journal
https://read.qxmd.com/read/38411079/emerging-roles-of-hotair-lncrna-in-the-pathogenesis-and-prognosis-of-cardiovascular-diseases
#21
REVIEW
Habib Haybar, Hakimeh Hadi, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki
Highlights HOTAIR, a long noncoding RNA, plays a role in the regulation of proteins involved in the pathogenesis of cardiovascular disease. Furthermore, it has been identified as a biomarker of this type of disease. Several factors and cells contribute to atherosclerosis, a progressive disease. However, the prognosis of HOTAIR in this disease varies depending on the path in which it plays a role. For this condition, there is no single prognosis to consider.
February 27, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38375795/predictive-role-of-neutrophil-to-platelet-ratio-in-futile-recanalization-of-patients-after-endovascular-therapy
#22
JOURNAL ARTICLE
Bing-Hu Li, Li-Rong Wang, Jie Huang, Shu Yang, Bin Huang, Li-Jun Jia, Sen Zhou, Fu-Qiang Guo, Jian-Hong Wang, Neng-Wei Yu
Aim: To explore the association between the neutrophil-to-platelet ratio (NPR) and futile recanalization (FR) in patients with acute ischemic stroke due to large vascular occlusions after endovascular therapy (EVT). Methods: FR after EVT was defined as a poor 90-day prognosis (modified Rankin scale [mRS] score ≥3) despite successful reperfusion (modified thrombolysis in cerebral infarction grade 2b-3). Patients were divided into high NPR (>35; n = 115) and low NPR (≤35; n = 81) groups...
February 20, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38358345/b-type-natriuretic-peptide-levels-at-admission-predict%C3%A2-the-prognosis-of-patients-with-infective-endocarditis-undergoing-cardiac-surgery
#23
JOURNAL ARTICLE
Ning Sun, Junyong Zhao, Wenjian Luo, Xiaolin Luo, Shaofa Wu, Zelan Wang, Pengda Li, Jia Li, Renjie Zhou, Shulin Ou, Zhexue Qin
Purpose: The objective of this study was to explore the relationship between elevated B-type natriuretic peptide (BNP) levels and the prognosis of patients with infective endocarditis (IE) undergoing cardiac surgery. Methods: In total, 162 IE patients with recorded BNP levels upon admission were included in the present study. The primary end point was all-cause mortality. Results: Multivariate Cox analysis revealed a significant association between log BNP and all-cause mortality. Kaplan-Meier analysis revealed a poorer prognosis for patients with BNP levels ≥ the 75th percentile...
February 15, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38358344/association-between-serum-homocysteine-and-postoperative-acute-kidney-injury-in-patients-undergoing-cardiac-surgery
#24
JOURNAL ARTICLE
Zheng-Rong Li, Cun-Fei Liu, De-Qun Guo, Yan-Jin Wei
Background: To explore the relationship between homocysteine (Hcy) and cardiac surgery-associated acute kidney injury (AKI). Methods: A total of 944 patients who underwent cardiac surgery were enrolled. The association between Hcy levels and the risk of cardiac surgery-associated AKI was evaluated. Results: A total of 135 patients were diagnosed with AKI and the prevalence of AKI was 14.30%. The AKI group had significantly higher levels of Hcy compared with the non-AKI group (16.90 vs 13.56 umol/l; p < 0...
February 15, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38334412/potential-clinical-significance-of-aldh3b1-in-auxiliary-diagnosis-of-gastric-cancer
#25
JOURNAL ARTICLE
Chenxue Tang, Jing Xu, Ming Zheng, Dongchen Qian, Zhihua Gao, Xian Li, Weiwei Zhang
Objective: This research aimed to explore a diagnostic method based on serum ALDH3B1 and to evaluate the clinical diagnostic efficacy in gastric cancer (GC) by comparing it with the traditional GC diagnostic method, the carcinoembryonic protein (CEA) assay. Methods: Serum samples were collected from 70 healthy volunteers and various patients (GC: 76, benign gastric lesions: 20, postoperative: 37, recurrence: 56). The diagnostic efficacy of serum ALDH3B1 , CEA and the co-diagnosis were evaluated by receiver operating characteristic curve...
