journal
https://read.qxmd.com/read/38230978/high-density-lipoprotein-related-inflammatory-indices-predict-repeat-revascularization-in-coronary-drug-eluting-stenting
#41
JOURNAL ARTICLE
Xuantong Guo, Ruihuan Shen, Yanni Su, Lihong Ma
Background: HDL-C-related inflammatory indices are potential predictors of repeat revascularization (RR) after coronary drug-eluting stenting. Methods: Multivariable Cox regression with restricted cubic splines and receiver operating curve was used. Results: The median follow-up was 50 months. A total of 521 (35.42%) patients experienced RR. The incidence of RR was positively associated with the monocyte-to-HDL-C ratio, neutrophil-to-HDL-C ratio and lymphocyte-to-HDL-C ratio (log-rank p < 0.05)...
January 17, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38230972/prognostic-value-of-mtss1-gene-expression-on-acute-leukemia-patients-outcome
#42
JOURNAL ARTICLE
Salah Aref, Mohamed Sabry, Nadia El Menshawy, Ahmed Aref, Ahmed El Tantawy, Mohamed Ayed, Ahmed El-Sebaie
Background: This study aimed to evaluate the prognostic value of the MTSS1 gene expression in patients with acute leukemia. Patients & methods: MTSS1 gene expression was quantified in 120 newly diagnosed acute leukemia patients, by quantitative reverse transcription PCR at diagnosis and after induction chemotherapy therapy. Results: Baseline MTSS1 gene expression was significantly higher in acute leukemia patients compared to the control group (p < 0.001). Acute leukemia patients with low baseline MTSS1 gene expression at diagnosis have significantly shorter overall survival and disease-free survival compared with those with higher expression (p < 0...
January 17, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38223950/blood-biomarkers-a-new-solution-to-the-silent-pandemic-of-traumatic-brain-injury
#43
EDITORIAL
Charalampos Tsakiris, Timoleon Siempis, Georgios D Lianos, Labrini Vlachodimitropoulou, Spyridon Voulgaris, George A Alexiou
No abstract text is available yet for this article.
January 15, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38223945/integrative-bioinformatics-analysis-identifies-apob-as-a-critical-biomarker-in-coronary-in-stent-restenosis
#44
JOURNAL ARTICLE
Xinghua Bai, Weizong Zhang, Tao Yu
Aim: Coronary artery disease (CAD) is a major contributor to the worldwide prevalence of cardiovascular disease. In-stent restenosis (ISR) is a common complication which can lead to stent implantation failure, necessitating repeated intervention and presenting a significant obstacle for CAD management. Methods: To accurately assess and determine the hub genes associated with ISR, CAD databases from the Gene Expression Omnibus were utilized and weighted gene coexpression network analysis was employed to identify key genes in blood samples...
January 15, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38214145/development-and-validation-of-a-nomogram-for-predicting-intraoperative-hypotension-in-cardiac-valve-replacement
#45
JOURNAL ARTICLE
Lei Wang, Liqiong Xiao, Lanyue Hu, Xin Chen, Xiaoliang Wang
Background: Cardiac valve replacement risks include intraoperative hypotension, endangering organ perfusion. Our nomogram predicted hypotension risk in valve surgery, guiding early intervention. Methods: Analyzing 561 patients from July to November 2022, we developed a nomogram to predict hypotension in valve replacement patients, validated using data from December 2022 to January 2023 on 241 patients, with robust statistical confirmation. Results: Our study identified age, hypertension, left ventricular ejection fraction and serum creatinine as hypotension predictors...
January 12, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38205594/application-value-of-mirna-182-as-a-biomarker-for-cancer-diagnosis-a-systematic-review-with-meta-analysis
#46
REVIEW
Mengyu Shang, Mengdan Ma, Ganglin Su, Liang Xiao
Aim: This study aims to establish the potential reliability and validity of miRNA-182 as a diagnostic tool in oncology, and hence to contribute to the decision-making process in clinical settings. Materials & methods: To further evaluate the role of miRNA-182 as a cancer biomarker, we conducted a search of the PubMed, Cochrane Library, Wanfang and China National Knowledge Infrastructure databases of existing literature. Conclusion: These results suggest that miRNA-182 could function as a potential molecular marker for cancer detection and diagnosis...
