journal
https://read.qxmd.com/read/36644017/unmet-needs-for-management-of-drug-resistant-infections-low-and-middle-income-countries-viewpoint
#21
JOURNAL ARTICLE
Monica Sharma, Kamini Walia, Nitin Bansal
Drug-resistant infections are a serious threat globally which demands cost-effective solutions to meet the unmet needs in their diagnosis and treatment. Gram-negative pathogens, drug-resistant tuberculosis, and multidrug-resistant Salmonella typhi have been reported as cause of resistant infections in developing countries. Here, we discuss the priority pathogens and conditions for which feasible solutions adaptable to low-resource settings are required to address the antimicrobial resistance in pathogens. These solutions will be helpful in containing the spread of antimicrobial resistance and better patient outcomes...
2022: Drug Target Insights
https://read.qxmd.com/read/36636735/mrsa-carriage-among-healthcare-workers-in-a-vietnamese-intensive-care-unit-a-prospective-cohort-study
#22
JOURNAL ARTICLE
Thuy B Duong, Minh C Duong, James I Campbell, Hoang V M Nguyen, Hien H Nguyen, Hanh T B Bui, Chau V V Nguyen, Anita Heywood
BACKGROUND: Little is known about the magnitude and patterns of methicillin-resistant Staphylococcus aureus (MRSA) carriage among intensive care unit (ICU) healthcare workers (HCWs), especially in lower-middle-income countries like Vietnam. MATERIALS AND METHODS: A prospective cohort study was conducted on HCWs working in the adult ICU of the Hospital for Tropical Diseases in Vietnam between October 28 and December 20, 2019. These HCWs included physicians, nurses, and nursing assistants who were responsible for all essential medical activities and basic patient care...
2022: Drug Target Insights
https://read.qxmd.com/read/36600886/amr-research-a-perspective-from-personal-experience
#23
EDITORIAL
Vijay Kothari
No abstract text is available yet for this article.
2022: Drug Target Insights
https://read.qxmd.com/read/36582782/success-of-14-day-triple-and-quadruple-therapy-for-the-control-of-helicobacter-pylori-infections-in-kohat-district
#24
JOURNAL ARTICLE
Syed Fahim Shah, Sohail Aziz Paracha, Waheed Ullah, Iqbal Muhammad, Somaid Iqbal, Aisha Gul, Mudassir Hussain, Hafiz Ullah, Sadir Zaman
INTRODUCTION: Helicobacter pylori is an important medical pathogen present in more than half of the world’s population. Various treatment regimen are in use for the eradication of H. pylori , but due to the emergence of antibiotic resistance, its management is a big issue for clinicians. METHODS: In this study all suspected cases that had visited District Headquarters Hospital Kohat were considered for screening of H. pylori infections. Preliminary information about their age, gender, general health conditions, occupation, etc...
2022: Drug Target Insights
https://read.qxmd.com/read/36582781/exploring-the-inhibitory-mechanisms-of-indazole-compounds-against-sah-mtan-mediated-quorum-sensing-utilizing-qsar-and-docking
#25
JOURNAL ARTICLE
Sisir Nandi, Mohit Kumar, Rashmi Kumari, Aaruni Saxena
The world is under the great threat of antimicrobial resistance (AMR) leading to premature deaths. Microorganisms can produce AMR via quorum sensing mechanisms utilizing S -adenosyl homocysteine/methylthioadenosine nucleosidase (SAH/MTAN) biosynthesis. But there is no specific drug developed to date to stop SAH/MTAN, which is a crucial target for the discovery of anti-quorum sensing compound. It has been shown that indazole compounds cause inhibition of SAH/MTAN-mediated quorum sensing, but the biochemical mechanisms have not yet been explored...
2022: Drug Target Insights
https://read.qxmd.com/read/36479338/antimicrobial-resistance-surveillance-system-mapping-in-different-countries
#26
JOURNAL ARTICLE
Ramendra Pati Pandey, Riya Mukherjee, Chung-Ming Chang
No abstract text is available yet for this article.