February 9, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38334411/platelet-to-lymphocyte-ratio-and-lymphocyte-to-monocyte-ratio-in-glaucoma-a-meta-analysis
#26
REVIEW
Shu-Han Chuang, Cheng-Hsien Chang
Aim: To explore the association between two systemic inflammation markers, platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), and glaucoma. Materials & methods: The authors searched PubMed, Embase and the Cochrane Library for eligible studies comparing PLR and LMR levels in glaucoma patients and healthy controls. Results: Analysis revealed that glaucoma patients exhibited significantly elevated PLR levels and reduced LMR compared with nonglaucoma controls. These findings were consistent across various glaucoma types, with the exception of secondary glaucoma, where the association with PLR was less significant...
February 9, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38323551/comparison-of-the-effect-of-uric-acid-albumin-ratio-on-coronary-slow-flow-with-other-inflammation-based-markers
#27
JOURNAL ARTICLE
Kenan Toprak, Kaya Özen, Tolga Memioğlu, Mehmet İnanır, Mustafa Kaplangöray, Selahattin Akyol, Mustafa B Tascanov, Asuman Biçer, Recep Demirbağ
Background: Many inflammation-based markers (IBMs) have been shown to be closely related to coronary slow flow (CSF), but the effect of the uric acid/albumin ratio (UAR) on CSF and its relationship with other IBMs are not clearly known. In this study, we aimed to compare the effects of UAR and other IBMs on CSF. Methods: After the exclusion criteria, 126 patients with CSF detected on coronary angiography and 126 subjects with normal coronary flow as the control group were included in the study. Results: UAR was determined as an independent predictor for CSF...
February 7, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38305225/assessment-of-biomarker-stability-and-assay-performance-parameters-for-medical-diagnosis-a-case-study-of-diagnosis-of-major-depressive-disorder
#28
JOURNAL ARTICLE
Mike Jentsch, Barry van der Strate, Marjolein Meddens, Marcus Meddens, Robert Schoevers
Aim: Assessing the stability profiles and assay performance of 24 biomarker assays in 32 biomarker/body fluid combinations identified as relevant for prediction of major depressive disorder. Materials & methods: Combinations were tested for stability and assay performance with ELISA at different storage and freeze-thaw conditions in pooled samples of 40 patients. Results: Stability and assay performance issues were found in almost all cases except three biomarkers in urine and three in serum. Conclusion: This study shows that, to produce reliable measurement data, assessments of stability and assay performance are essential...
February 2, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38456353/lipid-accumulation-product-is-a-valid-predictor-of-hepatic-steatosis-and-nonalcoholic-fatty-liver-disease
#29
JOURNAL ARTICLE
Qiaoli Huang, Xuying Tan, Qiongmei Wu, Hanqing Zhao, Hangjun Chen, Xinxue Yu, Jinting Wang, Xueyi Huang, Yurong Huang, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
Aims: To evaluate and compare lipid accumulation product (LAP) with alanine aminotransferase (ALT), aspartate aminotransferase (AST), visceral adiposity index (VAI) and triglyceride-glucose index (TyG) as biomarkers for hepatic steatosis and nonalcoholic fatty liver disease (NAFLD). Methods: LAP, ALT, AST, VAI and TyG were measured in 52 biopsy-proven NAFLD patients and 21 control subjects. Additionally, LAP was also measured in 448 ultrasound-proven NAFLD patients and 1009 control subjects. Results: LAP was positively associated with hepatic steatosis and inflammation in biopsy-proven NAFLD...
February 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38440872/c-reactive-protein-to-albumin-ratio-may-predict-in-hospital-mortality-in-non-st-elevation-myocardial-infarction
#30
JOURNAL ARTICLE
Tuğba S Menekşe, İlker Kaçer, Muhammet Hacımustafaoğlu, Murat Gül, Can Ateş
Objective: The authors investigated the value of novel inflammatory markers, systemic immune-inflammation index and C-reactive protein to albumin ratio (CAR), to predict in-hospital mortality in patients with non-ST elevation myocardial infarction (NSTEMI). Materials & methods: A total of 308 patients who underwent percutaneous coronary intervention because of NSTEMI were retrospectively included in the study. Killip classification, Thrombolysis in Myocardial Infarction score, SYNTAX score, and CAR and systemic immune-inflammation index values were calculated...
