journal
https://read.qxmd.com/read/39013830/usefulness-of-transbronchial-lung-cryobiopsy-when-starting-antifibrotic-treatment-and-predicting-progressive-fibrosing-interstitial-lung-disease-descriptive-research
#1
JOURNAL ARTICLE
Makiko Takatsuka, Hideaki Yamakawa, Tamiko Takemura, Shintaro Sato, Hiroki Ohta, Kenji Kusano, Tomohiro Oba, Rie Kawabe, Keiichi Akasaka, Hiroki Sasaki, Masako Amano, Jun Araya, Hidekazu Matsushima
BACKGROUND: Although transbronchial lung cryobiopsy (TBLC) is widely used in diagnostic algorithms for various interstitial lung diseases (ILDs), its real-world utility in the therapeutic decision-making strategy for ILD patients remains unclear, in particular, when judging the time to start antifibrotic agents. METHODS: We analyzed medical records of 40 consecutive patients with idiopathic or fibrotic hypersensitivity pneumonitis who underwent TBLC. A TBLC-based usual interstitial pneumonia (UIP) score was used to assess three morphologic descriptors: patchy fibrosis, fibroblastic foci, and honeycombing...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/39013440/clinical-characteristics-of-hospitalized-patients-with-covid-19-and-their-association-with-the-progression-to-critical-illness-and-death-a-single-center-retrospective-study-from-northwestern-mexico
#2
JOURNAL ARTICLE
Francisco A Martínez-Villa, Uriel A Angulo-Zamudio, Nidia Leon-Sicairos, Ricardo González-Esparza, Jaime Sanchez-Cuen, Jesus J Martinez-Garcia, Hector Flores-Villaseñor, Julio Medina-Serrano, Adrian Canizalez-Roman
OBJECTIVE: The objective of this study was to associate the epidemiological and clinical characteristics of patients hospitalized for COVID-19 with the progression to critical illness and death in northwestern Mexico. METHODS: From March to October 2020, we collected the demographic and clinical characteristics of 464 hospitalized patients from northwestern Mexico. RESULTS: Sixty-four percent (295/464) of the patients became critically ill...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/39012086/a-randomized-controlled-clinical-trial-investigating-the-weaning-process-from-mechanical-ventilation-in-elderly-patients-with-dementia
#3
RANDOMIZED CONTROLLED TRIAL
Jian-Feng Liang, Zhi-Yong Li, Hai-Shan Dong, Chang Xu, Chao-Qun Yin
BACKGROUND: Limited data is available regarding the weaning techniques employed for mechanical ventilation (MV) in elderly patients with dementia in China. OBJECTIVE: The primary objective of this study is to investigate diverse weaning methods in relation to the prognostic outcomes of elderly patients with dementia undergoing MV in the intensive care unit (ICU). Specifically, we seek to compare the prognosis, likelihood of successful withdrawal from MV, and the length of stay (LOS) in the ICU...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/39003635/the-novel-fusion-protein-melittin-mil-2-exhibits-strong-antitumor-immune-effect-in-lung-adenocarcinoma-cell-a549
#4
JOURNAL ARTICLE
Weize Gao, Wenshuai Li, Zhan Wang, Yongxin Li, Mingjun Liu
In previous studies, we developed a novel fusion protein named "melittin-MIL-2" which exhibited more anti-tumor activity. However, it remains unclear whether melittin-MIL-2 possesses antitumor immune effect on lung adenocarcinoma. In this study, the immune effect and mechanism of melittin-MIL-2 inhibiting the growth and invasion of lung adenocarcinoma will be investigated, in order to provide novel perspectives for the immunotherapy of lung cancer. The results indicated that melittin-MIL-2 promoted T cell proliferation, enhanced NK cell cytotoxicity, and boosted IFN-γ secretion in PBMCs...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38994643/efficacy-and-safety-of-azvudine-in-patients-with-covid-19-in-china-a-meta-analysis-of-observational-studies
#5
REVIEW
Tao Dong, Wentao Zhang, Tingting Wu, Yongxiang Ge, Qi Yang, Jia Xu, Yuna Liu
