journal
https://read.qxmd.com/read/38685746/clinical-characteristics-of-persistent-or-recurrent-pneumonia-combined-with-airway-malacia-in-children
#21
JOURNAL ARTICLE
Zhuxia Li, Xinxing Zhang, Huiquan Sun, Chuangli Hao, Xuejun Shao, Jun Xu, Xin Zhang, Yuqing Wang
OBJECTIVE: The aim of this study is to investigate the clinical characteristics and pathogens involved in persistent or recurrent pneumonia combined with airway malacia in children. METHODS: We retrospectively reviewed the information of children hospitalised with persistent or recurrent pneumonia, including clinical presentations, laboratory examination results and pathogens. RESULTS: A total of 554 patients were admitted, 285 (51.44%) of whom were found to have airway malacia...
May 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38685745/prognostic-utility-of-blood-inflammation-biomarkers-before-and-after-treatment-on-the-survival-of-patients-with-locally-advanced-non-small-cell-lung-cancer-undergoing-stereotactic-body-radiotherapy
#22
JOURNAL ARTICLE
Fang Fang, Zhen Jia, Hongliang Xie, Yangsen Cao, Xiaofei Zhu, Xiao Yu Yang, Xueling Guo, Huojun Zhang
BACKGROUND AND OBJECTIVE: The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were significant and succinct indicators of systemic inflammation. We assessed the influence of stereotactic body radiotherapy (SBRT) on NLR and PLR in patients with locally advanced non-small cell lung cancer (LA-NSCLC). METHODS: We reviewed the medical data of patients with LA-NSCLC who underwent SBRT between 1 January 2013 and 31 December 2018. NLR and PLR values recorded at pre- and post-SBRT were examined...
May 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38685730/causal-influence-of-gut-microbiota-on-small-cell-lung-cancer-a-mendelian-randomization-study
#23
JOURNAL ARTICLE
Wenjing Yang, Xinxia Fan, Wangshu Li, Yan Chen
BACKGROUND: Previous studies have hinted at a significant link between lung cancer and the gut microbiome, yet their causal relationship remains to be elucidated. METHODS: GWAS data for small cell lung cancer (SCLC) was extracted from the FinnGen consortium, comprising 179 cases and 218 613 controls. Genetic variation data for 211 gut microbiota were obtained as instrumental variables from MiBioGen. Mendelian randomization (MR) was employed to determine the causal relationship between the two, with inverse variance weighting (IVW) being the primary method for causal analysis...
May 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38664220/studying-of-anti-inflammatory-and-antioxidant-effects-of-tectorigenin-in-ovalbumin-induced-asthma-mice-models
#24
JOURNAL ARTICLE
Jingning Guo, Yanping Shi, Yujun Wang, Seyyed Shamsadin Athari, Tao Chen
BACKGROUND: Allergic asthma is an important respiratory system problem characterized by airway inflammation, breathlessness, and bronchoconstriction. Allergic asthma and its outcomes are triggered by type 2 allergic immune responses. Tectorigenin is a methoxy-isoflavone with anti-inflammatory effects. In this study, we investigated the effects of tectorigenin on the pathophysiology of allergic asthma in an animal model. METHODS: Asthmatic mice were treated with tectorigenin...
April 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38616354/comparative-study-of-imaging-and-pathology-of-primary-mucinous-adenocarcinoma-with-different-imaging-manifestations
#25
JOURNAL ARTICLE
Jun Han, Jie Gao, Demei Chen, Mou Du, Yuxin Wu, Xidong Ma, Mei Xie, Hua Han, Chongchong Wu, Xinying Xue
BACKGROUND: Pulmonary mucinous adenocarcinoma is a special type of lung cancer. Its imaging manifestations are diverse, which brings challenges to clinical diagnosis. However, its formation mechanism is unclear. OBJECTIVE: The objective of this study is to analyse the relevant mechanisms of the formation of pulmonary mucinous adenocarcinoma by observing its different imaging and pathological manifestations. DATA AND METHODS: Retrospective analysis was conducted on imaging manifestations and pathological data of 103 patients with pulmonary mucinous adenocarcinoma confirmed intraoperatively or pathologically...
