journal
Journals Journal of Complementary & Int...

Journal of Complementary & Integrative Medicine

https://read.qxmd.com/read/37974314/-pentaclethra-macrophylla-leaves-reduce-blood-glucose-level-improve-sexual-behavior-and-modulate-critical-enzymes-associated-with-diabetes-erectile-dysfunction-morbidity-in-rats
#21
JOURNAL ARTICLE
Onyinyechi Ruth Nwagwe, Stephen Adeniyi Adefegha, Ganiyu Oboh
OBJECTIVES: This research work studied the phenolic composition of Pentaclethra macrophylla (PM), the inclusion of dietary supplementation of PM leaves on sexual functions and its connection to inhibit enzymes (arginase and phosphodiesterase-5) and nitric oxide level, linked to type 2 diabetes-induced erectile dysfunction in rats. METHODS: Gallic acid, chlorogenic and ellagic acids, Kaempferol, and epicatechin etc. was spotted with High performance liquid chromatography-diode array detector from PM extract...
November 17, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37961756/oral-intake-of-collagen-hydrolysate-from-mackerel-scad-decapterus-macarellus-attenuates-skin-photoaging-by-suppressing-the-uvb-induced-expression-of-mmp-1-and-il-6
#22
JOURNAL ARTICLE
Rizki Sandhi Titisari, Elisa Herawati, Okid Parama Astirin
OBJECTIVES: Excessive skin exposure to UVB radiation can induce photoaging caused by an imbalance in oxidative stress and inflammatory responses, damaging the skin's structure and surface layer. A previous study revealed that collagen hydrolisate extracted from the skin of mackarel scads ( Decapterus macarellus ) had antiaging properties that were tested in vitro , which serves as a foundation for a subsequent study of its use in vivo . This study aimed at investigating the repair effect of the mackerel scad's skin collagen hydrolysate (MSS-CH) in photoaging conditions in a mouse model...
November 15, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37916849/anti-melanoma-and-antioxidant-properties-of-the-methanol-extract-from-the-leaves-of-phragmenthera-capitata-spreng-balle-and-globimetula-braunii-engl-van-tiegh
#23
JOURNAL ARTICLE
Azabadji Ashu Evariste Leonce, Priyanka Devi, Tagne Simo Richard, Biswajit Panda, Geetanjali Devabattula, Chandraiah Godugu, Telefo Phelix Bruno
OBJECTIVES: Phragmenthera capitata (Spreng.) Balle and Globimetula braunii (Engler.) Van Tiegh are African mistletoe traditionally used in cancers treatment. Thus, the aim of the study was to assess the anti-melanoma potential of the methanol extract of Phragmenthera capitata (Spreng.) Balle (PCMe-OH) and Globimetula braunii (Engler.) (GBMe-OH) Van Tiegh . METHODS: Antioxidant potential was evaluated using DPPH, FRAP and hydroxyl assays. Total flavonoid and phenolic contents was also determined...
November 3, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37831722/causes-of-adverse-outcomes-in-acute-intestinal-obstruction
#24
JOURNAL ARTICLE
Valentin Madyarov, Marat Kuzikeev, Maulen Malgazhdarov, Yestay Abzalbek, Gulnara Zhapbarkulova
OBJECTIVES: The purpose of this study is to analyse the effectiveness of methods of diagnosis and treatment of patients with acute intestinal obstruction. METHODS: A total of 123 patients were examined, who were diagnosed based on history, an overview X-ray of the abdominal cavity, a contrast examination of the intestine, and contrast marks according to Yu. L. Shalkov and irrigoscopy. 57.4 % of patients had all typical aspects of the disease, 17.7 % - indolent aspects, and 4...
October 16, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37831720/blood-pressure-lowering-effects-of-vernonia-amygdalina-del-aqueous-fraction-on-hypertensive-wistar-kyoto-rats
#25
JOURNAL ARTICLE
Dian Ayu Juwita, Rindang Farinka, Rahmad Abdillah, Fitri Rachmaini
OBJECTIVES: Vernonia amygdalina (VA) is a plant that consumed as vegetable by Indonesians contained numerous secondary metabolites. VA's pharmacological action, including its antioxidant properties, anticancer, antidiabetic, and hepatoprotective. The purpose of this research is to reveal the activity of Vernonia amygdalina . leafs aqueous fraction (VALAF) as a blood pressure-lowering agent in hypertensive model. METHODS: Combination of Prednisone and NaCl were used as hypertensive inducer...
