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ACS Nano

Jasper N Immink, J J Erik Maris, Jérôme J Crassous, Joakim Stenhammar, Peter Schurtenberger
We investigate the collective behavior of suspended thermoresponsive microgels, that expel solvent and subsequently decrease in size upon heating. Using a binary mixture of differently thermoresponsive microgels, we demonstrate how distinctly different gel structures form, depending on the heating profile used. Confocal laser scanning microscopy (CLSM) imaging shows that slow heating ramps yield a core-shell network through sequential gelation, while fast heating ramps yield a random binary network through homo-gelation...
February 14, 2019: ACS Nano
Weidong Nie, Wei Wei, Liping Zuo, Chengliang Lv, Fan Zhang, Gui-Hong Lu, Feng Li, Guanghao Wu, Li-Li Huang, Xiaobo Xi, Hai-Yan Xie
Although adoptive T-cell therapy has been successful in hematological malignancy treatment, its application in solid tumors remains a great challenge. Here, using a pH sensitive benzoic-imine bond and inverse electron-demand Diels-Alder cycloaddition, we prepared magnetic nano-clusters (NCs) armed with responsive PD-1 antibody (aP), which could then bind onto effector T cells due to their PD-1 expression. After adoptive transfer, the magnetization and superparamagnetism of NCs enabled us to magnetically recruit effector T cells and aP simultaneously to tumor sites with MRI guiding...
February 14, 2019: ACS Nano
Jacob R Jokisaari, Canhui Wang, Qiao Qiao, Xuan Hu, David A Reed, Reiner Bleher, Xianghong Luan, Robert F Klie, Thomas G H Diekwisch
Tooth enamel is a hard yet resilient biomaterial that derives its unique mechanical properties from decussating bundles of apatite crystals. To understand enamel crystal nucleation and growth at a nanoscale level and to minimize preparation artifacts, the developing mouse enamel matrix was imaged in situ using graphene liquid cells and atomic resolution scanning transmission electron and cryo-fracture electron microscopy. We report that 1-2nm diameter mineral precipitates aggregated to form larger 5nm particle assemblies within ameloblast secretory vesicles or annular organic matrix subunits...
February 14, 2019: ACS Nano
Xu-Jia Hong, Chun-Lei Song, Yan Yang, Hao-Chong Tang, Guo-Hui Li, Yue-Peng Cai, Hongxia Wang
In this work, we demonstrate cerium (Ce) based metal-organic-frameworks (MOFs) combined with carbon nanotubes (CNTs) to form Ce-MOF/CNT composites as separator coating material in Li-S battery system, which showed excellent electrochemical performance even under high sulfur loading, and much better capacity retention. At the sulfur loading of 2.5 mg/cm2, initial specific capacity of 1021.8 mAh/g at 1C was achieved in the Li-S cell with the Ce-MOF-2/CNT coated separator, which was slowly reduced to 838.8 mAh/g after 800 cycles with a decay rate of only 0...
February 14, 2019: ACS Nano
Shaowei Wang, Wenbo Wu, Purnima Manghnani, Shidang Xu, Yuanbo Wang, Chi Ching Goh, Lai Guan Ng, Bin Liu
Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep tissue and high spatiotemporal precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen (1O2) generation efficiency and large two-photon absorption (2PA) cross section are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that polymerization of small molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1O2 generation efficiency and large 2PA cross section...
February 14, 2019: ACS Nano
Paul S Weiss
No abstract text is available yet for this article.
February 14, 2019: ACS Nano
Peng Li, Jang-Yeon Hwang, Yang-Kook Sun
With the ever-increasing demand for lithium ion batteries (LIBs) with higher energy density, tremendous attention has been paid to design various silicon active materials as alternative electrodes due to its high theoretical capacity (ca. 3579 mAh g-1). However, replacing the commercially utilized graphite totally with silicon is still insurmountable owing to bottlenecks such as low electrode loading and insufficient areal capacity. Thus, in this study, we turn eyes back on enhanced graphite electrode through the cooperation of modified silicon via a novel, facile and scalable blending process...
February 13, 2019: ACS Nano
Xiaotian Zhang, Fu Zhang, Yuanxi Wang, Daniel S Schulman, Tianyi Zhang, Anushka Bansal, Nasim Alem, Saptarshi Das, Vincent H Crespi, Mauricio Terrones, Joan M Redwing
A defect-controlled approach for the nucleation and epitaxial growth of WSe2 on hBN is demonstrated. The WSe2 domains exhibit a preferred orientation of over 95% leading to a reduced density of inversion domain boundaries (IDBs) upon coalescence. First-principles calculations and experimental studies as a function of growth conditions and substrate pre-treatment confirm that WSe2 nucleation density and orientation are controlled by the hBN surface defect density rather than thermodynamic factors. Detailed transmission electron microscopy (TEM) analysis provides support for the role of single-atom vacancies on the hBN surface which trap W atoms and break surface symmetry leading to a reduced formation energy for one orientation of WSe2 domains...