BACKGROUND: Azvudine (FNC) is a novel small molecule antiviral drug for treating COVID-19 that is available only on the Chinese market. Despite being recommended for treating COVID-19 by the Chinese guidelines, its efficacy and safety are still unclear. This study aimed to evaluate the protective effect of FNC on COVID-19 outcomes and its safety. METHODS: We followed the PRISMA 2020 guidelines and searched the PubMed, Embase, Web of Science, Scopus, and China National Knowledge Infrastructure (CNKI) databases to evaluate studies on the effectiveness of FNC in treating COVID-19 in China, focusing on mortality and overall outcomes...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38994638/placental-transmogrification-of-the-lung-presenting-as-cystic-solid-mass-a-case-report
#6
JOURNAL ARTICLE
Chen Liu, Yunhui Zhang, Dengyuan Li, Danxiong Sun
The gradually progressive solitary cystic-solid mass of chest CT scans is highly suggestive of lung cancer. We report a case of a 29-year-old woman with a persistent cystic-solid lesion in the right upper lobe. A chest CT scan showed a 35 mm × 44 mm × 51 mm focal cystic-solid mass in the anterior segment of the right upper lobe. The size of lesion had increased over 3 years, especially for the solid component. The right upper lobe pneumonectomy was performed...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38987867/mrpl35-induces-proliferation-invasion-and-glutamine-metabolism-in-nsclc-cells-by-upregulating-slc7a5-expression
#7
JOURNAL ARTICLE
Wei Hou, Juan Chen, Yaoyuan Wang
BACKGROUND: Mitochondrial ribosomal protein L35 (MRPL35) has been reported to contribute to the growth of non-small cell lung cancer (NSCLC) cells. However, the functions and mechanisms of MRPL35 on glutamine metabolism in NSCLC remain unclear. METHODS: The detection of mRNA and protein of MRPL35, ubiquitin-specific protease 39 (USP39), and solute carrier family 7 member 5 (SLC7A5) was conducted using qRT-PCR and western blotting. Cell proliferation, apoptosis, and invasion were evaluated using the MTT assay, EdU assay, flow cytometry, and transwell assay, respectively...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38982540/ct-and-mri-findings-of-renal-angiomyolipoma-with-lung-metastasis-a-case-report-and-literature-review
#8
REVIEW
Zhiqiang He, Jing Wu, Xiao Ming Fu, Xiao Ran Li, Hai Xu, Yu-Chen Chen
Renal angiomyolipoma has two histological variants: classical and epithelioid. Epithelioid angiomyolipoma is considered as a potential malignant tumor, often leading to recurrence and metastasis, with rapid progression in most of the cases. The lung is one of the most commonly reported sites of metastasis, and pulmonary metastasis of renal angiomyolipoma is usually diagnostic by computed tomography (CT) scans. Here, we report for the first time renal angiomyolipoma with lung metastasis by combining CT and magnetic resonance imaging (MRI)...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38979664/keratin-17-and-collagen-type-1-genes-esophageal-cancer-molecular-marker-discovery-and-evaluation
#9
JOURNAL ARTICLE
Huiwen Pan, Jie Hong, Aizhong Shao, Zhiguo Zhao, Guowen Ding, Zhijie Fang, Keping Chen, Jingfeng Zhu
One hundred eighty pairs of tissues of esophageal squamous cell carcinoma (ESCC) were tested by the transcriptome sequencing in order to explore etiology factors. The chi-square test and correlation analysis demonstrated that the relative expression levels of keratin 17 (KRT17) and collagen type I α1 chain (COL1A1) were significantly higher in EC with diabetes. Expression of KRT17 was correlated with blood glucose (r = 0.204, p = 0.001) and tumor size (r = -0...
July 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38923707/a-commentary-on-the-role-of-pulmonary-function-parameters-in-idiopathic-pulmonary-fibrosis-follow-up
#10
LETTER
Guliz Degirmenci, Celal Satici
No abstract text is available yet for this article.