October 16, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37789574/comparative-effectiveness-is-the-common-denominator-in-health-services-research-experimental-effects-are-promising-real-world-effects-are-compelling
#26
REVIEW
Franz Porzsolt
OBJECTIVES: Sir Archibald Cochrane and Sir Austin Bradford Hill requested 80 years ago answers to three questions (Can it work? Does it work? Is it worth it?) before a new intervention is implemented in day-to-day healthcare. A critical analysis of currently accepted answers identified a terminology conflict that inherits the risk of misleading interpretations and inappropriate decisions. CONTENT: For detection of the terminology problem and the development of the solutions was possible through three recommendations (the "Ulm heritage"): (1) Albert Einstein (*1879 in Ulm/Germany) predicted, "A problem cannot be solved with the way of thinking that caused it"; (2) The "hochschule für gestaltung ulm (Academy of Design, 1953-1968)" disseminated the rules of American designers and architects e...
October 5, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37732506/scopoletin-a-potential-phytochemical-therapy-for-antitubercular-treatment-drug-induced-liver-injury-att-dili-model-in-wistar-rats
#27
JOURNAL ARTICLE
Swati Sharma, Vishal Sharma, Sunil Taneja, Alka Bhatia, Aishwarya Anand, Amol N Patil, Dibyajyoti Banerjee
OBJECTIVES: The hepatoprotective properties of scopoletin have been explored in carbon tetrachloride (CCl4) induced liver injury but not in drug-induced liver injury (DILI) scenarios. Only N-acetyl-cysteine (NAC) has proven efficacy in DILI treatment. Accordingly, we conducted a study to assess the hepatoprotective action of scopoletin in the anti-tubercular treatment (ATT)-DILI model in Wistar rats, if any . METHODS: A total of 36 rats were evaluated, with six in each group...
September 22, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37712769/a-solid-lipid-particle-formulation-of-long-pepper-extract-reduces-pain-and-astrocyte-activation-in-a-rat-model-of-neuropathic-pain
#28
JOURNAL ARTICLE
Sri-Arun Iamjan, Siriluk Veerasakul, Samur Thanoi, Waree Tiyaboonchai, Sutisa Nudmamud-Thanoi
OBJECTIVES: To investigate the effects of solid lipid microparticle (SLM) creams containing a long pepper extract (LPE) or piperine on neuropathy-related pain and the expression of Glial fibrillary acidic protein (GFAP) as a measure of astrogliosis. METHODS: Neuropathic pain in male Spraque Dawley rats was induced by sciatic nerve ligation (SNL) and followed by treatment with LPE-SLM, piperine-SLM, capsaicin or vehicle creams. The pain score was assessed by thermal hyperalgesia test...
September 18, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37712721/potential-anti-cancer-activity-of-moringa-oleifera-derived-bio-active-compounds-targeting-hypoxia-inducible-factor-1-alpha-in-breast-cancer
#29
REVIEW
Neha Masarkar, Suman Kumar Ray, Zirha Saleem, Sukhes Mukherjee
Breast cancer (BC) will become a highly detected malignancy in females worldwide in 2023, with over 2 million new cases. Studies have established the role of hypoxia-inducible factor-1α (HIF1α), a transcription factor that controls cellular response to hypoxic stress, and is essential for BC spread. HIF-1 is implicated in nearly every critical stage of the metastatic progression, including invasion, EMT, intravasation, extravasation, angiogenesis, and the formation of metastatic niches. HIF-1 overexpression has been associated with poor prognosis and increased mortality in BC patients...
September 18, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37561949/optimization-of-total-phenolic-content-total-flavonoid-content-and-anti-gout-properties-of-polyherbal-formulation
#30
JOURNAL ARTICLE
Lim Sin Yee, Mohd Fadzelly Abu Bakar, Norazlin Abdullah, Fazleen Izzany Abu Bakar, Sri Fatmawati
OBJECTIVES: An increase in gout prevalence has drawn attention among society and this situation drives the exploration of more favourable treatment using traditional medicinal plants which are rich in phenolic and flavonoid to avoid the side effects of modern medication. However, there are only few studies regarding the optimization of phytochemicals and anti-gout properties of medicinal plants and their combinations. The objectives of this study were to determine the optimal formulation of Strobilanthes crispus , Orthosiphon stamineus Benth and Stevia rebaudiana with maximum total phenolic and flavonoid contents as well as minimum IC50 of in vitro xanthine oxidase inhibitory activity and to examine their correlations among the formulations...
