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Dermatology Research and Practice

Amal Aboud Alasmari, Anadel Hassan Hakeem, Fatemah Saleh Bin Saleh, Shahad Yousef Alsaigh, Waleed Al Ajroush, Laila Ali Layqah, Salim Alawi Baharoon
Introduction. Skin manifestations are common in hematology ward patients and can result from infection, malignancy, or chemotherapy. The purpose of this study was to identify the most common dermatological problems encountered in the adult hematology ward at King Abdullah Specialist Children Hospital (KASCH). Methods. This was retrospective chart review of 78 dermatology consultations based on electronic health records for all inpatients in hematology wards at KASCH between January 2016 and December 2017. Data were presented as mean ± SD for continuous variables...
2019: Dermatology Research and Practice
Taisa Rocha Navasconi Berbert, Tatiane França Perles de Mello, Priscila Wolf Nassif, Camila Alves Mota, Aline Verzignassi Silveira, Giovana Chiqueto Duarte, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verziganassi Silveira
The first choice drugs for the treatment of cutaneous and mucocutaneous leishmaniasis are pentavalent antimonials, sodium stibogluconate, or meglumine antimoniate. However, the treatment with these drugs is expensive, can cause serious adverse effects, and is not always effective. The combination of two drugs by different routes or the combination of an alternative therapy with systemic therapy can increase the efficacy and decrease the collateral effects caused by the reference drugs. In this systematic review we investigated publications that described a combination of nonconventional treatment for cutaneous and mucocutaneous with pentavalent antimonials...
2018: Dermatology Research and Practice
Marília Bueno Savacini, Débora Tazinaffo Bueno, Ana Carolina Souza Molina, Ana Caroline Almeida Lopes, Caroline Nogueira Silva, Renata Gomes Moreira, Stephani Almeida, Renata Michelini Guidi, Estela Sant'Ana, Richard Eloin Liebano
Cryolipolysis is the noninvasive treatment of localized fat through cold-induced panniculitis. The purpose of the present study was to evaluate the safety and efficacy of contrast cryolipolysis for subcutaneous-fat reduction. Contrast cryolipolysis mixes the principles of conventional cryolipolysis and periods of heating in accordance with the contrast lipocryolysis process. Twenty-one subjects aged 34 ± 9 years were treated with contrast cryolipolysis in the regions of abdomen and flanks through the Polarys® device...
2018: Dermatology Research and Practice
Nasrin Saki, Shahla Hosseinpoor, Alireza Heiran, Ali Mohammadi, Mehdi Zeraatpishe
Background and Objective: Psoriasis is a common chronic inflammatory skin disorder affecting any age and gender. The clinical presentation of the nail disease depends on the location of the pathology: nail bed or nail matrix. We aimed to compare the therapeutic effects of triamcinolone acetonide iontophoresis (TI) and topical calcipotriol/betamethasone dipropionate in the nail bed and nail matrix involvements of psoriasis using Nail Psoriasis Severity Index (NAPSI). Materials and Methods: In the present bilateral comparison clinical trial, sixteen patients with clinical diagnosis of nail psoriasis were enrolled and randomized to receive six monthly TI treatment sessions either on their right or on the left hand target nails and daily application of topical calcipotriol/betamethasone dipropionate for six months on their other hand...
2018: Dermatology Research and Practice
Mehdi Ghahartars, Shiva Najafzadeh, Shabnam Abtahi, Mohammad Javad Fattahi, Abbas Ghaderi
IL-27 has been shown to have both tumor promoting and suppressing functions. IL-27, with its diverse influences on immune responses, has not been studied extensively in nonmelanoma skin cancers (NMSC), including Squamous and Basal Cell Carcinomas (SCC and BCC), and its roles in tumor initiation, progression, and its probable use in NMSC treatment have yet to be unveiled. A cross-sectional analytical study was designed to investigate the serum levels of IL-27 in NMSC patients in comparison to normal individuals...
2018: Dermatology Research and Practice
Dirk Höfer
Background: Antibacterial clothes are classified as a complementary treatment in line with antisepsis, although meta-studies are unable to find significant improvements of eczemas. Methods: The antibacterial effectiveness of conventional AD clothes was compared across each other by (i) standard suspension tests for the appraisal of antibacterial products and (ii) a real-life setup of affected AD skin using S. aureus colonised artificial skin, to assess if functional clothes are effective under practical wear conditions...