February 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38380989/meta-analysis-of-initial-natriuretic-peptides-in-the-setting-of-sepsis-induced-myocardial-dysfunction
#31
REVIEW
Boyong He, Xin Wang, Liguo Shi, Hongbin Cheng, Luyi Zhao
Aim: To investigate the association of initial brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) with the detection of sepsis-induced myocardial dysfunction (SIMD) in the setting of Sepsis 3.0. Methods: Three databases were searched to analyze initial BNP and NT-proBNP levels between SIMD and non-SIMD groups. Results: Eighteen studies were included, most of which defined SIMD based on echocardiography. The SIMD group exhibited higher initial BNP and NT-proBNP levels in blood. NT-proBNP higher than a certain cutoff value (>3000 pg/ml) was an independent risk factor for SIMD and its accuracy for SIMD diagnosis was moderate (pooled area under the curve: 0...
February 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38235565/role-of-inflammation-following-an-acute-myocardial-infarction-design-of-infinity
#32
JOURNAL ARTICLE
Andreas Mitsis, Panayiotis Avraamides, John Lakoumentas, Michaela Kyriakou, Stefanos Sokratous, Georgia Karmioti, Michail Drakomathioulakis, Konstantinos C Theodoropoulos, Athina Nasoufidou, Alexandros Evangeliou, Vassilios Vassilikos, Nikolaos Fragakis, Antonios Ziakas, Stergios Tzikas, George Kassimis
After a myocardial infarction, the inflammatory response is connected to major adverse outcomes such as ischemia-reperfusion injury, adverse cardiac remodeling, infarct size and poor prognosis. INFlammatIoN amI sTudY (INFINITY) is a multicenter, prospective, observational, cohort study designed to investigate the prognostic role of the cytokines IL-6, IL-10, IL-18 and IL-17 and the adipokines leptin, apelin and chemerin in patients with acute coronary syndrome. The study will test if these inflammatory biomarkers reflect different clinical manifestations of coronary artery disease and have a prognostic role in a 6-month follow-up period...
January 18, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38235564/predictive-value-of-blood-biomarkers-in-elderly-patients-with-non-small-cell-lung-cancer
#33
JOURNAL ARTICLE
Lianghua Guo, Bin Song, Jianhong Xiao, Hui Lin, Junhua Chen, Baoren Jian
Aim: Whether GRHL1 can be considered as a potential biomarker for screening non-small-cell lung cancer (NSCLC) is still uncertain. We aimed to investigate the value of circulating blood GRHL1 on detecting NSCLC in an older population. Materials & methods: Diagnostic models from 351 older patients with NSCLC were constructed to assess the predictive value of blood GRHL1 on distinguishing NSCLC. Results: We observed that GRHL1 (odds ratio: 3.25; 95% CI: 1.70-6.91; p < 0.001) maintained a strong relationship with an elevated rate of NSCLC after adequate clinical confounding factors were controlled for...
January 18, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38235562/can-c-reactive-protein%C3%A2-be-used-as-a-surrogate-marker-of-il-6-in-a-broad-array-of-clinical-entities
#34
JOURNAL ARTICLE
Syed B Ali, Amelia Cecchin, Cristina Lucchesi, Trishni Putty, Suzanne Edwards, Tina Petrou, Penelope Coates, Antonio Ferrante, Phillippa A Pucar, Jovanka King, Tatjana Banovic
Background: C-reactive protein (CRP) is commonly performed, whereas cytokine testing is limited to research. Aims: To determine CRP correlation to cytokines IL-6, IL-1β and TNF-α. Results:  Consecutive samples (n = 307) were collected over 24 h. Ninety-six patients (31%) had acute infections, and 23 patients (7.5%) had autoimmune or inflammatory disease presentations. A strong correlation between CRP and two IL-6 assays (r = 0.74 and r = 0.71; p < 0...
January 18, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38230984/impact-of-estrogen-and-progesterone-receptor-expression-on-the-incidence-of-endometrial-polyps
#35
JOURNAL ARTICLE
Cuiyun Yan, Chunping Xing, Tao Wei, Hui Zhou, Hua Wang, Tao Liu, Jiefang Gao
Aim: We studied the association of estrogen receptor (ER) and progesterone receptor (PR) with endometrial polyp (EP) formation. Methods: A total of 129 EP patients and an equal number of disease-free women were evaluated for ER and PR expression in endometrial tissues. Correlation with EP incidence was analyzed, as well as diagnostic value via receiver operating characteristic curve. Results: ER expression was higher and PR was lower in patients than in controls (p < 0.01). ER levels positively correlated with EP incidence, and PR negatively (p < 0...