August 14, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37474486/non-monotonic-dose-response-of-di-2-ethylhexyl-phthalate-isolated-from-penicillium-citrinum-xt6-on-adipogenesis-and-expression-of-ppar%C3%AE-and-glut4-in-3t3-l1-adipocytes
#31
JOURNAL ARTICLE
Fitra Fauziah, Hirowati Ali, Cimi Ilmiawati, Eko Fuji Ariyanto, Dwi Dinni Aulia Bakhtra, Deslina Setria Mita, Nova Syafni, Dian Handayani
OBJECTIVES: Adipogenesis is the fat cell formation process regulated by peroxisome proliferator-activated receptors ( PPARγ ). The insulin-responsive glucose transporter 4 ( GLUT4 ) has a major role in glucose uptake and metabolism in insulin target tissues (i.e., adipose and muscle cells). The interplay between PPARγ and GLUT4 is essential for proper glucose homeostasis. This study aimed to isolate, elucidate, and investigate the effect of an isolated compound from Penicillium citrinum XT6 on adipogenesis, PPARγ , and GLUT4 expression in 3T3-L1 adipocytes...
July 24, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37428454/alterations-in-expression-of-%C3%AE-1-adrenergic-receptors-possibly-are-involved-in-prevention-of-age-associated-apoptosis-in-rat-hippocampus-by-treadmill-exercise
#32
JOURNAL ARTICLE
Leila Chodari, Maedeh Ghasemi, Nasrin Mehranfard
OBJECTIVES: Exercise is assumed to attenuate age-related neuronal apoptosis, but the detailed mechanism(s) is not fully understood. α1-adrenergic receptors (ARs) can either trigger or suppress apoptosis, therefore, here we determined the impact of treadmill exercise on the expression of the apoptosis regulatory proteins as well as α1-AR subtypes α1A- and α1B-ARs, in order to elucidate a possible association between apoptosis and the hippocampal expression of α1-ARs in aged male rats...
July 11, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37401762/modulation-of-glucose-metabolism-related-genes-in-diabetic-rats-treated-with-herbal-synthetic-anti-diabetic-compound-%C3%AE-hsa-insights-from-transcriptomic-profiling
#33
JOURNAL ARTICLE
Nikhil Khurana, Suman Bala Sharma
BACKGROUND: Eugenia jambolana is a medicinal plant traditionally used for treating diabetes. The bioactive compound FIIc, which is derived from the fruit pulp of E. jambolana, has been identified and purified as α-HSA. Previous studies have demonstrated that administration of α-HSA for 6 weeks improved glycemic index and dyslipidemia in rats with T2D. OBJECTIVES: This study investigated the molecular mechanism underlying the potential therapeutic effects of α-HSA in experimentally induced diabetic rats...
July 4, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37384842/concept-of-dementia-nisy-%C3%A4-n-in-unani-system-of-medicine-and-scientific-validation-of-an-important-unani-pharmacopoeial-preparation-majoon-vaj-for-its-management-a-review
#34
JOURNAL ARTICLE
Mohd Aleem, Md Imran Khan
OBJECTIVES: This review focused on the concept of dementia in the Unani system of medicine and comprehensive, updated information on Majoon Vaj about the phytochemistry, nootropic, CNS activities and provide insights into potential opportunities for future research. METHODS: The classical literature on Majoon Vaj for its anti-dementic properties, and therapeutic uses were gathered from nearly thirteen classical Unani books including Unani Pharmacopoeia. The information of pharmacognosy, phytochemical and pharmacological activities of Majoon Vaj and its ingredient was collected by browsing the Internet (PubMed, ScienceDirect, Wiley online library, Google Scholar, ResearchGate)...
July 3, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37382892/gastroprotective-and-ulcer-healing-effects-of-nauclea-pobeguinii-rubiaceae-on-experimentally-induced-gastric-ulcers-in-male-wistar-rats
#35
JOURNAL ARTICLE
Karelle Kouam Yacine Madjo, Marius Mbiantcha, Linda Zenab Njoya Fagni, Vanessa Mba Matah Marthe, Elvira Azanze Ngoufack, Gonzal Eric Tsafack, Stephanie Flore Djuichou Nguemnang, Carine Flore Adjouzem, Gilbert Ateufack
OBJECTIVES: In this study, we determined the gastroprotective and ulcer-healing effects of extracts (aqueous and methanolic) of Nauclea pobeguinii stem-back. METHODS: Gastroprotective and healing activity were evaluated following a HCl/ethanol and an indomethacin-induced acute ulcers models; acetic acid, pylorus-ligature, pylorus ligature/histamine and pylorus ligature/acetylcholine-induced chronic ulcers models. RESULTS: It emerges from this study that, at 100, 200 and 400 mg/kg, the extracts significantly reduced the various ulceration parameters...