April 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38606731/prognostic-factors-and-predictive-models-for-patients-with-lung-large-cell-neuroendocrine-carcinoma-based-on-seer-database
#26
JOURNAL ARTICLE
Wenqiang Li, Qian Huang, Xiaoyu He, Qian He, Qun Lai, Quan Yuan, Zhiping Deng
BACKGROUND: Lung Large cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive, high-grade neuroendocrine carcinoma with a poor prognosis, mainly seen in elderly men. To date, we have found no studies on predictive models for LCNEC. METHODS: We extracted data from the Surveillance, Epidemiology, and End Results (SEER) database of confirmed LCNEC from 2010 to 2018. Univariate and multivariate Cox proportional risk regression analyses were used to identify independent risk factors, and then we constructed a novel nomogram and assessed the predictive effectiveness by receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA)...
April 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38584122/the-impact-of-egfr-t790m-mutation-status-following-the-development-of-osimertinib-resistance-on-the-efficacy-of-osimertinib-in-non-small-cell-lung-cancer-a-meta-analysis
#27
REVIEW
Liuxian Guo, Guojin Zhou, Min Huang, Kejing Tang, Jing Xu, Jie Chen
BACKGROUND: Previous studies have suggested that loss of the EGFR T790M gene mutation may contribute to the development of resistance to Osimertinib in non-small cell lung cancer (NSCLC). AIMS: This study aims to assess the relationship between the clinical effectiveness of Osimertinib in NSCLC patients and the T790M mutation status following resistance to Osimertinib and examine differences between plasma and tissue tests and between Asian and non-Asian groups...
April 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38566277/efficacy-of-immune-checkpoint-inhibitors-in-advanced-non-small-cell-lung-cancer-patients-with-kras-mutations-a-network-meta-analysis
#28
JOURNAL ARTICLE
Lin Zhang, Wei Chen, Hongtao Wei, Junxian Yu
OBJECTIVE: Previous studies have shown that immune checkpoint inhibitors can improve the survival of patients with advanced non-small cell lung cancer with KRAS mutations; however, there is a lack of comparisons between treatment regimens associated with immune checkpoint inhibitors, and our study aims to compare several treatment parties to find a more effective treatment regimen. METHOD: A comprehensive literature search was conducted across multiple databases, namely PubMed, Web of Science, Embase, and Cochrane Library, to identify relevant studies...
April 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38529683/value-of-rapid-on-site-evaluation-combined-with-interventional-pulmonology-techniques-in-the-diagnosis-of-pulmonary-cryptococcosis
#29
JOURNAL ARTICLE
Jiaqi Cao, Rong Zhou, Qian He, Ming Zhang, Chunlai Feng
OBJECTIVES: The aim of this study is to evaluate the diagnostic value of rapid on-site evaluation (ROSE) combined with computed tomography-guided percutaneous needle biopsy (CT-PNB) or radial endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) for pulmonary cryptococcosis (PC). METHODS: Clinical data of 33 patients diagnosed with PC at the Third Affiliated Hospital of Soochow University between February 2018 and June 2023 were retrospectively analysed...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38529681/radiological-and-clinical-features-of-large-consolidative-type-pulmonary-invasive-mucinous-adenocarcinoma
#30
JOURNAL ARTICLE
Jiaqi Chen, Linlin Qi, Jianwei Wang, Liyan Xue, Qi Xue, Jia Jia, Guochao Zhang, Jianing Liu, Fenglan Li, Shulei Cui
BACKGROUND: This study aimed to investigate the radiological, pathological, and prognostic characteristics of large consolidative-type pulmonary invasive mucinous adenocarcinomas (IMA). METHODS: We retrospectively reviewed 738 patients who confirmed IMA between January 2010 and August 2022, and two radiologists reviewed imaging data to determine subtypes. We included 41 patients with pathologically large consolidative-type IMA. We analyzed their radiological, pathological, and prognostic characteristics...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38529671/pleural-fluid-characteristics-of-patients-with-covid-19-infection
