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Journal of Breast Cancer

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https://read.qxmd.com/read/30607170/the-open-issues-regarding-cyclin-dependent-kinase-4-6-inhibitors-in-the-management-of-advanced-breast-cancer
#1
Lorenzo Rossi
No abstract text is available yet for this article.
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607169/lobular-breast-carcinoma-metastasis-to-the-thyroid-gland-case-report-and-literature-review
#2
Kevin Bourcier, Veronique Fermeaux, Sophie Leobon, Elise Deluche
Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. An 18 F-fluoro-deoxy-D-glucose positron emission tomography scan was performed for staging, and low uptakes were observed in the left supraclavicular and cervical lymph nodes. High uptake was seen in the posterior and lower left lobe of the thyroid...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607168/diagnostic-value-of-contrast-enhanced-digital-mammography-versus-contrast-enhanced-magnetic-resonance-imaging-for-the-preoperative-evaluation-of-breast-cancer
#3
Eun Young Kim, Inyoung Youn, Kwan Ho Lee, Ji-Sup Yun, Yong Lai Park, Chan Heun Park, Juhee Moon, Seon Hyeong Choi, Yoon Jung Choi, Soo-Youn Ham, Shin Ho Kook
Purpose: This study aimed to compare the diagnostic performance of contrast-enhanced digital mammography (CEDM) and contrast-enhanced magnetic resonance imaging (CEMRI) in preoperative evaluations, and to evaluate the effect of each modality on the surgical management of women with breast cancer. Methods: This single-center, prospective study was approved by the Institutional Review Board, and informed consent was obtained from all patients. From November 2016 to October 2017, 84 patients who were diagnosed with invasive carcinoma (69/84) and ductal carcinoma in situ (15/84), and underwent both CEDM and CEMRI, were enrolled...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607167/patterns-of-axillary-lymph-node-metastasis-in-breast-cancer-a-prospective-single-center-study
#4
Hee Jun Choi, Jae-Myung Kim, Jai Min Ryu, Isaac Kim, Seok Jin Nam, Jonghan Yu, Se Kyung Lee, Jeong Eon Lee, Seok Won Kim
Purpose: The recent trend in breast cancer treatment is to minimize axillary dissection. However, no pattern of axillary metastasis has been precisely established. The purpose of this study was to evaluate the metastatic lymphatic pattern using near-infrared fluorescence imaging with indocyanine green (ICG) in breast cancer with cytologically proven axillary metastasis. Methods: This was a prospective single-center study. We evaluated 147 patients with breast cancer involving cytologically proven axillary metastasis, and compared physiological and nonphysiological lymphatic metastasis...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607166/internal-mammary-sentinel-lymph-node-biopsy-after-neoadjuvant-chemotherapy-in-breast-cancer
#5
Zhao Bi, Peng Chen, Jingjing Liu, Yanbing Liu, Pengfei Qiu, Qifeng Yang, Weizhen Zheng, Yongsheng Wang
Purpose: The definition of nodal pathologic complete response (pCR) after a neoadjuvant chemotherapy (NAC) just included the evaluation of axillary lymph node (ALN) without internal mammary lymph node. This study aimed to evaluate the feasibility of internal mammary-sentinel lymph node biopsy (IM-SLNB) in patients with breast cancer who underwent NAC. Methods: From November 2011 to 2017, 179 patients with primary breast cancer who underwent operation after NAC were included in this study...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607165/use-of-sentinel-lymph-node-biopsy-after-neoadjuvant-chemotherapy-in-patients-with-axillary-node-positive-breast-cancer-in-diagnosis
#6
Hee Jun Choi, Isaac Kim, Emad Alsharif, Sungmin Park, Jae-Myung Kim, Jai Min Ryu, Seok Jin Nam, Seok Won Kim, Jonghan Yu, Se Kyung Lee, Jeong Eon Lee
Purpose: This study aimed to evaluate the effects of sentinel lymph node biopsy (SLNB) on recurrence and survival after neoadjuvant chemotherapy (NAC) in breast cancer patients with cytology-proven axillary node metastasis. Methods: We selected patients who were diagnosed with invasive breast cancer and axillary lymph node metastasis and were treated with NAC followed by curative surgery between January 2007 and December 2014. We classified patients into three groups: group A, negative sentinel lymph node (SLN) status and no further dissection; group B, negative SLN status with backup axillary lymph node dissection (ALND); and group C, no residual axillary metastasis on pathology with standard ALND...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607164/neoadjuvant-chemotherapy-and-prognosis-of-pregnancy-associated-breast-cancer-a-time-trends-study-of-the-korean-breast-cancer-registry-database
#7
Soo Youn Bae, Ku Sang Kim, Jeong-Soo Kim, Sae Byul Lee, Byeong-Woo Park, Seok Won Lee, Hyouk Jin Lee, Hong Kyu Kim, Ji-Young You, Seung Pil Jung
Purpose: Pregnancy-associated breast cancer (PABC) is rare, and its cause and prognosis are not well known. Additionally, treatment is limited with respect to the risk to the fetus. The purpose of this study was to investigate the characteristics and treatment trends of PABC and the survival rate according to the treatment. Methods: In the Korean Breast Cancer Society Registry database, women younger than 50 years and who were diagnosed with breast cancer from 1996 to 2015 were included...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607163/clinical-differences-in-triple-positive-operable-breast-cancer-subtypes-in-korean-patients-an-analysis-of-korean-breast-cancer-registry-data