June 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38888197/preventive-behaviors-of-respiratory-infections-in-staff-of-hospital-in-kazeroon-fars-iran-an-application-of-protection-motivation-theory
#11
JOURNAL ARTICLE
Tayebeh Rakhshani, Zohreh Shafiei, Samira Taravatmanesh, Seyyed Mansour Kashfi, Pooyan Afzali Harsini, Amirhossein Kamyab, Ali Khani Jeihooni
BACKGROUND: One of the most crucial and essential methods for the prevention and management of respiratory infections is for healthcare professionals to take precautions for their own safety. Using Protection Motivation Theory (PMT), the current study looked into effective elements influencing the staff at Kazeroon's Valiasr Hospital's preventive actions against respiratory diseases. METHODS: One hundred ninety-two male and 108 female employees of the Valiasr Hospital in Kazeroon, Iran, participated in this cross-sectional study, in May 2022...
June 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38886877/allergic-bronchopulmonary-aspergillosis-abpa-with-colonized-aspergillus-fumigatus-detected-by-metagenomic-next-generation-sequencing-on-tissue-samples-a-distinct-subset-of-abpa-with-a-higher-risk-of-exacerbation
#12
LETTER
Wanjun Wang, Mo Xian, Yongxia Lei, Juhua Yang, Lulu Wu
No abstract text is available yet for this article.
June 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38830831/association-between-plasma-proteome-and-pulmonary-heart-disease-a-two-stage-mendelian-randomization-analysis
#13
JOURNAL ARTICLE
Shiyang Li, Haifeng Ding, Qi Li, Xiaobin Zeng, Yanyu Zhang, Chengyi Lai, Xiaoshuang Xie, Yongjiang Tang, Jianjun Lan
Pulmonary heart disease (PHD) involves altered structure and function of the right ventricle caused by an abnormal respiratory system that causes pulmonary hypertension. However, the association between changes in plasma proteomics and PHD remains unclear. Hence, we aimed to identify causal associations between genetically predicted plasma protein levels and PHD. Mendelian randomization was performed to test the target proteins associated with PHD. Summary statistics for the human plasma proteome and pulmonary heart disease were acquired from the UK Biobank (6038 cases and 426 977 controls) and the FinnGen study (6753 cases and 302 401 controls)...
June 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38817043/copd-patients-with-high-blood-eosinophil-counts-exhibit-a-lower-rate-of-omicron-infection-and-milder-post-infection-symptoms
#14
JOURNAL ARTICLE
Xueli Bai, Yanan Niu, Shuang Wei, Zhifan Zhu, Min Xu, Hu Liu, Xiansheng Liu, Ruiying Wang
BACKGROUND: The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its subsequent Omicron variant has raised concerns for chronic obstructive pulmonary disease (COPD) patients due to the potential risk of disruptions to healthcare services and unknown comorbidities between COPD and Omicron. METHOD: In this study, we conducted a follow-up investigation of 315 COPD patients during the Omicron outbreak at Shanxi Bethune Hospital to understand the impact of the pandemic on this vulnerable population...
June 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38783645/zeb1-as1-mediates-bone-metastasis-through-targeting-mir-320b-bmpr1a-axis-in-lung-cancer
#15
JOURNAL ARTICLE
Nianxi Tan, Junyi Tang, Guang Chen, Weilin Jiang, Zhiqin Liu
OBJECTIVE: This study aimed to explore the role and regulatory mechanism of lncRNA ZEB1-AS1 in lung cancer. METHODS: The expression of ZEB1-AS1 and miR-320b was determined by qRT-PCR. Cell viability, proliferation migration, and invasion were assessed using the CCK-8, colony-forming, and Transwell assay. EMT markers were quantified using western blot. The growth of subcutaneous tumor growth and metastatic bone tumors was evaluated in mouse model of lung cancer. Additionally, metastatic bone tumors were examined using H&E staining...