February 13, 2019: ACS Nano
Paul Y Kim, Yige Gao, Yu Chai, Paul D Ashby, Alexander E Ribbe, David A Hoagland, Thomas P Russell
The pair interaction potentials of polymer-grafted silica nanoparticles (NPs) at a liquid surface were determined by scanning electron microscopy, exploiting the nonvolatility of ionic liquids to stabilize the specimens against microscope vacuum. Even at near contact, individual, two-dimensionally well-dispersed NPs were resolved. The potential of mean force, reduced to the pair interaction potential for dilute NPs, was extracted with good accuracy from the radial distribution function as both NP diameter and grafted polymer chain length were varied...
February 13, 2019: ACS Nano
Chuanqiang Zhou, Yuanyuan Ren, Jie Han, Qianqian Xu, Rong Guo
Controllable fabrication of complex chiral nanostructures of functional materials from achiral systems remains a great challenge. Herein, polyaniline (PANI) hollow nanotwists as a complex chiral nanostructure have been prepared by chemical oxidation of aniline in an achiral HCl/i-propanol/water mixed solvent. The chiral oligoaniline twisted nanoribbons generated at the early reaction stage have been established to act as reactive sacrificial templates for inducing the growth of PANI hollow nanotwists. Single-handed PANI hollow nanotwists achieved by tuning the alcohol content in the solvent have been applied to separate several chiral amino acids from their racemic mixtures with high performance, indicating their highly potential for enantioselective separation applications...
February 13, 2019: ACS Nano
Takao Yasui, Takeshi Yanagida, Taisuke Shimada, Kohei Otsuka, Masaki Takeuchi, Kazuki Nagashima, Sakon Rahong, Toyohiro Naito, Daiki Takeshita, Akihiro Yonese, Ryo Magofuku, Zetao Zhu, Noritada Kaji, Masaki Kanai, Tomoji Kawai, Yoshinobu Baba
Researchers have demonstrated great promise for inorganic nanowire use in analyzing cells or intracellular components. Although a stealth effect of nanowires toward cell surfaces allows preservation of the living intact cells when analyzing cells, as a completely opposite approach, the applicability to analyze intracellular components through disrupting cells is also central to understanding cellular information. However, the reported lysis strategy is insufficient for microbial cell lysis due to the cell robustness and wrong approach taken so far ( i...
February 13, 2019: ACS Nano
Donald L Kellis, Christopher Sarter, Brittany L Cannon, Paul H Davis, Elton Graugnard, Jeunghoon Lee, Ryan D Pensack, Theresa Kolmar, Andres Jäschke, Bernard Yurke, William B Knowlton
The excitonic circuitry found in photosynthetic organisms suggests an alternative to electronic circuits, but the assembly of optically active molecules to fabricate even simple excitonic devices has been hampered by the limited availability of suitable molecular scale assembly technologies. Here we have designed and operated a hybrid all-optical excitonic switch comprised of donor/acceptor chromophores and photochromic nucleotide modulators assembled with nanometer scale precision using DNA nanotechnology...
February 13, 2019: ACS Nano
Lindsay K Hill, Joseph A Frezzo, Priya Katyal, Minh Dung Hoang, Zakia Ben Youss, Cynthia Xu, Xuan Xie, Erika Delgado-Fukushima, Youssef Zaim Wadhghiri, Jin Kim Montclare
Engineered proteins provide an interesting template for designing fluorine-19 (19 F) magnetic resonance imaging (MRI) contrast agents, yet progress has been hindered by the unpredictable relaxation properties of fluorine. Herein, we present the biosynthesis of a protein block copolymer, termed "<u>f</u>luorinated <u>t</u>hermo-<u>r</u>esponsive <u>a</u>ssembled <u>p</u>rotein" (F-TRAP), which assembles into a monodisperse nanoscale micelle with interesting 19 F nuclear magnetic resonance relaxation (NMR) properties and the ability to encapsulate and release small therapeutic molecules, imparting potential as a diagnostic and therapeutic (theranostic) agent...