#31
JOURNAL ARTICLE
Ryan A Denu, Victoria Forth, Majid Shafiq
INTRODUCTION: Pleural effusions are known to occur in many cases of COVID-19. Data on typical characteristics of COVID-19-associated pleural effusions are limited. The goal of this project was to characterize the pleural fluid from patients with COVID-19. METHODS: We retrospectively collected electronic medical record data from adults hospitalized at a large metropolitan hospital system with COVID-19 infection who had a pleural effusion and a thoracentesis performed...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38529669/clinical-comparison-of-hmpv-and-rsv-infections-in-hospitalised-malaysian-children-a-propensity-score-matched-study
#32
JOURNAL ARTICLE
David Chun-Ern Ng, Chuin-Hen Liew, Kah Kee Tan, Elida Hanan Binti Awang, Farah Nuruliayana Binti Ahmad Nazri, Asuwani K Tamil Maran, Vishnu Arvindran A/L Chandra Mohan, Durairaaj Ramachandran, Michelle Chok, Cheah Hooi Teh, Airena Mohamad Nor, Suhaila Bt Baharuddin, Erwin Jiayuan Khoo
INTRODUCTION: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the clinical presentation, resource utilisation and outcomes between hMPV and RSV infections in hospitalised Malaysian children. METHODS: This retrospective, observational study included children aged ≤12 years old hospitalised with hMPV or RSV, confirmed via direct fluorescent antibody (DFA) methods, between 1 July to 30 October 2022 at Hospital Tuanku Ja'afar Seremban, Malaysia...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38504464/prescription-patterns-of-ambrisentan-in-some-cities-of-colombia
#33
JOURNAL ARTICLE
Luis Fernando Valladales-Restrepo, Andrés Gaviria-Mendoza, Manuel Enrique Machado-Duque, Álvaro Vallejos-Narváez, Jorge Enrique Machado-Alba
INTRODUCTION: Ambrisentan is a selective type A endothelin receptor antagonist that has shown significant effectiveness and safety in the management of patients with pulmonary hypertension. Its use pattern with real-world evidence in Colombia is unknown. OBJECTIVE: The objective of this study is to determine the prescription patterns of ambrisentan in some cities of Colombia. METHODS: A longitudinal descriptive study on the prescription patterns of ambrisentan in patients with pulmonary hypertension (all the groups) was conducted between January 2021 and December 2022 based on a population database of members of the Colombian Health System...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38497229/sox-1-antibodies-positive-lambert-eaton-myasthenic-syndrome-with-occult-small-cell-lung-cancer-a-case-report
#34
JOURNAL ARTICLE
Liming Zhao, Hongyan He, Weixin Han, Yizhe Meng, Lifei Kang, Yanqiang Chen
Lambert-Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic neurological syndrome of the neuromuscular transmission. The symptoms often progress slowly and can be misdiagnosed in early stage. Seropositive SOX-1 antibodies are support for the diagnosis of LEMS and have high specificity for small cell lung cancer (SCLC). In this paper, we report a case of a 56-year-old man with smoking history who was admitted to hospital with progressive muscle weakness of the proximal legs. LEMS was diagnosed by repetitive nerve stimulation (RNS) testing and seropositive SOX-1 antibodies...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38450981/primary-pulmonary-histiocytic-sarcoma-with-high-pd-l1-expression-benefited-from-immunotherapy-a-case-report-and-bioinformatic-analysis
#35
JOURNAL ARTICLE
Yuanjie Lin, Qian Cao, Aonan Hong, Xiao Liang