May 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38778673/exogenous-surfactant-for-lung-contusion-causing-ards-a-systematic-review-of-clinical-and-experimental-reports
#16
REVIEW
Tomáš Merkl, David Astapenko, Radek Štichhauer, Antonín Šafus, Tomáš Dušek, Jiří Kotek, David Řehák, Petr Lochman
This systematic review aimed to summarize the available data on the treatment of pulmonary contusions with exogenous surfactants, determine whether this treatment benefits patients with severe pulmonary contusions, and evaluate the optimal type of surfactant, method of administration, and drug concentration. Three databases (MEDline, Scopus, and Web of Science) were searched using the following keywords: pulmonary surfactant, surface-active agents, exogenous surfactant, pulmonary contusion, and lung contusion for articles published between 1945 and February 2023, with no language restrictions...
May 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38775379/emerging-trends-in-management-of-long-covid-with-a-focus-on-pulmonary-rehabilitation-a-review
#17
REVIEW
Allison Y Li, Willis X Li, Jinghong Li
Long COVID, or post-acute sequelae of COVID-19 (PASC), represents a complex condition with persistent symptoms following SARS-Cov-2 infection. The symptoms include fatigue, dyspnoea, cognitive impairment, decreased quality of life in variable levels of severity. Potential mechanisms behind long COVID include vascular damage, immune dysregulation and viral persistence. Diagnosing long COVID involves medical evaluation by multidisciplinary team and assessment of persistent symptoms with scoring systems in development...
May 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38757752/identification-and-analysis-of-prognostic-immune-cell-homeostasis-characteristics-in-lung-adenocarcinoma
#18
JOURNAL ARTICLE
Yidan Sun, Qianqian Ma, Yixun Chen, Dongying Liao, Fanming Kong
BACKGROUND: Lung adenocarcinoma (LUAD) is one of the most invasive malignant tumor of the respiratory system. It is also the common pathological type leading to the death of LUAD. Maintaining the homeostasis of immune cells is an important way for anti-tumor immunotherapy. However, the biological significance of maintaining immune homeostasis and immune therapeutic effect has not been well studied. METHODS: We constructed a diagnostic and prognostic model for LUAD based on B and T cells homeostasis-related genes...
May 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38747117/circst6gal1-knockdown-alleviates-pulmonary-arterial-hypertension-by-regulating-mir-509-5p-multiple-c2-and-transmembrane-domain-containing-2-axis
#19
JOURNAL ARTICLE
Xing Zhang, Hao Qin, Qiang Ma, Junbo Zhang, Hongyan Tian, Yan Meng
BACKGROUND: Hypertension is a main contributing factor of cardiovascular diseases; deregulated circular RNAs are involved in the pathogenesis of pulmonary arterial hypertension (PAH). Herein, we evaluated the function and mechanism of circST6GAL1 in PAH process. METHODS: Human pulmonary artery smooth muscle cells (HPASMCs) were cultured in hypoxic environment for functional analysis. The cell counting kit-8, 5-ethynyl-2'-deoxyuridine, wound healing, and flow cytometry assays were used to investigate cell proliferation, migration, and apoptosis...
May 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38742362/human-epididymis-protein-4-a-novel-potential-biomarker-for-diagnostic-and-prognosis-monitoring-of-lung-cancer
#20
JOURNAL ARTICLE
Tingting Zhang, Lanhe Chu, Wenchong Tan, Cuiping Ye, Hangming Dong
OBJECTIVE: This study aimed to explore the application value of human epididymis protein 4 (HE4) in diagnosing and monitoring the prognosis of lung cancer. METHODS: First, TCGA (The Cancer Genome Atlas) databases were used to analyze whey-acidic-protein 4-disulfide bond core domain 2 (WFDC2) gene expression levels in lung cancer tissues. Then, a total of 160 individuals were enrolled, categorized into three groups: the lung cancer group (n = 80), the benign lesions group (n = 40), and the healthy controls group (n = 40)...
May 2024: Clinical Respiratory Journal
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