February 13, 2019: ACS Nano
Yuan Xiao, Reza Riahi, Peter Torab, Donna D Zhang, Pak Kin Wong
Collective cell migration plays a pivotal role in development, wound healing, and metastasis, but little is known about the mechanisms and coordination of cell migration in 3D microenvironments. Here, we demonstrate a 3D wound healing assay by photothermal ablation for investigating collective cell migration in epithelial tissue structures. The nanoparticle-mediated photothermal technique creates local hyperthermia for selective cell ablation and induces collective cell migration of 3D tissue structures. By incorporating dynamic single cell gene expression analysis, live cell actin staining, and particle image velocimetry, we show that the wound healing response consists of 3D vortex motion moving toward the wound followed by the formation of multicellular actin bundles and leader cells with active actin-based protrusions...
February 13, 2019: ACS Nano
Xiaoyu Mu, Junying Wang, Yonghui Li, Fujuan Xu, Wei Long, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Haitao Dai, Qiang Liu, Yuanming Sun, Changlong Liu, Xiao-Dong Zhang
Metal nanozyme has attracted wide interest for biomedicine, and a highly catalytic material in physiological environment is highly desired. However, catalytic selectivity of nanozyme is still highly challenged, limiting its wide application. Here, we show a trimetallic (triM) nanozyme with highly catalytic activity and environmental selectivity. Enzyme-mimicked investigations find that triM system possesses multienzyme mimetics activity for removing reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as 1O2, H2O2, •OH, and •NO...
February 12, 2019: ACS Nano
Dae-Kyoung Kim, Seok-Bo Hong, Kwangsik Jeong, Changmin Lee, Hyoungsub Kim, Mann-Ho Cho
This study used a spatially controlled boron doping technique that enables a p-n junction diode to be realized within a single two-dimensional (2D) black phosphorus (BP) nanosheet for high performance photovoltaic application. The reliability of the BP surface and state-of-the-art 2D p-n heterostructure's gated junctions was obtained using the controllable pulsed plasma process technique. Chemical and structural analyses of the boron-doped BP were performed using X-ray photoelectron spectroscopy, transmission electron microscopy, and first-principles density functional theory (DFT) calculations, and the electrical characteristics of a field-effect transistor based on the p-n heterostructure were determined...
February 12, 2019: ACS Nano
Minfeng Huo, Liying Wang, Youwei Wang, Yu Chen, Jianlin Shi
Initiating localized catalytic chemical reactions in tumor microenvironment (TME) can achieve appealing tumor-therapeutic efficacy concurrently with high specificity and desirable biosafety, which is mainly dependent on the high-performance of biomedical nanocatalysts. This report demonstrates that PEGylated single-atom Fe-containing nanocatalysts (PSAF NCs) could effectively trigger the in situ tumor-specific Fenton reaction to generate abundant toxic hydroxyl radicals (•OH) selectively under the acidic TME...
February 12, 2019: ACS Nano
Bishnu P Khanal, Eugene R Zubarev
This manuscript describes a reversible wet chemical process for the tip selective one-dimensional (1D) growth and dissolution of gold nanorods (AuNRs) and gold nanowires (AuNWs). Tip selective dissolution was achieved by oxidation of AuNRs with Au(III)/CTAB complex, whereas the growth of AuNRs was carried out by the reduction of Au(I) ions on AuNRs surface with a mild reducing agent, ascorbic acid (AA). Both the dissolution and growth processes are highly tip selective and proceed exclusively in one dimension...
February 12, 2019: ACS Nano
Haiyan Duan, Pengbo Lyu, Jingjing Liu, Yanli Zhao, Yuxi Xu
The efficient synthesis of crystalline two-dimensional polymers (2DPs) with designed structures and properties is highly desired but remains a considerable challenge. Herein we report the synthesis of two-dimensional polyimide (2DPI) nanosheets via hydrogen bond induced preorganization and subsequent imidization reaction. The formed intermolecular hydrogen bonds can significantly benefit the internal order and in-plane periodicity of 2DPI. The crystalline few-layer 2DPI nanosheets are micrometer-size, solvent dispersible, and thermally stable...
February 12, 2019: ACS Nano
Yan Shen, Huanjun Chen, Ningsheng Xu, Yang Xing, Hao Wang, Runze Zhan, Li Gong, Jinxiu Wen, Chao Zhuang, Xuexian Chen, Ximiao Wang, Yu Zhang, Fei Liu, Jun Chen, Juncong She, Shaozhi Deng
Light-driven electron emission plays an important role in modern optoelectronic devices. However, such a process usually requires a light field either with a high intensity or a high frequency, which is not favor for its implementations and difficult for its integrations. To solve these issues, we propose to combine plasmonic nanostructures with nano-electron-emitters of low work function. In such a heterostructure, hot-electrons generated by plasmon resonances upon light excitation can be directly injected into the adjacent emitter, which can subsequently be emitted into the vacuum...
February 12, 2019: ACS Nano
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