#8
Sun Hyong You, Byung Joo Chae, Yong Hwa Eom, Tae-Kyung Yoo, Yong-Seok Kim, Jeong Soo Kim, Woo-Chan Park
Purpose: Triple-positive breast cancer is defined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) positivity. Several systemic breast cancer therapies target hormonal and HER2 responsiveness. We compared clinical outcomes of triple-positive disease with those of HER2-enriched and luminal HER2-negative disease and investigated the clinical efficacy of anti-HER2 therapy for triple-positive disease. Methods: We retrospectively compared overall and recurrence-free survival among cases included in the Korean Breast Cancer Society (KBCS) and Seoul St...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607162/t-cell-immunoglobulin-mucin-3-expression-on-tumor-infiltrating-lymphocytes-as-a-positive-prognosticator-in-triple-negative-breast-cancer
#9
Kyung Do Byun, Hyo Jun Hwang, Ki Jae Park, Min Chan Kim, Se Heon Cho, Mi Ha Ju, Jin Hwa Lee, Jin Sook Jeong
Purpose: T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is an emerging immune response molecule related to T-cell anergy. There has been tremendous interest in breast cancer targeting immune checkpoint molecules, especially in the triple-negative breast cancer (TNBC). This study was designed to investigate TIM-3 expression on tumor infiltrating lymphocytes (TILs), its relationships with clinicopathological para-meters and expression of programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 (PD-L1), and its prognostic role...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607161/significance-of-vesicle-associated-membrane-protein-8-expression-in-predicting-survival-in-breast-cancer
#10
Mengci Yuan, Jianhua Liao, Ji Luo, Mengyao Cui, Feng Jin
Purpose: Vesicle-associated membrane protein 8 (VAMP8) is a soluble N-ethylmaleimide-sensitive factor receptor protein that participates in autophagy by directly regulating autophagosome membrane fusion and has been reported to be involved in tumor progression. Nevertheless, the expression and prognostic value of VAMP8 in breast cancer (BC) remain unknown. This study aimed to evaluate the clinical significance and biological function of VAMP8 in BC. Methods: A total of 112 BC samples and 30 normal mammary gland samples were collected...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607160/shorter-telomere-length-is-associated-with-increased-breast-cancer-risk-in-a-chinese-han-population-a-case-control-analysis
#11
Zhaoxia Wang, Zhenxing Zhang, Yanling Guo, Huifeng Shui, Guoqi Liu, Tianbo Jin, Huijie Wang
Purpose: The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods: We used real-time quantitative polymerase chain reaction to measure relative telomere length (RTL) in genomic DNA extracted from peripheral blood from 183 breast cancer cases and 191 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607159/-pik3ca-mutations-and-neoadjuvant-therapy-outcome-in-patients-with-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-a-sequential-analysis
#12
Youjeong Seo, Yeon Hee Park, Jin Seok Ahn, Young-Hyuck Im, Seok Jin Nam, Soo Youn Cho, Eun Yoon Cho
Purpose: PIK3CA mutation is considered to be a possible cause for resistance to neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. We investigated the association between PIK3CA mutations and the outcome of NAC in HER2-positive breast cancers. Methods: A total of 100 HER2-positive breast cancer patients who had undergone NAC and surgery between 2004 and 2016 were examined. Mutation status was sequentially assessed in pre-NAC, post-NAC, and recurrent specimens taken from these patients...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607158/mir-195-mir-497-regulate-cd274-expression-of-immune-regulatory-ligands-in-triple-negative-breast-cancer
#13
Lianzhou Yang, Yuchen Cai, Dongsheng Zhang, Jian Sun, Chenyu Xu, Wenli Zhao, Wenqi Jiang, Chunhua Pan
Purpose: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7 family members that were able to predict the immune status of patients, and which may serve as potential targets for the treatment of breast cancer. We also aimed to identify microRNAs that may regulate the expression of B7 family members. Methods: The Cancer Genome Atlas data from 1,092 patients with breast cancer, including gene expression, microRNA expression and survival data, were used for statistical and survival analyses...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607157/identification-and-validation-of-circulating-microrna-signatures-for-breast-cancer-early-detection-based-on-large-scale-tissue-derived-data
#14
Xiaokang Yu, Jinsheng Liang, Jiarui Xu, Xingsong Li, Shan Xing, Huilan Li, Wanli Liu, Dongdong Liu, Jianhua Xu, Lizhen Huang, Hongli Du
