22 March 2020) in South Korea...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38140896/effects-of-external-diaphragm-pacing-combined-with-conventional-rehabilitation-therapies-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Linhong Jiang, Pingping Sun, Peijun Li, Weibing Wu, Zhenwei Wang, Xiaodan Liu
BACKGROUND: Numerous randomized controlled trials (RCTs) have reported the benefits of external diaphragm pacing combined with conventional rehabilitation therapies (EDP-CRTs) on pulmonary function and exercise capacity in patients with chronic obstructive pulmonary disease (COPD). However, evidence-based regarding its effects remains unclear. OBJECTIVES: This systematic review and meta-analysis aimed to evaluate the effects of EDP-CRTs versus CRTs on patients with COPD...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38131281/a-diagnostic-model-for-distinguishing-between-active-tuberculosis-and-latent-tuberculosis-infection-based-on-the-blood-expression-profiles-of-autophagy-related-genes
#19
JOURNAL ARTICLE
Chengbin Wang, Jie Hua, Xiaopu He, Liang Chen, Shuhan Lv
BACKGROUND: Autophagy is closely involved in the control of mycobacterial infection. OBJECTIVES: Here, a diagnostic model was developed using the levels of autophagy-related genes (ARGs) in the blood to differentiate active tuberculosis (ATB) and latent tuberculosis infection (LTBI). DESIGN: Secondary data analysis of three prospective cohorts. METHODS: The expression of ARGs in patients with ATB and LTBI were analyzed using the GSE37250, GSE19491, and GSE28623 datasets from the GEO database...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38108295/associations-between-depression-and-anxiety-index-and-frequency-of-acute-exacerbation-in-chronic-obstructive-pulmonary-disease
#20
JOURNAL ARTICLE
Yu Jin Hong, Youlim Kim, Ji-Yong Moon, Shinhee Park, Jung-Kyu Lee, Ki-Suck Jung, Kwang Ha Yoo, Yu-Il Kim, Joon Young Choi
BACKGROUND: Comorbidities of chronic obstructive pulmonary disease (COPD) influence clinical characteristics and prognosis. OBJECTIVES: This study compared the clinical characteristics and exacerbation rate of COPD according to the presence of depression or anxiety. DESIGN: This study used data from The Korea COPD Subgroup Study (KOCOSS) cohort, a nationwide prospective cohort from 54 medical centers, between April 2012 and 2019. METHODS: Depression and anxiety were diagnosed with the Beck Depression Inventory and Beck Anxiety Inventory...
2023: Therapeutic Advances in Respiratory Disease
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