January 11, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38197403/aat-does-it-have-a-place-in-acute-leukemia
#47
JOURNAL ARTICLE
Mehmet H Dogu, Berfin Ozcelik, Yusuf E Akbulut, Mert Kantarci, Ezgi Bektas, Istemi Serin
Aim: In this study, the authors aimed to investigate the change of AAT, its effect on the response to induction and its effects on the treatment process in acute myeloid leukemia and acute lymphoblastic leukemia patients. Materials & methods: This study included 94 patients who were hospitalized and followed up in Istanbul Training and Research Hospital, Hematology Clinic, between October 2019 and December 2021. Results: Patients with a complete response had higher serum AAT levels than those with a non-complete response (p < 0...
January 10, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38197366/relationship-between-platelet-hemoglobin-and-radial-thrombus-in-patients-with-coronary-angiography-via-radial-access
#48
JOURNAL ARTICLE
Sidar Ş Aydın, Emrah Aksakal, İbrahim Saraç, Faruk Aydınyılmaz, Murat Özmen, Oktay Gülcü, Selim Aydemir, Kamuran Kalkan
Aim: To predict the development of radial artery thrombus (RAT) in patients with radial approach coronary angiography of platelet-to-hemoglobin ratio (PHR). Materials & methods: This study was designed to evaluate the relationship between RAT and PHR. A total of 1156 patients who had coronary angiography via the transradial approach between 2021 and 2022 in the authors' center were included in the study. Results: Radial thrombus was detected in 52 (4.5%) patients. PHR was higher in the group with thrombus and was statistically significant...
January 10, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38197316/-tcf21-rs2327429-and-tcf21-rs12190287-are-associated-with-colorectal-cancer-in-a-chinese-population
#49
JOURNAL ARTICLE
Jian-Guo Wang, Xia-Fang Jin, Yi-Min Huang, Zheng-Fen Xu, Shou-Ju Huang, Yingjie Zhu, Ling Ai, Tian Hang
Aims: TCF21 is considered a tumor suppressor gene. This work was designed to explore the associations between TCF21 polymorphisms and colorectal cancer (CRC) susceptibility. Methods: A case-control study was designed with 421 patients with CRC and 469 non-CRC controls. Six tagging single-nucleotide polymorphisms (rs2327429 T>C, rs2327430 T>C, rs2327433 A>G, rs12190287 C>G, rs7766238 G>A and rs4896011 T>A) were genotyped by ligase detection reaction of PCR. Results: TCF21 rs2327429 and rs12190287 polymorphisms were associated with CRC susceptibility in a Chinese Han population...
January 10, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38179996/serum-jkap-reflects-th2-and-th17-cell-levels-and-diabetic-nephropathy-risk-and-severity-in-diabetes-mellitus-patients
#50
JOURNAL ARTICLE
Meili Tong, Changrui Gu, Qiuzhi Yu, Jian Ma
Objective: This study aimed to explore the potency of serum JKAP for estimating diabetic nephropathy risk in diabetes mellitus (DM) patients. Methods: Serum JKAP was detected in 212 DM patients. According to urinary albumin-to-creatinine ratio, DM patients were divided into normoalbuminuria, microalbuminuria and macroalbuminuria groups. Results: JKAP declined in the macroalbuminuria group versus normoalbuminuria group (p < 0.001). In DM patients, JKAP inversely correlated with Th17 cells (p < 0...
January 5, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38179991/performance-of-noninvasive-fibrosis-indices-in-chronic-hepatitis-b-during-pretreatment-and-post-treatment-periods
#51
JOURNAL ARTICLE
Yusuf E Ozdemir, Meryem S Ozdemir, Osman F Bayramlar, Sibel Y Kaya, Rıdvan Karaali, Ilker I Balkan, Bilgul Mete, Gokhan Aygun, Nese Saltoglu, Fehmi Tabak
Background: Pretreatment and post-treatment performances of noninvasive fibrosis indices were determined in patients with chronic hepatitis B. Method: This was a retrospective, single-center study. Results: The best area under the receiver operating characteristic curve values were detected for aspartate aminotransferase-to-alanine aminotransferase ratio (0.685) for ≥F2, Fibrosis Index (FI; 0.703) for ≥F3; FI (0.872) for ≥F4 and FI (0.864) for cirrhosis. After antiviral treatment, the best area under the receiver operating characteristic curve values were detected in aspartate aminotransferase-to-alanine aminotransferase ratio (0...