January 17, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38230979/dysregulation-of-mirna-expression-in-patients-with-chronic-myelogenous-leukemia-at-diagnosis-a-systematic-review
#36
REVIEW
Mohammad Parsa-Kondelaji, Maryam Musavi, Faezeh Barzegar, Neda Abbasian, Mehrdad Rostami, Mohammad R Seyedtaghia, Seyyed S Hashemi, Mahdiyeh Modi, Banafsheh Nikfar, Amir A Momtazi-Borojeni
Aim: The present systematic review aimed to explore miRNAs as a potential biomarker for early diagnosis of chronic myeloid leukemia (CML). Materials & methods: A systematic search was conducted in three electronic databases, including Web of Science, Scopus, and PubMed, to obtain relevant articles investigating the alteration of miRNA expression in patients with CML. Results: The authors found miRNAs whose expression changes are effective in the induction of CML disease. Among them, miR-21 and miR-155 were identified as the most common miRNAs with increased expression and miR-150 and miR-146 as the most common miRNAs with decreased expression...
January 17, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38230978/high-density-lipoprotein-related-inflammatory-indices-predict-repeat-revascularization-in-coronary-drug-eluting-stenting
#37
JOURNAL ARTICLE
Xuantong Guo, Ruihuan Shen, Yanni Su, Lihong Ma
Background: HDL-C-related inflammatory indices are potential predictors of repeat revascularization (RR) after coronary drug-eluting stenting. Methods: Multivariable Cox regression with restricted cubic splines and receiver operating curve was used. Results: The median follow-up was 50 months. A total of 521 (35.42%) patients experienced RR. The incidence of RR was positively associated with the monocyte-to-HDL-C ratio, neutrophil-to-HDL-C ratio and lymphocyte-to-HDL-C ratio (log-rank p < 0.05)...
January 17, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38230972/prognostic-value-of-mtss1-gene-expression-on-acute-leukemia-patients-outcome
#38
JOURNAL ARTICLE
Salah Aref, Mohamed Sabry, Nadia El Menshawy, Ahmed Aref, Ahmed El Tantawy, Mohamed Ayed, Ahmed El-Sebaie
Background: This study aimed to evaluate the prognostic value of the MTSS1 gene expression in patients with acute leukemia. Patients & methods: MTSS1 gene expression was quantified in 120 newly diagnosed acute leukemia patients, by quantitative reverse transcription PCR at diagnosis and after induction chemotherapy therapy. Results: Baseline MTSS1 gene expression was significantly higher in acute leukemia patients compared to the control group (p < 0.001). Acute leukemia patients with low baseline MTSS1 gene expression at diagnosis have significantly shorter overall survival and disease-free survival compared with those with higher expression (p < 0...
January 17, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38223950/blood-biomarkers-a-new-solution-to-the-silent-pandemic-of-traumatic-brain-injury
#39
EDITORIAL
Charalampos Tsakiris, Timoleon Siempis, Georgios D Lianos, Labrini Vlachodimitropoulou, Spyridon Voulgaris, George A Alexiou
No abstract text is available yet for this article.
January 15, 2024: Biomarkers in Medicine
https://read.qxmd.com/read/38223945/integrative-bioinformatics-analysis-identifies-apob-as-a-critical-biomarker-in-coronary-in-stent-restenosis
#40
JOURNAL ARTICLE
Xinghua Bai, Weizong Zhang, Tao Yu
Aim: Coronary artery disease (CAD) is a major contributor to the worldwide prevalence of cardiovascular disease. In-stent restenosis (ISR) is a common complication which can lead to stent implantation failure, necessitating repeated intervention and presenting a significant obstacle for CAD management. Methods: To accurately assess and determine the hub genes associated with ISR, CAD databases from the Gene Expression Omnibus were utilized and weighted gene coexpression network analysis was employed to identify key genes in blood samples...
January 15, 2024: Biomarkers in Medicine
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