June 30, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37311120/vitamin-a-and-vitamin-d3-protect-the-visual-apparatus-during-the-development-of-dopamine-2-receptor-knockout-mouse-model-of-parkinsonism
#36
JOURNAL ARTICLE
Mujittapha Sirajo Umar, Badamasi Muhammed Ibrahim
BACKGROUND: Dopamine-related movement disorders are associated with a loss of visual acuity. Studies have shown that chemical stimulation of the Vitamin D3 receptor (VDR) ameliorates movement disorders; however, the chemical stimulation is not effective when there is a deficiency of Vitamin A in the cells. In the study, we examine the role of VDR and its interplay with vitamin A in impaired visual function in the dopamine deficit model. METHODS: Thirty (30) male mice with an average weight of 26 g ± (2) were divided into six group (NS,-D2,-D2 + VD D2 + VD, -D2 + VA, -D2 + (VD + VA) and -D2 + D2 groups)...
June 15, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37300384/acute-and-sub-acute-toxicity-of-amirdha-gandhi-kukkil-vallathy-an-effective-siddha-herbo-mineral-formulation-used-in-the-treatment-of-rheumatoid-arthritis-in-wistar-albino-rat-model
#37
JOURNAL ARTICLE
Juliet Lawrence, Sugin Lal Jabaris S, Ramadevi Bhogireddy, Kanakavalli Kadarkarai, Kabilan Natarajan, Christian Gnanaraj Jhonson, Ganesan Rathinam, Sivakkumar Sandhirappan
BACKGROUND: Amirdha Gandhi Kukkil Vallathy (AGKV) is a herbo mineral Siddha formulation which has Sulphur, Kukkil, Seendhil and Serankottai as major ingredients and it is indicated for 80 types of Vatham diseases. Uthiravatha suronitham is one among the vatham diseases and it's clinical symptoms are correlated with Rheumatoid arthritis (RA). Since AGKV is a promising drug for RA, the safety of this drug has been validated by performing the acute and 28 days repeated oral dose toxicity study following the OECD guidelines 423 and 407...
June 12, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37300330/vitamin-c-supplementation-modulates-crude-oil-contaminated-water-induced-gravid-uterine-impaired-contractile-mechanism-and-foetal-outcomes-in-wistar-rats
#38
JOURNAL ARTICLE
Shakiru Ademola Salami, Fatai O Oreagba, Hussein M Salahdeen, Ibiyemi I Olatunji-Bello, Babatunde A Murtala
OBJECTIVES: Crude oil is a common environmental contaminant that impacts the reproductive functions of women. Understanding the contractile mechanism of the gravid uterus and how it impacts fetal outcomes during crude oil-contaminated water (CCW) exposure is still evolving. This study investigates the effect of vitamin C supplementation during the ingestion of CCW from Bayelsa, Nigeria, on the contractile mechanism of the gravid uterus and fetal outcomes. METHODS: Fifteen nulliparous pregnant rats were randomly divided into 3 groups of 5 rats each and treated with normal saline (control), CCW (2...
June 12, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37283183/icosapent-ethyl-vascepa-%C3%A2-as-treatment-for-post-acute-sequelae-of-sars-cov-2-pasc-vaccine-induced-injury-and-infection
#39
JOURNAL ARTICLE
Sean M Cruess, Joseph Xavier Callahan, Isabella Raso, Bryceida Valencia, Jonathan Eskander
OBJECTIVES: As the COVID-19 pandemic continues, a prolonged post-infectious syndrome or "long COVID" has been reported. This is a multi-organ post viral syndrome that persists well after infection. Currently, there is no available treatment. Emerging evidence credits this "long COVID" syndrome to ongoing inflammatory response following resolution of symptoms during infection. An omega-three fatty acid derivative used in the treatment of hypertriglyceridemia, Icosapent Ethyl (IPE, VASCEPA® /Epadel® ), was previously shown to reduce cardiovascular risk, likely via immunomodulatory effects...
June 7, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37277938/intra-stromal-injection-of-honey-treated-keratocytes-as-a-cell-based-therapy-for-experimental-corneal-laceration
#40
JOURNAL ARTICLE
Fatemeh Sanie-Jahromi, M Hossein Nowroozzadeh, Zahra Emadi, Masoomeh Eghtedari, Zohreh Khajehahmadi
OBJECTIVES: This study aimed to investigate the potential of honey-supplemented medium (HSM) for expanding corneal keratocytes and its transplantation in a model of corneal laceration. METHODS: Keratocytes were cultured in 1 % HSM- or 10 % fetal bovine serum (FBS)-supplemented medium for 24 h. The effect of HSM on keratocyte proliferation was evaluated using the MTT assay. The relative expression of Lum , Kera , and ALDH3A1 , known markers of native keratocytes, was quantified by real-time PCR...
June 7, 2023: Journal of Complementary & Integrative Medicine
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