2022: Drug Target Insights
https://read.qxmd.com/read/36458152/understanding-the-environmental-drivers-of-clinical-azole-resistance-in-aspergillus-species
#27
REVIEW
Pooja Sen, Mukund Vijay, Shweta Singh, Saif Hameed, Pooja Vijayaraghavan
Aspergilli are ubiquitous fungal pathogens associated with severe life-threatening infections, especially in immunocompromised patients. Azoles are the first line of defence in the fight against most Aspergillus -related infections. However, resistance to these therapeutic compounds has developed, which is mainly due to the existence of mutations in lanosterol 14 alpha-demethylase (Cyp51A), a crucial enzyme in the pathway that produces ergosterol and is the target of azole antifungals. Azole-based antifungal medications are ineffective because of infections brought on by azole-resistant Aspergillus species, leading to a high fatality rate...
2022: Drug Target Insights
https://read.qxmd.com/read/36415217/redefining-genomic-view-of-clostridioides-difficile-through-pangenome-analysis-and-identification-of-drug-targets-from-its-core-genome
#28
JOURNAL ARTICLE
Nikita Chordia Golchha, Anand Nighojkar, Sadhana Nighojkar
INTRODUCTION: Clostridioides difficile infection (CDI) is a leading cause of gastrointestinal infections and in the present day is a major concern for global health care system. The unavailability of specific antibiotics for CDI treatment and its emerging cases worldwide further broaden the challenge to control CDI. METHODS: The availability of a large number of genome sequences for C. difficile and many bioinformatics tools for genome analysis provides the opportunity for in silico pangenomic analysis...
2022: Drug Target Insights
https://read.qxmd.com/read/36304435/the-association-of-esbl-escherichia-coli-with-mortality-in-patients-with-escherichia-coli-bacteremia-at-the-emergency-department
#29
JOURNAL ARTICLE
Pariwat Phungoen, Jessada Sarunyaparit, Korakot Apiratwarakul, Lumyai Wonglakorn, Atibordee Meesing, Kittisak Sawanyawisuth
No abstract text is available yet for this article.
January 2022: Drug Target Insights
https://read.qxmd.com/read/35360670/anatomical-and-functional-responses-to-single-brolucizumab-injection-in-neovascular-age-related-macular-degeneration-patients-not-responding-to-antiangiogenics-a-case-series
#30
JOURNAL ARTICLE
Silvio Zuccarini, Fabrizio Puce, Alessandro Crisà
No abstract text is available yet for this article.
January 2022: Drug Target Insights
https://read.qxmd.com/read/35309848/erythrodermic-psoriasis-and-palmoplantar-hyperkeratosis-successfully-treated-with-secukinumab-a-case-report
#31
Martino Carriero
No abstract text is available yet for this article.
January 2022: Drug Target Insights
https://read.qxmd.com/read/34871336/hexarelin-modulates-lung-mechanics-inflammation-and-fibrosis-in-acute-lung-injury
#32
JOURNAL ARTICLE
Vanessa Zambelli, Laura Rizzi, Paolo Delvecchio, Elena Bresciani, Emanuele Rezoagli, Laura Molteni, Ramona Meanti, Maria Serena Cuttin, Giorgio Bovo, Silvia Coco, Robert J Omeljaniuk, Vittorio Locatelli, Giacomo Bellani, Antonio Torsello
No abstract text is available yet for this article.
January 2021: Drug Target Insights
https://read.qxmd.com/read/34803374/clinical-factors-predictive-of-appropriate-treatment-in-copd-a-community-hospital-setting
#33
REVIEW
Sukanya Tongdee, Bundit Sawunyavisuth, Wattana Sukeepaisarnjaroen, Watchara Boonsawat, Sittichai Khamsai, Kittisak Sawanyawisuth
No abstract text is available yet for this article.
January 2021: Drug Target Insights
https://read.qxmd.com/read/34785884/the-role-of-patient-preferences-in-adherence-to-treatment-in-chronic-disease-a-narrative-review
#34
REVIEW
Serena Losi, Cesare Celeste Federico Berra, Riccardo Fornengo, Dario Pitocco, Giovanni Biricolti, Marco Orsini Federici
No abstract text is available yet for this article.