2018: Dermatology Research and Practice
Adane Bitew
Background: Dermatophytosis is a disease of major public health problem around the globe causing a considerable morbidity. Objective: To study the prevalence of dermatophytosis and the spectrum of fungi implicated in causing the infection. Methods: Nail, skin, and scalp scrapings were collected from 318 patients and were used for microscopy and culture study. Fungal pathogens were identified by studying the macroscopic and microscopic characteristics of their colonies...
2018: Dermatology Research and Practice
Giuseppe Giudice, Giorgio Favia, Angela Tempesta, Luisa Limongelli, Michelangelo Vestita
From 2005 to 2010, 20 consecutive patients with fully manifested neurofibromatosis type 1 (NF1) underwent elective neurofibroma resection at our institution (Departments of Plastic Surgery and of Odontostomatology). Specimens were photographed under optical microscope and confocal laser scanning microscopy (CLSM) with ultra-high accuracy of detail, including depth of field. Patients were followed up for a minimum of 4 years and up to a maximum of 12 years, postsurgery. While all nonrecurring lesions showed intense fluorescence, six of the seven lesions with absence of fluorescence under CLSM recurred at a mean of 5...
2018: Dermatology Research and Practice
Debajit Debbarma, Varinder Uppal, Neelam Bansal, Anuradha Gupta
The study was conducted on skin of 24 buffaloes collected from slaughter house. The skin tissues were collected from dorsal, lateral, and ventral parts of head, neck, thorax, abdomen, and tail regions and fixed in 10% neutral buffered formalin. The tissues were processed for paraffin blocks preparation by acetone benzene schedule. The paraffin sections of 5-6  μ m were cut with rotary microtome and stained with hematoxylin and eosin. The sweat glands in buffaloes were of saccular and simple coiled tubular type...
2018: Dermatology Research and Practice
Faisel Abu-Duhier, Vivetha Pooranachandran, Andrew J G McDonagh, Andrew G Messenger, Johnathan Cooper-Knock, Youssef Bakri, Paul R Heath, Rachid Tazi-Ahnini
We report a family from Tabuk, Saudi Arabia, previously screened for Acrodermatitis Enteropathica (AE), in which two siblings presented with typical features of acral dermatitis and a pustular eruption but differing severity. Affected members of our family carry a rare genetic variant, p.Gly512Trp in the SLC39A4 gene which encodes a zinc transporter; disease is thought to result from zinc deficiency. Similar mutations have been reported previously; however, the variable severity within cases carrying the p...
2018: Dermatology Research and Practice
Mehdi Gheisari, Arman Ahmadzadeh, Nilofar Nobari, Behzad Iranmanesh, Nikoo Mozafari
Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of systemic sclerosis are extremely disabling and treatment options are limited. In this study, we aimed to assess the safety and efficacy of autologous fat grafting in the face of patients with systemic sclerosis. We enrolled 16 SSc patients suffering from facial sclerosis and limited mouth opening capacity. Autologous fat injection ranging from 15 to 40 ml was administered per patient, based on their face morphology...
2018: Dermatology Research and Practice
Priyatam Khadka, Soniya Koirala, Januka Thapaliya
The clinicopathological manifestations of cutaneous tuberculosis are diverse. The precise diagnosis is often overlooked, due to clinical presentations as those of cutaneous diseases with different etiology and the relative paucity of the pathogens in the lesions. Meanwhile, almost all of the diagnostic methods confer lower sensitivity and specificities which augments further diagnostic challenges. This article revises the current scenario of the disease's physiopathology and underscores clinicopathological challenges, due to multifaceted presentations of cutaneous tuberculosis, in the diagnosis...
2018: Dermatology Research and Practice
Gerald B Fogarty, Angela Hong, Alex Economides, Pascale Guitera
Lentigo maligna (LM) is a form of melanoma in situ that occurs on exposed, sun-damaged skin; LM can progress to invasive melanoma. Conventional surgical treatment is the preferred management option as it is usually a one-treatment episode and generates a histopathology report that records completion of excision. Some patients may not be surgical candidates due to comorbidities, patient preference, impact on function, and cosmesis or they have failed surgery with a positive margin. Other therapies, including radiotherapy (RT) and topical medicines, may then become appropriate...