January 5, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38179966/biomarkers-in-exhaled-breath-condensate-as-fingerprints-of-asthma-chronic-obstructive-pulmonary-disease-and-asthma-chronic-obstructive-pulmonary-disease-overlap-a-critical-review
#52
REVIEW
Behrouz Seyfinejad, Emirhan Nemutlu, Ali Taghizadieh, Maryam Khoubnasabjafari, Sibel A Ozkan, Abolghasem Jouyban
Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap are the third leading cause of mortality around the world. They share some common features, which can lead to misdiagnosis. To properly manage these conditions, reliable markers for early and accurate diagnosis are needed. Over the past 20 years, many molecules have been investigated in the exhaled breath condensate to better understand inflammation pathways and mechanisms related to these disorders. Recently, more advanced techniques, such as sensitive metabolomic and proteomic profiling, have been used to obtain a more comprehensive understanding...
January 5, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38179952/application-of-24-h-respiratory-rate-and-oxygenation-index-variation-to-predict-the-outcome-of-high-flow-nasal-cannula-therapy-in-patients-with-acute-hypoxemic-respiratory-failure-in-a%C3%A2-respiratory-intensive-care-unit
#53
JOURNAL ARTICLE
Jing Ge, Danhong Zhou, Yang Wang, Weiwei Ning, Beilei Zhang, Cheng Chen
Background: An evaluation system is urgently needed to describe early predictors of the outcome of high-flow nasal cannula (HFNC) oxygen therapy in acute hypoxemic respiratory failure (AHRF) patients. Methods: All consecutive AHRF patients in a Respiratory Intensive Care Unit (RICU) receiving HFNC therapy between January 2019 and December 2021 were enrolled. Results: Of the 106 enrolled AHRF subjects, 57 (53.8%) succeeded in HFNC therapy and 49 (46.2%) failed. Being male (p = 0.006), initial respiratory rate oxygenation (ROX) index (p = 0...
January 5, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38415668/biomarkers-paving-the-way-for-diagnosis-prognosis%C3%A2-and-disease-monitoring-welcome-to-volume-18
#54
JOURNAL ARTICLE
Afra Paleel
No abstract text is available yet for this article.
January 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38380988/relation-between-lrg1-and-cd4-t-cells-cognitive-impairment%C3%A2-and-neurological-function-in-patients-with%C3%A2-acute-ischemic-stroke
#55
JOURNAL ARTICLE
Xiao Cheng, Hongen Wei, Yi Liu, Yaxuan Sun, Jianxin Ye, Pengyu Lu, Bin Han
Objective: To assess the relationship between LRG1 and CD4+ T cells, cognitive impairment and neurological function in acute ischemic stroke (AIS). Methods: Plasma LRG1 was detected by ELISA in 175 patients with AIS at baseline, day (D) 1, D7, month (M) 1 and M3. Results: LRG1 was negatively related to Th2 and Treg cells and positively linked to Th17 (all p < 0.05). LRG1 increased from baseline to D1, then decreased until M3 (p < 0.001). LRG1 at each assessment point was increased in patients with cognitive impairment or poor neurological function at M3 versus those without (all p < 0...
January 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38117143/could-serum-hmgb1-levels-be-a-predictor-associated-with-psoriatic-arthritis
#56
JOURNAL ARTICLE
Derya Yildirim, Merve Baykul, Yusuf C Edek, Mehmet Gulengul, Gizem T Alp, Fatma S Eroglu, Esra Adisen, Hamit Kucuk, Abdulsamet Erden, Berna Goker, Kemal Nas, Mehmet A Ozturk
Background/aim: Psoriasis is a chronic autoimmune disease that predominantly affects the skin and musculoskeletal system. We hypothesized that HMGB1, an inflammatory nuclear protein, may play a role in the musculoskeletal involvement of psoriasis. Methods: Forty patients with psoriasis and 45 with psoriatic arthritis were involved in the study; the results were compared with 22 healthy controls. Serum HMGB1 levels were evaluated from peripheral blood samples. Results: Serum HMGB1 levels were found to be significantly higher in patients with psoriasis regardless of joint involvement (p < 0...