Histiocytic sarcoma is an aggressive haematopoietic malignancy accounting for less than 1% of haematolymphoid neoplasms with a diagnosis based on morphology and immunophenotype of tissue biopsies with a very poor prognosis. Here, we report a 45-year-old man who was diagnosed with primary pulmonary histiocytic sarcoma with systemic metastases, with partial remission (PR) treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, but it relapsed soon after therapy above. Tests demonstrated that TMB was 21 Muts/Mb PD-L1 expression was 90% positive, and the disease has been well-controlled over 3 years using immune checkpoint inhibitors (nivolumab and pembrolizumab)...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38433370/pulmonary-scedosporiosis-in-an-intractable-immunocompetent-host-a-case-report-and-literature-review
#36
REVIEW
Hong Yu Liang, Chun Hua Han, Wen Juan Xu, Jian Sun, Qiang Wang
Pulmonary scedosporiosis is a rare pulmonary infection that often presents with nonspecific symptoms and radiological findings. In this report, we present a case of localized pulmonary scedosporiosis in an immunocompetent patient and analyze a total of 25 immunocompetent patients with pulmonary scedosporiosis. Through this case and the literature, we highlight the importance of considering pulmonary scedosporiosis in patients with nonspecific clinical symptoms and radiological findings resembling aspergilloma...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38403875/the-inhibitory-effect-of-apatinib-on-different-small-cell-lung-cancer-cells-and-in-lung-cancer-bearing-mice-and-patients
#37
JOURNAL ARTICLE
Mingtao Liu, Hui Li, Ranran Guo, Xia Yu, Yu Li
PURPOSE: To observe the inhibitory effect of the small molecule tyrosine kinase inhibitor apatinib on small cell lung cancer in vitro and vivo. MATERIAL AND METHODS: Three small lung cancer cells were selected CCK-8 and monoclonal assay was used to determine the effect of apatinib on proliferation. The effects on cell cycle and apoptosis were detected by flow cytometry and TUNEL. We observed the inhibitory effect of different doses of apatinib on xenograft tumor...
February 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38350674/efficacy-of-airway-stenting-and-nasogastric-tube-insertion-in-airway-esophageal-fistula-patients-with-airways-compromised-by-advanced-malignancy
#38
JOURNAL ARTICLE
Xue Wu, Guangbing Lu, Lin Cheng Luo, Hailong Wei, Qun Yi, Wei Luo
INTRODUCTION: Whether airway-compromised airway-esophageal fistula (AEF) patients should undergo combined airway and esophageal stenting is controversial. This study was designed to evaluate the survival prognosis and poststent interventions in AEF patients with airways compromised by advanced malignancy with or without airway stents. METHODS: A retrospective analysis of the medical records, survival times, and poststent interventions of 17 patients with or without airway stents was performed...
February 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38343070/distinct-age-adjusted-d-dimer-threshold-to-rule-out-acute-pulmonary-embolism-in-outpatients-and-inpatients
#39
JOURNAL ARTICLE
Peng Liu, Haixu Yu, Wei Liu, Lin Lin, Ying Qun Ji
INTRODUCTION: The diagnosis of acute pulmonary embolism (PE) is combinations of clinical probability assessments, plasma D-dimer (DD) test results, and/or computed tomographic pulmonary angiography (CTPA). OBJECTIVE: The aim of this study is to explore the appropriate DD cutoff using the immunoturbidimetric method in outpatients and inpatients. METHODS: We retrospectively enrolled 2689 patients with suspected PE between January 2014 and December 2019...
February 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38666787/acquired-tracheomalacia-due-to-sars-cov-2-pneumonia
#40
LETTER
David Espejo, Marta Zapata, Saliha Omari, Xavier Muñoz, Maria-Jesús Cruz
INTRODUCTION: Several studies mentioned parenchymal findings after SARS-CoV-2 pneumonia, but few studies have mentioned alterations in the airways. The aim of this study was to estimate the prevalence of tracheomalacia and to analyse the clinical characteristics in a cohort of patients with SARS-CoV-2. METHODS: The study population consisted of all patients with SARS-CoV-2 admitted a hospital serving a population of 500 000 inhabitants. Patients were visited between 2 and 6 months after hospital discharge...
January 2024: Clinical Respiratory Journal
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