Purpose: Breast cancer is the most commonly occurring cancer among women worldwide, and therefore, improved approaches for its early detection are urgently needed. As microRNAs (miRNAs) are increasingly recognized as critical regulators in tumorigenesis and possess excellent stability in plasma, this study focused on using miRNAs to develop a method for identifying noninvasive biomarkers. Methods: To discover critical candidates, differential expression analysis was performed on tissue-originated miRNA profiles of 409 early breast cancer patients and 87 healthy controls from The Cancer Genome Atlas database...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607156/new-insights-into-the-role-of-endoplasmic-reticulum-stress-in-breast-cancer-metastasis
#15
REVIEW
Chang-Chang Han, Fu-Sheng Wan
Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To accommodate the occurrence of ERS, cells have evolved a highly conserved, self-protecting signal transduction pathway called the unfolded protein response. Notably, ERS signaling is involved in the development of a variety of diseases and is closely related to tumor development, particularly in breast cancer...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30607155/current-approaches-in-development-of-immunotherapeutic-vaccines-for-breast-cancer
#16
REVIEW
Adil Allahverdiyev, Gamze Tari, Melahat Bagirova, Emrah Sefik Abamor
Cancer is the leading cause of death worldwide. In developed as well as developing countries, breast cancer is the most common cancer found among women. Currently, treatment of breast cancer consists mainly of surgery, chemotherapy, hormone therapy, and radiotherapy. In recent years, because of increased understanding of the therapeutic potential of immunotherapy in cancer prevention, cancer vaccines have gained importance. Here, we review various immunotherapeutic breast cancer vaccines including peptide-based vaccines, whole tumor cell vaccines, gene-based vaccines, and dendritic cell vaccines...
December 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30275864/extraocular-muscles-involvement-as-the-initial-presentation-in-metastatic-breast-cancer
#17
Inês Coutinho, Marco Marques, Rui Almeida, Sofia Custódio, Teresa Simões Silva, Fernanda Águas
Orbital metastasis is a rare event, and metastatic disease affecting the extraocular muscles is an even less frequent complication of solid tumors. Herein, we report an unusual case of ptosis as the initial presentation of an invasive breast cancer. A 68-year-old woman presented with III and VI partial nerve paresis, secondary to a compressive retrobulbar mass. Magnetic resonance imaging revealed an infiltrative lesion involving the extraocular muscles. Tissue biopsy yielded a result compatible with metastasis to the orbit, with immunohistochemistry analysis suggesting breast as the primary organ...
September 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30275863/gasless-robot-assisted-nipple-sparing-mastectomy-a-case-report
#18
Hyung Seok Park, Joo Heung Kim, Dong Won Lee, Seung Yong Song, Seho Park, Seung Il Kim, Dae Hyun Ryu, Young Up Cho
Robotic surgical systems enhance surgical accuracy and efficiency by applying advanced technologies such as artificial arm joints to provide higher degrees of freedom of movement and high-quality three-dimensional images. However, the application of robotic surgical systems to breast surgery has not been widely attempted. The robotic system would improve cosmesis by enabling surgery using a single small incision. We report the first case of a gasless robot-assisted nipple-sparing mastectomy and immediate reconstruction in a patient with early breast cancer...
September 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30275862/the-novel-pathogenic-mutation-c-849dupt-in-brca2-contributes-to-the-nonsense-mediated-mrna-decay-of-brca2-in-familial-breast-cancer
#19
Sanrong Li, Jing Ma, Caiying Hu, Xing Zhang, Deyong Xiao, Lili Hao, Wenjun Xia, Jichun Yang, Ling Hu, Xiaowei Liu, Minghui Dong, Duan Ma, Rensheng Liu
In this study, we used next-generation sequencing methods to screen 300 individuals for BRCA1 and BRCA2 . A novel mutation (c.849dupT) in BRCA2 was identified in a female patient and her unaffected brothers. This mutation leads to the truncation of BRCA2 functional domains. Moreover, BRCA2 mRNA expression levels in mutation carriers are significantly reduced compared to noncarriers. Immunofluorescence and western blot assays showed that this mutation resulted in reduced BRCA2 protein expression. Thus, we identified a novel mutation that damaged the function and expression of BRCA2 in a family with breast cancer history...
September 2018: Journal of Breast Cancer
https://read.qxmd.com/read/30275861/comparison-of-oncoplastic-breast-conserving-surgery-and-breast-conserving-surgery-alone-a-meta-analysis
#20
Jun-Ying Chen, Yi-Jie Huang, Liu-Lu Zhang, Ci-Qiu Yang, Kun Wang
Purpose: The use of oncoplastic reconstruction for breast-conserving surgery (BCS) extends benefits beyond merely minimizing poor cosmetic results. However, the feasibility and oncological safety of oncoplastic surgery (OPS) are controversial. Methods: This meta-analysis aimed to compare the short-term and long-term oncological outcomes of BCS alone and BCS plus OPS. Relevant studies published before July 2017 in the Embase, the Cochrane Library, PubMed, and Web of Science databases were screened and collected...
September 2018: Journal of Breast Cancer
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