December 20, 2023: Biomarkers in Medicine
https://read.qxmd.com/read/38095986/the-emerging-role-of-mir-320a-in-lung-cancer-a-comprehensive-review
#57
REVIEW
Adrija Mohanta, Rajiv R Kumar, Rahul K Singh, Surojit Mandal, Ritu Yadav, Rinku Khatkar, Uttam Sharma, Vivek Uttam, Manjit K Rana, Amrit Ps Rana, Aklank Jain
A specialized biomarker(s) for lung cancer is imperative owing to its high mortality. Continuing our earlier work demonstrating the role of miR-320a as a tumor suppressor, here we discuss the most recent updates on miR-320a in lung cancer pathogenesis. We found that miR-320a modulates levels of diverse cancer-associated molecules and signaling pathways, and is also involved in modulating the immune microenvironment of lung cancer during its pathogenesis. We also discuss how miR-320a encapsulated in exosomes inhibits invasive phenotypes of lung cancer...
December 14, 2023: Biomarkers in Medicine
https://read.qxmd.com/read/38095985/low-expression-of-got2-promotes-tumor-progress-and-predicts-poor-prognosis-in-hepatocellular-carcinoma
#58
JOURNAL ARTICLE
Qiuli Liang, Shun Liu, Fuqiang Yin, Meiliang Liu, Lijun Wang, Erna Guo, Lei Lei, Liuyu Wu, Yu Yang, Di Zhang, Xiaoyun Zeng
Background: To explore the biological function and the underlying mechanisms of GOT2 in hepatocellular carcinoma (HCC). Materials & methods: The expression level and prognostic value of GOT2 were examined using International Cancer Genome Consortium and International Cancer Proteogenome Consortium databases. The cell counting kit-8 method, clone formation, Transwell® assays and western blotting were used to evaluate the effects of GOT2 on the biological function and autophagy of HCC cells. Results: The expression of GOT2 was downregulated in HCC tissues and correlated with poor prognosis of HCC patients...
December 14, 2023: Biomarkers in Medicine
https://read.qxmd.com/read/38095984/diagnostic-value-of-serum-autotaxin-level-in-colorectal-cancer
#59
JOURNAL ARTICLE
Abdurrahman Başpınar, Didem Özkan, Serhat Tokgöz, Alper Bilal Özkardeş, İsmail Oskay Kaya
Background: Autotaxin (ATX) is a nucleotide enzyme linked to cell growth, differentiation and migration. This study investigated serum levels of ATX in colorectal cancer (CRC). Methods: The study involved stage I-III CRC diagnosed between December 2020 and 2021, excluding those with neoadjuvant or adjuvant therapy, or metastasis. Healthy volunteers were controls. Serum ATX levels were measured by ELISA and compared. Results: This study included 129 patients (91 in the patient group and 38 in the control group)...
December 14, 2023: Biomarkers in Medicine
https://read.qxmd.com/read/38085167/neutrophil-to-serum-iron-ratio-as-a-promising-inflammatory-biomarker-for-acute-myocardial-infarction-and-gensini-score
#60
JOURNAL ARTICLE
Jiedong Ma, Xiaojin Liu, Hongqi Zhang, Yufei Chen, Jiamin Tian, Wei Shen
Background: We aim to investigate whether the neutrophil-to-serum iron ratio (N/SI) is a promising biomarker for acute myocardial infarction group (AMI) and Gensini score. Methods: A total of 263 patients were enrolled and divided into four groups. The Gensini score was used to gauge the severity of coronary artery stenosis, and inflammatory biomarkers were calculated. Results: The N/SI was substantially higher in the AMI group than those in other groups, and N/SI was an independent risk factor for AMI. In ROC analyses, N/SI had the highest area under curve (AUC) for AMI among those inflammatory biomarkers...
December 12, 2023: Biomarkers in Medicine
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