January 2021: Drug Target Insights
https://read.qxmd.com/read/33840996/hash-0x76644b8
#35
REVIEW
Ana H de A Morais, Amanda F de Medeiros, Isaiane Medeiros, Vanessa C O de Lima, Anna B S Luz, Bruna L L Maciel, Thaís S Passos
No abstract text is available yet for this article.
January 2021: Drug Target Insights
https://read.qxmd.com/read/33840995/corticosteroid-treatment-reduces-headache-in-eosinophilic-meningitis-a-systematic-review
#36
REVIEW
Sittichai Khamsai, Kittisak Sawanyawisuth, Vichai Senthong, Panita Limpawattana, Jarin Chindaprasirt, Pewpan M Intapan, Wanchai Maleewong, Somsak Tiamkao, Verajit Chotmongkol, Chetta Ngamjarus
No abstract text is available yet for this article.
January 2021: Drug Target Insights
https://read.qxmd.com/read/33510571/interaction-of-drugs-with-lipid-raft-membrane-domains-as-a-possible-target
#37
REVIEW
Hironori Tsuchiya, Maki Mizogami
No abstract text is available yet for this article.
2020: Drug Target Insights
https://read.qxmd.com/read/33132696/targeting-streptococcus-pneumoniae-udp-glucose-pyrophosphorylase-ugpase-in-vitro-validation-of-a-putative-inhibitor
#38
JOURNAL ARTICLE
Monica Sharma, Swati Sharma, Pallab Ray, Anuradha Chakraborti
Background: Genome plasticity of Streptococcus pneumoniae is responsible for the reduced efficacy of various antibiotics and capsular polysaccharide-based vaccines. Therefore, targets independent of capsular types are sought to control the pneumococcal pathogenicity. UDP-glucose pyrophosphorylase (UGPase) is one such desired candidate being responsible for the synthesis of UDP-glucose, a sugar precursor in capsular biosynthesis and metabolic Leloir pathway. Being crucial to pneumococcal pathobiology, the effect of UGPase inhibition on virulence was evaluated in vitro...
2020: Drug Target Insights
https://read.qxmd.com/read/33132695/prevalence-of-multidrug-resistant-and-extended-spectrum-beta-lactamase-esbl-producing-gram-negative-bacilli-a-meta-analysis-report-in-ethiopia
#39
REVIEW
Mengistu Abayneh, Teshale Worku
Multidrug-resistant (MDR) extended-spectrum beta-lactamase (ESBL)-producing bacterial isolates have emerged as a global threat to human health. Little is known about the overall prevalence of multidrug resistance profile and ESBL-producing gram-negative bacilli (GNB) in Ethiopia. Therefore, this meta-analysis was performed to produce proportional estimates of multidrug resistance and ESBL-producing GNB in Ethiopia. A web-based search was conducted in PubMed, Google Scholar, Research Gate, Scopus and other databases...
2020: Drug Target Insights
https://read.qxmd.com/read/33132694/paradoxical-bronchoconstriction-caused-by-%C3%AE-2-adrenoceptor-agonists
#40
JOURNAL ARTICLE
Khadija Ayed, Islam Latifa Hadj Khalifa, Salma Mokaddem, Saloua Ben Khamsa Jameleddine
INTRODUCTION: Salbutamol and terbutaline are short-acting β2 adrenergic agonists that produce bronchial smooth muscle relaxation and are widely used in obstructive pulmonary diseases. Nevertheless, their use has been the cause of a paradoxical bronchoconstriction, which is a rare and potentially serious adverse reaction. The aim of this study is to report a case of paradoxical bronchoconstriction caused by β2 adrenergic agonists. METHODS: This case is about a 50-year-old asthmatic patient who describes a history of repeated acute asthma attacks after salbutamol inhalation or terbutaline nebulization...
2020: Drug Target Insights
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