2018: Dermatology Research and Practice
Zohreh Tehranchinia, Bita Saghi, Hoda Rahimi
Introduction: Melasma is an acquired pigmentary disorder characterized by hyperpigmented macules and/or patches affecting sun-exposed skin. Tranexamic acid (TA) can reduce melanin content of epidermis. Thus, we conducted this study to evaluate the efficacy and safety of tranexamic acid local infiltration in combination with topical 4% hydroquinone cream compared to topical 4% hydroquinone cream alone in patients with melasma. Material and Methods: This study was a prospective assessor- and analyst-blind, randomized split-face clinical trial which was performed on patients with bilateral malar epidermal melasma...
2018: Dermatology Research and Practice
Mohammad Shahidi-Dadras, Fahimeh Abdollahimajd, Razieh Jahangard, Ali Javinani, Amir Ashraf-Ganjouei, Parviz Toossi
Background: Morphea is an inflammatory disease of the connective tissue that may lead to thickening and hardening of the skin due to fibrosis. The aim of this study was to document magnetic resonance imaging (MRI) changes in patients with linear morphea who were treated with methotrexate (MTX) and high-dose corticosteroid. Methods: This study was conducted on 33 patients from the outpatient's dermatology clinic of our institute, who fulfilled the inclusion criteria...
2018: Dermatology Research and Practice
Kotaro Ito, Saori Masaki, Manabu Hamada, Tetsuo Tokunaga, Hisashi Kokuba, Kenji Tashiro, Ichiro Yano, Shinichiro Yasumoto, Shinichi Imafuku
Several traditional Japanese medicines including Keigairengyoto (KRT) are used to treat acne vulgaris, but there is no robust evidence of their effectiveness. In this study, we examined the effectiveness and safety of KRT in treating acne vulgaris. An open-label, randomized, parallel control group comparison was conducted with a conventional treatment group (adapalene and topical antibiotics; control group) and a KRT group (control treatment plus KRT). The test drugs were administered for 12 weeks to patients (15 to 64 years, outpatient) with inflammatory acne on their face, and the amount of acne at 2, 4, 8, and 12 weeks was measured...
2018: Dermatology Research and Practice
David G Li, Jeffrey M Cohen, Anar Mikailov, Ramone F Williams, Alvaro C Laga, Arash Mostaghimi
Although onychomycosis can be diagnosed clinically, many guidelines still recommend pathologic confirmation of the diagnosis prior to initiation of systemic treatment. We retrospectively reviewed results from 541 toenail clippings (160 by dermatologists, 198 by podiatrists, and 183 by other provider types) sent to the Brigham and Women's Department of Dermatopathology between January 2000 and December 2013 for confirmatory periodic acid-Schiff (PAS) testing of clinically diagnosed onychomycosis. Of these, 93 (58...
2018: Dermatology Research and Practice
Jarso Sara, Yusuf Haji, Achamyelesh Gebretsadik
Introduction: Scabies is one of the common public health problem but neglected parasitic diseases caused by Sarcoptes scabiei var. Methods: A community-based unmatched case control (1 : 2 ratios) study was conducted in East Badewacho District, using collected scabies line listed data and face-to-face interview to assess risk factors during October 23-30, 2016. The data were collected using structured questionnaire, and then the data were coded, entered, cleaned, and analyzed using SPSS statistical software, whereas, line listed data was entered into Microsoft excel for descriptive analyses...
2018: Dermatology Research and Practice
Reem Dina Matzen, Julie Zinck Leth-Espensen, Therese Jansson, Dennis Sandris Nielsen, Marianne N Lund, Steen Matzen
The mechanism behind the biologic actions of honey as a wound remedy has been intensively studied; however, there is no published data regarding any antibacterial effect of honey derived from Danish flora. We surveyed 11 honeys of various Danish floral sources for their antibacterial activity and compared them to a culinary processed commercial honey (Jakobsens) and a raw and a medical grade Manuka ( Leptospermum scoparium ) honey using the agar-well diffusion method. We tested the effect on three gram-positive bacteria (two strains of Staphylococcus aureus and one strain of Staphylococcus epidermidis ) and two gram-negative bacteria ( Pseudomonas aeruginosa and Escherichia coli )...
2018: Dermatology Research and Practice
Jorge Sánchez, Andres Sánchez, Ricardo Cardona
Background: Many patients with chronic spontaneous urticaria (CSU) identify different foods as triggers of their symptoms and frequently make dietary restrictions without enough information. Objective: To explore the diet habits of CSU patients and estimate the clinical impact of the foods most frequently reported to be suspect. Methodology: Patients were interrogated about their clinical history of urticaria. Skin prick test and sIgE serum were done for most frequently reported foods by patients...
2018: Dermatology Research and Practice
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